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  • test
  • To test their contribution at the network and the behavioral level, we generated genetically modified mice in which the excitatory drive was selectively reduced either by the knockout of the GluR-D or by conditional ablation of the GluR-A subunit in parvalbumin-positive cells. (ox.ac.uk)
  • demonstrate
  • These findings directly show the effects of insufficient recruitment of fast-spiking cells at the network and behavioral level and demonstrate the role of this subpopulation for working and episodic-like memory. (ox.ac.uk)
  • network
  • Previously, we found that parvalbumin-expressing basket, axo-axonic, bistratified, and oriens-lacunosum moleculare cells, innervating different domains of pyramidal cells, have distinct firing patterns during network oscillations in vivo. (ox.ac.uk)
  • We suggest that the specific spike timing of cholecystokinin interneurons and their sensitivity to endocannabinoids might contribute to differentiate subgroups of pyramidal cells forming neuronal assemblies, whereas parvalbumin interneurons contribute to synchronizing the entire network. (ox.ac.uk)
  • neuronal
  • In this study, we investigate the potency of Ptf1a to cell autonomously confer a specific neuronal identity outside of its endogenous environment, using mouse in utero electroporation and a conditional genetic strategy to misexpress Ptf1a exclusively in developing cortical pyramidal cells. (jneurosci.org)
  • Moreover, Ptf1a alters neuronal morphology, inducing the radial redistribution and branching of neurites in cortical pyramidal cells. (jneurosci.org)
  • However, the full complement of transcription factors that confer subtype-specific identities has yet to be elucidated, and their abilities to cell autonomously direct neuronal identity have yet to be fully characterized. (jneurosci.org)
  • Different thalamocortical neuronal assemblies would give rise to sleep spindles, and these cell assemblies would affect the burst initiator for the sharp waves. (wikipedia.org)
  • Additionally, there are other neuronal cell types that manifest varying degrees of amplitude decrement during backpropagation. (wikipedia.org)
  • It is thought that this is due to the fact that each neuronal cell type contains varying numbers of the voltage-gated channels required to propagate a dendritic action potential. (wikipedia.org)
  • neural
  • The neural cell adhesion molecule (NCAM), has been shown to be an obligate regulator of synaptic stability and pruning during critical periods of cortical maturation. (frontiersin.org)
  • The "far-fetched" possibility of using light for selectively controlling precise neural activity (action potential) patterns within subtypes of cells in the brain was thought of by Francis Crick in his Kuffler Lectures at the University of California in San Diego in 1999. (wikipedia.org)
  • cortical layers
  • Considering the interlaminar connectivity of pyramidal cells, the reverberating excitation could occur in individual cortical layers ( Thomson and Morris, 2002 ), perhaps within layer V ( Sanchez-Vives and McCormick, 2000 ). (jneurosci.org)
  • slices
  • Previous studies revealed the basic features governing the integration of LOT synaptic input and spike output of layer 2/3 (L2/3) principal cells in APC slices. (jneurosci.org)
  • interneuron
  • PV-positive basket cell terminals were unaffected in mutant mice, demonstrating interneuron subtype-specific function of dystroglycan. (jneurosci.org)
  • subcellular
  • We applied a combination of ultrastructural and functional imaging methods to assess the subcellular distribution and role of NCX1 in rat CA1 pyramidal cells. (pnas.org)
  • collaterals
  • Using paired recordings of retrogradely labeled cells, we investigated the synaptic connectivity between two projection cell types: those projecting to the pons [corticopontine (CPn) cell], often with collaterals to the striatum, and those projecting to both sides of the striatum but not to the pons [crossed corticostriatal (CCS) cell]. (jneurosci.org)
  • membrane
  • Na + /Ca 2+ exchanger (NCX) and plasma membrane Ca 2+ -ATPase (PMCA) molecules play an essential role in Ca 2+ clearance across the plasma membrane in excitable cells ( 10 ). (pnas.org)
