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  • Membrane Proteins
  • Our results indicate that TCR signaling assemblies in plasma membrane subdomains, rather than generally concentrating raft-associated membrane proteins and lipids, form by a selective protein-mediated anchoring of the raft membrane protein LAT in vicinity of TCR. (nih.gov)
  • Phosphorylation
  • The increase of both MLC phosphorylation and MLCK protein expression induced by IFN-γ and TNF-α was significantly inhibited by berberine treatment. (nih.gov)
  • We found that the raft transmembrane protein linker for activation of T cells (LAT), but not a palmitoylation-deficient non-raft LAT mutant, strongly accumulated in TCR-enriched immunoisolates in a tyrosine phosphorylation-dependent manner. (nih.gov)
  • These four proteins of the feedback loop are later degraded by a casein kinase-mediated phosphorylation cycle, allowing fluctuations in gene expression according to environmental cues. (wikipedia.org)
  • precursor protein
  • Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing. (nih.gov)
  • In addition to its documented role in the proteolytic processing of Notch-1 and the beta-amyloid precursor protein, presenilin 1 (PS1) associates with beta-catenin. (nih.gov)
  • In contrast, PS1Deltacat restores Notch-1 proteolytic cleavage and Abeta generation in PS1-deficient cells, indicating that PS1 function in modulating beta-catenin levels can be separated from its roles in facilitating gamma-secretase cleavage of beta-amyloid precursor protein and in Notch-1 signaling. (nih.gov)
  • MeSH
  • GeneReviews/NIH/NCBI/UW entry on Pulmonary Fibrosis, Familial Pulmonary Surfactant-Associated Protein B at the US National Library of Medicine Medical Subject Headings (MeSH) Pérez-Gil J (2002). (wikipedia.org)
  • PTMs
  • In the current study, we used proteomic analyses to determine the presence of PTMs on the highly abundant leptospiral protein, LipL32, from rat urine-isolated L. interrogans serovar Copenhageni compared to in vitro-grown organisms. (nih.gov)
  • Receptor
  • In addition to tankyrase-2, peptides derived from tankyrase-1, GA-binding protein subunit beta-2 (GABPB2) and the transient receptor potential vanilloid-4 (TRPV4) ARD all displayed +16 Da mass shifts after reaction with FIH (Fig. 6B). (nih.gov)
  • Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies. (nih.gov)
  • Activation of T cell antigen receptor (TCR) induces tyrosine phosphorylations that mediate the assembly of signaling protein complexes. (nih.gov)
  • Thiol S-nitrosylation and NO transfer reactions (transnitrosation reactions) are involved in virtually all classes of cell signaling, ranging from regulation of ion channels and G-protein coupled reactions to receptor stimulation and activation of nuclear regulatory protein. (wikipedia.org)
  • gene
  • What does this gene/protein do? (cancerindex.org)
  • Tenomodulin (also referred to as tendin, myodulin, Tnmd and TeM) is a protein encoded by the TNMD (Tnmd) gene and was discovered independently by Brandau and Shukunami in 2001 as a gene sharing high similarity with the already known chondromodulin-1 (Chm1). (wikipedia.org)
  • The gene is localized on the X chromosome and accounts for an approximately 1.4 kb transcript and a predicted protein consisting of 317 amino acids. (wikipedia.org)
  • The last exon of TNMD gene encodes the conserved C-terminal cysteine-rich domain, which makes up the part of the protein sharing highest resemblance to chondromodulin-I (77% similarity/66% identity). (wikipedia.org)
  • The protein encoded by this gene is a approximately 345 kDa specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by synovial lining cells. (wikipedia.org)
  • Cycle (cyc) is a gene in Drosophila melanogaster that encodes the CYCLE protein (CYC). (wikipedia.org)
  • Gene/protein names are sometimes used interchangeably to designate various "hydrogenase cluster" proteins unrelated to each other in various organisms. (wikipedia.org)
  • subunit
  • 40S Small Subunit w/ 34 Proteins. (brainscape.com)
  • and HyaD is assumed to be involved in processing of the large subunit of hydrogenase 1. (wikipedia.org)
  • The proteasome subcomponents are often referred to by their Svedberg sedimentation coefficient (denoted S). The proteasome most exclusively used in mammals is the cytosolic 26S proteasome, which is about 2000 kilodaltons (kDa) in molecular mass containing one 20S protein subunit and two 19S regulatory cap subunits. (wikipedia.org)
  • Chemical
  • Arginine ADP-ribosylation, thus, causes a notable change in size and chemical property at the ADP-ribosylation site of the target protein. (nih.gov)
  • Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. (wikipedia.org)
  • regulation
  • Regulation thus occurs primarily through the negative feedback by the PER-TIM protein complex in the transcription-translation feedback loop described above. (wikipedia.org)
  • complexes
  • We employed a novel method to immunoisolate plasma membrane subfragments that were highly concentrated in activated TCR-CD3 complexes and associated signaling proteins. (nih.gov)
