• PMID
  • Guanine nucleotide binding proteins (G proteins) are membrane-associated, heterotrimeric proteins composed of three subunits: alpha ( IPR001019 ), beta ( IPR001632 ) and gamma ( IPR001770 ) [ PMID: 14762218 ]. (ebi.ac.uk)
  • G proteins and their receptors (GPCRs) form one of the most prevalent signalling systems in mammalian cells, regulating systems as diverse as sensory perception, cell growth and hormonal regulation [ PMID: 15294442 ]. (ebi.ac.uk)
  • The cycle is completed by the hydrolysis of alpha subunit-bound GTP to GDP, resulting in the re-association of the alpha and beta/gamma subunits and their binding to the receptor, which terminates the signal [ PMID: 15119945 ]. (ebi.ac.uk)
  • The length of the G protein signal is controlled by the duration of the GTP-bound alpha subunit, which can be regulated by RGS (regulator of G protein signalling) proteins or by covalent modifications [ PMID: 11313912 ]. (ebi.ac.uk)
  • The specific combination of subunits in heterotrimeric G proteins affects not only which receptor it can bind to, but also which downstream target is affected, providing the means to target specific physiological processes in response to specific external stimuli [ PMID: 9278091 , PMID: 11882385 ]. (ebi.ac.uk)
  • The dissociated subunits activate the downstream pheromone signalling MAP kinase cascade that induce changes necessary to produce mating-competent cells [ PMID: 14536090 , PMID: 7796906 ]. (ebi.ac.uk)
  • Neither of the subunits shows sequence similarity to other filament-capping proteins [ PMID: 2341404 ]. (ebi.ac.uk)
  • This entry represent the alpha subunit (CAPZA), which is a protein of about 268 to 286 amino acid residues whose sequence is well conserved in eukaryotic species [ PMID: 1711931 ]. (ebi.ac.uk)
  • In Drosophila mutations in the alpha and beta subunits cause actin accumulation and subsequent retinal degeneration [ PMID: 16143599 ]. (ebi.ac.uk)
  • 2002
  • 2002). "Identification and localization of T-type voltage-operated calcium channel subunits in human male germ cells. (wikipedia.org)
  • hydrolysis
  • Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (uniprot.org)
  • assists the folding of proteins upon ATP hydrolysis. (uniprot.org)
  • novel
  • Despite enormous advances since then, there remain multiple emerging and unanswered questions about the fundamental details of the biochemical roles for Gβγ in GPCR-dependent G protein activation, as well as questions about broader roles in novel signaling mechanisms, physiology and pathophysiology. (pubmedcentralcanada.ca)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • The sequence identity between different fungal alpha subunits is relatively low and is equivalent to the level of similarity observed between mammalian alpha subtypes. (ebi.ac.uk)
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • This work showed that α-gustducin's protein sequence gives it 80% identity to both rod and cone a-transducin. (wikipedia.org)
  • retinal
  • This experiment revealed transducin and gustducin were both expressed in taste tissue (1:25 ratio) and that both G proteins are capable of activating retinal PDE. (wikipedia.org)
  • interact
  • Whatever the mode of G protein activation, the Gα and Gβγ subunits both interact with effector molecules, such as phospholipases and ion channels, in a manner that leads to their activation. (pubmedcentralcanada.ca)
  • complex
  • Essential subunit of the farnesyltransferase complex. (uniprot.org)
  • Part of the Sec protein translocase complex. (uniprot.org)
  • Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. (uniprot.org)
  • In structural biology, a protein subunit is a single protein molecule that assembles (or "coassembles") with other protein molecules to form a protein complex. (wikipedia.org)
  • It should not be confused with cyclic AMP-activated protein kinase (protein kinase A). AMPK is a heterotrimeric protein complex that is formed by α, β, and γ subunits. (wikipedia.org)
  • The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. (wikipedia.org)
  • Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of α1, α2δ, β, and γ subunits in a 1:1:1:1 ratio. (wikipedia.org)
  • functionally
  • They physically associate with both proteasomes and ubiquitin ligases, and are thus thought to functionally link the ubiquitination machinery to the proteasome to effect in vivo protein degradation. (wikipedia.org)
  • These two G proteins have been shown to be structurally and functionally similar, leading researchers to believe that the sense of taste evolved in a similar fashion to the sense of sight. (wikipedia.org)
  • enzyme
  • 5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular energy homeostasis. (wikipedia.org)
  • It consists of three proteins (subunits) that together make a functional enzyme, conserved from yeast to humans. (wikipedia.org)
  • This non-functioning enzyme leads to the accumulation of ubiquinated proteins in the lower motor neurons and upper corticospinal motor neurons, due to the fact that ubiquilin 2 normally degrades these ubiquinated proteins, but cannot if the ALS mutation is present. (wikipedia.org)