  • In this chapter we describe the membrane conductance system of the pyramidal cells that allows burst generation. (springer.com)
  • All PFC cells exhibited either subthreshold oscillation in membrane voltage or pacemaker-like rhythmic firing. (jneurosci.org)
  • patterns
  • Alexander and Crutcher, 1990 ), knowledge of the patterns of synaptic connectivity between corticostriatal cells may suggest a physiological substrate for cortical influence on the basal ganglia circuitry. (jneurosci.org)
  • Our results demonstrate distinct morphologies and selective patterns of synaptic connectivity between CCS and CPn cells. (jneurosci.org)
  • Protopapas A.D., Bower J.M. (1997) Pyramidal Cell Response to Patterns of Synaptic Input Believed to Underlie Gamma Oscillations. (springer.com)
  • glial
  • By using monoclonal antibodies, the NCX1 protein was localized to pyramidal cells, whereas NCX2 was predominantly found on glial cell plasma membranes in cell culture ( 19 ). (pnas.org)
  • whereas
  • Crossed corticostriatal (CCS) cells innervate both the ipsilateral and contralateral striatum, whereas other corticostriatal cells selectively innervate the ipsilateral striatum but project also to the brainstem through the pyramidal tract. (jneurosci.org)
  • distinct
  • Therefore, our data demonstrate that these two types of corticostriatal cells distinct in their dendritic morphologies show directional and domain-dependent preferences in their synaptic connectivity. (jneurosci.org)
  • We show that the combined activity of distinct glomerular pathways recruits ensembles of pyramidal cells that are not activated by the individual pathways alone. (jneurosci.org)
  • mammalian
  • Formation of Hirano bodies in Dictyostelium and mammalian cells induces by expression of a modified form of an actin-crosslinking protein," J.Cell Sci. (wikipedia.org)
  • protein
  • To identify expressing cells, they replaced the cytoplasmic tail of the algal protein with the fluorescent protein YFP, generating the first generally applicable optogenetic tool. (wikipedia.org)
  • calcium
  • Whole-cell patch-clamp recordings obtained from CA3 pyramidal cells in organotypic slice cultures revealed that under conditions of low intracellular calcium buffering application of muscarine-depressed NMDA receptor current. (uzh.ch)
  • types
  • Four principal pyramidal cell types were identified and classified as regular spiking (RS) (19%), intrinsic bursting (IB) (64%), repetitive oscillatory bursting (ROB) (13%), and intermediate (IM) (4%) types. (jneurosci.org)
  • These electrophysiological and morphological properties of the four principal pyramidal PFC cell types have provided valuable details for understanding further how PFC processes input and transmit outputs to regions such as the NAc. (jneurosci.org)
  • undergo
  • Immature pyramidal cells undergo migration to occupy the cortical plate, where they further diversify. (wikipedia.org)
  • Ultimately, information from combinations of activated M/T cells belonging to different glomeruli is proposed to undergo a synthetic process in cortical brain regions to generate odor perception. (jneurosci.org)
  • These cells undergo synchronous and paroxysmal depolarizations, firing short sequences of action potentials called bursts. (wikipedia.org)
  • mice
  • Through the use of mice that are deficient in GalR1 receptors, a picrotoxin-kindled model was utilized to show that galanin plays a role in modulating and preventing hilar cell loss as well as decreasing the duration of induced seizures. (wikipedia.org)
  • ganglion cells
  • 1959) looked beyond the mechanisms for signal-noise discrimination in the frog's retina and were able to identify four classes of ganglion cells in the frog retina: sustained contrast detectors, net convexity detectors (or bug detectors), moving edge detectors, and net dimming detectors. (wikipedia.org)
  • sufficient
  • Together, these results indicated that CA1-restricted genetic manipulation of particular mRNA translations is sufficient to impair the consolidation and that consolidation of memories in CA1 pyramidal cells through eIF2α dephosphorylation depends more on transcription/translation of particular genes than on overall levels of general translation. (jneurosci.org)
