OrganismsDiseasesChemicals and Drugs
Pseudorabies VaccinesPseudorabiesHerpesvirus 1, SuidVaccines
AntibodiesImmunityEconomic losses to the swine industryVirusInactivated and live-attenuatedPigletsAUJESZKY'S DISEASEPRRSRabies VaccinesRecombinant vaccinesViralPRRSVCancer vaccinesCommercial vaccineAntibodyInfectionSubunitCommercially availableMolecularCRISPREfficacySmallpoxWidelyPigs inoculatedMeshUptakeHerdsClinical studiesEffectivenessDevelopmentVaccinationAdvancesOutbreaksProteinsInfectiousCandidate
Antibodies8
  • Both farms can provide breeding pigs that are negative for pseudorabies gE antibodies and are free of wild virus infection. (denimbear.com)
  • The piglets immunized with PRV GDFS-delgI/gE/US9/US2 vaccine did not produce PRV gE-specific antibodies but could generate PRV gB-specific antibodies and high neutralizing titers against PRV GDFS strain (variant PRV strain) or PRV Ea strain (older PRV strain). (authorea.com)
  • These antibodies will then be used to identify highly conserved vaccine targets that may be engineered to induce cross-protection. (pirbright.ac.uk)
  • The passive transfer of antibodies may interfere with the response to live viral vaccines (7). (nih.gov)
  • In mice, vaccines inducing antibodies to the extracellular domain of the M2 protein (M2e) can confer protection to influenza A virus infection. (microbiologyresearch.org)
  • In this study, the protection conferred by vaccines inducing antibodies to M2e was evaluated in a challenge model for swine influenza in pigs. (microbiologyresearch.org)
  • He said in the year 2000, Uruguay's Ministry of Agriculture and the swine industry completed a serological study of pigs there, looking for antibodies of PRRS, pseudorabies virus (PRV), classical swine fever (CSF), and other diseases. (swinehealth.org)
  • Subunit, DNA and vectored vaccine candidates have been developed using this glycoprotein as the primary antigen, demonstrating that gD has the capacity to induce robust virus neutralizing antibodies and strong cell-mediated immune responses, as well as protection from clinical symptoms, in target species. (biomedcentral.com)
Immunity8
  • A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. (wikipedia.org)
  • Some vaccines offer full sterilizing immunity, in which infection is prevented completely. (wikipedia.org)
  • In some cases vaccines may result in partial immune protection (in which immunity is less than 100% effective but still reduces risk of infection) or in temporary immune protection (in which immunity wanes over time) rather than full or permanent immunity. (wikipedia.org)
  • In conclusion, the use of gIp2 in piglets as a vaccine virus is safe and induces an immunity comparable to that exerted by commercially available vaccines. (csic.es)
  • The results demonstrated that both inactivated and live-attenuated chimeric PCV1-2b vaccines were effective to induce protective immunity against PCV2b infection. (biomedcentral.com)
  • We have a longstanding interest in understanding immunological mechanisms underlying protective immunity and the application of this knowledge to the development of new or improved vaccines. (pirbright.ac.uk)
  • Genotypic shifts may be relevant to changes in pathogenicity and vaccine immunity. (biomedcentral.com)
  • In view of its role in the induction of protective immunity, gD has been tested in new vaccine development strategies against both viruses. (biomedcentral.com)
Economic losses to the swine industry1
  • Pseudorabies virus (PRV) causes Aujeszky's disease or pseudorabies (PR) in pigs worldwide, which leads to heavy economic losses to the swine industry. (authorea.com)
Virus34
  • Isolates from pseudorabies virus epidemics in swine herds were characterized. (cdc.gov)
  • Evidence confirmed that the pathogenic pseudorabies virus was the etiologic agent of this epidemic. (cdc.gov)
  • Pseudorabies virus (PRV), also called Aujeszky disease virus or suid herpesvirus type 1, is a member of the Alphaherpesvirinae subfamily within the family Herpesviridae . (cdc.gov)
  • Thus, both the virus in the vaccine and the super-virulent wild-type strain can establish latency within the same animal ( 13 - 15 ). (cdc.gov)
  • Necropsy specimens from pigs infected with pseudorabies virus. (cdc.gov)
  • Alignment the partial sequences of glycoprotein (g) C (A), gD (B), and gE (C) genes of pseudorabies virus at the nucleotide level. (cdc.gov)
  • In a previous study we obtained and characterized in vitro a novel pseudorabies virus (PRV) variant named gIp2 with a TK, gI/gE, 11k and 28k negative phenotype and a duplication of PK gene. (csic.es)
  • Additionally, the inoculation of gIp2 induced an immune response able to provide clinical and virological protection against pseudorabies virus after challenge. (csic.es)
  • Immunogenic response to a recombinant pseudorabies virus carrying bp26 gene of Brucella melitensis in mice. (ijmedrev.com)
