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  • Parkinson's
  • The putamen also plays a role in degenerative neurological disorders, such as Parkinson's disease. (wikipedia.org)
  • Alpha and beta nicotinic acetylcholine receptors subunits and synaptophysin in putamen from Parkinson's disease. (semanticscholar.org)
  • Autopsy tissue from the putamen of 12 Parkinson's disease cases and 12 age-matched control subjects was analysed by immunoblotting using antibodies against recombinant peptides specific for alpha3, alpha4, alpha7, beta2 and beta4 nicotinic acetylcholine receptor (nAChR) subunits and the synaptic marker synaptophysin, in conjunction with assessment of [(3)H]nicotine binding by autoradiography. (semanticscholar.org)
  • The data indicate that there is no loss of alpha3, alpha4, alpha7 and beta2 immunoreactivity in the putamen in Parkinson's disease, despite a highly significant reduction in [(3)H]nicotine binding. (semanticscholar.org)
  • These results suggest that the loss of nicotine binding in the putamen in Parkinson's disease may involve an nAChR subunit (e.g., alpha5 and/or alpha6) other than those investigated. (semanticscholar.org)
  • striatal
  • In line with the hypothesis that functional connectivity between the midbrain and the putamen reflects the integrity of the dopaminergic neurotransmitter system, putamen-midbrain functional connectivity was significantly correlated with striatal DAT availability even after stringent control for effects of head motion. (diva-portal.org)
  • posterior
  • Topographical organization of the putamen combines the following elements: anterior-to-posterior functional and somatotopic gradients, lateral-to-medial functional and somatotopic gradients, diffuse terminal output, patchy localized terminal output, segregated terminals from adjacent regions, finely interdigiated terminals from distal cortical regions in a seemingly overlapping fashion. (wikipedia.org)
  • Group differences in hypercapnic vasoreactivity were significant only in the posterior putamen, with greater CBF responses in LID subjects compared with the other subjects. (jci.org)
  • Double dissociation of the anterior and posterior dorsomedial caudate-putamen in the acquisition and expression of associative learning with the nicotine stimulus. (sigmaaldrich.com)
  • membranes
  • The endogenous ligand of the kappa opioid receptor, dynorphin A(l-17) (Dyn A(l-17)), produced a significant concentration-dependent inhibition of AC activity in membranes prepared from the caudate putamen (CPu) of naive Fischer 344 rats. (aspetjournals.org)
  • fMRI
  • Since then, more extensive neuronal tracing, stimulation, and imaging research methods (e.g. fMRI, DWI) that allow for investigation of the putamen have been developed. (wikipedia.org)
  • GABA
  • The present study examined the effect of inactivation of the putamen via local injection of the GABA A receptor agonist muscimol in monkeys engaged in a manual reward-based multi-step choice task. (springer.com)
  • In the present study, we addressed this issue by blocking neuronal activity in the putamen via local injection of the GABA A receptor agonist muscimol into the putamen of monkeys engaged in a reinforcement-based multi-step choice task. (springer.com)
  • nicotine
  • Because the neurobiological substrates underlying these processes are virtually unexplored, the present study investigated the functional involvement of the dorsomedial caudate putamen (dmCPu) in learning processes with nicotine as an interoceptive stimulus. (sigmaaldrich.com)
  • mutation
  • To address this, we have used next generation sequencing of mtDNA-enriched libraries (Mito-Seq) to investigate mtDNA mutation spectra of putamen from young and aged donors. (nih.gov)
  • Compared with healthy controls, mutation carriers had significantly higher phase shift in the putamen (p=0.0002) and caudate nucleus (p=0.006). (bmj.com)
  • circuits
  • These results support a view that the putamen is involved selectively and critically in neuronal circuits for reward history-based action selection. (springer.com)
  • levels
  • However, acutely administered fluoxetine (2.5, 5.0, or 10.0 mg/kg, i.p.) failed to elevate extracellular levels of DA, or its metabolites in the NAc or caudate-putamen (CP). (drugawareness.org)
  • function
  • A primary function of the putamen is to regulate movements at various stages (e.g. preparation and execution) and influence various types of learning. (wikipedia.org)
  • We hypothesized that bioenergetic function in the putamen might play a crucial role in the development of dyskinesias. (springer.com)
  • results
  • B ) Display of the hypercapnic CBF responses (Δ HC = CBF HC - CBF NC ) for each group measured in the putamen levodopa dissociation region (see Results). (jci.org)
  • control
  • But monkeys could control the motivation level depending on the reward value of individual trial types before and after putamen inactivation. (springer.com)
  • patients
  • Conclusions This study demonstrates increased diffuse iron accumulation in the putamen and caudate nucleus in patients with the small vessel disease CADASIL. (bmj.com)
  • make
  • Inactivation of the putamen impaired the ability of monkeys to make optimal choices during third trial in which they were required to choose a target different from those selected in the two previous trials by updating the values of the three options. (springer.com)