AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Protein CPorphyrinsOncogene Proteins v-sisOncogene Protein tpr-metOncogene Protein v-mafProtein C DeficiencyOncogene Protein gp140(v-fms)Oncogene Proteins v-mosProtein C InhibitorOncogene Protein p55(v-myc)Oncogene Protein p65(gag-jun)Oncogene Proteins v-rafOncogene Proteins v-fosActivated Protein C ResistanceOncogene Protein v-crkOncogene Proteins v-mybOncogene Protein v-cblOncogene Proteins v-erbBOncogene Proteins v-ablOncogenesOncogene Proteins v-relProtein SOncogene Proteins v-erbAThrombomodulinOncogene ProteinsOncogene Protein p21(ras)Blood Coagulation FactorsPulmonary Surfactant-Associated Protein CProto-Oncogene Proteins c-etsProto-Oncogene Protein c-ets-1Factor VOncogene Protein pp60(v-src)Proto-Oncogene Protein c-ets-2Factor VaThrombinOncogene Proteins, FusionOncogene Proteins, ViralBlood CoagulationGenes, rasCell Transformation, NeoplasticOncogene Protein v-aktProthrombinMolecular Sequence DataProto-Oncogene ProteinsProtein S DeficiencyBase SequenceReceptors, Cell SurfaceReceptors, ThrombinThrombophiliaAmino Acid SequenceBlood Coagulation DisordersTranscription FactorsMutationPartial Thromboplastin TimeReceptor, PAR-1Proto-OncogenesCell LineAnticoagulantsBinding SitesRecombinant ProteinsFactor Xa1-Carboxyglutamic AcidGlycoproteinsBlood Coagulation TestsTransfectionProtein BindingRetroviridae Proteins, OncogenicDisseminated Intravascular CoagulationDNA-Binding ProteinsAntithrombin IIIGene Expression Regulation, NeoplasticThrombosisThrombophlebitisPromoter Regions, GeneticFactor V DeficiencyGenes, mycFactor XTranscription, GeneticProto-Oncogene Proteins p21(ras)RNA, MessengerGene Expression RegulationProto-Oncogene Proteins c-mycProto-Oncogene Protein c-fli-1Gene AmplificationAntithrombinsEnzyme ActivationHemostasisSignal TransductionCells, CulturedSepsisFactor VIIIaCell Line, TransformedPurpura FulminansAntithrombin III DeficiencyCell Line, TumorKineticsTumor Cells, CulturedTrans-ActivatorsMice, TransgenicPoint Mutation
TranscriptionGenesTumor suppressorsReceptorsKinasesReceptorKinaseFLI1D12.776GeneSignal TransductionTranscriptionalInhibitionGTPaseNucleotideMechanismsOncogenicTernary complexFamilyViralMRNATumorigenesisFusionDifferentiationRegulateDescriptorComplexesHumanMolecularSequencesFactorAmyloidMediatesSequence-specificAntibodyIntegrationCancerCellActivityDomain
Transcription22
  • In a set of 15 potential biomarkers differentiating SLE patients and controls, two of the proteins were transcription factors, i.e. (nih.gov)
  • IRF5 and SAM pointed domain containing ETS transcription factor (SPDEF). (nih.gov)
  • A member of the c-ets family of transcription factors that is preferentially expressed in cells of hematopoietic lineages and vascular endothelial cells. (childrensmercy.org)
  • We previously reported overexpression of Prostate derived Ets transcription factor (PDEF) in breast cancer and its role in breast cancer progression, supporting PDEF as an attractive target in this cancer. (elsevierpure.com)
  • We show that knockout of the prolactin-regulated Ets transcription factor Elf5 prevented formation of the secretory epithelium during pregnancy. (elsevierpure.com)
  • The Ets family of eukaryotic transcription factors is based around the conserved Ets DNA-binding domain. (hud.ac.uk)
  • Using a combination of targeted mutagenesis of transcription factor-binding sites and gene silencing of transcription factors, we found that Gata and Ets factors are required for Flk1in10 enhancer activity in all endothelial cells. (ox.ac.uk)
  • The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors. (musc.edu)
  • Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. (childrensmercy.org)
  • The transcription factor ETS-1 can mediate the transcription of some downstream genes that play specific roles in the regulation of cancerous cell invasion and metastasis. (geneticsmr.com)
  • A family of double-stranded RNA-binding proteins that are related to NFATC TRANSCRIPTION FACTORS. (ouhsc.edu)
  • In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation. (ouhsc.edu)
