Protein tyrosine phosphatase non receptor type 3. Medical search. Frequent questions

Receptor tyrosine kinases (RTKs) play fundamental tasks in varied cell functions including proliferation differentiation survival migration and rate of metabolism (16). (exposed-skin-care.net)
OBJECTIVE: The receptor-like protein-tyrosine phosphatase (PTP) CD148 and the nontransmembrane PTP1-B have been shown to be net positive regulators of Src family kinases in platelets. (ox.ac.uk)

CD45, previously called LCA (leukocyte common antigen), T200, or Ly5 in mouse, is member C of the class 1 (receptor-like) protein tyrosine phosphatase family (PTPRC) (1, 2). (rndsystems.com)

A subclass of receptor-like protein tryosine phosphatases that contain a single cytosolic protein tyrosine phosphate domain and multiple extracellular fibronectin III-like domains. (online-medical-dictionary.org)
GCA (grancalcin) is usually a cytosolic protein that is translocated to the granule membrane upon neutrophil activation [26,27]. (abic2004.org)

Description: A sandwich ELISA kit for detection of Protein Tyrosine Phosphatase Like Protein A from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (ibiomagazine.org)
Description: Quantitativesandwich ELISA kit for measuring Human Receptor-type tyrosine-protein phosphatase F (PTPRF) in samples from serum, plasma, urine, tissue homogenates, cell lysates. (scalegen.com)
Description: A sandwich ELISA kit for detection of Protein Tyrosine Phosphatase, Non Receptor Type 11 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (worldcarecouncil.org)

In the present study, we compared the relative contributions of these PTPs in platelet activation by the major glycoprotein, glycoprotein VI, α(IIb)β(3), and C-type lectin-like receptor 2 (CLEC-2). (ox.ac.uk)
Signal transduction of FMS-like tyrosine kinase 3 (FLT3) is regulated by protein-tyrosine phosphatases (PTPs). (nih.gov)
Among these negative regulators, protein tyrosine phosphatases (PTPs) are likely to play a pivotal role in IR signaling. (bioone.org)

It is a variably glycosylated 180‑220 kDa transmembrane protein that is abundantly expressed on all nucleated cells of hematopoietic origin (1‑3). (rndsystems.com)

CD45 has several isoforms, expressed according to cell type, developmental stage and antigenic exposure (1‑5). (rndsystems.com)
CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds (3, 6‑8). (rndsystems.com)
Immunoprecipitation of CD45 protein from BaF3 cell extracts. (cellsignal.com)
Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP ® Isotype Control #3900, and lane 3 is CD45 (D3F8Q) Rabbit mAb. (cellsignal.com)
Confocal immunofluorescent analysis of wild-type mouse retina and optic nerve labeled with CD45 (D3F8Q) Rabbit mAb #70257 (green) and Neurofilament-L (DA2) Mouse mAb #2835 (red). (cellsignal.com)

The mouse CD45RABC cDNA encodes 1291 amino acids (aa), including a 23 aa signal sequence, a 541 aa extracellular domain containing the splicing region, a cysteine-rich region and two fibronectin type III domains, a 22 aa transmembrane sequence, and a 705 aa cytoplasmic domain that contains two phosphatase domains, D1 and D2. (rndsystems.com)
Abnormal cytoplasmic inclusions of these DPR proteins have been found in C9ORF72-ALS/FTD patient tissues and cells. (mdaconference.org)

[ 2 , 3 ] Non-HLA genes that have been implicated in PGA-II include CD25-interleukin-2 receptor, cytotoxic T-lymphocyte protein 4 ( CTLA-4 ), and protein tyrosine-protein phosphatase, non-receptor type 22 ( PTPN22 ). (medscape.com)
It is also related to increased adiponectin (APN) expression associated with adipocyte differentiation, as well as the expression of adipogenic genes such as peroxisome proliferator-activated receptor ( PPAR) ( 22 , 23 ). (frontiersin.org)
Noonan syndrome and related disorders are caused by mutations in genes encoding for proteins of the RAS-ERK1/2 signaling pathway, which affect development by enhanced ERK1/2 activity. (sdbonline.org)
3 Identification of the genes predisposing to cancer could yield targets for treatment or chemoprevention. (bmj.com)
Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea. (cdc.gov)