  • test
  • To test their contribution at the network and the behavioral level, we generated genetically modified mice in which the excitatory drive was selectively reduced either by the knockout of the GluR-D or by conditional ablation of the GluR-A subunit in parvalbumin-positive cells. (ox.ac.uk)
  • demonstrate
  • These findings directly show the effects of insufficient recruitment of fast-spiking cells at the network and behavioral level and demonstrate the role of this subpopulation for working and episodic-like memory. (ox.ac.uk)
  • network
  • Previously, we found that parvalbumin-expressing basket, axo-axonic, bistratified, and oriens-lacunosum moleculare cells, innervating different domains of pyramidal cells, have distinct firing patterns during network oscillations in vivo. (ox.ac.uk)
  • We suggest that the specific spike timing of cholecystokinin interneurons and their sensitivity to endocannabinoids might contribute to differentiate subgroups of pyramidal cells forming neuronal assemblies, whereas parvalbumin interneurons contribute to synchronizing the entire network. (ox.ac.uk)
  • neuronal
  • In this study, we investigate the potency of Ptf1a to cell autonomously confer a specific neuronal identity outside of its endogenous environment, using mouse in utero electroporation and a conditional genetic strategy to misexpress Ptf1a exclusively in developing cortical pyramidal cells. (jneurosci.org)
  • Moreover, Ptf1a alters neuronal morphology, inducing the radial redistribution and branching of neurites in cortical pyramidal cells. (jneurosci.org)
  • However, the full complement of transcription factors that confer subtype-specific identities has yet to be elucidated, and their abilities to cell autonomously direct neuronal identity have yet to be fully characterized. (jneurosci.org)
  • Different thalamocortical neuronal assemblies would give rise to sleep spindles, and these cell assemblies would affect the burst initiator for the sharp waves. (wikipedia.org)
  • Additionally, there are other neuronal cell types that manifest varying degrees of amplitude decrement during backpropagation. (wikipedia.org)
  • It is thought that this is due to the fact that each neuronal cell type contains varying numbers of the voltage-gated channels required to propagate a dendritic action potential. (wikipedia.org)
  • neural
  • The neural cell adhesion molecule (NCAM), has been shown to be an obligate regulator of synaptic stability and pruning during critical periods of cortical maturation. (frontiersin.org)
  • The "far-fetched" possibility of using light for selectively controlling precise neural activity (action potential) patterns within subtypes of cells in the brain was thought of by Francis Crick in his Kuffler Lectures at the University of California in San Diego in 1999. (wikipedia.org)
  • cortical layers
  • Considering the interlaminar connectivity of pyramidal cells, the reverberating excitation could occur in individual cortical layers ( Thomson and Morris, 2002 ), perhaps within layer V ( Sanchez-Vives and McCormick, 2000 ). (jneurosci.org)
  • slices
  • Previous studies revealed the basic features governing the integration of LOT synaptic input and spike output of layer 2/3 (L2/3) principal cells in APC slices. (jneurosci.org)
  • interneuron
  • PV-positive basket cell terminals were unaffected in mutant mice, demonstrating interneuron subtype-specific function of dystroglycan. (jneurosci.org)
  • subcellular
  • We applied a combination of ultrastructural and functional imaging methods to assess the subcellular distribution and role of NCX1 in rat CA1 pyramidal cells. (pnas.org)
  • collaterals
  • Using paired recordings of retrogradely labeled cells, we investigated the synaptic connectivity between two projection cell types: those projecting to the pons [corticopontine (CPn) cell], often with collaterals to the striatum, and those projecting to both sides of the striatum but not to the pons [crossed corticostriatal (CCS) cell]. (jneurosci.org)
  • membrane
  • Na + /Ca 2+ exchanger (NCX) and plasma membrane Ca 2+ -ATPase (PMCA) molecules play an essential role in Ca 2+ clearance across the plasma membrane in excitable cells ( 10 ). (pnas.org)
