• novo
  • Apicomplexan parasites causing these lethal diseases are deficient in pyrimidine salvage, suggesting that selective inhibition of de novo pyrimidine biosynthesis can lead to a severe loss of uridine 5'-monophosphate (UMP) and thymidine 5'-monophosphate (dTMP) pools, thereby inhibiting parasite RNA and DNA synthesis. (blogspot.com)
  • Generally UMP synthase is involved in the formation of UMP by adding ribose-5-monophosphate ring into the orotic acid in de novo synthesis of pyrimidine. (medicalrealm.net)