Protein synthesis inhibitors. Medical search. Frequent questions

On the contrary, treatment with the protein synthesis inhibitors cycloheximide, anisomycin, or puromycin as well as prolonged exposure to the RNA synthesis inhibitor actinomycin D mimicked the biochemical modulating effects of 6AN on cisplatin action. (aspetjournals.org)
Using commonly employed cycloheximide as a representative compound, we show that protein synthesis inhibition increased nanoclustering and effector recruitment specifically of active H-ras but not of K-ras. (abo.fi)
This protection was blocked if cells were treated with the protein synthesis inhibitor cycloheximide. (cdc.gov)
The fact that cycloheximide delays tepal senescence demonstrates the synthesis of particular proteins probably enzymes, responsible for degradation of cellular constituents, executes the cell death programme in flower tepals. (scialert.net)
Cycloheximide is a protein synthesis inhibitor in eukaryotic cells. (goldbio.com)

They also suggest an unexpected feedback from protein synthesis inhibition to Ras signaling, which might present a vulnerability in certain tumor cell types. (abo.fi)
its inhibition could disrupt stemness properties, but translation inhibitors are limited clinically due to toxicity. (nih.gov)
Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis. (wikipedia.org)
We find that elevated basal protein synthesis in Fmr1 KO mice is selectively reduced to wild-type levels by acute inhibition of mGluR5 or ERK1/2, but not by inhibition of mTOR (mammalian target of rapamycin). (jneurosci.org)
Cue-dependent amnesia could likewise be induced by protein synthesis inhibition in much the same way that newly acquired memories are. (frontiersin.org)

Anisomycin , also known as flagecidin , is an antibiotic produced by Streptomyces griseolus which inhibits eukaryotic protein synthesis . (wikipedia.org)
[2] Anisomycin can activate stress-activated protein kinases , MAP kinase and other signal transduction pathways. (wikipedia.org)
Anisomycin interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. (wikipedia.org)
Because of anisomycin's wide use as a protein synthesis inhibitor, there have been many studies centered on the biosynthesis of anisomycin. (wikipedia.org)
The protein synthesis inhibitor anisomycin was injected systemically at different time intervals after a single memory reactivation, consisting of a brief exposure to the training context. (frontiersin.org)
Anisomycin, a protein synthesis inhibitor, prevented the appearance of GWS in vivo. (bvsalud.org)

citation needed] alpha-Amanitin is a powerful inhibitor of eukaryotic DNA transcription machinery. (wikipedia.org)
In both eukaryotic and prokaryotic cells, protein synthesis involves initiation, elongation, and termination. (osmosis.org)

Trichothecene mycotoxins are potent and non selective inhibitors of peptide elongation. (wikipedia.org)
the system of selective translation repression by this lead anti-cancer substance, we provide a good example of a medication stabilizing sequence-selective RNA-protein connections. (ampkpathway.com)
GSK2606414 is a novel, highly selective inhibitor of protein kinase R‑like endoplasmic reticulum kinase (PERK). (spandidos-publications.com)
Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I. (nyu.edu)

Our data suggest that elevated protein synthesis in the Fmr1 KO is due to saturation of mRNA translation downstream of the MAP kinase ERK1/2 which is basally activated by mGluR5. (jneurosci.org)
This process activates protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), inositol-requiring kinase 1 and activating transcription factor (ATF) 6, and initiates unfolded protein response (UPR) signaling pathways ( 13 , 14 ). (spandidos-publications.com)
Checkpoint kinase 1 (Chk1, CHEK1) is a Ser/Thr protein kinase that plays a key role in mediating the cellular response to DNA-damage. (rcsb.org)
Discovery of a Novel Class of Triazolones as Checkpoint Kinase Inhibitors--Hit to Lead Exploration. (rcsb.org)

citation needed] In general, protein synthesis inhibitors work at different stages of bacterial mRNA translation into proteins, like initiation, elongation (including aminoacyl tRNA entry, proofreading, peptidyl transfer, and bacterial translocation) and termination: Rifamycin inhibits bacterial DNA transcription into mRNA by inhibiting DNA-dependent RNA polymerase by binding its beta-subunit. (wikipedia.org)
The mTOR inhibitor PP242, which inhibits formation of eIF4F (a complicated of eIF4E/G/A)14,15, represses a subset of the Hipp-sensitive mRNAs (Prolonged Data Shape 4f and g). (ampkpathway.com)
The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases. (bvsalud.org)

