AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Protein CPorphyrinsOncogene Proteins v-sisOncogene Protein tpr-metOncogene Protein v-mafProtein C DeficiencyOncogene Protein gp140(v-fms)Oncogene Proteins v-mosProtein C InhibitorOncogene Protein p55(v-myc)Oncogene Protein v-crkProto-Oncogene Proteins c-crkOncogene Protein p65(gag-jun)Oncogene Proteins v-rafOncogene Proteins v-fosActivated Protein C ResistanceOncogene Proteins v-mybOncogene Protein v-cblOncogene Proteins v-erbBOncogene Proteins v-ablOncogenesOncogene Proteins v-relProtein SOncogene Proteins v-erbAThrombomodulinOncogene ProteinsOncogene Protein p21(ras)Blood Coagulation FactorsPulmonary Surfactant-Associated Protein COncogene Protein pp60(v-src)Factor VFactor VaThrombinOncogene Proteins, ViralBlood CoagulationOncogene Proteins, FusionGenes, rasCell Transformation, NeoplasticOncogene Protein v-aktProthrombinProtein S DeficiencyMolecular Sequence DataProto-Oncogene ProteinsReceptors, Cell SurfaceReceptors, ThrombinAmino Acid SequenceCrk-Associated Substrate ProteinRetroviridae Proteins, OncogenicThrombophiliaBlood Coagulation DisordersMutationBase SequencePartial Thromboplastin Timesrc Homology DomainsRecombinant ProteinsReceptor, PAR-1Cell LineAnticoagulantsProtein BindingFactor Xa1-Carboxyglutamic AcidGlycoproteinsSignal TransductionProto-OncogenesBlood Coagulation TestsTransfectionEnzyme ActivationDisseminated Intravascular CoagulationAntithrombin IIIThrombosisThrombophlebitisFactor V DeficiencyBinding SitesFactor XRetinoblastoma-Like Protein p130Genes, mycNuclear ProteinsAdaptor Proteins, Signal TransducingGene AmplificationAntithrombinsProto-Oncogene Proteins c-mycProto-Oncogene Proteins p21(ras)HemostasisGuanine Nucleotide-Releasing Factor 2Gene Expression Regulation, NeoplasticCell Line, TransformedSepsisCells, CulturedFactor VIIIaPhosphorylationKineticsPurpura FulminansAntithrombin III DeficiencyRNA, MessengerProto-Oncogene Proteins c-ablPoint MutationProtein-Tyrosine KinasesPhosphoproteinsFibrinolysisThromboplastin
Adaptor ProteinsHomologCrkLSarcomaPhosphorylationReceptorViral oncogeneAdapter proteinEncodesTyrosine phosphataseReceptorsSubstrateKinasesP130CasTranscription FactorsGENESBinding ProteinsRegulatorLigandCellularSubunitPathwaysGeneIsoformsEndogenousFamilySpeciesBiologicalBreast CancerApoptosisCellsTumorOriginally identifiedBindsRegulatesSerine
Adaptor Proteins6
  • The insulin-receptor substrate (IRS), SHC, GRB2, CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell. (nih.gov)
  • Signal transducing adaptor proteins that contain SRC HOMOLOGY DOMAINS and play a role in CYTOSKELETON reorganization. (bvsalud.org)
  • Intracellular signaling adaptor proteins that play a role in the coupling of SYNDECANS to CYTOSKELETAL PROTEINS . (nih.gov)
  • Nod Signaling Adaptor Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Cytosolic signaling adaptor proteins that were initially discovered by their role in the innate immunity (IMMUNITY, INNATE) response of organisms that lack an adaptive immune system. (uchicago.edu)
  • Below are the most recent publications written about "Nod Signaling Adaptor Proteins" by people in Profiles. (uchicago.edu)
Homolog4
  • Discs Large Homolog 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Below are the most recent publications written about "Discs Large Homolog 1 Protein" by people in Profiles. (umassmed.edu)
  • This gene encodes the human homolog of the proto-oncogene c-kit. (arigobio.com)
  • C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. (arigobio.com)
CrkL5
  • Crk together with CrkL participates in the Reelin signaling cascade downstream of DAB1. (wikipedia.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Crk Like Protein (CRKL) in tissue homogenates, cell lysates and other biological fluids. (1elisakits.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Crk Like Protein (CRKL) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)
  • Description: A competitive ELISA for quantitative measurement of Rat Crk like protein(CRKL) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (1elisakits.com)
