• benign
  • A 2003 study proposed using a truncated form of the MSMB protein called PSP61 as a biomarker for benign prostatic hyperplasia (BPH): this study found PSP61 in the expressed prostatic secretion of 10 out of ten 10 men suffering from BPH, but did not find it in 10 out of 10 age-matched BPH-free men. (wikipedia.org)
  • The procedure is used to treat prostate cancer (PROSTATIC NEOPLASMS) and benign prostatic hypertrophy (PROSTATIC HYPERPLASIA). (bioportfolio.com)
  • It is generally believed that direct estrogenic effects in prostate or their possible roles in prostate cancer and benign prostatic hyperplasia are partially mediated through their specific receptors, estrogen receptor (ER) α and ERβ, which bind directly to estrogen response elements (ERE) or other response sites via indirect interactions with other heterologous transcription factors [e.g. (aacrjournals.org)
  • luminal
  • Neuroendocrine tumor cells express cytokeratins that are typically expressed by luminal secretory type cells, but lack basal cell markers such as high molecular weight cytokeratin and p63. (wikipedia.org)
  • human
  • Human MSMB full-length ORF ( AAH05257.1, 1 a.a. - 114 a.a.) recombinant protein with GST-tag at N-terminal. (abnova.com)
  • Female ejaculate, which may emerge during sexual activity for some women, especially during female orgasm, has a composition somewhat similar to the fluid generated in males by the prostate gland, containing biochemical markers of sexual function like human urinary protein 1 and the enzyme PDE5, whereas women without the gland had lower concentrations of these proteins. (wikipedia.org)
  • These combined data indicate that NT-trk receptor axes may play a role in the development and progression of both human prostatic and pancreatic adenocarcinoma. (aacrjournals.org)
  • Messenger RNA contained in microvesicles secreted from glioblastomal cells were shown to generate a functional protein in recipient (human brain microvascular endothelial) cells in vitro. (wikipedia.org)
  • PSMA
  • PSMA is a protein abundantly expressed on the surface of prostate cancer cells, with an increased expression in high-grade cancers, metastatic disease and hormone-refractory prostate cancer. (rxpgnews.com)
  • PSMA is a type II transmembrane protein with a short, NH 2 -terminal cytoplasmic tail, a single transmembrane domain, and a large extracellular COOH-terminal domain and exhibits both N -acetylated α-linked acidic peptidase (NAALADase) and folate hydrolase activities ( 1 , 2 ). (aacrjournals.org)
  • mRNA
  • Although Agr2 mRNA levels are correlated with the tamoxifen therapy response, AGR2 protein levels have yet to be statistically associated with the therapy. (wikipedia.org)
  • AGR2 may help regulate the protein and mRNA levels in a cell overall as well. (wikipedia.org)
  • During late pregnancy and lactation, AGR2 levels peak when milk proteins are produced, and mammary-specific Agr2 knockout mice had downregulated milk protein mRNA expression. (wikipedia.org)
  • cells
  • The protein inhibits growth of cancer cells in an experimental model of prostate cancer, though this property is cell line specific. (wikipedia.org)
  • These proteins are found in gram negative bacteria, vertebrate cells, and invertebrate cells, and in plants. (wikipedia.org)
  • Prostatic neuroendocrine cells, also known as endocrine-paracrine cells, are part of a larger regulatory cell population scattered throughout the whole organism, collectively known as diffuse neuroendocrine system or APUD cells. (wikipedia.org)
  • They are thought to arise from a different precursor than other epithelial prostatic cells, possibly through a neurogenic lineage of their own, which is therefore distinct from the secretory and basal cells that derive from urogenital sinus. (wikipedia.org)
  • The Skene's glands are homologous with the prostate gland in males, containing numerous microanatomical structures in common with the prostate gland, such as secretory cells. (wikipedia.org)
  • Abgent has over fifteen years of experience producing recombinant proteins in E. coli and mammalian cells (CHO and HEK293, etc), and we have added a powerful yeast expression platform to our menu of services. (abgent.com)
  • In breast cancer, HSP90 is a molecular chaperone expressed in tumor cells when there exists an excess of unfolded protein, and its co-chaperone has been reported to induce expression of AGR2, so AGR2 may be used by the endoplasmic reticulum to assist with protein folding to alleviate proteotoxic stress. (wikipedia.org)
  • In vitro experiments have shown the transfer of specific exRNAs into recipient cells inhibiting protein expression and preventing cancer cell growth. (wikipedia.org)