Description: A sandwich quantitative ELISA assay kit for detection of Human Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) in samples from tissue homogenates or other biological fluids. (worldcarecouncil.org)
Sixteen known and 3 novel PTPN11 mutations could be detected in 60% of index patients, in all familial and in 52% of the sporadic cases. (nih.gov)
Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. (affbiotech.com)

PTPN23 is a regulator of endosomal trafficking functioning to move activated membrane receptors, such as EGFR, from the endosomal sorting complex towards the ESCRT-III complex for multivesicular body biogenesis, lysosomal degradation, and subsequent downregulation of receptor signaling. (edu.sa)
We show that PTPRK acts via the transmembrane E3 ubiquitin ligase ZNRF3, a negative regulator of Wnt signaling promoting Wnt receptor degradation, which is also expressed in the organizer. (elifesciences.org)
Our discovery of PTPRK as a negative regulator of Wnt receptor turnover provides a rationale for its tumor suppressive function and reveals that in PTPRK-RSPO3 recurrent cancer fusions both fusion partners, in fact, encode ZNRF3 regulators. (elifesciences.org)
Gas6 is the product of growth arrest-specific gene 6 which was in the beginning cloned from serum-starved fibroblasts and shares about CUDC-305 (DEBIO-0932 ) 44% sequence identity and related website organization with protein S a negative regulator of blood coagulation (48). (exposed-skin-care.net)
A fly-human cross-species comparison of the phosphoinositide-3-kinase (PI3K) interactome was conducted in a Drosophila S2R+ cell line and several NSCLC and human multiple myeloma cell lines to identify conserved interacting proteins to PI3K, a critical signaling regulator of the AKT pathway. (sdbonline.org)

Here we demonstrate that elevation of cyclic AMP (cAMP) levels in human umbilical vein endothelial cells (HUVECs) specifically attenuates ERK1,2 activation in response to either leptin or a soluble interleukin IL-6 receptor-α/IL-6 (sIL-6R-α/IL-6) trans-signalling complex but not protein kinase C activator phorbol 12-myristate 13-acetate. (gla.ac.uk)
A novel pathogenic mutation on the interleukin-7 receptor has been described in a newborn. (medscape.com)

2016) . A cross-species study of PI3K protein-protein interactions reveals the direct interaction of P85 and SHP2 . (sdbonline.org)
These data revealed an unexpected direct binding of Corkscrew, the Drosophila ortholog of the non-receptor protein tyrosine phosphatase type II (SHP2) to the Pi3k21B (p60) regulatory subunit of PI3K (p50/p85 human ortholog) but no association with Pi3k92e , the human ortholog of the p110 catalytic subunit. (sdbonline.org)
The p85-SHP2 association was validated in human cell lines, and formed a ternary regulatory complex with GRB2-associated-binding protein 2 (human GAB2 but not Drosophila Dos ). (sdbonline.org)
Validation experiments with knockdown of GAB2 and Far-Western blots proved the direct interaction of SHP2 with p85, independent of adaptor proteins and transfected FLAG-p85 provided evidence that SHP2 binding on p85 occurred on the SH2 domains. (sdbonline.org)
This study identified that the protein most commonly affected in Noonan syndrome, the phosphatase SHP2, known in Drosophila as corkscrew (CSW) , controls life span, triglyceride levels, and metabolism without affecting ERK signaling pathway. (sdbonline.org)
Noonan syndrome (NS) and NS with multiple lentigines (NSML) cognitive dysfunction are linked to SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) gain-of-function (GoF) and loss-of-function (LoF), respectively. (sdbonline.org)

