• structural
  • Are you looking for a way to identify structural hotspots within your potential biotherapeutic protein? (bruker.com)
  • The important structural and functional roles played by proteins in the proper functioning of cellular processes cannot be overstated. (iastate.edu)
  • To comprehensively understand their functional behaviors, structural models derived from experimental data have been developed and these models have played a significant role in explaining the functional mechanisms of proteins. (iastate.edu)
  • To incorporate dynamics into structural representations, ensembles of conformations, instead of a single structure, are used frequently in recent literature and are found to be successful in explaining the functions of many proteins. (iastate.edu)
  • This allows for the easy identification of regions and types of structural flexibility present in a protein of interest. (rcsb.org)
  • yeast
  • Recent emergence of oseltamivir and zanamivir resistant human influenza A(H1N1) H274Y has emphasized the need for suitable expression systems to obtain large quantities of highly pure and stable, recombinant neuraminidase through two separate artificial tetramerization domains that facilitate the formation of catalytically active neuraminidase homotetramers from yeast and Staphylothermus marinus, which allow for secretion of FLAG-tagged proteins and further purification. (wikipedia.org)
  • Prions based on heritable protein structure also exist in yeast. (wikipedia.org)
  • peptide
  • In this paper, we have used PROTOFOLD to predict the final conformation of a small peptide chain segment, an alpha helix, and the Triponin protein chains from a denatured configuration. (asme.org)
  • sequence
  • 44 prolines were found along the protein, making up 12.3% of the total amino acid sequence. (wikipedia.org)
  • A cross-program consensus predicted that UPF0575 protein C19orf67 forms four alpha helices and two beta sheets in the following locations in the amino acid sequence: Acetylation is likely to occur at the N-terminus while the C-terminus is unlikely to be modified. (wikipedia.org)
  • He has also worked on simplified representations of protein structure for analysing folding and packing, as well as developing scoring systems for large-scale sequence-structure comparisons. (wikipedia.org)
  • vitro
  • It should then be expected that T-cell recognition of protein antigens in vitro will be independent of protein conformation. (biochemj.org)
  • Three T-cell lines were made by passage in vitro with native lysozyme of T cells from two mouse strains (B10.BR and DBA/1) that had been primed with the same protein. (biochemj.org)
  • scrapie
  • The protein can exist in multiple isoforms, the normal PrPC, and as Protease resistant PrPRes like the disease-causing PrPSc(scrapie) and an isoform located in mitochondria. (wikipedia.org)
  • computational
  • This paper presents an efficient and novel computational protein prediction methodology called kineto-static compliance method. (asme.org)
  • Levitt was a PhD student in Computational biology at Peterhouse, Cambridge, and was based at the Laboratory of Molecular Biology from 1968 to 1972, where he developed a computer program for studying the conformations of molecules that underpinned much of his later work. (wikipedia.org)
  • Subsequent
  • Subsequent to the elucidation of the primary structure of PLP, several topologies for this protein have been proposed based on mathematical modeling, chemical labeling, limited protease digestion, and immunolabeling. (jneurosci.org)
  • The effect of pullet growth curve on body conformation and subsequent reproductive performance and effect of breeder feed protein level on reproductive performance was determined. (umm.ac.id)
  • molecules
  • Tanaka, M., Machida, Y., and Nukina, N. A novel therapeutic strategy for polyglutamine diseases by stabilizing aggregation-prone proteins with small molecules. (riken.jp)
  • Gow and Lazzarini, 1996 ), but precisely how these molecules may interact and how they may influence the conformation of one another is at present unknown. (jneurosci.org)
  • function
  • Where it is expressed, the protein is predicted to be localized in the nucleus to carry out a function. (wikipedia.org)
  • The highly conserved and slowly evolving DUFF3314 region is predicted to form numerous alpha helices and may be vital to the function of the protein. (wikipedia.org)
