• cerebral
  • The caudate works with the putamen to receive the input from cerebral cortex. (wikipedia.org)
  • Hypercapnic cerebral blood flow responses in the putamen levodopa dissociation region. (jci.org)
  • Globally normalized cerebral blood flow (CBF) values were measured in the unmedicated state under normocapnic (NC) and hypercapnic (HC) conditions in the area of dissociated vasomotor and metabolic levodopa responses previously described in the posterior putamen (see Results). (jci.org)
  • striatal
  • In line with the hypothesis that functional connectivity between the midbrain and the putamen reflects the integrity of the dopaminergic neurotransmitter system, putamen-midbrain functional connectivity was significantly correlated with striatal DAT availability even after stringent control for effects of head motion. (diva-portal.org)
  • medial
  • Topographical organization of the putamen combines the following elements: anterior-to-posterior functional and somatotopic gradients, lateral-to-medial functional and somatotopic gradients, diffuse terminal output, patchy localized terminal output, segregated terminals from adjacent regions, finely interdigiated terminals from distal cortical regions in a seemingly overlapping fashion. (wikipedia.org)
  • membranes
  • The endogenous ligand of the kappa opioid receptor, dynorphin A(l-17) (Dyn A(l-17)), produced a significant concentration-dependent inhibition of AC activity in membranes prepared from the caudate putamen (CPu) of naive Fischer 344 rats. (aspetjournals.org)
  • fMRI
  • Since then, more extensive neuronal tracing, stimulation, and imaging research methods (e.g. fMRI, DWI) that allow for investigation of the putamen have been developed. (wikipedia.org)
  • GABA
  • The present study examined the effect of inactivation of the putamen via local injection of the GABA A receptor agonist muscimol in monkeys engaged in a manual reward-based multi-step choice task. (springer.com)
  • In the present study, we addressed this issue by blocking neuronal activity in the putamen via local injection of the GABA A receptor agonist muscimol into the putamen of monkeys engaged in a reinforcement-based multi-step choice task. (springer.com)
  • mutation
  • To address this, we have used next generation sequencing of mtDNA-enriched libraries (Mito-Seq) to investigate mtDNA mutation spectra of putamen from young and aged donors. (nih.gov)
  • circuits
  • These results support a view that the putamen is involved selectively and critically in neuronal circuits for reward history-based action selection. (springer.com)
  • levels
  • However, acutely administered fluoxetine (2.5, 5.0, or 10.0 mg/kg, i.p.) failed to elevate extracellular levels of DA, or its metabolites in the NAc or caudate-putamen (CP). (drugawareness.org)
  • results
  • B ) Display of the hypercapnic CBF responses (Δ HC = CBF HC - CBF NC ) for each group measured in the putamen levodopa dissociation region (see Results). (jci.org)
  • control
  • But monkeys could control the motivation level depending on the reward value of individual trial types before and after putamen inactivation. (springer.com)
  • types
  • A primary function of the putamen is to regulate movements at various stages (e.g. preparation and execution) and influence various types of learning. (wikipedia.org)
  • group
  • Group differences in hypercapnic vasoreactivity were significant only in the posterior putamen, with greater CBF responses in LID subjects compared with the other subjects. (jci.org)
  • make
  • Inactivation of the putamen impaired the ability of monkeys to make optimal choices during third trial in which they were required to choose a target different from those selected in the two previous trials by updating the values of the three options. (springer.com)