  • In this chapter we describe the membrane conductance system of the pyramidal cells that allows burst generation. (springer.com)
  • All PFC cells exhibited either subthreshold oscillation in membrane voltage or pacemaker-like rhythmic firing. (jneurosci.org)
  • patterns
  • Alexander and Crutcher, 1990 ), knowledge of the patterns of synaptic connectivity between corticostriatal cells may suggest a physiological substrate for cortical influence on the basal ganglia circuitry. (jneurosci.org)
  • Our results demonstrate distinct morphologies and selective patterns of synaptic connectivity between CCS and CPn cells. (jneurosci.org)
  • Protopapas A.D., Bower J.M. (1997) Pyramidal Cell Response to Patterns of Synaptic Input Believed to Underlie Gamma Oscillations. (springer.com)
  • glial
  • By using monoclonal antibodies, the NCX1 protein was localized to pyramidal cells, whereas NCX2 was predominantly found on glial cell plasma membranes in cell culture ( 19 ). (pnas.org)
  • whereas
  • Crossed corticostriatal (CCS) cells innervate both the ipsilateral and contralateral striatum, whereas other corticostriatal cells selectively innervate the ipsilateral striatum but project also to the brainstem through the pyramidal tract. (jneurosci.org)
  • distinct
  • Therefore, our data demonstrate that these two types of corticostriatal cells distinct in their dendritic morphologies show directional and domain-dependent preferences in their synaptic connectivity. (jneurosci.org)
  • We show that the combined activity of distinct glomerular pathways recruits ensembles of pyramidal cells that are not activated by the individual pathways alone. (jneurosci.org)
  • mammalian
  • Formation of Hirano bodies in Dictyostelium and mammalian cells induces by expression of a modified form of an actin-crosslinking protein," J.Cell Sci. (wikipedia.org)
  • protein
  • To identify expressing cells, they replaced the cytoplasmic tail of the algal protein with the fluorescent protein YFP, generating the first generally applicable optogenetic tool. (wikipedia.org)
  • calcium
  • Whole-cell patch-clamp recordings obtained from CA3 pyramidal cells in organotypic slice cultures revealed that under conditions of low intracellular calcium buffering application of muscarine-depressed NMDA receptor current. (uzh.ch)
  • types
  • Four principal pyramidal cell types were identified and classified as regular spiking (RS) (19%), intrinsic bursting (IB) (64%), repetitive oscillatory bursting (ROB) (13%), and intermediate (IM) (4%) types. (jneurosci.org)
  • These electrophysiological and morphological properties of the four principal pyramidal PFC cell types have provided valuable details for understanding further how PFC processes input and transmit outputs to regions such as the NAc. (jneurosci.org)
  • undergo
  • Immature pyramidal cells undergo migration to occupy the cortical plate, where they further diversify. (wikipedia.org)
  • Ultimately, information from combinations of activated M/T cells belonging to different glomeruli is proposed to undergo a synthetic process in cortical brain regions to generate odor perception. (jneurosci.org)
  • These cells undergo synchronous and paroxysmal depolarizations, firing short sequences of action potentials called bursts. (wikipedia.org)
  • mice
  • Through the use of mice that are deficient in GalR1 receptors, a picrotoxin-kindled model was utilized to show that galanin plays a role in modulating and preventing hilar cell loss as well as decreasing the duration of induced seizures. (wikipedia.org)
  • ganglion cells
  • 1959) looked beyond the mechanisms for signal-noise discrimination in the frog's retina and were able to identify four classes of ganglion cells in the frog retina: sustained contrast detectors, net convexity detectors (or bug detectors), moving edge detectors, and net dimming detectors. (wikipedia.org)
  • sufficient
  • Together, these results indicated that CA1-restricted genetic manipulation of particular mRNA translations is sufficient to impair the consolidation and that consolidation of memories in CA1 pyramidal cells through eIF2α dephosphorylation depends more on transcription/translation of particular genes than on overall levels of general translation. (jneurosci.org)