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  • cDNA
  • Isoforms at the DNA level are readily characterized by cDNA transcript studies. (wikipedia.org)
  • Northern blotting with these cDNAs together with mouse cardiac (C) C-protein cDNA was performed. (semanticscholar.org)
  • EFS (Embryonal Fyn-associated Substrate), also known as SIN (Src INteracting or Signal Integrating protein) was originally identified using cDNA library screening of mouse embryonal libraries for proteins containing SH3-interacting domains, or interacting with the SRC SH3 domain, in two independent studies by Ishino et al. (wikipedia.org)
  • mRNA
  • Through RNA splicing mechanisms, mRNA has the ability to select different protein-coding segments (exons) of a gene, or even different parts of exons from RNA to form different mRNA sequences. (wikipedia.org)
  • All these proteins are different both in structure and composition and this process is regulated by alternative splicing of mRNA and have a large impact in proteome diversity. (wikipedia.org)
  • There are three main components of a common alternative splicing mechanism: cis-acting regulatory sequences RNA-binding protein splicing factors RNA-RNA base pairing In short, during the transcription process, mRNA may include (enhance) or exclude (silent) one or multiple exons of a gene. (wikipedia.org)
  • Reduced mRNA and protein expression of the genomic caretaker RAD9A in primary fibroblasts of individuals with childhood and independent second cancer. (nih.gov)
  • There are six other mRNA isoforms produced by alternative splicing and variation in exon length. (wikipedia.org)
  • sequences
  • Select one or more mouse PIRSF members to download protein sequences or forward to NCBI BLAST. (jax.org)
  • You can select a given mouse superfamily member and download (or forward to NCBI BLAST) FASTA formatted protein sequences of that mouse gene and its mouse, human and rat homologs, as defined in the corresponding HomoloGene Class. (jax.org)
  • You can also "Select all" mouse superfamily members to obtain their protein sequences and the protein sequences for all mouse, human and rat homologs of the mouse superfamily members. (jax.org)
  • The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. (nih.gov)
  • kinase
  • Creatine kinase, the presence of which in the blood can be used as an aid in the diagnosis of myocardial infarction, exists in 3 isoforms. (wikipedia.org)
  • This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. (abcam.com)
  • ATP is crucial for ALOX5's metabolic activity A proline-rich region (residues 566-577), sometimes termed a SH3-binding domain, which promotes its binding to proteins with SH3 domains such as Grb2 and may thereby link the enzyme's regulation to tyrosine kinase receptors. (wikipedia.org)
  • Plakophilin is necessary for normal localization and content of desmoplakin to desmosomes, which may in part be due the recruitment of protein kinase C alpha to desmoplakin. (wikipedia.org)
  • expression
  • Changes in the expression level or regulatory dysfunctions of isoforms often lead to developmental or pathological disorders. (wiley.com)
  • Expression Patterns of Insulin-Like Growth Factor Binding Protein Isoforms in Medulloblastoma Subtypes and Clinical Correlation. (biomedsearch.com)
  • Differential expression of C-protein isoforms in developing and degenerating mouse striated muscles. (semanticscholar.org)
  • One key transcription factor that activates skeletal actin gene expression is Serum Response Factor ("SRF"), a protein that binds to specific sites on the promoter DNA of the actin gene. (wikipedia.org)
  • SRF may bring a number of other proteins to the promoter of skeletal actin, such as andogen receptor, and thereby contribute to induction of skeletal actin gene expression by androgenic (often termed "anabolic") steroids. (wikipedia.org)
  • Expression of isoforms 1 and 2 has been detected in multiple tissues, with maximal expression in the placenta, and the embryonal central nervous system, heart, testes and lungs. (wikipedia.org)
  • Decreased expression of plakophilin-2 via siRNA leads to a decrease in and redistribution of connexin 43 protein, as well as a decrease in coupling of adjacent cardiomyocytes. (wikipedia.org)
  • CCAAT
  • Little is known about the transcriptional regulation of EFS, but several transcriptional regulators for EFS have been proposed based on consensus binding sites in its promoter region for ATF (Activating transcription factor), NF-κβ, NF-κβ1, GATA-3, C/EBPα (CCAAT/enhancer-binding protein alpha), glucocorticoid receptors α and β, and p53. (wikipedia.org)
  • phosphorylation
  • To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. (wikipedia.org)
  • functional
  • Our studies reveal important differences between the two ryanodine receptor isoforms with respect to their functional interaction with FKBP12 and FKBP12.6. (lu.se)
  • So the location of the TSS is important for understanding the biogenesis of specific isoforms.The idea that different binding partners confer different functional properties has been well studied in tissue-specific gene regulation. (wikipedia.org)
  • Isoforms harboring changes in the CDS have been the most thoroughly characterized because they commonly give rise to proteins with different functional properties. (wikipedia.org)
  • inhibit
  • They also appear to inhibit protein adsorption to the capillary wall, making the isoform separations highly reproducible both in peak areas and apparent mobility. (wiley.com)
  • downstream
  • Panel (b) shows a truncated isoform of the human CLK3 gene which was found to initiate at an AUG codon downstream of the annotated AUG start codon (Reprinted with permission from Ref 12. (nih.gov)
  • As discussed in the section Ribosome Profiling of Initiating Ribosomes, initiation at alternative sites both upstream and downstream of the annotated protein coding ORFs is pervasive. (nih.gov)
  • Figure 10b shows a truncated isoform of the human CLK3 gene which Lee et al.12 found to initiate at an AUG codon downstream of the annotated AUG start codon. (nih.gov)
  • Fritsch et al.13 also reported 546 N-terminal protein extensions in human (regions downstream of annotated starts were not analyzed). (nih.gov)
  • It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. (abcam.com)
  • facilitates
  • The checkpoint clamp protein Rad9 facilitates DNA-end resection and prevents alternative non-homologous end joining. (nih.gov)
  • receptors
  • FCH and Double SH3 Domains 2 (FCHSD2) - Function has not yet been defined Heat Shock Protein Family B Member 1 (HSPB1) - Aids cell's resistance to stress SH3 Domain Binding Protein 4 (SH3BP4) - Involved in endocytosis of specific cell surface receptors The function of C2orf73 is currently not well understood by the scientific community or anyone else. (wikipedia.org)
  • suitable
  • Figure 3 illustrates why ribosome profiling of initiating ribosomes is particularly suitable for the detection of alternative protein isoforms (extensions and truncations of annotated CDS). (nih.gov)
  • superfamily
  • UDP-glucuronosyltransferase, an enzyme superfamily responsible for the detoxification pathway of many drugs, environmental pollutants, and toxic endogenous compounds has 16 known isoforms encoded in the human genome. (wikipedia.org)
  • MGI protein superfamily detail pages represent the protein classification set for a homeomorphic superfamily from the Protein Information Resource SuperFamily ( PIRSF ) site. (jax.org)
  • different
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • cleavage
  • It was found that the spliceosome, a large ribonucleoprotein, is the place where the RNA cleavage and ligation proceeds for the removal of non protein coding segments or introns. (wikipedia.org)
  • annotation
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. (uniprot.org)
  • interaction
  • This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. (abcam.com)
  • novel
  • Here we demonstrate the ability to quickly resolve isoforms of three model proteins (bovine serum albumin, transferrin, α 1 -antitrypsin) in capillaries coated with novel dynamic coatings. (wiley.com)
  • Myosin binding protein C1: a novel gene for autosomal dominant distal arthrogryposis type 1. (semanticscholar.org)