Upon immobilization sAxl advertised cell migration and induced the phosphorylation of Axl and phosphatidylinositol 3-kinase. (exposed-skin-care.net)
However, they exhibited a marginal reduction in α(IIb)β(3)-mediated Src family kinase activation and tyrosine phosphorylation. (ox.ac.uk)
Intersecting analysis, molecular docking, and pathway validation analysis showed that risperidone influences the adipocytokine signaling pathway by targeting MAPK14 (mitogen-activated protein kinase 14), MAPK8 (mitogen-activated protein kinase 8), and RXRA (retinoic acid receptor RXR-alpha), thereby inhibiting long-chain fatty acid β-oxidation by decreasing STAT3 (signal transducer and activator of transcription 3) expression and phosphorylation. (frontiersin.org)
The inhibitory effects of cAMP on sIL-6Ra/IL-6-stimulated phosphorylation of ERK1,2 and STAT3 were abolished by either short interfering (si) RNA-mediated knockdown or genetic ablation of suppressor of cytokine signalling-3 (SOCS-3). (gla.ac.uk)
Together, these observations suggest that while SOCS-3 induction and subsequent inhibition of cytokine-mediated phosphorylation of ERK1,2 and STAT3 in response to cAMP require Epac1 and a transient PKA-independent activation of the ERK pathway, these two events are controlled by distinct mechanisms. (gla.ac.uk)
Wild type as well as substrate-trapping DA forms of PTPϵM suppressed phosphorylation of IR downstream enzymes such as Akt, extracellular regulated kinase (ERK) and glycogen synthase kinase 3 (GSK3). (bioone.org)

[ 5 ] Ideally, SCID can be detected in a newborn before the onset of infections, with one well-documented example by screening of T-cell-receptor excision circles. (medscape.com)

In silico analysis, therefore, was performed to identify small drug-like molecules as potential inhibitors of transforming growth factor beta-2 receptor (TGFβRII). (brjnmims.org)
Several inhibitors of the IR tyrosine kinase activity have recently been described and associated with human insulin resistance. (bioone.org)

The survival of the GR-expressing i3Neurons is significantly improved when the gene is knocked down, probably via restoring the phosphatidylinositol 3-phosphate (PI3P) level. (mdaconference.org)

During the progression of colitis, genetic alterations associated with mucosal permeability [ e.g. those in extracellular matrix protein 1 ( ECM1 ), cadherin 1 ( CDH1 ), and hepatocyte nuclear factor 4 alpha ( HNF4A )] have been observed and considered to confer the risk of severe UC ( 11 , 12 ). (iiarjournals.org)
Woolson, H. D. , Thomson, V. S. , Rutherford, C. , Yarwood, S. J. and Palmer, T. M. (2009) Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic amp via Epac1-dependent induction of suppressor of cytokine signalling-3. (gla.ac.uk)

In addition, it reveals a novel Epac-dependent mechanism by which cAMP can specifically inhibit ERK in response to cytokine receptor activation. (gla.ac.uk)
Cytokine gene polymorphisms in type I and type II reactions in Hansen's disease. (cdc.gov)

Furthermore, our data strongly suggest that the virus isolate from which SG33 is derived results from an in vivo recombination between a wild-type South America (Lausanne) strain and a California MSD-derived strain. (cdc.gov)
We present the analysis of the genome sequence of MYXV SG33 vaccine strain, which confirms the presence of a large right-end deletion and shows evidence of a field recombination between a wild-type and a vaccine strain. (cdc.gov)

Uneétude descriptive, transversale portant sur les patientes traitées en radiothérapie à l'Hôpital Général de Douala pour cancer du col de l'utérus a été réalisée d'octobre 2020 à janvier 2021.Résultats. (bvsalud.org)
Il s'agissait d'une étude rétrospective descriptive d'une durée de 2 ans 3 mois allant du 1er janvier 2018 au 31 Mars 2020 portant sur 80 dossiers de malades porteurs d'hémopathies malignes et prise en charge dans le centre. (bvsalud.org)
This was a descriptive retrospective study lasting 2 years 3 months from January 1st, 2018 to March 31st, 2020 concerning 80 patients with hematologic neoplasms who were managed in the CNRAO. (bvsalud.org)

Dominant role of the protein-tyrosine phosphatase CD148 in regulating platelet activation relative to protein-tyrosine phosphatase-1B. (ox.ac.uk)
In contrast, CD148-deficient platelets exhibited a dramatic reduction in activation by glycoprotein VI and α(IIb)β(3) and a marginal reduction in response to activation by CLEC-2, which was further enhanced in the absence of PTP-1B. (ox.ac.uk)

The inhibitory effect of cAMP could not be reversed by inhibition of cAMP-dependent protein kinase (PKA) but was blocked by depletion of the alternative intracellular cAMP sensor exchange protein activated by cAMP 1 (Epac1), which is also required to observe SOCS-3 accumulation in response to cAMP. (gla.ac.uk)