  • CRKL (CRK Like Proto-Oncogene ) belongs to the Crk family and is a 39-kDa adapter protein that encodes SH2 and SH3 (src homologs) domains. (bvsalud.org)
Sarcoma1
  • v-Crk, a transforming oncoprotein from avian sarcoma viruses, is a fusion of viral "gag" protein with the SH2 and SH3 domains of cellular Crk. (wikipedia.org)
Phosphorylation6
  • The name Crk is from "CT10 Regulator of Kinase" where CT10 is the avian virus from which was isolated a protein, lacking kinase domains, but capable of stimulating phosphorylation of tyrosines in cells. (wikipedia.org)
  • Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis. (umassmed.edu)
  • It is a signal transducing adaptor protein that undergoes tyrosine PHOSPHORYLATION in signaling pathways that regulate CELL MIGRATION and CELL PROLIFERATION. (ucdenver.edu)
  • Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. (arigobio.com)
  • Kinase activity is down-regulated by phosphorylation on serine residues by protein kinase C family members. (arigobio.com)
  • Phosphorylation at Tyr-568 is required for interaction with PTPN11/SHP-2, CRK (isoform Crk-II) and members of the SRC tyrosine-protein kinase family. (arigobio.com)
Receptor8
  • After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. (genome.jp)
  • A SH2 DOMAIN-containing protein that mediates SIGNAL TRANSDUCTION pathways from multiple CELL SURFACE RECEPTORS , including the EPHB1 RECEPTOR . (nih.gov)
  • Kim E, Cho KO, Rothschild A, Sheng M. Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. (umassmed.edu)
  • This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). (arigobio.com)
  • Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. (arigobio.com)
  • KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. (arigobio.com)
  • The engulfment of a dying cell involves two parallel signal transduction pathways: theABC transporter CED-7 promotes cell-corpse recognition by the CED-1 transmembrane receptor, while the CED-2 Crk protein and the CED-10 Rac GTPase promote cytoskeletal reorganization and cell shape changes by the engulfing cell. (pdfdrugs.com)
  • The tyrosine kinase Src is a member of a family of related kinases known as the Src family kinases (SFKs) that share a common structural organization and function as key regulators of signal transduction pathways triggered by a wide variety of surface receptors, including receptor tyrosine kinases, integrins, G-protein-coupled receptors, and antigen receptors (Thomas and Brugge 1997). (mdm2-receptor.com)
Viral oncogene1
  • A novel viral oncogene with structural similarity to phospholipase C". Nature. (wikipedia.org)
Adapter protein1
  • Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. (wikipedia.org)
Encodes2
  • One of these genes, let-60 , encodes a Ras protein that functions as aswitch in the pathway of vulval induction. (pdfdrugs.com)
  • One of these genes, lin-35 , encodes a protein similar to the product of the human tumor suppressor gene Rb, and two other genes, dpl-1 and efl-1 , encode DP and E2F transcription factors, respectively. (pdfdrugs.com)
Tyrosine phosphatase1
  • Functional proteomics identifies protein-tyrosine phosphatase 1B as a target of RhoA signaling. (ucdenver.edu)
Receptors1
  • The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (genome.jp)
Substrate5
  • Crk-Associated Substrate Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • Crk-associated substrate was originally identified as a highly phosphorylated 130 kDa protein that associates with ONCOGENE PROTEIN CRK and ONCOGENE PROTEIN SRC. (ucdenver.edu)
  • This graph shows the total number of publications written about "Crk-Associated Substrate Protein" by people in this website by year, and whether "Crk-Associated Substrate Protein" was a major or minor topic of these publications. (ucdenver.edu)
  • Below are the most recent publications written about "Crk-Associated Substrate Protein" by people in Profiles. (ucdenver.edu)
  • Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. (ucdenver.edu)
Kinases1
P130Cas1
  • AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. (molvis.org)
Transcription Factors1