  • The TIM protein in these complexes mediate the accumulation of the dimeric PER-TIM protein complex and their subsequent importation into the nucleus, where the PER protein in these complexes then mediates the release of CYC-CLK from the chromatin, repressing CYC-CLK dependent transcription. (wikipedia.org)
  • encodes
  • The cDNA encodes a protein of 1,404 amino acids (human A isoform) with a somatomedin B homology domain, heparin-binding domains, multiple mucin-like repeats, a hemopexin domain, and an aggregation domain. (wikipedia.org)
  • subunits
  • The outer two rings each contain seven α subunits whose function is to maintain a "gate" through which proteins enter the barrel. (wikipedia.org)
  • residues
  • Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. (nih.gov)
  • The green fluorescent protein (GFP) is a protein composed of 238 amino acid residues (26.9 kDa) that exhibits bright green fluorescence when exposed to light in the blue to ultraviolet range. (wikipedia.org)
  • Biochemistry
  • Interaction between perdeuterated dimyristoylphosphatidylcholine and low molecular weight pulmonary surfactant protein SP-C". Biochemistry. (wikipedia.org)
  • molecular
  • The appearance of molecular markers for satellite secretory pathways provides further evidence that the spine apparatus plays a role in local integral membrane protein translocation and processing. (wikipedia.org)
  • proteolytic
  • At one step of this process, after nickel incorporation, each hydrogenase isoenzyme is processed by proteolytic cleavage at the C-terminal end by the corresponding hydrogenase maturation endopeptidase. (wikipedia.org)
  • The proteolytic activities of this system was isolated as a multi-protein complex originally called the multi-catalytic proteinase complex by Sherwin Wilk and Marion Orlowski. (wikipedia.org)
  • chemistry
  • Scientists Roger Y. Tsien, Osamu Shimomura, and Martin Chalfie were awarded the 2008 Nobel Prize in Chemistry on 10 October 2008 for their discovery and development of the green fluorescent protein. (wikipedia.org)
  • Golgi
  • The Golgi apparatus is a major collection and dispatch station of protein products received from the endoplasmic reticulum (ER). (wikipedia.org)
  • Proteins synthesized in the ER are packaged into vesicles, which then fuse with the Golgi apparatus. (wikipedia.org)
  • More specifically, the protein translocation site marker (Sec61α) and the Golgi cisternae markers (giantin and α-mannosidase II) have been observed in the spine apparatus. (wikipedia.org)
  • pathway
  • The connection to the smooth endoplasmic reticulum also suggests a potential pathway for the transfer of proteins between the spine and dendrite. (wikipedia.org)
  • Endopeptidases
  • Immunofluorescence microscopy indicated that the IseA-3xFLAG fusion protein was specifically localized at cell separation sites and poles on the vegetative cell surface in a similar manner of the d,l-endopeptidases. (biomedsearch.com)
  • Tertiary
  • The α-LTX protein tertiary structure can be divided in three parts: the N-terminal wing (36 kDa), the body (76 kDa), and the C-terminal head (18.5 kDa). (wikipedia.org)
  • function
  • ADP-ribosylarginine specific hydrolases (ARHs) can restore target protein function by hydrolytic removal of the entire ADP-ribose moiety. (nih.gov)
  • The propeptide of pulmonary surfactant C has an N-terminal alpha-helical segment whose suggested function was stabilization of the protein structure, since the latter can irreversibly transform from its native alpha-helical structure to beta-sheet aggregates and form amyloid fibrils. (wikipedia.org)
  • The RNA can be directly functional or be the intermediate template for a protein that performs a function. (wikipedia.org)
  • Mechanisms
  • The 19 chapters are divided into four sectors: A) describes and explores the genome, its evolution, expression and the mechanisms that contribute to protein, and hence biological, diversity. (wiley.com)
  • Epigenomic maintenance is a continuous process and plays an important role in stability of eukaryotic genomes by taking part in crucial biological mechanisms like DNA repair. (wikipedia.org)
  • cell surface
  • Three murine mammary tumor virus (MuMTV)-producing epithelial cell lines derived from murine mammary tumors were examined in order to identify the MuMTV-specific cell surface antigens and their distribution on the cell surface, to study the kinetics of the MuMTV envelope precursor processing, virus assembly, and release, and to characterize the soluble MuMTV antigens that are shed into culture medium. (biomedsearch.com)
  • The TGN is the final cisternal structure, from which proteins are packaged into vesicles destined to lysosomes, secretory vesicles, or the cell surface. (wikipedia.org)
  • green fluores
  • To directly examine the Rab5-mediated endosomal trafficking in ALS2(-/-) neurons, we introduced green fluorescent protein (GFP)-tagged Rab5 into cultured hippocampal neurons to monitor the morphology and motility of Rab5-associated early endosomes. (whiterose.ac.uk)