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  • gene
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • The α-neuraminidase protein is coded for by the NEU1 gene and is, a glycohydrolitic enzyme that is active in the lysosome. (up.edu)
  • Alternatively, the missense mutation identified in the GLB1 gene may alter the ß-galactosidase protein sufficiently that it impairs the overall structure of the LMC resulting in the secondary deficiency of α-neuraminidase. (up.edu)
  • source
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • cell
  • COPE Full-Length MS Protein Standard (NP_009194), Labeled with [U- 13C6, 15NL-Arginine and [U- 13C6, 15NL-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. (creative-proteomics.com)
  • YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. (ox.ac.uk)
  • membrane protein
  • A membrane transport protein (or simply transporter) is a membrane protein that acts as such a carrier. (wikipedia.org)
  • This entry represents the integral membrane protein CbiM, which forms part of the energy-coupling factor (ECF) transporter complex CbiMNOQ that is involved in cobalt import [ PMID: 16352848 , PMID: 20868747 ], and plays a role in the cobalamin synthesis pathway. (ebi.ac.uk)
  • To analyze the involvement of the endosomal/lysosomal system in the processing of APP695 into βA4, we created APP695 chimeras by exchanging the cytoplasmic domain of APP695 with that of the human lysosomal-associated membrane protein-1 (hLAMP-1) and the human cation-dependent mannose 6-phosphate receptor (CD-MPR). (jneurosci.org)
  • subunit
  • The two smaller proteins are a medium subunit named μ (mu ∼50 kD) and a small subunit σ (sigma ∼20 kD), and named 1 through 5 corresponding to the 5 AP complexes. (wikipedia.org)
  • The enzyme transfers CO2 from glutaconyl-CoA to a biotin carrier protein (the γ-subunit) that is subsequently decarboxylated by the carboxybiotin decarboxylation site within the Na+ pumping beta subunit (Gcdβ). (wikipedia.org)
  • Homologous
  • The α-δ subunits of these enzymes are homologous to proteins encoded within the genomes of archaea, such as Pyrococcus abyssi (Cohen et al. (wikipedia.org)
  • The α-subunits of the oxaloacetate and methylmalonyl-CoA decarboxylases are homologous to many biotin-containing enzymes including (1) pyruvate carboxylases, (2) homocitrate synthases, (3) biotin carboxyl carrier proteins, (4) isopropylmalate synthases and (5) acyl-CoA carboxylase. (wikipedia.org)
  • organic anion
  • Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATP-binding cassette sub-family C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 gene. (wikipedia.org)
  • clathrin
  • AP-5 is associated with 2 proteins, SPG11 and SPG15, which have some structural similarity to clathrin, and may form the coat around the AP-5 complex, but the ultrastructure of that coat is not known. (wikipedia.org)
  • bacteria
  • The researchers tested three Amt proteins that are present in the bacteria and also determined the speed with which they allow ammonium to pass through the membrane. (innovations-report.com)
  • We discovered a novel protein transport system, the TAM, found in most sequenced gram-negative bacteria that's required for autotransporter biogenesis. (edu.au)
  • These sugars are taken up into cells, no matter whether these are bacteria, yeast, human cells or plant cells, by proteins that create sugar-specific pores in the membrane that surrounds a cell. (eurekalert.org)
  • transmembrane
  • They are still transmembrane carrier proteins, but these are gated transmembrane channels, meaning they do not internally translocate, nor require ATP to function. (wikipedia.org)
  • CbiM is the substrate-specific component of the complex and is a seven-transmembrane protein [ PMID: 16352848 ]. (ebi.ac.uk)
  • Gene
  • p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors. (uniprot.org)
  • You can select a given mouse superfamily member and download (or forward to NCBI BLAST) FASTA formatted protein sequences of that mouse gene and its mouse, human and rat homologs, as defined in the corresponding HomoloGene Class. (jax.org)
  • Intraflagellar transport protein 46 homolog is a protein that in humans is encoded by the IFT46 gene. (wikipedia.org)
  • The protein encoded by this gene contains 258 amino acids, and forms a homodimer with another chain. (wikipedia.org)
  • biological
  • A team of scientists led by Prof. Dr. Susana Andrade from the Institute of Biochemistry of the University of Freiburg and the Cluster of Excellence BIOSS Centre for Biological Signalling Studies has now determined the transport properties of Amt proteins with great precision on the basis of electrophysiology tests on artificial lipid systems. (innovations-report.com)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • Studies of multiple motors are inspired by the fact that multiple motors are involved in many biological processes such as intra-cellular transport and mitosis. (wikipedia.org)
  • superfamily
  • MGI protein superfamily detail pages represent the protein classification set for a homeomorphic superfamily from the Protein Information Resource SuperFamily ( PIRSF ) site. (jax.org)
  • You can also "Select all" mouse superfamily members to obtain their protein sequences and the protein sequences for all mouse, human and rat homologs of the mouse superfamily members. (jax.org)
  • For mouse superfamily members not included in any HomoloGene Class, only the mouse protein sequence is returned. (jax.org)
  • The Na+-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family (TC# 3.B.1) is a family of porters that belong to the CPA superfamily. (wikipedia.org)
  • family
  • Functional analysis of the TAM in Citrobacter rodentium , Salmonella enterica and Escherichia coli showed that it consists of an Omp85-family protein, TamA, in the outer membrane and TamB in the inner membrane of diverse bacterial species. (edu.au)
