Irritant receptorsIdiopathic PulmonarCapillary wedge pressureHering BreuerTotal pulmonary resistanceLungsSurfactantChronicTyrosine kinaseBaroreceptorRestrictiveVenousBaroreceptorsEmbolismSensoryVagalEdemaObstructiveMechanoreceptorsSmall-airwayVasoactiveArteryFibrosisPeripheralNeuromuscularInhalationCritical Care MedTRPV4ResistanceAfferentsProximalInflammatorySevereInhibitSpinalPhrenicCarotidDisordersFluidDiseaseActivitySystemicCirculationFrequencyFunctionWallsPatternInputCommonlyRole
Irritant receptors2
- 40 %) might provoke pulmonary venous hypertension and thereby stimulation of pulmonary stretch and irritant receptors. (qxmd.com)
- The laryngeal and pulmonary irritant receptors and pulmonary stretch receptors are affected by inhalation agents. (anesthesiageneral.com)
Idiopathic Pulmonar2
Capillary wedge pressure2
- In this population, the use of NATRECOR reduced pulmonary capillary wedge pressure and improved symptomatic dyspnea when measured at 3 hours of infusion. (nih.gov)
- In this population, the use of NATRECOR reduced pulmonary capillary wedge pressure and improved short term (3 hours) symptoms of dyspnea. (nih.gov)
Hering Breuer1
- When the lung expands, the receptors initiate the Hering-Breuer reflex, which reduces the respiratory rate. (wikipedia.org)
Total pulmonary resistance1
- PAE increased both Ptr and total pulmonary resistance but decreased dynamic lung compliance. (tmu.edu.tw)
Lungs5
- Pulmonary stretch receptors are mechanoreceptors found in the lungs. (wikipedia.org)
- Intercostal muscles and thoracic diaphragm receive impulses from the respiratory center, stretch receptors in the lungs send impulses to the respiratory center giving information about the state of the lungs. (wikipedia.org)
- We suggest that the response of a SAPSR to PAE depends on the location of the receptor within the lungs, and we speculate that threshold and fiber type are also related to location. (tmu.edu.tw)
- Lungs contain receptors that are highly sensitive to mechanical stimuli such as pressure changes, cyclic strain, and shear flow. (ucalgary.ca)
- Sensory input to the central nervous system from the lungs and airways: a prominent role for purinergic signalling via P2X2/3 receptors. (elispot.biz)
Surfactant2
- Increased firing from the stretch receptors also increases production of pulmonary surfactant. (wikipedia.org)
- Normally pulmonary surfactant reduces the work of breathing by reducing the alveo lar surface tension Volatile anaesthetics produce progressive yet reversible reductions in phosphatidyicholine the main lipid component of surfactant and also affect type II alveolar cell function. (anesthesiageneral.com)
Chronic9
- Percutaneous balloon pulmonary angioplasty, another interventional therapy, has re-emerged in the last few years as a clear alternative for the management of patients with distal, inoperable, chronic thromboembolic pulmonary hypertension. (revespcardiol.org)
- Alterations to lung function, such as acute respiratory illnesses (pneumonia, upper respiratory tract infection, etc.), acute bronchoconstriction (such as asthma), and chronic illnesses (COPD, emphysema, pulmonary fibrosis, etc.) all can cause impaired gas exchange at the levels of the lung. (biostrap.com)
- Treatment of mitral regurgitation should be directed at minimizing mitral regurgitation, improving forward blood flow, minimizing chronic stretch of myocardial fibers, improving lung function, regulating the ventricular rate, and preventing "down-regulation" high pressure baroreceptors and B1 receptors. (vin.com)
- A review of the effectiveness of psychological interventions used for anxiety and depression in chronic obstructive pulmonary disease. (elispot.biz)
- Comorbidities that cause pain and the contributors to pain in individuals with chronic obstructive pulmonary disease. (elispot.biz)
- 4. Bordoni B, Marelli F, Morabito B, Sacconi B. Depression, anxiety and chronic pain in patients with chronic obstructive pulmonary disease: the influence of breath. (elispot.biz)
- Occurrence, characteristics, and predictors of pain in patients with chronic obstructive pulmonary disease. (elispot.biz)
- Prevalence of thoracic pain in patients with chronic obstructive pulmonary disease and relationship with patient characteristics: a cross-sectional observational study. (elispot.biz)
- Phrenic nerve conduction abnormalities correlate with diaphragmatic descent in chronic obstructive pulmonary disease. (elispot.biz)
Tyrosine kinase4
- VEGFA-165 signals by activating its receptor tyrosine kinase VEGF receptor-2 (VEGFR-2). (jneurosci.org)