  • Both farms can provide swine fever vaccine-positive, pigs without wild virus infection. (denimbear.com)
  • One vaccine is based on the inactivated PCV2a virus [ 6 ]. (biomedcentral.com)
  • In addition, we are applying our expertise in porcine immunology and vaccinology to contribute to the development of vaccines to combat new and emerging zoonotic viruses, such as the Nipah virus and SARS-CoV-2. (pirbright.ac.uk)
  • We also aim to develop a safe and efficacious Nipah virus vaccine for pigs that will aid the prevention and control of Nipah outbreaks. (pirbright.ac.uk)
  • Development of a Nipah virus vaccine to eliminate porcine reservoirs and safeguard human health. (pirbright.ac.uk)
  • We are working with colleagues and partners to develop a prototype Nipah virus vaccine for pigs. (pirbright.ac.uk)
  • We are also exploring the potential for live attenuated PRRSV and pseudorabies virus to act as vaccine vectors for Nipah and thus provide a bivalent vaccine. (pirbright.ac.uk)
  • PRRS control is hampered by the rapid evolution of the virus and shortcomings with existing vaccines. (pirbright.ac.uk)
  • Pseudorabies virus EP0 protein counteracts an interferon-induced antiviral state in a species-specific manner. (geneticsmr.com)
  • 2000). The response of pigs inoculated with a thymidine kinase-negative (TK-) pseudorabies virus to challenge infection with virulent virus. (geneticsmr.com)
  • Alphaherpesviruses, specifically pseudorabies virus (PRV) and Herpes Simplex virus type 1 (HSV-1), have demonstrated at least two forms of SIE. (montana.edu)
  • Simian virus (SV40), which was placed into polio vaccines for many years in the United States. (governmentpropaganda.net)
  • Porcine NK Cells Stimulate Proliferation of Pseudorabies Virus-Experienced CD8 and CD4CD8 T Cells. (sciensano.be)
  • Vaccines used to prevent infection by MUMPS VIRUS. (childrensmercy.org)
  • Best known is the live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had mumps or been immunized with live mumps vaccine. (childrensmercy.org)
  • Pseudorabies virus (PRV) can infect multiple hosts and lead to fatal encephalitis. (biomedcentral.com)
  • However, there is limited information on epidemiology and coinfection rate of PCV2 with other critical swine diseases in this area, such as porcine reproductive and respiratory syndrome virus (PRRSV), classical swine fever virus (CSFV), Pseudorabies virus (PRV), and porcine epidemic diarrhea virus (PEDV). (biomedcentral.com)
  • Besides of PCVs, there are other viral pathogens threatening the pig raising industry at regional, national and global level, including porcine epidemic diarrhea virus (PEDV), porcine reproductive and respiratory syndrome virus (PRRSV), pseudorabies virus (PRV), classical swine fever virus (CSFV). (biomedcentral.com)
  • All vaccines induced an antibody response against M2e, and the M2eNP DNA vaccine additionally induced an influenza virus-specific lymphoproliferation response. (microbiologyresearch.org)
  • 113.200 - General requirements for killed virus vaccines. (customsmobile.com)
  • 113.212 - Bursal Disease Vaccine, Killed Virus. (customsmobile.com)
  • Pseudorabies is another virus deadly for piglets and transferrable to dogs and cats but not humans. (mom.com)
  • The Centers for Disease Control and Prevention notes that flu vaccines for pigs help but, as with humans, the annual vaccine may be for a different strain of virus than the one affecting pigs in your area. (mom.com)
  • We amplified a 816-bp sequence of the UL31 gene from the pseudorabies virus (PRV) Becker strain genome. (geneticsmr.com)
  • DIVA vaccines include genetically engineered gene-deleted viruses, for example gE − virus, and subunit or vectored vaccines based on a viral envelope glycoprotein such as gD. (biomedcentral.com)
Inactivated and live-attenuated3
  • In this study, the efficacy of inactivated and live-attenuated (2 × 10 3.5 or 2 × 10 4.0 50 % tissue culture infective dose [TCID 50 ] dose) chimeric PCV1-2b vaccines was compared side-by-side in conventional pigs. (biomedcentral.com)
  • Both inactivated and live-attenuated chimeric PCV1-2b vaccines induced a robust antibody responses, and significantly decreased microscopic lesion and lower viral loads in serum or superficial inguinal lymph nodes (SILN) compared with that in the nonvaccinated challenged group. (biomedcentral.com)
  • Vaccination is a key element to PRRS control and while both inactivated and live attenuated PRRS vaccines are widely used neither provides sufficiently effective protection against the diversity of circulating PRRSV strains. (pirbright.ac.uk)
Piglets6
  • No adverse reactions or clinical signs were observed in any group after immunization, indicating that the application of up to 10 times the conventional dose included in a commercial vaccine (i.e. 10E5.5 TCID sub(50)) of gIp2 was safe in piglets. (csic.es)
