• Pyrazinamide is only used in combination with other drugs such as isoniazid and rifampicin in the treatment of Mycobacterium tuberculosis and as directly observed therapy (DOT). (wikipedia.org)
  • In the standard four-drug regimen (isoniazid, rifampicin, pyrazinamide, ethambutol), pyrazinamide is the most common cause of drug-induced hepatitis. (wikipedia.org)
  • isoniazid, pyrazinamide. (medscape.com)
  • Minor (1) isoniazid, pyrazinamide. (medscape.com)
  • however, the treatment involves a first-line four-drug standard regimen for 6 months: an intensive phase comprising a 2-month regimen of isoniazid, rifampicin, pyrazinamide and ethambutol, followed by a continuous phase involving a 4-month regimen of isoniazid and rifampicin (Box 1 ). (nature.com)
  • This report provides a recommendation for using a 4-month regimen consisting of 8 weeks of daily treatment with rifapentine (RPT), isoniazid (INH), pyrazinamide, and moxifloxacin (MOX), followed by 9-weeks of daily treatment with RPT, INH, and MOX in patients with drug-susceptible tuberculosis. (cdc.gov)
  • On May 5, 2021, CDC's Tuberculosis Trials Consortium and the National Institutes of Health (NIH)-sponsored AIDS Clinical Trials Group (ACTG) published results from a randomized controlled trial indicating that a 4-month regimen containing rifapentine (RPT), moxifloxacin (MOX), isoniazid (INH), and pyrazinamide (PZA) was as effective as the standard 6-month regimen for tuberculosis (TB) treatment ( 1 ). (cdc.gov)
  • During a 2 year period, 1053 HIV-positive individuals without evidence of clinical TB were randomly assigned to receive 6 months of isoniazid twice a week (H), or 3 months of rifampicin twice a week (R) plus pyrazinamide (Z), or a placebo. (nih.gov)
  • This study has demonstrated that preventive therapy with either twice weekly isoniazid for 6 months or a combination of rifampicin and pyrazinamide for 3 months reduced the incidence of TB in HIV-infected persons in Zambia. (nih.gov)
  • A 6-mo regimen consisting of isoniazid, rifampin, and pyrazinamide given for 2 mo followed by isoniazid and rifampin for 4 mo is the preferred treatment for patients with fully susceptible organisms who adhere to treatment. (cdc.gov)
  • Alternatively, a 9-mo regimen of isoniazid and rifampin is acceptable for persons who cannot or should not take pyrazinamide. (cdc.gov)
  • Naïve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitis. (lstmed.ac.uk)
  • ORCID: https://orcid.org/0000-0002-9109-350X , Thwaites, Guy E , Tarning, Joel and Day, Jeremy N (2016) 'Naïve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitis. (lstmed.ac.uk)
  • The aim of this prospective study was to describe the pharmacokinetics of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of children with tuberculous meningitis treated with the standard TBM regimen. (lstmed.ac.uk)
  • Children were treated according to the 2006 WHO recommended pediatric treatment regimen consisting of isoniazid (5 mg/kg), rifampicin (10 mg/kg) and ethambutol (15 mg/kg) for 8 months, with the addition of pyrazinamide (25 mg/kg) for the first 3 months and streptomycin (15 mg/kg) for the first 2 months. (lstmed.ac.uk)
  • Pyrazinamide, isoniazid and rifampicin concentrations were measured in plasma at day 14 and in cerebrospinal fluid (CSF) at 1 month by HPLC-UV. (lstmed.ac.uk)
  • Younger children, when compared to older children, presented a higher body weight-normalized clearance and volume of distribution, and lower median total plasma exposures for the three studied drugs with -14%, -22% and -16% for Pyrazinamide, Isoniazid and Rifampicin, respectively. (lstmed.ac.uk)
  • There is an age-dependent variation in the plasma and cerebrospinal fluid pharmacokinetics of rifampicin, isoniazid and pyrazinamide. (lstmed.ac.uk)
  • Resistance to isoniazid and ethambutol was significantly more common in recurrent cases, but there were no differences in rates of resistance to rifampin, pyrazinamide, streptomycin or the rate of multi-drug resistant strains. (who.int)
  • "BPaMZ" is an all-oral TB treatment regimen consisting of bedaquiline (B) , pretomanid (Pa) , moxifloxacin (M) and pyrazinamide (Z) . BPaMZ is currently being tested in those with drug-sensitive (DS-) as well as those with drug-resistant (MDR-) pulmonary tuberculosis (specifically multidrug-resistant TB and mono-resistance to isoniazid and rifampicin) in the pivotal SimpliciTB trial . (tballiance.org)
  • All were tested for sensitivity to isoniazid, rifampicin, and ethambutol and 12 692 of the isolates were also tested for sensitivity to pyrazinamide and streptomycin. (bmj.com)
  • New cases are initially treated with four drugs: isoniazid, rifampin, pyrazinamide, and either ethambutol or streptomycin. (medscape.com)
  • Patients requiring retreatment should initially receive at least 5 drugs, including isoniazid, rifampin, pyrazinamide, and at least 2 (preferably 3) new drugs to which the patient has not been exposed. (medscape.com)
  • Reports of fatal and severe liver injury associated with treatment of latent tuberculosis infection (LTBI) with the drug combination rifampin and pyrazinamide (RZ) prompted CDC to issue revised guidelines for the use of this regimen on August 31, 2001 ( 1 ). (cdc.gov)
  • rifampin, pyrazinamide. (medscape.com)
  • Bactericidal with the highest EBA  Rifampicin (R) - bactericidal with high EBA and a key sterilizing drug in short-course treatment regimens of TB  Pyrazinamide (Z) - high sterilizing agent. (slideshare.net)