Inhibitors of protein biosynthesis. (wikipedia.org)
Interestingly, simple soluble xylopyranosides can not only initiate the biosynthesis of soluble GAG chains but also function as inhibitors of important enzymes in the biosynthesis of proteoglycans. (lu.se)

Potent JAK3 inhibitor. (rndsystems.com)
Our investigation of structure-activity relationships led to the identification of potent inhibitors 14c, 14h and 16e. (rcsb.org)
Protein farnesyltransferase inhibitors exhibit potent anti-malarial activity. (nyu.edu)

Protein synthesis involves initiation, elongation, and termination. (osmosis.org)
SVC112 is a synthetic derivative of bouvardin, a plant-derived translation elongation inhibitor. (nih.gov)
SIGNIFICANCE: Inhibiting protein elongation with SVC112 reduces tumor growth in head and neck squamous cell carcinoma and increases the effects of radiation by targeting the cancer stem cell pool. (nih.gov)
Studied on ribosomal proteins and elongation factor structure and function: Worked on 3D structures of elongation factor G (EF-G), ribosomal recycling factor (RRF), ribosomal proteins L1, L22, S8, TL5 and some mutants and complexes of these. (lu.se)

Highly specific proteins catalysts, "enzymes" can be used to control the "fire" in useful ways. (slideserve.com)
Used in the manufacture of all proteins and enzymes. (slideserve.com)
Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. (bvsalud.org)

Retapamulin Mupirocin Fusidic acid The following antibiotics bind to the 30S subunit of the ribosome: Aminoglycosides Tetracyclines The following antibiotics bind to the 50S ribosomal subunit: Chloramphenicol Clindamycin Linezolid (an oxazolidinone) Macrolides Telithromycin Streptogramins Retapamulin Biology portal Protein biosynthesis Bacterial translation Eukaryotic translation Archaeal translation Frank Lowy. (wikipedia.org)
Tetracyclines are antimicrobial antibiotics that inhibit bacterial ribosomes which are the organelles that make proteins. (osmosis.org)
Tetracyclines are a class of antibiotics that inhibit bacterial protein synthesis by binding to the 30s subunit of their ribosomes and preventing tRNA from binding. (osmosis.org)
Protein synthesis inhibitors are a class of antibiotics which prevent bacterial ribosomes from synthesizing proteins. (osmosis.org)

However, it does not engage in translocation and quickly dissociates from the ribosome, causing a premature termination of polypeptide synthesis. (wikipedia.org)

Impact of rSCs on protein kinases' gene manifestation expressed by HUVECs. (medicalconsultingcenter.com)
Guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinases (PKG) are kinases regulating diverse physiological functions including vascular smooth muscle relaxation, neuronal synaptic plasticity, and platelet activities. (elsevierpure.com)
A family of protein serine/threonine kinases which act as intracellular signalling intermediates. (bvsalud.org)
Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. (bvsalud.org)
Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. (bvsalud.org)

One source of confusion may be that proxy measures of protein synthesis, such as mGluR-LTD or phosphorylation of signaling molecules, have been used in intact hippocampal slice preparations, whereas metabolic labeling experiments have been performed in synaptoneurosome preparations of cortex that are not easily related to altered hippocampal synaptic plasticity. (jneurosci.org)

HDAC6: one protein, two domains, diverse therapeutic opportunities. (ugent.be)
These results suggest that the ERK1/2 pathway, and other neurotransmitter systems that stimulate protein synthesis via ERK1/2, represent additional therapeutic targets for FXS. (jneurosci.org)

Aminoglycosides, among other potential mechanisms of action, interfere with the proofreading process, causing increased rate of error in synthesis with premature termination. (wikipedia.org)
Repression of protein synthesis by miRNAs: just how many mechanisms? (geogise.com)
Here, we use an in vitro assay of protein synthesis in the hippocampus of male Fmr1 knock-out (KO) mice to explore the molecular mechanisms involved in this core biochemical phenotype under conditions where aberrant synaptic physiology has been observed. (jneurosci.org)

