• Tissue
  • Antibody microarrays are often used for detecting protein expression from various biofluids including serum, plasma and cell or tissue lysates. (wikipedia.org)
  • capture
  • Ciphergen's ProteinChip arrays have been developed for affinity capture of proteins from biological samples. (bio-medicine.org)
  • The latter method, in which analyte detection requires the binding of 2 distinct antibodies (a capture antibody and a reporter antibody, each binding to a unique epitope), confers greater specificity and lower background signal compared with label-based immunodetection (where only 1 capture antibody is used and detection is achieved by chemically labeling all proteins in the starting sample). (wikipedia.org)
  • surface
  • ProteinChip WCX2: is a weak cation exchange array with a carboxylate surface to bind cationic proteins. (bio-medicine.org)
  • The negatively charged carboxylate groups on the surface of the WCX2 chip interact with the positive charges exposed on the target proteins. (bio-medicine.org)
  • While 96-well plate-based antibody arrays have high-throughput capability, the small surface area in each well limits the number of antibody spots and thus, the number of analytes detected. (wikipedia.org)
  • Chemically derivatized glass slides allow for printing of sub-microliter sized antibody spots, reducing the array surface area without sacrificing spot density. (wikipedia.org)