  • Although the function is not yet well understood, conservation among numerous taxa indicate that it may be important to the function of the protein. (wikipedia.org)
  • Alpha-synuclein is a synuclein protein of unknown function primarily found in neural tissue, making up as much as 1% of all proteins in the cytosol of brain cells. (wikipedia.org)
  • In this field, the main interest is on proteins, because discovering their three-dimensional conformation allows us to get clues about the function they are able to perform. (wikipedia.org)
  • abundant
  • The proline content by percentage was found to be higher in UPF0575 than 95% of comparable human proteins.However, the amount of asparagine the protein is less abundant when compared to the human proteome. (wikipedia.org)
  • The protein product is less abundant than most of the human proteome in many tissues. (wikipedia.org)
  • Alpha-synuclein is a protein that is abundant in the human brain. (wikipedia.org)
  • Predicting
  • Successive kineto-static fold compliance is a methodology for predicting a protein molecule's motion under the effect of an inter-atomic force field without the need for molecular-dynamic simulation. (asme.org)
  • Disease
  • Neame, P. J. and Gallagher, J. T. (2005) Extracellular Matrix Heparan Sulfate Proteoglycans, in Amyloid Proteins: The Beta Sheet Conformation and Disease (ed J. D. Sipe), Wiley-VCH Verlag GmbH, Weinheim, Germany. (wiley.com)
  • An alpha-synuclein fragment, known as the non-Abeta component (NAC) of Alzheimer's disease amyloid, originally found in an amyloid-enriched fraction, was shown to be a fragment of its precursor protein, NACP. (wikipedia.org)
  • Atoms
  • He has authored or co-authored several books including From Cells to Atoms: an illustrated introduction to molecular biology, Protein Engineering: a practical approach and Protein Structure Prediction: a practical approach. (wikipedia.org)
  • Experimental techniques are able to estimate distances between pairs of atoms of a given molecule, and the problem becomes the one of identifying the three-dimensional conformation of the molecule, i.e. the positions of all its atoms. (wikipedia.org)
  • gene
  • The spliceosome: NMR spFRET dice up protein complex spectroscopyNOW.com Cells convert DNA to RNA to template protein production but before that final step, gene expression, the non-coding regions of the genome have to be removed by the so-called spliceosome. (bionmr.com)
  • UPF0575 protein C19orf67 is a protein which in humans (Homo sapiens) is encoded by the C19orf67 gene. (wikipedia.org)
  • The DUF3314 region of the gene appears to have diverged at a slower rate relative to the rest of the gene, indicating that that region may have been undergoing purifying selection because that region played an important role in the protein. (wikipedia.org)
  • His current research interests include promotor analysis, non-coding RNA, gene prediction and protein structure prediction. (wikipedia.org)
  • significantly
  • The protein level of the breeder feed significantly affected body weight at 35 and 40 weeks of age. (umm.ac.id)
  • It has been shown that alpha-synuclein significantly interacts with tubulin, and that alpha-synuclein may have activity as a potential microtubule-associated protein, like tau. (wikipedia.org)
  • simulation
  • The exquisite dependency of the recognition by the clones on the conformation of the protein antigen and their ability to recognize the surface-simulation synthetic sites indicate that the native (unprocessed) protein was the trigger of MHC-restricted T-cell recognition. (biochemj.org)
  • Constrained Geometric Simulation of Diffusive Motion in Proteins. (wikipedia.org)
  • highly
  • Thus, the study of proteins in the gas-phase on this time-scale is highly desirable. (pubmedcentralcanada.ca)
  • In humans, UPF0575 protein C19orf67 is highly expressed in the testis and breast tissue, although it is also expressed at low levels in the stomach, cerebral cortex, thyroid gland, and salivary gland. (wikipedia.org)
  • Cells
  • Presentation of a protein antigen to T cells is believed to follow its intracellular breakdown by the antigen-presenting cell, with the fragments constituting the trigger of immune recognition. (biochemj.org)
  • It is predominantly a neuronal protein, but can also be found in the neuroglial cells. (wikipedia.org)
  • However
  • However both protein unfolding and superactivity is reversed back to a native-like condition with UV illumination. (usc.edu)