Inhibitor synthesis and validation in cellular disease models. (ugent.be)
Several types of cellular stress, including hypoxia ( 8 ), infection ( 9 ), nutrient deprivation ( 10 ), oxidative stress ( 11 ) and dysfunctional calcium homeostasis ( 12 ), may induce accumulation of unfolded proteins in the ER lumen. (spandidos-publications.com)

The present study investigated the effects of GSK2606414 on proliferation, apoptosis, and the expression of activating transcription factor 4 (ATF4), CCAAT/enhancer‑binding protein homologous protein (CHOP) and vascular endothelial growth factor (VEGF) in human retinal pigment epithelial (RPE) cells under endoplasmic reticulum (ER) stress. (spandidos-publications.com)
ATF4 induces expression of the proapoptotic transcription factor CCAAT/enhancer-binding protein homologous protein (CHOP), which mediates PERK-induced apoptosis ( 16 ). (spandidos-publications.com)
Farnesyltransferase inhibitor R115777 (zarnestra, tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells. (nyu.edu)

SVC112 preferentially impeded ribosomal processing of mRNAs critical for stress response and decreased CSC-related proteins including Myc and Sox2. (nih.gov)
It prevents ribosomal mRNA translocation during protein translation. (goldbio.com)

Sulfa drugs arrest cell growth by inhibiting the synthesis of folic acid, a component required for growth by bacteria. (americanaquariumproducts.com)

The X-ray structures of trimers of the protein and their complexes with various metals, single-particle electron microscopic structure of iron-free and iron-loaded 24-subunit oligomers. (lu.se)

Protein synthesis inhibitors include many different classes of medications that prevent bacterial ribosomes from synthesizing proteins. (osmosis.org)

The mRNA serves as a blueprint for the protein that will be synthesized. (osmosis.org)
During transcription , a specific gene on the DNA is "read" and a copy is made called a messenger RNA, or mRNA, which is like a blueprint with instructions on what protein to build. (osmosis.org)
Certainly, we discovered that the eIF4A inhibitor Hippuristanol (Hipp), which reduces the affinity between eIF4A and RNA12,13, produces a different spectral range of mRNA-specific repression (Prolonged Data Shape 4a-e). (ampkpathway.com)
Fragile X syndrome (FXS) is caused by loss of the FMR1 gene product FMRP (fragile X mental retardation protein), a repressor of mRNA translation. (jneurosci.org)

According to the metabotropic glutamate receptor (mGluR) theory of FXS, excessive protein synthesis downstream of mGluR5 activation causes the synaptic pathophysiology that underlies multiple aspects of FXS. (jneurosci.org)
Although it is now clear that mGluR5 participates in the pathogenesis of FXS, at least in animal models, it is still poorly understood how Gp1 mGluRs trigger protein synthesis and how this process is altered in the absence of FMRP to disrupt synaptic function. (jneurosci.org)

Using a positive control template to verify protein synthesis can be useful when unfamiliar with in vitro transcription-translation protocols. (neb.com)
Rifampin is not a protein synthesis inhibitor, it may also be used in combination therapy based on in vitro synergy. (cdc.gov)

Translation is also known as protein synthesis, and it's when organelles called ribosomes assemble the protein from amino acids within the cytoplasm. (osmosis.org)

Conversely, 6AN inhibited protein synthesis, whereas 18 6AN analogs that failed to enhance Pt-DNA adducts and cisplatin cytotoxicity failed to inhibit protein synthesis. (aspetjournals.org)

A strong rationale for taking this approach is that slice has been shown to accurately reproduce the in vivo phenotype of elevated basal protein synthesis in the Fmr1 KO hippocampus (cf. (jneurosci.org)

These observations are consistent with a model in which 6AN and other inhibitors of protein synthesis act as modulating agents by increasing cisplatin accumulation, thereby enhancing the formation of Pt-DNA adducts and subsequent cisplatin-induced cell death. (aspetjournals.org)
Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha). (nyu.edu)

Okay, first, let's look at how genes become proteins. (osmosis.org)

