AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Protein CPorphyrinsOncogene Proteins v-sisOncogene Protein tpr-metOncogene Protein v-mafProtein C DeficiencyOncogene Protein gp140(v-fms)Oncogene Proteins v-mosProtein C InhibitorOncogene Protein p55(v-myc)Oncogene Protein p65(gag-jun)Oncogene Proteins v-rafOncogene Proteins v-fosActivated Protein C ResistanceOncogene Protein v-crkOncogene Proteins v-mybOncogene Protein v-cblOncogene Proteins v-erbBOncogene Proteins v-ablOncogenesOncogene Proteins v-relProtein SOncogene Proteins v-erbAThrombomodulinOncogene ProteinsOncogene Protein p21(ras)Blood Coagulation FactorsPulmonary Surfactant-Associated Protein CFactor VOncogene Protein pp60(v-src)Factor VaThrombinOncogene Proteins, ViralBlood CoagulationOncogene Proteins, FusionGenes, rasOncogene Protein v-aktProthrombinCell Transformation, NeoplasticProtein S DeficiencyReceptors, Cell SurfaceMolecular Sequence DataReceptors, ThrombinThrombophiliaBlood Coagulation DisordersBase SequencePartial Thromboplastin TimeAmino Acid SequenceReceptor, PAR-1MutationGenes, mosAnticoagulantsFactor Xa1-Carboxyglutamic AcidRecombinant ProteinsGlycoproteinsProto-OncogenesBlood Coagulation TestsProto-Oncogene ProteinsCell LineDisseminated Intravascular CoagulationAntithrombin IIIThrombosisThrombophlebitisFactor V DeficiencyFactor XGenes, mycTransfectionProtein BindingGene AmplificationAntithrombinsEnzyme ActivationHemostasisProto-Oncogene Proteins p21(ras)Proto-Oncogene Proteins c-mycGene Expression Regulation, NeoplasticSepsisFactor VIIIaBinding SitesPurpura FulminansRNA, MessengerRetroviridae Proteins, OncogenicAntithrombin III DeficiencyKineticsCells, CulturedSignal TransductionCell Line, TransformedFibrinolysisThromboplastinCarrier ProteinsPoint MutationCell Transformation, ViralMice, TransgenicGene Expression RegulationCell Line, TumorFactor VIIaProteolipidsVitamin KTumor Cells, CulturedVenous Thrombosis
KinaseAmino AcidsViralSomatic cellsCellularRegulateReceptorOncogenicGenes c-mosMeshImmunohistochemistryMutationsSequencesApoptosisHumansNoteProductsPathwayStabilityActivityFactorHumanExpressionLargeCell cyclePublicationsShown
Kinase12
  • Proto-oncogene serine/threonine-protein kinase mos is an enzyme that in humans is encoded by the MOS gene. (wikipedia.org)
  • They function in the cell cycle to maintain MATURATION PROMOTING FACTOR in the active state and have protein-serine/threonine kinase activity. (bvsalud.org)
  • AIMS: Reports concerning the expression of cytoplasmic components of the mitogen-activating protein kinase (MAPK) pathway in lung cancer are limited. (edgehill.ac.uk)
  • Protein kinase Cd and c-Abl kinase are required for transforming growth factor ß induction of endothelial-mesenchymal transition in vitro. (jefferson.edu)
  • Deregulated activity of the Abl protein tyrosine kinase is oncogenic in humans and in animals. (torvergata.it)
  • Abl-enhanced maturation was normal as judged by accumulation of Mos as well as activation of MAP kinase and Cdc2/CyclinB (MPF). (torvergata.it)
  • Regulation of mitogen-activated protein kinase activation by protein kinases A and C in a cell-free system. (ox.ac.uk)
  • Previously pp60v-src, cyclin A, p39mos, and maturation-promoting factor (composed of Cdc2 and cyclin B) have been shown to activate mitogen-activated protein kinase (MAPK) and MAPK kinase (MEK) in cell-free extracts of Xenopus oocytes. (ox.ac.uk)
  • Here we show that protein kinase C (PKC) is also able to stimulate MAPK in a Ras-dependent manner, but PKC is not necessary for signaling by pp60v-src. (ox.ac.uk)
  • In addition, preincubation of extracts with cAMP-dependent protein kinase (PKA) blocks stimulation of MAPK by cyclin, p21V12ras, PKC, or pp60v-src, by at least 50%, but stimulation by c-Mos is unaffected. (ox.ac.uk)
  • Proto-oncogene proteins that negatively regulate RECEPTOR PROTEIN-TYROSINE KINASE signaling. (nih.gov)
  • Its product is a GTP-binding protein which probably activates phospholipase C that generates the internal promoter diazylglycerol for kinase C, thus signalizing cell proliferation [14-16]. (science-connections.com)
Amino Acids1
  • Antidiuretic hormone is a polypeptide with eight amino acids, too small to accurately be called a protein. (50webs.org)
Viral1
Somatic cells2
  • What does Mos do in oocytes and somatic cells? (wikipedia.org)
  • In vitro investigations, in somatic cells, have shown that c-mos expression has opposing effects on cell cycle progression suggesting that it may represent an important determinant of aberrant cell function. (edgehill.ac.uk)
Cellular5
  • Cellular proteins encoded by the c-mos genes (GENES, MOS). (bvsalud.org)
  • Cellular proteins encoded by the H-ras, K-ras and N-ras genes. (uchicago.edu)
  • Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). (childrensmercy.org)
  • FLNA interacts with more than 90 partner proteins to execute multiple cellular functions [ 7 ] , and mainly helps to provide scaffolding to its interacting partners. (encyclopedia.pub)
  • AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. (biomedcentral.com)
Regulate4
  • Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. (childrensmercy.org)
  • Some proto-oncogenes work to regulate cell death. (cancerquest.org)
  • The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)
  • Results from zebrafish embryos injected with murine Stat3 mRNA and stat3 morpholino suggest that Ambra1b could indirectly regulate this protein through CUL4-DDB1 interaction. (biomedcentral.com)
Receptor2
  • The blood carries the hormones to target cells that contain specific receptor proteins for the hormones, and which therefore can respond in a specific fashion to them. (50webs.org)
  • HERZUMA (trastuzumab-pkrb) is a humanized IgG1 kappa monoclonal antibody that selectively binds with high affinity to the extracellular domain of the human epidermal growth factor receptor 2 protein, HER2 . (rxlist.com)
Oncogenic1
  • Oncogenic transformation can take place when c-mos proteins are expressed at the wrong time. (bvsalud.org)
Genes c-mos1
  • Proteínas celulares codificadas por los genes c-mos (GENES MOS). (bvsalud.org)
Mesh2
  • Proto-Oncogene Proteins c-mdm2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Proto-Oncogene Proteins p21(ras)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
Immunohistochemistry1
  • Immunohistochemistry quantified HIF-1α and P70S6K1 protein expression in xenografts. (bvsalud.org)
Mutations2
  • Different cancer types tend to depend on a limited number of 'driver' oncogene mutations. (cancerquest.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
Sequences1
  • This supposition does not exclude the idea that certain sequences of ras (and other oncogenes) might have been evolved before thc heterotrophs in the history of life. (science-connections.com)
Apoptosis1
  • We found that PPan protein is localized in the nucleoli and mitochondria and that loss of PPan results in increased apoptosis. (silverchair.com)
Humans1
  • As one moves up the evolutionary scale to the multicellular organization of the living beings, i. e., to the Metazoa, the ,src oncogene appears in the parazoic sponges and is, thereafter, traceable through the Eumetazoa up to humans [2, 17, 18]. (science-connections.com)
Note1
  • Note that by convention gene names are italicized and the proteins they make are not. (cancerquest.org)
Products2
  • Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
  • Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
Pathway1
  • One of the molecules participating in this pathway is the product of the c-mos proto-oncogene. (edgehill.ac.uk)
Stability1
  • Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis. (umassmed.edu)
Activity4
  • The proteins have GTPase activity and are involved in signal transduction as monomeric GTP-binding proteins. (uchicago.edu)
  • In normal cells, both internal and external signals control the activity of the oncogenes. (cancerquest.org)
  • A key feature of oncogene activity is that a single altered copy leads to unregulated growth. (cancerquest.org)
  • Furthermore, inhibition of endogenous PKA by the heat-stable PKA inhibitor is sufficient to stimulate MAPK activity in these extracts in the absence of protein synthesis and without dependence on a functional Ras protein. (ox.ac.uk)
Factor1
  • Funcionan en el ciclo celular para mantener el FACTOR PROMOTOR DE LA MADURACION en estado activo y tienen actividad de proteína-serina/treonina cinasa. (bvsalud.org)
Human1
  • A. Oncogenes in Phylogeny Neoplasia is not limited to human beings, or to mammals, but develops in all taxonomic groups of recent Eumetazoa and even in multicellular plants. (science-connections.com)
Expression2
  • Das perfekte Fotobuch system: The protein of using post-infectious to Caucasians in the failure and speed of the stimulation over expression. (augenta.net)
  • It also suppressed HIF-1α, EGFR, p-PI3K, Akt, p-Akt, and p-mTOR expression in tumors while enhancing PTEN oncogene expression. (bvsalud.org)
Large3
  • Proteins are large polypeptides, so the distinction between the two categories is somewhat arbitrary. (50webs.org)
  • Filamin A (FLNA) is a large actin-binding cytoskeletal protein that is important for cell motility by stabilizing actin networks and integrating them with cell membranes. (encyclopedia.pub)
  • A large variety of taxonomic groups containing a large packet of oncogenes has been evolved. (science-connections.com)
Cell cycle2
  • Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. (nih.gov)
  • Additionally, DBC1 knockdown eliminated the up-regulation of MMP7, EMT-related proteins, and cell cycle-related proteins as well as the enhanced proliferation and invasiveness induced by ZNF326. (cancerindex.org)
Publications3
  • This graph shows the total number of publications written about "Proto-Oncogene Proteins c-mdm2" by people in this website by year, and whether "Proto-Oncogene Proteins c-mdm2" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Proto-Oncogene Proteins c-mdm2" by people in Profiles. (umassmed.edu)
  • Below are the most recent publications written about "Proto-Oncogene Proteins p21(ras)" by people in Profiles. (uchicago.edu)
Shown1