• receptor
  • Outcomes Identity of IGPR-1 as a story cell surface area receptor Searching the individual genome series data source for Ig-containing protein, we discovered an uncharacterized proteintransmembrane and immunoglobulin domainCcontaining proteins 2 (TMIGD2)that provides a one Ig area, a one transmembrane area, and a extend of 110Camino acidity cytoplasmic area extremely wealthy in proline residues (Body 1A). (code3systems.com)
  • Kidneys were harvested for histopathology and for the study the gene expression of c-Jun N-terminal kinases ( JNK ), Mitogen-activated protein kinase 4 ( MKK4 ), MKK7 , P38 mitogen-activated protein kinases ( P38 ), tumor necrosis factors alpha ( TNF-α ), TNF Receptor-Associated Factor 2 ( TRAF2 ), and interleukin-1 alpha ( IL-1-α ). (biomedcentral.com)
  • The microbe-G-protein-coupled receptor (GPR) and microbe-histone deacetylase (HDAC) axes might be the major pathway mediating these effects. (biomedcentral.com)
  • It was shown that cocaine- and amphetamine-regulated transcript protein (CART) increases the transcriptional activity of estrogen receptor alpha (zeige ESR1 ELISA Kits ) and that CART stimulates an autocrine/paracrine loop within tumor cells to amplify the CART signal. (antikoerper-online.de)
  • Desensitization of receptors that control disease is prevented by inhibiting G-protein receptor kinases. (google.com)
  • thus, cortactin must also be activated by receptor kinases that pick up a large variety of chemical signals. (wikipedia.org)
  • These changes facilitate the recruitment of specific adapter proteins such as the insulin receptor substrate proteins (IRS) in addition to SH2-B (Src Homology 2 - B ), APS and protein phosphatases, such as PTP1B, eventually promoting downstream processes involving blood glucose homeostasis. (wikipedia.org)
  • The nature and function of these interactions, detailed in tables 1-1 and 1-2, portray Densin-180 as a key interactor in the midst of receptor proteins, scaffolding proteins and structural proteins. (wikipedia.org)
  • enzyme
  • Calcium/calmodulin-dependent protein kinase type II beta chain is an enzyme that in humans is encoded by the CAMK2B gene. (wikipedia.org)
  • A medicinal enzyme inhibitor is often judged by its specificity (its lack of binding to other proteins) and its potency (its dissociation constant, which indicates the concentration needed to inhibit the enzyme). (wikipedia.org)
  • Other cellular enzyme inhibitors are proteins that specifically bind to and inhibit an enzyme target. (wikipedia.org)
  • PF-4800567 is a drug developed by Pfizer which acts as a selective inhibitor of the enzyme Casein kinase 1 epsilon (CK1-ε), and has mainly been used in the study of the casein kinase 1 enzymes in the regulation of circadian rhythm, as well as showing potential neuroprotective effects. (wikipedia.org)
  • Before annealing can occur, one of the strands may need to be phosphorylated by an enzyme such as kinase to allow proper hydrogen bonding to occur. (wikipedia.org)
  • gene
  • Computational and experimental research has previously been carried out to define a minimal protein-encoding gene set. (pnas.org)
  • To obtain an independent and possibly more reliable estimate of a minimal protein-encoding gene set for bacteria, we systematically inactivated Bacillus subtilis genes. (pnas.org)
  • A gene on chromosome 12p13 that encodes a member of the highly conserved cyclin family, which regulates CDK kinases. (thefreedictionary.com)
  • The researchers identified several mutations that may contribute as cooperating mutations, including changes in CCND2 , a gene that makes a protein involved in the cell cycle. (thefreedictionary.com)
  • Alpha II-spectrin, also known as Spectrin alpha chain, brain is a protein that in humans is encoded by the SPTAN1 gene. (wikipedia.org)
  • This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. (wikipedia.org)
  • Presenilin-1 (PS-1) is a presenilin protein that in humans is encoded by the PSEN1 gene. (wikipedia.org)
  • Calcium channel, voltage-dependent, L type, alpha 1C subunit (also known as Cav1.2) is a protein that in humans is encoded by the CACNA1C gene. (wikipedia.org)
  • Protein numb homolog is a protein that in humans is encoded by the NUMB gene. (wikipedia.org)
  • The protein encoded by this gene plays a role in the determination of cell fates during development. (wikipedia.org)
  • The protein Numb is coded for by the gene, NUMB, whose mechanism appears to be evolutionarily conserved. (wikipedia.org)
  • The numb gene protein product controls binary cell fate decisions in the peripheral and central nervous systems of both invertebrates and mammals during neurogenesis. (wikipedia.org)
  • Among the Notch target genes are members of the HES and HEY gene families whose protein products can act as transcriptional repressors for tissue-specific transcription factors, thus maintaining the cell's potential for self-renewal. (wikipedia.org)
  • Ras-related protein Rap-1A is a protein that in humans is encoded by the RAP1A gene. (wikipedia.org)
  • The product of this gene belongs to the family of Ras-related proteins. (wikipedia.org)
  • Two transcript variants encoding the same protein have been identified for this gene. (wikipedia.org)
  • isolated the lin-4 gene, they found that instead of producing an mRNA encoding a protein, it produced short non-coding RNAs, one of which was a ~22-nucleotide RNA that contained sequences partially complementary to multiple sequences in the 3' UTR of the lin-14 mRNA. (wikipedia.org)
  • Leucine rich repeat containing 7 also known as LRRC7, Densin-180, or LAP1 is a protein which in humans is encoded by the LRRC7 gene. (wikipedia.org)
  • NR2B