- Because another growth/trophic factor that signals via a receptor tyrosine kinase (brain derived neurotrophic factor) elicits a long-lasting facilitation of respiratory motor activity in the phrenic nerve, we tested the hypothesis that VEGFA-165 elicits similar phrenic motor facilitation (pMF). (jneurosci.org)
- Vascular endothelial growth factor (VEGF) acts through its receptor KDR, a receptor tyrosine kinase 85. (comprehensivephysiology.com)
- EGF (epidermal growth factor), TNF‐α, and PDGF (platelet‐derived growth factor) act through tyrosine kinase receptors and are partially transduced by intracellular reactive oxidant species (ROS) 95. (comprehensivephysiology.com)
Baroreceptor2
- The null hypotheses were that heart beat interval fluctuations at usual breathing frequencies are baroreflex mediated, that they persist during apnoea, and that autonomic responses to apnoea result from changes of chemoreceptor, baroreceptor or lung stretch receptor inputs. (elsevierpure.com)
- Apnoea sets in motion a continuous and ever changing reorganization of the relations among stimulatory and inhibitory inputs and autonomic outputs, which, in our study, could not be attributed to altered chemoreceptor, baroreceptor, or pulmonary stretch receptor activity. (elsevierpure.com)
Restrictive1
- This volume is decreased below the expected value in obstructive and restrictive pulmonary diseases. (ehd.org)
Venous2
- It is characterized by left atrial and left ventricular enlargement (predominantly eccentric hypertrophy), and in later stages with pulmonary venous engorgement. (vin.com)
- Finally when left-sided heart failure develops, pulmonary venous engorgement, dramatic left-sided cardiomegaly, pulmonary edema, and severe exercise intolerance are observed. (vin.com)
Baroreceptors1
- The baroreceptors are stretch receptors in the walls of the heart and blood vessels. (dailytechguides.com)
Embolism2
- Pulmonary air embolism (PAE) usually causes small-airway collapse. (tmu.edu.tw)
- abstract = "Pulmonary air embolism (PAE) usually causes small-airway collapse. (tmu.edu.tw)
Sensory1
- The cardiovascular system is under neural influences coming from several parts of the brain, which in turn receive feedback from sensory receptors in the vasculature. (dailytechguides.com)
Vagal3
- or altered pulmonary stretch receptor activity (major breathing frequency and tidal volume changes did not alter vagal tone or sympathetic activity). (elsevierpure.com)
- It had been hypothesized that the regions of prefrontal cortex which are involved in respiratory control can modulate Hering-Breuer reflexes evoked by vagal input from pulmonary stretch receptors. (biomedcentral.com)
- Sensing pulmonary oxidative stress by lung vagal afferents. (elispot.biz)
Edema1
- In later stages pulmonary edema and increased heart rate develop, leading to signs/symptoms of left-sided congestive heart failure and to exercise intolerance. (vin.com)
Obstructive1
- In obstructive sleep apnea (OSA) the apnea-associated triggers of hypoxia and intrathoracic pressure swings lead to repetitive rises of pulmonary artery pressure during sleep. (qxmd.com)
Mechanoreceptors1
- In this body of work, we investigated how mechanoreceptors (and more specifically TRPV4) modify the pulmonary immune response during host defense and inflammation. (ucalgary.ca)
Small-airway1
- Pulmonary stretch receptors are located in the small airway smooth muscle and respond to changes in stretching or changes in lung volume. (anesthesiageneral.com)
Vasoactive1
- The receptor (5‐HTR) and transporter (5‐HTT) of serotonin (5‐HT), and VPAC [the receptors of vasoactive intestinal peptide (VIP)] are all coupled to G‐protein 128,136. (comprehensivephysiology.com)
Artery2
- Pulmonary hypertension (PH), i. e. an increase of mean pulmonary artery pressure above 20 mm Hg under resting conditions, can be observed in different forms of sleep-disordered breathing (SDB). (qxmd.com)
- Atrial septostomy, Potts anastomosis, and pulmonary artery denervation are interventional procedures serving this purpose. (revespcardiol.org)
Fibrosis1
- The cation channel transient receptor potential vanilloid 4 (TRPV4) is a critical mediator of myofibroblast transdifferentiation and in vivo fibrosis through its mechanosensitivity to extracellular matrix stiffness. (bvsalud.org)
Peripheral1
- Brainstem structures receive input from peripheral oxygen, pH, and stretch receptors and generate automatic respiration. (thoracickey.com)
Neuromuscular2
- Disorders are grouped according to which functional unit of the neuromuscular system is affected, focusing on pulmonary manifestations of these disease processes ( Table 29-1 ). (thoracickey.com)
- It is an autoimmune disorder, in which weakness is caused by circulating antibodies that block acetylcholine receptors at the post-synaptic neuromuscular junction, [1] inhibiting the stimulative effect of the neurotransmitter acetylcholine. (doctorbhatia.com)