Here we identify the tumor suppressor Protein tyrosine phosphatase receptor-type kappa (Ptprk), as a Wnt inhibitor of the Spemann organizer. (elifesciences.org)
ABBV-CLS-484 hydrochloride is an inhibitor of phosphatase PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1), and a highly effective immunotherapy agent with monotherapy efficacy across mouse tumor models. (axonmedchem.com)
Analogous studies in a murine syngeneic tumor model using surrogate antibodies demonstrated significant synergy between LAG-3 and PD-1 blockade-combination treatment led to a marked improvement in therapeutic efficacy, increased T-cell proliferation, IFNγ production, and elicited durable immunologic memory upon tumor rechallenge. (aacrjournals.org)
Tumor persistence leads to sustained exposure of T cells to neoantigens-this results in repeated cycles of activation which culminate in a state of severe T-cell dysfunction or exhaustion, characterized by distinct epigenetic and transcriptional profiles ( 1-3 ). (aacrjournals.org)

Quantitative-real time-reverse transcription PCR (Q-RT-PCR) is widely used and is a sensitive and robust technique for the detection and quantification of often rare mRNA targets [ 3 ]. (biomedcentral.com)

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Protein Tyrosine Phosphatase Like Protein A (PTPLA) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (ibiomagazine.org)

These defects were associated with reduced activation of Src family kinase and spleen tyrosine kinase, suggesting a causal relationship. (ox.ac.uk)

The eighth fibronectin type III domain of protein tyrosine phosphatase receptor J influences the formation of protein complexes and cell localization. (unina.it)
However, other PTPRJ complexes, dependent on the formation of disulfide bonds, are detected by treatment with the oxidant agent H(2)O(2) or by a mutation Asp872Cys, located in the eighth fibronectin type III domain of PTPRJ. (unina.it)

It is characterized by the obligatory occurrence of autoimmune Addison disease in combination with thyroid autoimmune diseases and/or type 1 diabetes mellitus (also known as insulin-dependent diabetes mellitus, or IDDM). (medscape.com)
The most frequent clinical combination association is Addison disease and Hashimoto thyroiditis (Schmidt syndrome), while the least frequent clinical combination is Addison disease, Graves disease, and type 1 diabetes mellitus. (medscape.com)
Type 1 diabetes mellitus is rare in children with PGA-I. (medscape.com)
Type III, although ill defined, is the co-occurrence of autoimmune thyroid disease with 2 other autoimmune disorders, including diabetes mellitus type 1, pernicious anemia , or a nonendocrine, organ-specific autoimmune disorder in the absence of Addison disease. (medscape.com)
Impaired insulin receptor (IR) signaling leads to insulin resistance and type 2 diabetes mellitus. (bioone.org)
Diabetes mellitus is a metabolic disorder characterized by hyperglycaemia and alterations in carbohydrate, lipid, and protein metabolism, associated with absolute or relative deficiencies in insulin secretion and/or insulin action [ 1 ]. (hindawi.com)
[ 6 ] Another report from Japan described a 61-year-old woman with slowly progressive type 1 diabetes mellitus associated with chronic thyroiditis, pernicious anemia, and idiopathic thrombocytopenic purpura. (medscape.com)
Recently, an occurrence of growth hormone deficiency was reported in an 8-year-old child who has type 1 diabetes mellitus and received iodine I 131 ablation at age 5 years for hyperthyroidism, suggesting that it could also be a component of PAS III. (medscape.com)

It results from a mutation in the IL-2 receptor gamma gene ( IL-2RG ). (msdmanuals.com)

The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. (cancerindex.org)

We identify a '4Y' endocytic signal in ZNRF3, which Ptprk maintains unphosphorylated to promote Wnt receptor depletion. (elifesciences.org)

Mol Cancer Ther (2019) 18 (3): 632-641. (aacrjournals.org)

In this study we show the formation of different higher-order structures of the receptor-type phosphatase PTPRJ, detected in HEK293A cells transfected with different PTPRJ expression constructs. (unina.it)
In the plasma membrane PTPRJ forms dimers detectable by treatment with the cross-linking reagent BS(3) (bis[sulfosuccinimidyl]suberate). (unina.it)

In this study, we showed that receptor-type PTPϵ (PTPϵM) dephosphorylated IR in rat primary hepatocytes and tyrosines 972, 1158, 1162 and 1163 were primary targets of PTPϵM. (bioone.org)

