• neurons
  • These receptors are greatly distributed in neurons and glial cells throughout the central and peripheral nervous systems. (wikipedia.org)
  • Moreover, these receptors have been implicated in integrating functional activity between neurons, glial, and vascular cells in the central nervous system, thereby mediating the effects of neural activity during development, neurodegeneration, inflammation, and cancer. (wikipedia.org)
  • Further research determined that a large majority of μ-opioid-expressing neurons also expressed CCK2 receptors. (wikipedia.org)
  • Microinjection in the RVM with either a CCK-saporin or a dermorphin-saporin conjugate eliminated neurons expressing either receptor. (wikipedia.org)
  • control
  • Released nucleotides can be hydrolyzed extracellularly by a variety of cell surface-located enzymes referred to as ectonucleotidases that control purinergic signalling. (wikipedia.org)
  • further
  • To distinguish P2 receptors further, the subclasses have been divided into families of metabotropic (P2Y, P2U, and P2T) and ionotropic receptors (P2X and P2Z). (wikipedia.org)
  • In contrast, the administration of an NK1 antagonist further increased the tactile hyperalgesia induced by CFA. (wikipedia.org)
  • role
  • Taken together, these findings indicate a role for 5-HT7 receptors in opioid-induced antinociception, and a role for 5-HT3 in pro-nociceptive facilitation. (wikipedia.org)
  • effect
  • Stimulation of the A1 receptor has a myocardial depressant effect by decreasing the conduction of electrical impulses and suppressing pacemaker cell function, resulting in a decrease in heart rate. (wikipedia.org)
  • This effect on the A1 receptor also explains why there is a brief moment of cardiac standstill when adenosine is administered as a rapid IV push during cardiac resuscitation. (wikipedia.org)
  • function
  • The A1 receptor has been shown to stimulate osteoclast differentiation and function. (wikipedia.org)
  • There are two types of NTs: Concentrative nucleoside transporters (CNTs): Na+-dependent symporters Equilibrative nucleoside transporters (ENTs): Na+-independent passive transporters The extracellular concentration of adenosine can be regulated by NTs, possibly in the form of a feedback loop connecting receptor signaling with transporter function. (wikipedia.org)
  • release
  • The Pannexin-1 channel (PANX1) is an integral component of the P2X/P2Y purinergic signaling pathway and the key contributor to pathophysiological ATP release. (wikipedia.org)
  • Levels
  • To establish the extent to which BIIB014, following 8 to 12 consecutive days of dosing at selected dose levels, occupies the brain's A2A receptors. (clinicaltrials.gov)