  • Pyrazinamide is a medication used to treat tuberculosis. (wikipedia.org)
  • medical citation needed] Pyrazinamide is a prodrug that stops the growth of M. tuberculosis. (wikipedia.org)
  • citation needed] Pyrazinamide diffuses into the granuloma of M. tuberculosis, where the tuberculosis enzyme pyrazinamidase converts pyrazinamide to the active form pyrazinoic acid. (wikipedia.org)
  • Pyrazinamide kills or stops the growth of certain bacteria that cause tuberculosis (TB). (medlineplus.gov)
  • Pyrazinamide works by interfering with the metabolic processes of the tuberculosis bacteria, which ultimately results in the death of the bacteria and assists in the management of the infection. (365chemists.com)
  • Pyrazinamide is an anti-tuberculosis medication that is particularly effective against tuberculosis bacteria that thrive in acidic environments within the body, such as those that can be found in the lungs. (365chemists.com)
  • Buy Pyzina Tablet generic drug of Pyrazinamide online at a low price from the most trusted pharmacy for Tuberculosis (TB). (safegenericpharmacy.com)
  • Although pyrazinamide is commonly used for tuberculosis treatment, drug-susceptibility testing is not routinely available. (blogspot.com)
  • Assessment of pyrazinamide susceptibility may be prudent before using it in regimens for drug-resistant tuberculosis. (blogspot.com)
  • Pyrazinamide is the primary component of the pharmaceutical product known as Pyzina 750mg Tablet. (365chemists.com)
  • We found novel mutations encoding resistance to streptomycin (in gidB) and pyrazinamide (in kefB). (bvsalud.org)
  • The most dangerous side effect of pyrazinamide is hepatotoxicity, which is dose-related. (wikipedia.org)
  • Metabolism and Hepatotoxicity of Pyrazinamide, an Antituberculosis Drug. (nih.gov)
  • Regimens not containing pyrazinamide must be taken for 9 months or more. (wikipedia.org)
  • We observed lineage-specific gene variations encoding resistance to streptomycin and pyrazinamide. (bvsalud.org)
  • However, since an acidic environment is not essential for pyrazinamide susceptibility and pyrazinamide treatment does not lead to intrabacterial acidification nor rapid disruption of membrane potential, this model has also been discounted. (wikipedia.org)
  • Pyrazinamide is in the antimycobacterial class of medications. (wikipedia.org)
  • Pyrazinamide is available as a generic medication. (wikipedia.org)
  • Pyrazinamide is used in the first 2 months of treatment to reduce the duration of treatment required. (wikipedia.org)
  • Pyrazinamide (PZA) is an important drug used in both first and second line treatment regimes. (edu.sa)
  • 4 The main strategies to do this included the promotion of the standard treatment regimen containing pyrazinamide (PZA), treatment support by using DOT in hospitals and the community and monitoring and evaluating case management. (who.int)
  • The old dose for pyrazinamide was 40-70 mg/kg daily and the incidence of drug-induced hepatitis has fallen significantly since the recommended dose has been reduced to 12-30 mg/kg daily. (wikipedia.org)
  • Mycobacterium bovis and Mycobacterium leprae are innately resistant to pyrazinamide. (wikipedia.org)
  • Pyrazinamide is a potent antiuricosuric drug and consequently has an off-label use in the diagnosis of causes of hypouricemia and hyperuricosuria. (wikipedia.org)
  • It contains a generic drug of Pyrazinamide as an active ingredient. (safegenericpharmacy.com)
  • Pyrazinamide can precipitate gout flares by decreasing renal excretion of uric acid. (wikipedia.org)
  • A case reported demonstrated a decrease in cyclosporine plasma levels after pyrazinamide was added onto a renal transplant patient's therapy. (medscape.com)
  • If you have diabetes, pyrazinamide may interfere with urine ketone tests. (medlineplus.gov)
  • A simple test for the detection of pyrazinamide and cycloserine in urine has been described. (nirt.res.in)
  • The test is sensitive and can detect the presence of these drugs in urine for about 24 hours after administration of pyrazinamide 1 g. or cycloserine 0.5 g. (nirt.res.in)
  • Catering to diverse requirements of clients, we are renowned as the most reputed manufacturer and supplier of an excellent stock of Pyrazinamide . (axispharmachem.com)
  • This is an unusual mechanism of action in that pyrazinamide does not directly block the action of its target, but indirectly triggers its destruction. (wikipedia.org)
  • pyrazinamide decreases levels of cyclosporine by unknown mechanism. (medscape.com)
  • pyrazinamide decreases effects of probenecid by unknown mechanism. (medscape.com)
  • This Pyrazinamide is stringently tested on various standard quality parameters prior to final dispatch in market. (axispharmachem.com)
  • In the US, pyrazinamide is not used in pregnancy, citing insufficient evidence of safety. (wikipedia.org)
  • The most common (roughly 1%) side effect of pyrazinamide is joint pains (arthralgia), but this is not usually so severe that patients need to stop taking it. (wikipedia.org)
  • Pyrazinamide may cause side effects. (medlineplus.gov)
  • High-level prescribing trends for Pyrazinamide (BNF code 0501090N0) across all GP practices in NHS England for the last five years. (openprescribing.net)
  • Once you receive your AFB-MTb Antibiogram Pyrazinamide test results, your physician might advise you with corrective measures if they are not in the normal range. (bajajfinservhealth.in)
  • How lab sample collection for Afb-mtb Antibiogram Pyrazinamide Test in Kannur works? (bajajfinservhealth.in)