• PPIs
  • Ideally, the inferred DDIs used to support the predicted PPIs are highly reliable themselves, that is there is a large overlap between the set of inferred DDIs and the set of DDIs confirmed to interact by 3D crystal structures of proteins. (plos.org)
  • It is parsimonious to re-use domain-pairs that can interact to facilitate PPIs. (plos.org)
  • Unfortunately, the density measure for a cluster of proteins, being a predicted complex, works less for smaller ones because the connectivity of PPIs within such a complex has small variations. (biomedcentral.com)
  • components
  • From the original setting of mouse ESC culture, scientists identified the active components leukaemia inhibitory factor (LIF) and bone morphogenic proteins (BMP), which maintain the pluripotency in ESCs through activating the Jak/Stat3 signaling pathway and inducing the inhibitors of differentiation (Id) genes, respectively [ 4 , 5 , 6 ]. (mdpi.com)
  • For example, a cluster with two components either has an interaction or not. (biomedcentral.com)