  • This marks the SWEET family of proteins as drastically different from other sugar transport proteins. (eurekalert.org)
  • These proteins are members of the solute carrier family, subfamily 22. (wikipedia.org)
  • Members of the GLUT family of glucose uniporters then transport the glucose across the basolateral membrane, and into the peritubular capillaries. (wikipedia.org)
  • Cotransport Cotransporter Glucose-galactose malabsorption Renal sodium reabsorption Discovery and development of SGLT-2 inhibitors Ensembl release 48: Homo sapiens Ensembl protein family ENSF00000000509 Wright EM, Hirayama BA, Loo DF (January 2007). (wikipedia.org)
  • A representative list of proteins belonging to the NaT-DC family can be found in the Transporter Classification Database. (wikipedia.org)
  • kinase
  • A number of other cellular events are also mediated via acyl-CoAs, for example signal transduction through protein kinase C, inhibition of retinoic acid-induced apoptosis, and involvement in budding and fusion of the endomembrane system. (wikipedia.org)
  • Moreover
  • Moreover, SDS-treated proteins translocate through the nanopore in the direction prescribed by the electrophoretic force due to the negative charge impaired by SDS. (rsc.org)
  • outer
  • Transport proteins are responsible for moving materials such as nutrients and metabolic products through a cell's outer membrane, which seals and protects all living cells, to the cell's interior. (phys.org)
  • epithelium
  • Specifically, he proposed that the accumulation of glucose in the intestinal epithelium across the brush border membrane was [is] coupled to downhill Na+ transport cross the brush border. (wikipedia.org)
  • mRNA
  • During neuronal differentiation, miR-124 reduces PTBP1 levels, leading to the accumulation of correctly spliced PTBP2 mRNA and a dramatic increase in PTBP2 protein. (wikipedia.org)
  • bind
  • Adaptins recognise and bind to clathrin through their hinge region (clathrin box), and recruit accessory proteins that modulate AP function through their C-terminal ear (appendage) domains. (wikipedia.org)
  • eukaryotic
  • Retention within the lumen of the ER correlates with an additional signal located at the C terminus, represented by the sequence Lys-Asp-Glu-Leu, known to be responsible for preventing secretion of proteins from the lumen of the ER in eukaryotic cells. (wikipedia.org)
  • cells
  • The main functional part of the voltage-sensitive protein domain of these channels generally contains a region composed of S3b and S4 helices, known as the "paddle" due to its shape, which appears to be a conserved sequence, interchangeable across a wide variety of cells and species. (wikipedia.org)
  • Expression
  • Daxx is uniformly expressed throughout the body, except in the testes and thymus, which have especially high expression of the protein. (wikipedia.org)
  • Genetic
  • Genetic combinatorial marking using lentiviral vectors encoding fluorescent proteins (FPs) enabled cell fate mapping through advanced microscopy imaging. (jove.com)
  • carbohydrates
  • citation needed] A high-calorie dish, haleem provides protein from the meat and fibre and carbohydrates from the various combinations of grains and pulses. (wikipedia.org)
  • Carbohydrates are the most abundant biological molecules, and fill numerous roles, such as the storage and transport of energy (starch, glycogen) and structural components (cellulose in plants, chitin in animals). (wikipedia.org)
  • complex
  • The ephedrine, mixed with noradrenaline, is transported through the noradrenaline reuptake complex and packaged (along with real noradrenaline) into vesicles that reside at the terminal button of a nerve cell. (drugbank.ca)
  • The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). (wikipedia.org)
  • nuclear
  • Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. (wikipedia.org)
  • Domain
  • The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric GGA (Golgi-localising, Gamma-adaptin ear domain homology, ARF-binding proteins) adaptors. (wikipedia.org)
  • function
  • The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. (wikipedia.org)
  • While at first Daxx was said to be a "death protein", it is suggested that associating with centromeric components leads to another function of Daxx. (wikipedia.org)
  • known
  • Death-associated protein 6 also known as Daxx is a protein that in humans is encoded by the DAXX gene. (wikipedia.org)
  • Wheat-germ agglutinin (WGA) and Phaseolus vulgaris leucoagglutinin are the most well known tracers, however they are not strict anterograde tracers: especially WGA is known to be transported anterogradely as well as retrogradely. (wikipedia.org)
  • functions
  • Other proteins have structural or mechanical functions, such as those that form the cytoskeleton, a system of scaffolding that maintains the cell shape. (wikipedia.org)
  • together
  • Fomtec FFFP 3% ICAO is a film forming fluoroprotein foam concentrate (FFFP) containing hydrolysed protein and preservatives, together with a blend of fluorinated surfactants to achieve the maximum synergistic effect. (firesafetysearch.com)
  • These biochemicals can be joined together to make polymers such as DNA and proteins, essential macromolecules of life. (wikipedia.org)
  • Products
  • In enzymology, a phosphate-transporting ATPase (EC 3.6.3.27) is an enzyme that catalyzes the chemical reaction ATP + H2O + phosphate(out) ⇌ {\displaystyle \rightleftharpoons } ADP + phosphate + phosphate(in) The 3 substrates of this enzyme are ATP, H2O, and phosphate, whereas its two products are ADP and phosphate. (wikipedia.org)
  • There is also a group of tracers that consist of protein products that can be taken up by the cell and transported across the synapse into the next cell. (wikipedia.org)
  • contains
  • Isolab Distribution Ltd is recalling its Pro Pharma 100% Whey High Protein Powder Food Supplement because it contains soya, which is not mentioned in the list of ingredients. (buckinghamtoday.co.uk)