  • Identified interaction partners include: CaMKII-alpha, alpha-Actinin and NR2B (via CaMKII-alpha), Cav1.3 (L-type Ca2+) channels, MAGUIN-1, Shank, PSD-95 (via Shank and MAGUIN-1), beta-Catenin, delta-Catenins and NCadherin (via the Catenins). (wikipedia.org)
  • regulates
  • Recent studies revealed that Tonicity-responsive enhancer binding protein (TonEBP) directly regulates the transcription of aldose reductase (AR), which catalyzes the first step of the polyol pathway of glucose metabolism. (unist.ac.kr)
  • Subsequent work revealed that let-7 regulates a number of other oncogenes, including CCND2 (cyclin D2), CDK6 (cyclin-dependent kinase 6), CDC25 [cell division cycle 25 homolog C (S. (thefreedictionary.com)
  • residues
  • These carbons are electrophiles that readily form covalent bonds by acting as acceptors in Michael reactions to form covalent bonds with exposed nucleophile sites, particularly thiol residues, in diverse proteins. (wikipedia.org)
  • Found to be densely associated to the postsynaptic density (PSD), it has been characterised as a 188 kDa (originally thought to be 180 kDa, hence nomenclature), 1495 residues long, brain-specific protein containing 16 leucine-rich repeats (LRRs) within the 500 N-terminal residues, and one Psd95/Discs large/Zona occludens (PDZ) domain within the 200 C-terminal residues. (wikipedia.org)
  • species
  • KRT18 Mouse Monoclonal Antibody mus musculus murine KRT18 Mouse Monoclonal Antibody detects proteins from variouse species most likely human. (antibody-antibodies.com)
  • Other experiments show that a single miRNA species may repress the production of hundreds of proteins, but that this repression often is relatively mild (much less than 2-fold). (wikipedia.org)
  • 1998
  • 1998 ), and various other Camera protein, such as PECAM-1, ICAM-1, and Alogliptin IC50 JAM-A, are also connected to angiogenesis Alogliptin IC50 (Bach et al . (code3systems.com)
  • actin
  • The spectrins are a family of widely distributed cytoskeletal proteins which are involved in actin crosslinking, cell adhesion, intercellular communication and cell cycle regulation. (wikipedia.org)
  • Cortactin (from "cortical actin binding protein") is a monomeric protein located in the cytoplasm of cells that can be activated by external stimuli to promote polymerization and rearrangement of the actin cytoskeleton, especially the actin cortex around the cellular periphery. (wikipedia.org)
  • When activated, it will recruit Arp2/3 complex proteins to existing actin microfilaments, facilitating and stabilizing nucleation sites for actin branching. (wikipedia.org)
  • mRNA
  • As a result, these mRNA molecules are silenced, by one or more of the following processes: Cleavage of the mRNA strand into two pieces, Destabilization of the mRNA through shortening of its poly(A) tail, and Less efficient translation of the mRNA into proteins by ribosomes. (wikipedia.org)
  • This complementarity was proposed to inhibit the translation of the lin-14 mRNA into the LIN-14 protein. (wikipedia.org)
  • vitro
  • Even more significantly, IGPR-1 colleagues with many SH3-formulated with protein and adjusts angiogenesis in vivo and in vitro. (code3systems.com)
  • interactions
  • The ability of these other NPFs to bind the Arp2/3 complex while cortactin is also bound could come from new interactions with cortactin's SH3 domain, which is in a different conformation when phosphorylated by Ser/Thr kinases and thus may be more open to interactions with other NPFs. (wikipedia.org)
  • The currently exposed interactions of Densin-180 portray the protein as a promiscuous player amongst key synaptic players, fitting with the original observation of the protein's dense presence among core PSD proteins by Mary B. Kennedy's Laboratory. (wikipedia.org)
  • family
  • Vascular endothelial cadherin (VE-cadherin), an endothelium-specific member of the cadherin family members of adhesion protein (Bach et al . (code3systems.com)
  • cell
  • The reaction inactivates or reduces the activity of various functionally important target proteins and is one mechanism by which cylopentenone PGs influence cell function. (wikipedia.org)
  • Numb protein signaling plays a key role in binary cell fate decisions following asymmetric cell divisions. (wikipedia.org)
  • In both invertebrates and mammals, Numb is localized using the Pins/GαI complex and the PAR complex of Bazooka (Par3 in mammals), Par6, and aPKC (atypical protein kinase C). In the sensory organ precursor (SOP) cell, the PAR proteins localize to the posterior pole of the cell, and the Pins/GαI complex is localized to the anterior pole of the cell. (wikipedia.org)
  • Inactive cortactin diffuses throughout the cytoplasm, but upon phosphorylation, the protein begins to target certain areas in the cell. (wikipedia.org)
  • gamma
  • Presenilin-1 is one of the four core proteins in the gamma secretase complex, which is considered to play an important role in generation of amyloid beta (Aβ) from amyloid precursor protein (APP). (wikipedia.org)
  • alpha
  • 1999. Transfection of antisense oligos to Protein kinase C alpha or delta inhibits lipoprotein Lipase activity in Adipocytes. (sylvester.org)
  • Elevated protein expression of alpha II-spectrin has been detected in cerebrospinal fluid in patients with Guillain-Barré syndrome. (wikipedia.org)
  • complex
  • Another proposed component of the localization complex is Partner of Numb (PON), which is asymmetrically localized during mitosis and acts as an adaptor protein by binding and mediating the anchoring of Numb. (wikipedia.org)
  • site
  • Thirdly, an insert of five amino acids in the fifteenth spectrin motif bears a highly antigenic epitope resembling an ankyrin-like p53 binding protein binding site. (wikipedia.org)