Unlike other SGAs, such as clozapine and olanzapine, risperidone is a derivative of benzisoxazole with multiple receptor antagonist properties, making it more effective against negative symptoms and more beneficial on both affective symptoms and cognitive impairments ( 11 ). (frontiersin.org)
We have generated a high affinity and selective humanized monoclonal IgG4 antibody, TSR-033, which binds human LAG-3 and serves as a functional antagonist, enhancing in vitro T-cell activation both in mixed lymphocyte reactions and staphylococcal enterotoxin B-driven stimulation assays. (aacrjournals.org)

Regulation of receptor-type phosphatases can involve the formation of higher-order structures, but the exact role played in this process by protein domains is not well understood. (unina.it)

Several studies shown that Axl could mediate cell adhesion and aggregation through homotypic ectodomain associations (9 23 Both CUDC-305 (DEBIO-0932 ) murine and human being Axl proteins undergo proteolytic processing to yield a soluble form of this molecule. (exposed-skin-care.net)

Polyglandular autoimmune syndrome type II (PGA-II) is the most common of the immunoendocrinopathy syndromes. (medscape.com)
Two other related autoimmune endocrinopathies exist, namely type I and type III. (medscape.com)
The pathogenesis of polyglandular autoimmune syndrome type II (PGA-II) is poorly understood. (medscape.com)
In patients with infection-triggered onset, the associations of low sCD26 with elevated autoantibodies (AAB) against alpha1 adrenergic (AR) and M3 muscarinic acetylcholine receptors (mAChR) point to a pathomechanism of infection-triggered autoimmune-mediated vascular and immunological dysregulation. (frontiersin.org)
The pathomechanism of ME/CFS is unresolved yet, but there is ample evidence for an autoimmune process involved ( 3 ). (frontiersin.org)
These antibodies belong to a network of natural antibodies against adrenergic, cholinergic and other G-protein coupled receptors (GPCR) which were shown to be dysregulated and dysfunctional in various autoimmune diseases ( 9 ). (frontiersin.org)
[ 3 ] This patient had PAS III due to the presence of autoimmune thyroiditis, hypergonadotropic hypogonadism, and growth hormone deficiency, without adrenal or parathyroid disease. (medscape.com)

This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. (wikipedia.org)

Ectodomain dropping has emerged as an important posttranslational mechanism to regulate the functions of various integral membrane-bound proteins including adhesion molecules cytokines growth factors and their receptors (57 60 Both. (exposed-skin-care.net)
One potential pathogenic mechanism is the aberrant accumulation of dipeptide repeat (DPR) proteins produced by repeat-associated non-AUG (RAN) translation in all six reading frames (poly-GA, poly-GR, poly-PA, poly-PR, and poly-PG) of both sense and antisense RNAs. (mdaconference.org)

[ 7 ] This patient had DQA1 0102, 0103 and DQB1 0602, 0601 that were considered as type 1 diabetes-protective HLA alleles. (medscape.com)

This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. (wikipedia.org)

Tyrosine-protein phosphatase non-receptor type 3 is an enzyme that in humans is encoded by the PTPN3 gene. (wikipedia.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Protein Tyrosine Phosphatase Like Protein A (PTPLA) in tissue homogenates, cell lysates and other biological fluids. (ibiomagazine.org)

Anatomy23

Organisms11

Diseases3

Chemicals and Drugs150

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes46

Disciplines and Occupations1

Information Science3

Kinases2

PTPRC1

Cytosolic protein2

ELISA Kit3

PTPs3

Transmembrane protein1

CD455

Cytoplasmic2

Genes5

PTPN113

Regulator5

Interleukin2

SHP26

Phosphorylation6

Cell receptor1

Inhibitors2

Phosphatidylinositol1

Extracellular2

Cytokine2

Recombination2

20203

CD1482

Intracellular1

Tumor4

MRNA1

Species1

Spleen1

Fibronectin2

Diabetes mellitus8

Gamma1

Ligands1

Ptprk1

20191

PTPRJ2

Hepatocytes1

Antagonist2

Domains1

Soluble1

Autoimmune7

SuperFamily1

Mechanism2

Alleles1

Adaptor1

Enzyme2