• We studied a model of experimental tubulointerstitial nephritis associated with puromycin aminonucleoside (PAN) nephrosis. (nih.gov)
  • Pharmacological Melanocortin 5 Receptor Activation Attenuates Glomerular Injury and Proteinuria in Rats with Puromycin Aminonucleoside Nephrosis. (utoledo.edu)
  • Our group shows previously that rats with puromycin aminonucleoside- (Skillet-) induced NS (PAN-NS) display a blunted activity of the renal dopaminergic program evidenced by reduced urine dopamine result and reduced aromatic L-amino acidity decarboxylase activity the enzyme in charge of dopamine synthesis in renal proximal tubules [13]. (bioxorio.com)
  • The biosynthetic pathway of the aminonucleoside antibiotic puromycin, as deduced from the molecular analysis of the pur cluster of Streptomyces alboniger. (kegg.jp)
  • 2010. Cytochrome-P450 2B1 gene silencing attenuates puromycin aminonucleoside-induced cytotoxicity in glomerular epithelial cells. (nih.gov)
  • Isolated and purified glomerular basement membranes (GBM) of normal and aminonucleoside (PAN) nephrotic rats were observed by electron microscopy after negative staining. (elsevierpure.com)
  • Podocyte expression of membrane transporters involved in puromycin aminonucleoside-mediated injury. (units.it)
  • Podocyte injury may be induced by injecting puromycin aminonucleoside (PA), adriamycin, lipopolysaccharide, protamine sulfate or other podocyte FLI1 toxins in the whole animal or in the incubation medium of isolated glomeruli or cultured podocytes. (cckn-ia.org)
  • Over-expression of adenosine deaminase in mouse podocytes does not reverse puromycin aminonucleoside resistance. (medscape.com)
  • Puromycin is soluble in water and is often used as a selective agent in molecular biology research. (goldbio.com)
  • Its gene product is puromycin-N-acetyl-transferase which inactivates puromycin through acetylation. (goldbio.com)
  • While selection for E. coli cells is possible with puromycin, it is more commonly and effectively used for mammalian cell selection. (goldbio.com)