• PPIs
  • Ideally, the inferred DDIs used to support the predicted PPIs are highly reliable themselves, that is there is a large overlap between the set of inferred DDIs and the set of DDIs confirmed to interact by 3D crystal structures of proteins. (plos.org)
  • It is parsimonious to re-use domain-pairs that can interact to facilitate PPIs. (plos.org)
  • Unfortunately, the density measure for a cluster of proteins, being a predicted complex, works less for smaller ones because the connectivity of PPIs within such a complex has small variations. (biomedcentral.com)
  • However
  • However, proteins can become cross-linked, most commonly by disulfide bonds, and the primary structure also requires specifying the cross-linking atoms, e.g., specifying the cysteines involved in the protein's disulfide bonds. (wikipedia.org)
  • ideal
  • Instead of a simple methyl group, the myristoyl group has a tail of 14 hydrophobic carbons, which make it ideal for anchoring proteins to cellular membranes. (wikipedia.org)
  • Another
  • The phosphorylated tyrosines are often used as "handles" by which proteins can bind to one another, whereas phosphorylation of Ser/Thr often induces conformational changes, presumably because of the introduced negative charge. (wikipedia.org)