Inhalation1
- For pharmacodynamics of inhaled anesthetics , the pulmonary effects of inhalation agents are many and important as this is the portal of entry. (anesthesiageneral.com)
Critical Care Med1
- Pulmonary and Critical Care Medicine at EvergreenHealth in Kirkland, Washington. (cdc.gov)
TRPV44
- In this review, we discuss the role of mechanosensitive ion channels, such as Piezo1 and transient receptor potential vanilloid 4 (TRPV4), and cell adhesion molecules, such as integrins, selectins, and cadherins in biology and human disease. (bvsalud.org)
- Transient receptor potential vanilloid 4 (TRPV4) function in lung injury has been shown to be stimulus- and cell-type specific. (bvsalud.org)
- Expanding knowledge regarding the downstream mechanisms by which TRPV4 acts to tailor macrophage function in pulmonary inflammatory diseases will allow for formulation of novel therapeutics. (bvsalud.org)
- This study was undertaken to understand the molecular mechanism by which the mechanosensitive cation channel, transient receptor potential vanilloid 4 (TRPV4), alters the in vivo response to lung infection. (bvsalud.org)
Resistance1
- Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. (puvanameta.com.my)
Afferents1
- Afferents from these receptors (with a high concentration of receptors at the carina) inhibit further inspiration. (anesthesiageneral.com)
Proximal1
- Functional subtyping of neurokinin receptors on canine proximal colonic mucosa. (mcmaster.ca)
Inflammatory2
- Main inflammatory mediators in pulmonary vascular remodeling in pulmonary arterial hypertension. (comprehensivephysiology.com)
- Schematic inflammatory pathways involving growth factors, vasomodulators, and infectious stimuli in the pathogenesis of pulmonary arterial hypertension. (comprehensivephysiology.com)
Severe1
- The current review discusses the physiological background, experimental evidence, and potential clinical and hemodynamic benefits of all these interventional therapies regarding their use in the setting of RHF due to severe pulmonary hypertension. (revespcardiol.org)
Inhibit1
- Tachykinin receptor antagonists inhibit hyperpnea-induced bronchoconstriction in guinea pigs. (mcmaster.ca)
Spinal1
- Here, we use phrenic motor facilitation (pMF) as a general term, including pLTF after acute intermittent hypoxia and other forms induced, for example, by spinal administration of receptor agonists. (jneurosci.org)
Phrenic1
- 22. Bałkowiec A, Kukuła K, Szulczyk P. Functional classification of afferent phrenic nerve fibres and diaphragmatic receptors in cats. (elispot.biz)
Carotid1
- The carotid sinus and aortic arch receptors monitor arterial circulation. (dailytechguides.com)
Disorders1
- Pulmonary hypertension and sleep-related breathing disorders]. (qxmd.com)
Fluid1
- In addition, this compression aids in expelling pulmonary fluid. (atsjournals.org)
Disease1
- Despite advances in drug therapy, pulmonary hypertension-particularly arterial hypertension (PAH)-remains a fatal disease. (revespcardiol.org)
Activity1
- Local transpulmonary pressure (Ptr) is thought to be closely associated with the activity of slowly adapting pulmonary stretch receptors (SAPSRs). (tmu.edu.tw)
Systemic1
- It can be divided into two small circulations which are the minor (pulmonary) blood circulation, and the major (systemic) blood circulation. (robhosking.com)
Circulation1
- Receptors are also located in the walls of the right and left atria at the entrance of the superior and inferior venae cavae and the pulmonary veins, as well as in the pulmonary circulation. (dailytechguides.com)
Frequency1
- PAE increased the peak firing rate of 18 of these receptors, and there was a close relationship between the discharge frequency of these SAPSRs and the Ptr during PAE. (tmu.edu.tw)
Function1
- These are the basic elements of a ventilatory pulmonary function test . (wikidoc.org)
Walls1
- These receptors read the stretching of the arterial walls, heart and. (robhosking.com)
Pattern1
- Patients suffering from advanced idiopathic pulmonary arterial hypertension (IPAH) might show a similar breathing pattern while asleep. (qxmd.com)
Input1
- Lowering pulmonary input impedance with different PAH-specific drugs is the obvious therapeutic target in RHF due to chronically increased afterload. (revespcardiol.org)
Commonly1
- In MG, the autoantibodies are directed most commonly against the acetylcholine receptor (nicotinic type), the receptor in the motor end plate for the neurotransmitter acetylcholine that stimulates muscular contraction. (doctorbhatia.com)
Role1
- The EC system plays a critical and modulatory role in respiratory homeostasis and pulmonary functionality. (arizona.edu)