  • Many of these genes encode proteins similar to known transcription factors, and our studies indicate that the generation of cell diversity during development is in part regulated by a cascade of interacting transcription factors. (pdfdrugs.com)
GENES4
Binding Proteins2
Regulator2
  • The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. (wikipedia.org)
  • Our previous study has shown that CCAAT-enhancer binding protein β (C/EBPβ) is an important regulator in METH-induced neuronal autophagy and apoptosis. (cancerindex.org)
Ligand1
  • This class of proteins contains three domains, a C-terminal ligand recognition domain, an N-terminal effector-binding domain, and a centrally located nuclear-binding oligomerization domain. (uchicago.edu)
Cellular2
  • Crk should not be confused with Src, which also has cellular (c-Src) and viral (v-Src) forms and is involved in some of the same signaling pathways but is a protein tyrosine-kinase. (wikipedia.org)
  • Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus. (wikidata.org)
Subunit2
  • The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. (cancerindex.org)
  • It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. (jefferson.edu)
Pathways3
  • This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. (wikipedia.org)
  • They play a role in cell signaling pathways such as those involving G-PROTEINS and the HIPPO-SIGNALING PATHWAY . (nih.gov)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
Gene6
Isoforms1
Endogenous2
  • Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
  • A family of endogenous regulatory proteins that associate with RETINOBLASTOMA PROTEIN via a specific high-affinity binding domain. (bvsalud.org)
Family1
  • The Bcl-2 homology 3 (BH3) domain is crucial for the death-inducing and dimerization properties of pro-apoptotic members of the Bcl-2 protein family, including Bak, Bax, and Bad. (lookformedical.com)
Species4
  • Proteins that originate from insect species belonging to the genus DROSOPHILA. (lookformedical.com)
  • The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development. (lookformedical.com)
  • Kumar J, Yadav VN, Phulera S, Kamble A, Gautam AK, Panwar HS, Sahu A. Species Specificity of Vaccinia Virus Complement Control Protein for the Bovine Classical Pathway Is Governed Primarily by Direct Interaction of Its Acidic Residues with Factor I. J Virol. (childrensmercy.org)
  • Yadav VN, Pyaram K, Ahmad M, Sahu A. Species selectivity in poxviral complement regulators is dictated by the charge reversal in the central complement control protein modules. (childrensmercy.org)
Biological1
  • Description: A sandwich ELISA kit for detection of Crk Like Protein from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (1elisakits.com)
Breast Cancer1
  • In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (jefferson.edu)
Apoptosis1
  • Pseudomonas aeruginosa ExoT Induces Atypical Anoikis Apoptosis in Target Host Cells by Transforming Crk Adaptor Protein into a Cytotoxin. (rush.edu)
Cells2
  • We also measured the levels of phosphorylated tuberous sclerosis complex 2 (TSC2) protein and Parkin protein level in SH-SY5Y cells. (cancerindex.org)
  • Western blot analysis and in situ hybridization confirmed the presence of AND-34 RNA and protein in lens epithelial cells, particularly at the lens equator. (molvis.org)
Tumor1
  • Its ability to ubiquitinate p53 is regulated by TUMOR SUPPRESSOR PROTEIN P14ARF. (umassmed.edu)
Originally identified1
  • A class of intracellular signaling proteins that were originally identified as inhibitors of ANGIOSTATIN activity. (nih.gov)
Binds1
  • Programmed cell death appears to be initiated by the transcriptional activation of egl-1 , the protein product of which binds the mitochondrial protein CED-9 and causes the release of CED-4 from CED-9 and the translocation of CED-4from the mitochondrial to the nuclear membrane. (pdfdrugs.com)
Regulates1
  • Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L. (childrensmercy.org)
Serine1
  • All NSP proteins contain an NH 2 -terminal SH2 (Src homology domain 2) domain, a central proline/serine-rich domain, and a COOH-terminal domain with modest homology to Ras subfamily GDP-exchange factors (GEFs). (molvis.org)