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  • focus
  • The v- myb oncogenes transform hematopoietic cells in tissue culture and induce leukemias in animals, and a mouse knockout of c- myb leads to severe hematopoietic defects [ 13 ], which has led many researchers to focus on the role of the Myb proteins in hematopoietic cells. (biomedcentral.com)
  • Nevertheless, detailed downstream system where LRIG1 mediates focus on proteins down-regulation is certainly unknown. (health-e-nc.org)
  • cells
  • Expression of the c- myb gene in human breast cancer cells is dependent on estrogen stimulation, but little is known about the activities of the c-Myb protein or what genes it regulates in estrogen-stimulated cells. (biomedcentral.com)
  • By using different antibodies and different growth conditions, the c-Myb protein was found associated with over 10,000 promoters in MCF-7 cells, including many genes that encode cell cycle regulators or transcription factors and more than 60 genes that encode microRNAs. (biomedcentral.com)
  • Although the expression of c-Myb protein is important for estrogen-stimulated proliferation of breast cancer cells [ 6 ], the functions of c-Myb and the target genes that it regulates in response to stimulation of ERs have yet to be identified. (biomedcentral.com)
  • Upon treatment with SAIT301 for 1?hour, total proteins degree of LRIG1 decreased in EBC1 cells (Body 1a). (health-e-nc.org)
  • avian
  • The name Crk is from "CT10 Regulator of Kinase" where CT10 is the avian virus from which was isolated a protein, lacking kinase domains, but capable of stimulating phosphorylation of tyrosines in cells. (wikipedia.org)
  • downstream
  • The CRK protein participates in the Reelin signaling cascade downstream of DAB1. (wikipedia.org)
  • Following MET activation, transphosphorylation occurs on Tyr 1234 and Tyr 1235 C-terminal region contains two crucial tyrosines (Tyr 1349 and Tyr 1356), which are inserted into the multisubstrate docking site, capable of recruiting downstream adapter proteins with Src homology-2 (SH2) domains. (wikipedia.org)
  • regulation
  • This proto-oncogene may play a role in the regulation of embryonic development and cell growth. (wikipedia.org)
  • This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis, including the regulation of miR-155 in B-cells. (wikipedia.org)
  • These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. (wikipedia.org)
  • Regulation of neuronal survival by the Ser/Thr protein kinase Akt. (wikipedia.org)
  • mutations
  • These types of mutations are associated with papillary thyroid carcinoma (PTC), and the fusion oncoproteins generated are termed RET/PTC proteins. (wikipedia.org)
  • molecules
  • Myc Proto Oncogene Protein Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC pipeline Target constitutes close to 13 molecules. (bioportfolio.com)
  • Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. (wikipedia.org)
  • mTORC2 therefore functionally acts as the long-sought PDK2 molecule, although other molecules, including integrin-linked kinase (ILK) and mitogen-activated protein kinase-activated protein kinase-2 (MAPKAPK2) can also serve as PDK2. (wikipedia.org)
  • He was awarded the 2001 Nobel Prize in Physiology or Medicine with Paul Nurse and Leland H. Hartwell for their discoveries of protein molecules that control the division of cells. (wikipedia.org)
  • Subcellular
  • Src contains at least three flexible protein domains, which, in conjunction with myristoylation, can mediate attachment to membranes and determine subcellular localization. (wikipedia.org)
  • mRNA
  • MET is transcribed into a 6,641 bp mature mRNA, which is then translated into a 1,390 amino-acid MET protein. (wikipedia.org)
  • regulates
  • In sorghum, the corresponding yellow seed 1 gene (y1) also encodes a R2R3 type of Myb domain protein that regulates the expression of chalcone synthase, chalcone isomerase and dihydroflavonol reductase genes required for the biosynthesis of 3-deoxyflavonoids. (wikipedia.org)
  • genes
  • Myc protein is a transcription factor that activates expression of many genes through binding enhancer box sequences and recruiting histone acetyltransferases. (bioportfolio.com)
  • cell
  • In particular, Hunt discovered what he called cyclin: a protein in fertilised sea urchin eggs which cyclically aggregates and is depleted during cell division cycles. (wikipedia.org)
  • Cyclins are proteins that play a key role in regulating the cell-division cycle. (wikipedia.org)
  • constitutive
  • Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis. (labome.org)
  • Chromosomal rearrangements that generate a fusion gene, resulting in the juxtaposition of the C-terminal region of the RET protein with an N-terminal portion of another protein, can also lead to constitutive activation of the RET kinase. (wikipedia.org)
  • defects
  • Mice deficient in GDNF, GFRα1 or the RET protein itself exhibit severe defects in kidney and enteric nervous system development. (wikipedia.org)
  • interaction
  • Region of homology to semaphorins (Sema domain), which includes the full α-chain and the N-terminal part of the β-chain Cysteine-rich MET-related sequence (MRS domain) Glycine-proline-rich repeats (G-P repeats) Four immunoglobulin-like structures (Ig domains), a typical protein-protein interaction region. (wikipedia.org)
  • synthesis
  • While there, they discovered that tiny amounts of glutathione inhibited protein synthesis in reticulocytes and that tiny amounts of RNA killed the synthesis altogether. (wikipedia.org)
  • The location provided a ready supply of surf clams and sea urchins amongst the reefs and fishing docks, and it was these invertebrates that were particularly useful for the study of the synthesis of proteins in embryogenesis, as the embryos were simply generated with the application of filtered sea water, and the transparency of the embryo cells was well suited to microscopic study. (wikipedia.org)
  • names
  • p>This subsection of the 'Names and Taxonomy' section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein. (uniprot.org)
  • a href='/help/protein_names' target='_top'>More. (uniprot.org)
  • p>This subsection of the 'Names and taxonomy' section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)