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  • substrates
  • To meet such complicated demands in biological process via spatial and temporal proteolysis, protein substrates have to be recognized, recruited, and eventually hydrolyzed in a well controlled fashion. (wikipedia.org)
  • Extracellular Proteolysis
  • Extracellular proteolysis of receptors irreversibly inactivates receptor-mediated adhesion and signaling, as well as releasing soluble fragments into the plasma where they act as potential markers or modulators. (ahajournals.org)
  • The Gordon Research Seminar on Plasminogen Activation and Extracellular Proteolysis is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. (grc.org)
  • This meeting will highlight the breadth of potential that extracellular proteolysis holds for the treatment of diseases, including (but not limited to): cardiovascular and cerebrovascular diseases, cancer, and disorders of the central nervous system. (grc.org)
  • This GRS will be held in conjunction with the "Plasminogen Activation and Extracellular Proteolysis" Gordon Research Conference (GRC). (grc.org)
  • pathways
  • Recent biochemical and cellular studies on shedding pathways 7-10 and surface expression 11-13 of GPVI illustrate some of the key mechanisms underlying platelet receptor proteolysis, and recent preclinical studies 14 show how significant these findings may be in the context of thrombotic risk. (ahajournals.org)
  • induce
  • The action of mineral acids and heat also may induce proteolysis. (thefreedictionary.com)
  • Fig. 1, B and C ). We next asked if the differential susceptibilities to proteolysis of these model antigens affected their capacity to induce IgG responses as a physiological in vivo measure of their ability to be presented on MHC class II molecules and to prime CD4 + T cells in vivo. (rupress.org)
  • factor
  • A heat-stable polypeptide present in these extracts, ATP-dependent proteolysis factor 1 (APF-1), was found to become covalently attached to the model protein substrate lysozyme in an ATP- and Mg2+-dependent process. (wikipedia.org)
  • known
  • The high-intensity training protocols used in both randomised trials described above may have provided an adequate training stimulus to halt or reverse the atrophy and proteolysis that is known to occur in patients undergoing MV (Figure 1). (thefreedictionary.com)
  • activity
  • There was no significant difference, however, in plasmin activity among the AAA wall, JMT, and LT. There were significant amounts of latent gelatinase B (matrix metalloproteinase [MMP]-9) in the AAA, JMT, and LT. Mean levels of activated MMP-9 activity were similar in the AAA, JMT, and LT. Plasmin activation of MMPs at the interface between intraluminal thrombus and the aneurysm wall may enhance proteolysis and accelerate aneurysm expansion. (biomedsearch.com)
  • cells
  • Unlike full-length RbmA, the association of RbmA* with cells is no longer VPS-dependent, likely due to an electropositive surface revealed by proteolysis. (pnas.org)