  • Canonical Notch signaling activates the transcription of BMI1 proto‑oncogene polycomb ring finger, cyclin D1, CD44, cyclin dependent kinase inhibitor 1A, hes family bHLH transcription factor 1, hes related family bHLH transcription factor with YRPW motif 1, MYC, NOTCH3, RE1 silencing transcription factor and transcription factor 7 in a cellular context‑dependent manner, while non‑canonical Notch signaling activates NF‑κB and Rac family small GTPase 1. (spandidos-publications.com)
  • Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family member, acts as an oncogenic driver in hematological malignancies and promotes tumor growth in solid tumors. (biomedcentral.com)
  • E74 like ETS transcription factor 2 [S. (gsea-msigdb.org)
  • This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. (nih.gov)
  • Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells. (nih.gov)
  • First, the general TFs (GTFs), including preinitiation complex components TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and THIIH, are the primary protein factors that are required for the initiation of transcription from the TATA box (or TATA element), then elongation is executed by RNA polymerase II (RNA pol II) [ 1 ]. (intechopen.com)
  • ETS family of transcription factors including Elk1, ETS1 and ETS2 are some of the well-known targets for the EGFR-Ras-MEK1/2 signaling pathway [11]. (researchassistantresume.com)
  • ETS1 is usually Narlaprevir a founding family member of ETS-domain transcription factors. (researchassistantresume.com)
  • Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)
  • An exciting finding is that in approximately half of the cases, there are recurrent chromosomal rearrangements resulting in the fusion of transmembrane protease serine 2 (TMPRSS2 ) and a member of the ETS family transcription factors , most commonly ERG . (medscape.com)
Genes15
  • The mouse and human Fli1 genes are similarly regulated by Ets factors in T cells. (musc.edu)
  • Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). (childrensmercy.org)
  • Cellular proteins encoded by the H-ras, K-ras and N-ras genes. (uchicago.edu)
  • Overexpression of ELF4 boosted CRC metastasis via transactivating its downstream target genes, fibroblast growth factor receptor 4 (FGFR4) and SRC proto-oncogene, non-receptor tyrosine kinase, SRC . (thno.org)
  • Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
  • Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
  • The normal versions of genes in the first group are called proto-oncogenes. (cancerquest.org)
  • The mutated or otherwise damaged versions of these genes are called oncogenes. (cancerquest.org)
  • Numerous genes have been identified as proto-oncogenes. (cancerquest.org)
  • As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
  • This domain occurred 6 times on human genes ( 21 proteins). (umbc.edu)
  • Driver events in pediatric malignancies can occur through loss of function in tumor suppressor genes or gain of function in proto-oncogenes. (medscape.com)
  • Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
  • We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
  • By contrast, the 10 downregulated genes were primarily associated with epithelial membrane proteins ( 11 ). (spandidos-publications.com)
Tumor suppressors3
  • A useful analogy to consider when thinking about tumor suppressors and oncogenes is an automobile. (cancerquest.org)
  • We will discuss three key proteins that function as tumor suppressors implicated in the development of pediatric (and some adult) cancers: pRB, p53, and PTEN. (medscape.com)
  • These genetic alterations often results in overexpression or activity of proto-oncogenes and inhibition of the function of tumor suppressor [1], [2].Therefore, understanding of the mechanisms by which the activity of both proto-oncogenes and tumor suppressors is usually altered in malignancy is usually crucially important both academically, and for development of new approaches to target malignancy cells for therapy. (researchassistantresume.com)
Receptors1
  • Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified. (nih.gov)
Kinases1
  • The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. (nih.gov)
Receptor2
  • Unique and selective effects of five Ets family members, Elf3, Ets1, Ets2, PEA3, and PU.1, on the promoter of the type II transforming growth factor-beta receptor gene. (musc.edu)