The scope of this review is to describe synthesis of xylopyranosyl donors, as well as protective group chemistry, modifications, and conformational analysis of xylose. (lu.se)

In summary, these data demonstrate that SVC112 suppresses CSC-related proteins, enhances the effects of radiation, and blocks growth of HNSCC PDXs by inhibiting CSCs. (nih.gov)
To assess the role of the polyamine transport system in radioprotection by amifostine derivatives, human DU-145 prostate cancer cells were transfected with a cDNA that encodes antizyme (OAZ), a polyamine-inducible protein that suppresses polyamine transport under control of a minimal heat shock promoter. (aacrjournals.org)

The second major membrane system that breaks down proteins and lipids. (slideserve.com)

The first three proposals, on protein-based diagnosis, diagnostic materials and assays for less reactogenic vaccines, have been approved for one year. (who.int)

Recognition of cytochrome c by tetraphenylporphyrin-based protein surface receptors. (nyu.edu)

Trichothecene mycotoxins are extremely stable proteins that are resistant to heat and ultraviolet light inactivation. (medscape.com)

SVC112 had greater antiproliferative effects on HNSCC cells compared with the FDA-approved translation inhibitor omacetaxine mepesuccinate (HHT). (nih.gov)
Rocaglamide A (RocA) typifies a course of proteins synthesis inhibitors that selectively wipe out aneuploid tumor cells and repress translation of particular mRNAs1-4. (ampkpathway.com)

RocA treatment of HEK 293 cells triggered a dose-dependent reduction in polysome development and proteins synthesis (Prolonged Data Statistics 1a and ?and2a).2a). (ampkpathway.com)

Adherence was not affected by pretreatment of the cells with virus particles or viral proteins. (lu.se)

Nonlethal concentrations of PAT produced a dose-dependent increase in HO-1, HSP70, and HSP25/27 protein levels but did not increase HSP60 levels. (cdc.gov)
Results demonstrate that low concentrations of PAT increase GSH levels and stress protein synthesis, which may be responsible for the protection that low level PAT exposure offers against the subsequent toxicity of higher concentrations of PAT. (cdc.gov)

An increase in total sugar, phenolic and soluble protein content was observed with a concomitant decrease in α-amino acid content. (scialert.net)

The interactions between proteases and their inhibitors have been linked to modulation of cell death processes in plants and in certain cut flowers. (scialert.net)
Detecting Protein-Protein Interactions with a Green Fluorescent Protein Fragment Reassembly Trap: Scope and Mechanism. (nyu.edu)
Strategies for targeting protein-protein interactions with synthetic agents. (nyu.edu)

Cytosol: a gel like substance consisting of water-soluble proteins and a variety of insoluble filaments that form the cytoskeleton. (slideserve.com)

To achieve such objectives, we applied natural language processing techniques to identify drugs and linked entities (eg, disease, gene, protein, chemical compounds). (jmir.org)

EM studies of complexes with ferrochelatase and with components of the Fe-S cluster synthesis machinery. (lu.se)

A protein synthesis inhibitor is a compound that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins. (wikipedia.org)
Protein synthesis correlates with these enduring processes. (bvsalud.org)

Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites. (nyu.edu)

Anatomy29

Organisms13

Diseases1

Chemicals and Drugs137

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Psychiatry and Psychology9

Phenomena and Processes50

Information Science3

Health Care3

Cycloheximide5

Inhibition5

Anisomycin6

Eukaryotic2

Selective4

Kinase4

Inhibits3

Biosynthesis2

Potent3

Elongation4

Enzymes3

Antibiotics4

Ribosome1

Kinases5

Phosphorylation1

Therapeutic2

Mechanisms3

Cellular2

Apoptosis3

Ribosomal2

Bacteria1

Subunit1

Bacterial ribosomes1

MRNA4

Synaptic2

Vitro2

Ribosomes1

Inhibit1

Vivo1

Formation2

Genes1

Chemistry1

Suppresses2

Lipids1

Assays1

Receptors1

Mycotoxins1

Translation2

Triggered a dose-dependent1

Viral1

Concentrations2

Amino1

Interactions3

Soluble1

Chemical1

Machinery1

Processes2

Arrest1