  • After emerging PRV GDFS variant challenge, all piglets immunized with PRV GDFS-delgI/gE/US9/US2 vaccine did not show any clinical signs, and the rectal temperature was normal. (authorea.com)
  • Moreover, the autopsy and histopathological analyses revealed that the piglets in the PRV GDFS-delgI/gE/US9/US2 vaccine group did not show apparent gross and pathological lesions. (authorea.com)
  • Furthermore, the piglets did not present weight loss in the PRV GDFS-delgI/gE/US9/US2 vaccine groups. (authorea.com)
  • According to the criteria of OIE terrestrial manual, the results of the experiment confirmed that the PRV GDFS-delgI/gE/US9/US2 vaccine could provide full protection against emerging PRV variant strain in piglets. (authorea.com)
  • The trials were conducted with 48 piglets, acquired from a farm free from PRRSv, Aujeszky's Disease (pseudorabies), Pasteurella multocida and Brachyspira hyodysenteriae . (pigprogress.net)
AUJESZKY'S DISEASE2
  • Vaccines or candidate vaccines used to prevent PSEUDORABIES (Aujeszky's disease), a herpesvirus of swine and other animals. (nih.gov)
  • Aujeszky's disease, also known as pseudorabies, is caused by an alphaherpesvirus that infects the central nervous system and other organs, such as the respiratory tract, in a variety of mammals except humans and the tailless apes. (gov.ie)
PRRS3
  • Our major research focus is the development of improved vaccines for porcine reproductive and respiratory syndrome (PRRS). (pirbright.ac.uk)
  • We are working with colleagues and collaborators on ambitious complimentary approaches aimed at the development of improved PRRS vaccines. (pirbright.ac.uk)
  • Even though it is PRRS, it appears non-virulent, perhaps vaccine-like. (swinehealth.org)
Rabies Vaccines1
Recombinant vaccines1
  • Herpesvirus of turkeys (HVT), used originally as a vaccine against Marek's disease (MD), has recently been shown to be a highly effective viral vector for generation of recombinant vaccines that deliver protective antigens of other avian pathogens. (mdpi.com)
Viral4
  • Influenza viral vectors expressing the Brucella OMP16 or L7/L12 proteins as vaccines against B. abortus infection. (ijmedrev.com)
  • Viral vector-based vaccines offer the potential to provide protection against virulent pathogens entering via the mucosal route. (pirbright.ac.uk)
  • We are evaluating a range of recombinant vaccine candidates, based on protein subunits as well as viral and mRNA vectors. (pirbright.ac.uk)
  • It accepts basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. (biomedcentral.com)
PRRSV5
  • There is therefore an urgent need to develop more efficacious vaccines to aid PRRSV control. (pirbright.ac.uk)
  • We have therefore identified and characterised conserved T cell antigens from PRRSV and are evaluating their vaccine potential using a novel vaccine vector platform based on an attenuated herpesvirus. (pirbright.ac.uk)
  • Identifying the key determinants of PRRSV proteins that mediate immune evasion or contribute to disease to provide rational targets for the production of attenuated vaccine strains. (pirbright.ac.uk)
  • Evaluating a novel solid dose vaccine formulation technology for delivery of PRRSV vaccines. (pirbright.ac.uk)
  • By dissecting the pathological and protective immune responses evoked by PRRSV, we will be able to design safer and more effective vaccines. (pirbright.ac.uk)
Cancer vaccines3
  • Indeed, TAAs can be used to develop off-the-shelf cancer vaccines appropriate to all patients affected by the same malignancy. (biomedcentral.com)
  • Therefore, overcoming such limitations is a major goal, given that TAAs represent the most suitable target antigens for developing cancer vaccines on a large scale. (biomedcentral.com)
  • Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. (childrensmercy.org)
Commercial vaccine1
  • There are currently several types of commercial vaccine products available worldwide and they differ in antigen. (biomedcentral.com)
Antibody2
  • PCV2 antibody titers decreased after 7 days post challenge (DPC) in pigs administered the inactivated PCV1-2b vaccine and they were lower than those in pigs inoculated with live-attenuated PCV1-2b on the day of necropsy. (biomedcentral.com)
  • Antibody responses among adolescent females receiving two or three quadrivalent human papillomavirus vaccine doses at standard and prolonged intervals. (childrensmercy.org)
Infection7
  • Vaccination of pigs with attenuated live or inactivated vaccines is widely performed to reduce the huge economic losses caused by PRV infection ( 10 - 12 ). (cdc.gov)
  • Vaccines can be prophylactic (to prevent or alleviate the effects of a future infection by a natural or "wild" pathogen), or therapeutic (to fight a disease that has already occurred, such as cancer). (wikipedia.org)