  • A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS . (nih.gov)
Kinase4
  • Protein kinase Cd and c-Abl kinase are required for transforming growth factor ß induction of endothelial-mesenchymal transition in vitro. (jefferson.edu)
  • CONCLUSION: These results suggest that overexpression of TrkB and activation of mitogen-activated protein kinase and AP-1, which may in turn induce the expression of vascular endothelial growth factor and interleukin 8, may mediate the cardinal clinical features of locally aggressive growth and metastasis of pancreatic cancer. (duke.edu)
  • death associated protein kinase 1 [Sou. (gsea-msigdb.org)
  • PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
FLI12
  • Ets factors and a newly identified polymorphism regulate Fli1 promoter activity in lymphocytes. (musc.edu)
  • Among the ETS family members, Friend leukemia virus integration 1 ( FLI1 ) was first identified as a proto-oncogene activated by proviral integration in F-MuLV-induced erythroleukemias [ 4 ]. (biomedcentral.com)
D12.7761
  • MeSH D12.776.503.280.249.500 - mannose-binding lectin MeSH D12.776.503.280.249.600 - pulmonary surfactant-associated protein a MeSH D12.776.503.280.249.625 - pulmonary surfactant-associated protein d MeSH D12.776.503.499.968.900 - wheat germ agglutinin-horseradish peroxidase conjugate See List of MeSH codes (D12.776.543). (wikipedia.org)
Gene4
  • Note that by convention gene names are italicized and the proteins they make are not. (cancerquest.org)
  • As an example TP 53 refers to the gene and p53 refers to the protein. (cancerquest.org)
  • We have two copies of each gene and for oncogenes, a single defective copy is enough to cause a cell to divide. (cancerquest.org)
  • RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
Signal Transduction1
Transcriptional3
  • Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors. (ox.ac.uk)
  • SAM Pointed domain of FLI-1 (Friend Leukemia Integration) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. (umbc.edu)
  • A cellular transcriptional coactivator that was originally identified by its requirement for the stable assembly IMMEDIATE-EARLY PROTEINS of the HERPES SIMPLEX VIRUS. (rush.edu)
Inhibition2
  • Furthermore, we discuss recent advances in drug development for inhibition of Ets factors, and the roles structural biology can play in their future. (hud.ac.uk)
  • These results also suggest that in addition to its established role in invasion and angiogenesis, ETS1 may support malignant cellular Narlaprevir growth via regulation of CIP2A expression and protein phosphatase 2A inhibition. (researchassistantresume.com)
GTPase1
Nucleotide1
  • The human proto-oncogene long interspersed nucleotide acid element-1 (LINE-1) open reading frame-1 protein (ORF-1p) is involved in the progress of several cancers. (geneticsmr.com)
Mechanisms3
  • In the present paper, we review the progress made over the last decade to elucidate the structural mechanisms involved in modulation of DNA binding and protein partner selection during dimerization. (hud.ac.uk)
  • We see that Ets domains, although conserved around a core architecture, have evolved to utilize a variety of interaction surfaces and binding mechanisms, reflecting Ets domains as dynamic interfaces for both DNA and protein interaction. (hud.ac.uk)
  • However, little is known about the mechanisms underlying the activation of this proto-oncogene in tumors. (biomedcentral.com)
Oncogenic1
  • It has been linked to malignancy since its identification as an oncogenic fusion with the product of c-Myb proto-oncogene in the. (researchassistantresume.com)
Ternary complex1
  • Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. (nih.gov)
Family4
  • We identified Interferon regulating factor 5 (IRF5), solute carrier family 22 member 2 (SLC22A2) and S100 calcium binding protein A12 (S100A12) as the three proteins with the largest fold change between SLE patients and controls (SLE/Control = 1.4, 1.4, and 1.2 respectively). (nih.gov)
  • Here, we investigated the function of E74-like factor 4 (ELF4), an ETS family member, in facilitating CRC progression. (thno.org)
  • DnaJ heat shock protein family (Hsp40). (gsea-msigdb.org)
  • HCK proto-oncogene, Src family tyrosin. (gsea-msigdb.org)
Viral2