  • This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. (wikipedia.org)
  • somatostatin
  • Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. (wikipedia.org)
  • The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. (wikipedia.org)
  • The encoded protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach. (wikipedia.org)
  • adenocarcinoma
  • Thus, this protein alone is enough to distinguish Barrett's esophagus, which is linked to esophageal adenocarcinoma, from a normal esophagus. (wikipedia.org)
  • MSMB
  • citation needed] MSMB is a rapidly evolving protein. (wikipedia.org)
  • Two large genome-wide association studies showed that decreased expression of the MSMB protein caused by the rs10993994 single nucleotide polymorphism is associated with an increased risk of developing prostate cancer (odds ratio for CT allele pair ~1.2x, and for TT allele pair ~1.6x when compared to the low risk CC allele pair). (wikipedia.org)
  • This truncated form of the MSMB protein lacks the fungicidal peptide identified in 2012. (wikipedia.org)
  • fluid
  • The prostatic fluid is expelled in the first ejaculate fractions, together with most of the spermatozoa. (wikipedia.org)
  • In comparison with the few spermatozoa expelled together with mainly seminal vesicular fluid, those expelled in prostatic fluid have better motility, longer survival and better protection of the genetic material. (wikipedia.org)
  • growth
  • The four CYR61 domains are, from N- to C-termini, the insulin-like growth factor binding protein (IGFBP) domain, von Willebrand type C repeats (vWC) domain, thrombospondin type 1 repeat domain (TSR), and the C-terminal (CT) domain that contains a cysteine-knot motif. (wikipedia.org)
  • mainly
  • In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. (wikipedia.org)
  • plasma
  • After intake, they are converted to retinol, successively metabolized, and finally bound to retinol binding proteins (lipocalins) in the blood plasma. (wikipedia.org)
  • biological
  • Structural information for many immune system influencing lipocalin proteins is available, while their exact role in biological systems is still somewhat unclear. (wikipedia.org)
  • This family of proteins plays a part in the biological system of terminal prostaglandin synthesis. (wikipedia.org)
  • mammalian
  • The lipocalin family has been connected with the transport of mammalian pheromones due to easily observable protein-pheromone interactions. (wikipedia.org)
  • Immune
  • Lipocalin proteins are involved in inflammation and detoxification processes caused by immune system activation in mammals. (wikipedia.org)
  • Examples of lipocalin proteins involved in immune system responses include alpha-1-microglobulin, alpha-1-acid glycoprotein, and C8gamma. (wikipedia.org)
  • transcription
  • As forkhead transcription factors widely participate in the development of various organs ( Carlsson and Mahlapuu, 2002 ), it was reasonable to expect that Foxa proteins may play an important role in prostate development, e.g. the specification/maturation of the prostate epithelial cell. (biologists.org)
  • arise
  • The prostate gland has four distinct glandular regions, two of which arise from different segments of the prostatic urethra: The "lobe" classification is more often used in anatomy. (wikipedia.org)
  • Endodermal outgrowths arise from the prostatic part of the urethra and grow into the surrounding mesenchyme. (wikipedia.org)
  • regulation
  • Furthermore, several proteins involved in spindle assembly checkpoint function and temporal regulation of mitosis have also been localized to the centrosomes and spindle poles, including Mad2, Bub2, and Bfa1 ( 11 - 14 ). (aacrjournals.org)
  • role
  • Prostasomes: a role in prostatic disease? (wikipedia.org)
  • Inside this barrel is located a ligand binding site, which plays an important role in the lipocalin classification as a transport protein. (wikipedia.org)
  • AGR2 is suggested to play a role in protein folding, and it has a KTEL C-terminal motif similar to KDEL and KVEL endoplasmic reticulum retention sequences. (wikipedia.org)
  • molecules
  • The lipocalins are a family of proteins which transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids. (wikipedia.org)
  • expression
  • With state-of-the art molecular biology and protein biochemistry labs, we work with our clients to rapidly evaluate in parallel to identify the optimal expression system for candidate proteins. (abgent.com)
  • Its protein expression has been shown to be regulated by both androgens and estrogens. (wikipedia.org)
  • major
  • Check out links to articles that cite our custom service antibodies, peptides, and proteins in major peer-reviewed journals, organized by research category. (abgent.com)