  • Bahador A, Esmaeili D, Mansoori N, Mahdavi M. Protection against Brucella abortus 544 Strain Infection in BALB/c Mice by Subcutaneouse Administration of Multicomponent Vaccine of rCagA Conjugated with LPS + CpG. (ijmedrev.com)
  • PRV live-attenuated vaccines could control PRV infection, which has become a consensus. (authorea.com)
  • Therefore, PRV GDFS-delgI/gE/US9/US2 strain is a potential live-attenuated vaccine against emerging PRV variant strain infection in China. (authorea.com)
  • Research on this topic will stimulate development of vaccines in global health by providing targets for disruption of alphaherpesvirus infection and information on unknown aspects of alphaherpesvirus infection. (montana.edu)
  • Development of effective vaccines is considered the only ideal way to control T . gondii infection. (geneticsmr.com)
Subunit1
Commercially available1
  • However, only one live vaccine is commercially available for use in sheep and goats. (geneticsmr.com)
Molecular1
  • The protein moiety of Brucella abortus outer membrane protein 16 is a new bacterial pathogen-associated molecular pattern that activates dendritic cells in vivo, induces a Th1 immune response, and is a promising self-adjuvanting vaccine against systemic and oral acquired brucellosis. (ijmedrev.com)
CRISPR1
  • In this study, a Bartha-K61-like vaccine based on emerging PRV variant was generated by the CRISPR/Cas9 method, which has deleted the gI, gE, US9, and US2 genes. (authorea.com)
Efficacy2
  • The main objective of the present study was to determine the safety and efficacy, as a vaccine candidate, of this recombinant PRV. (csic.es)
  • Finally, such T cell populations may be removed from the immune repertoire by central and peripheral tolerance and the efficacy of vaccines based on TAAs may be lost [ 9 ]. (biomedcentral.com)
Smallpox1
  • The terms vaccine and vaccination are derived from Variolae vaccinae (smallpox of the cow), the term devised by Edward Jenner (who both developed the concept of vaccines and created the first vaccine) to denote cowpox. (wikipedia.org)
Widely1
Pigs inoculated1
  • Moreover, no viremia was present in pigs inoculated with live-attenuated PCV1-2b vaccine at 21 DPC regardless of the dose difference. (biomedcentral.com)
Mesh1
  • Papillomavirus Vaccines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
Uptake1
  • Bradley-Ewing A, Lee BR, Doctor JN, Meredith G, Goggin K, Myers A. A pilot intervention combining assessment and feedback with communication training and behavioral nudges to increase HPV vaccine uptake. (childrensmercy.org)
Herds1
  • The disease is controlled by containment of infected herds and by the use of vaccines and/or removal of latently infected animals. (gov.ie)
Clinical studies1
  • Essential Apitolisib research buy training regarding anti-A experiment with immunotherapeutic tactics had been discovered selleck inhibitor through the initial active vaccine clinical studies. (liverx-receptor.com)
Effectiveness1
Development6
  • The science of vaccine development and production is termed vaccinology. (wikipedia.org)
  • Progress in Brucella vaccine development. (ijmedrev.com)
  • [17] The science of vaccine development and production is termed vaccinology . (webot.org)
  • And to support the development of COVID-19 vaccine candidates by utilising the pig as a preclinical model to study vaccine immunogenicity. (pirbright.ac.uk)
  • We are supporting the UK response to the COVID-19 pandemic by evaluating a range of vaccine candidates for immunogenicity in pigs to inform further clinical development. (pirbright.ac.uk)
  • New strategies for vaccine development against both BoHV-1 and BoHV-5 have been focused on the design of marker vaccines, which differentiate infected from vaccinated animals (also known as DIVA vaccines). (biomedcentral.com)
Vaccination2
  • The administration of vaccines is called vaccination. (wikipedia.org)
  • Sometimes, protection fails for vaccine-related reasons such as failures in vaccine attenuation, vaccination regimens or administration. (wikipedia.org)
Advances1
Outbreaks1
  • The PR outbreaks demonstrated that Bartha-K61 vaccine did not provide full protection against the emerging PRV variant. (authorea.com)
Proteins1
  • A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. (wikipedia.org)
Infectious3
  • There is overwhelming scientific consensus that vaccines are a very safe and effective way to fight and eradicate infectious diseases. (wikipedia.org)
  • Infectious diseases before and after a vaccine was introduced. (webot.org)
  • Since the early clinical manifestations caused by dengue fever are similar to those of respiratory infectious diseases, coupled with the fact that the relevant vaccine has not yet been approved for. (mapperbio.com)
Candidate2
  • The OMPs of Brucella could be used as a suitable vaccine candidate versus brucellosis. (ijmedrev.com)
  • Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. (childrensmercy.org)