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  • novo
  • Apicomplexan parasites causing these lethal diseases are deficient in pyrimidine salvage, suggesting that selective inhibition of de novo pyrimidine biosynthesis can lead to a severe loss of uridine 5'-monophosphate (UMP) and thymidine 5'-monophosphate (dTMP) pools, thereby inhibiting parasite RNA and DNA synthesis. (blogspot.com)
  • Generally UMP synthase is involved in the formation of UMP by adding ribose-5-monophosphate ring into the orotic acid in de novo synthesis of pyrimidine. (medicalrealm.net)
  • cytosine
  • Floxuridine (FUDR) Cytarabine (Cytosine arabinoside) 6-azauracil (6-AU) Pyrimidine Fluorouracil Floxuridine Gemcitabine Pyrimidine antimetabolites are commonly used to treat cancer by interfering with DNA replication. (wikipedia.org)
  • Of the many difficulties encountered by those in the field, the most frustrating has been the failure to find any way of properly joining the pyrimidine nucleobases - cytosine and uracil - to ribose (Fig. 1a). (wordnik.com)
  • To Simon and Cyclefree who hold such credulous views about evolution, I wonder if they have considered the origin of pyrimidine nucleotides, especially cytosine - has it really come from outer space as the wildest contemporary theories suggest? (wordnik.com)
  • inhibitors
  • To improve the fit, researchers led by chemical biologist Nathanael Gray, PhD, prepared a group of inhibitors with a different structural scaffold, known as a pyrimidine core, which, it was thought, would mesh more thoroughly. (wordnik.com)
  • enzymes
  • The recent finding of a gene fusion encoding three pyrimidine biosynthetic enzymes, shared only by Dictyostelium, fungi andMetazoa, indicates that the amoebozoa are a true sister group of the fungi and Metazoa. (wordnik.com)
  • structures
  • Superpositions of dipole states of base pairs consisting of purine (A, G) and pyrimidine (C, T) ring structures play the role of qubits, and quantum communication (coherence, entanglement, non-locality) occur in the "pi stack" region of the DNA molecule. (wordnik.com)
  • class
  • From these results Funk believed the vitamine to belong to a class of substances known as the pyrimidine bases. (wordnik.com)
  • Although
  • Furthermore, although Powner and colleagues 'synthetic sequence yields the pyrimidine ribonucleotides, it cannot explain how purine ribonucleotides (which incorporate guanine and adenine) might have formed. (wordnik.com)