  • The name derives from viral oncogene-derived protein oncogene protein v-ets of the AVIAN ERYTHROBLASTOSIS VIRUS. (bvsalud.org)
  • Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. (cusabio.com)
MRNA1
  • OSM stimulated a rapid and transient increase in c-Fos mRNA and nuclear protein that coincided with complex 2 formation. (uea.ac.uk)
Tumorigenesis1
  • Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis. (umassmed.edu)
Fusion1
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA563995(MMP1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (cusabio.com)
Differentiation1
  • The FLI-1 protein participates in regulation of cellular differentiation, proliferation, and survival. (umbc.edu)
Regulate2
  • Some proto-oncogenes work to regulate cell death. (cancerquest.org)
  • The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)
Descriptor3
  • Proto-Oncogene Protein c-fli-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • Proto-Oncogene Proteins p21(ras)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Nuclear Factor 90 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
Complexes1
  • Although their DNA-binding selectivity is biochemically and structurally well characterized, structures of homodimeric and ternary complexes point to Ets domains functioning as versatile protein-interaction modules. (hud.ac.uk)
Human2
  • In this study, the effects of LINE-1 ORF-1p on ETS-1 activity and on the proliferation and invasion of human colorectal cancer LoVo cells were investigated. (geneticsmr.com)
  • Cancerous inhibitor of protein phosphatase 2A (CIP2A) is usually a recently characterized human oncoprotein. (researchassistantresume.com)
Molecular2
  • Our objective was to obtain protein profiles to identify potential general biomarkers of SLE and to determine molecular subgroups within SLE for patient stratification. (nih.gov)
  • Unsupervised clustering of all investigated proteins identified three molecular subgroups among SLE patients, characterized by (1) high levels of rheumatoid factor-IgM, (2) low IRF5, and (3) high IRF5. (nih.gov)
Sequences1
  • Nuclear factors bound to SP1 and Ets sequences were detected, but were not altered upon OSM stimulation. (uea.ac.uk)
Factor3
  • This graph shows the total number of publications written about "Nuclear Factor 90 Proteins" by people in this website by year, and whether "Nuclear Factor 90 Proteins" was a major or minor topic of these publications. (ouhsc.edu)
  • Below are the most recent publications written about "Nuclear Factor 90 Proteins" by people in Profiles. (ouhsc.edu)
  • Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. (nih.gov)
Amyloid1
Mediates1
  • A DNA-binding protein that mediates DNA REPAIR of double strand breaks, and HOMOLOGOUS RECOMBINATION . (nih.gov)
Sequence-specific1
  • The others are the site-specific TFs or the DNA sequence-specific binding proteins. (intechopen.com)
Antibody1
  • Plasma samples from a cross-sectional study of well-characterized SLE patients ( n = 379) and matched population controls ( n = 316) were analyzed by antibody suspension bead array targeting 281 proteins. (nih.gov)
Integration1
  • It was originally identified as a protein that provides a retroviral integration site for integration of FRIEND MURINE LEUKEMIA VIRUS. (childrensmercy.org)
Cancer2
  • Different cancer types tend to depend on a limited number of 'driver' oncogene mutations. (cancerquest.org)
  • Selected oncogenes that have been associated with numerous cancer types are described in more detail below. (cancerquest.org)
Cell2
  • We further demonstrate that de-ubiquitinating enzyme USP7 interacts with SAMHD1 and de-ubiquitinates it at lysine 421, thus stabilizing SAMHD1 protein expression for further interaction with CtIP for DDR, which promotes tumor cell survival under genotoxic stress. (bvsalud.org)
  • The proto-oncogenes that have been identified so far have many different functions in the cell. (cancerquest.org)
Activity2
  • In normal cells, both internal and external signals control the activity of the oncogenes. (cancerquest.org)
  • A key feature of oncogene activity is that a single altered copy leads to unregulated growth. (cancerquest.org)
Domain1
  • If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position. (umbc.edu)