Association of proprotein convertase subtilisin/kexin type 9 (PCSK9) levels with abnormally high ankle-brachial index in atrial fibrillation. (nih.gov)
PC7 (proprotein convertase subtilisin/kexin type 7) is closely related to PACE and PACE4. (eu.org)
Melanocortin-4 receptor agonists are approved for weight management in patients with rare genetic conditions (ie, proopiomelanocortin, proprotein convertase subtilisin/kexin type 1, and leptin receptor deficiencies). (medscape.com)
Recent efforts to develop LDL-lowering prescription drugs have focused on a new target, PCSK9, or proprotein convertase subtilisin/kexin type 9. (fatsoflife.com)
Real-World Analyses of the Treatment Conditions in Patients Initiating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor in Taiwan. (sinica.edu.tw)
The functional maturation of dormant pro-proteins is catalyzed by the proprotein convertase subtilisin/kexin (PCSK) enzymes (PCSK1-2, FURIN, PCSK5-7, membrane-bound transcription factor site 1, PCSK9) [ 1 ]. (oncotarget.com)
METHODS: Taking advantage of a large sample of Caucasian patients (n = 529) with a diagnosis of T2DM followed for a median of 16.8 years, the present study was aimed at testing the hypothesis that fasting serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels could be prognostic for major adverse cardiovascular events (MACE) and all-cause mortality. (bvsalud.org)
Proprotein convertase subtilisin kexin 9 (PCSK9), also named neural apoptosis-regulated convertase 1 (NARC-1), is a member of the proteinase K subfamily of subtilisin-related serine endoproteases. (nexelis.com)
Expert consensus on the rational clinical use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. (cdc.gov)
Results of the clinical-trial program with the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor bococizumab (Pfizer), including final data from the major outcome trials SPIRE 1 and 2 , show that antidrug antibodies developed in a large proportion of patients and significantly attenuated the LDL -lowering effect [ 1 , 2 ] . (medscape.com)
PCSK13
Proprotein convertase 1, also known as prohormone convertase, prohormone convertase 3, or neuroendocrine convertase 1 and often abbreviated as PC1/3 is an enzyme that in humans is encoded by the PCSK1 gene. (wikipedia.org)
PCSK1 (proprotein convertase 1, NEC1) and PCSK2 (proprotein convertase 2, NEC2) are type I proinsulin-processing enzymes that play a key role in regulating insulin biosynthesis. (eu.org)
The proprotein convertases (PCs) furin, PC5, PACE4, and PC7 cleave secretory proteins after basic residues, including the HIV envelope glycoprotein (gp160) and Vpr. (utmb.edu)
Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters. (wikigenes.org)
Furin (PACE, paired basic amino acid cleaving enzyme, membrane associated receptor protein) is serine endoprotease responsible for processing a variety of substrates (proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor). (eu.org)
Furin is a ubiquitous subtilisin-like proprotein convertase. (neb.com)
Two fold dilutions of Furin are incubated with 25 µg MBP-FN-paramyosin-ΔSal substrate in 20 mM HEPES, 0.1% Triton X-100, 1 mM CaCl 2, 0.2mM β-mercaptoenthanol (pH 7.5 @ 25°C) in a 25 µl reaction. (neb.com)
FURIN is usually induced by its substrate TGF-1 [41]. (woofahs.com)
Accordingly, the expression of was enhanced in the absence of FURIN, similarly to what was seen in TGF-1 null cells [42]. (woofahs.com)
FURIN was required for the normal production of the bioactive TGF-β1 cytokine, but it inhibited the maturation of the inflammation-provoking TACE and Caspase-1 enzymes. (oncotarget.com)
Furin, the best-characterized member of the mammalian proprotein convertases, is an ubiquitously expressed single pass type 1 transmembrane protein. (bvsalud.org)
Subtilisin-like proprotein convertase1
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. (nih.gov)
PCSK92
PCSK9 promotes T helper 1 and T helper 17 cell differentiation by activating the nuclear factor-κB pathway in ankylosing spondylitis. (nih.gov)
An isolated monoclonal antibody, wherein the monoclonal antibody can neutralise binding of PCSK 9 to LDLR protein, and competes for binding to PCSK9 with an antibody including a heavy chain, including CDR 1, 2 and 3 consisting of an amino acid sequence in SEQ ID NO: 368, 175 and 180, respectively and a light chain including CDR 1, 2 and 3 consisting of SEQ ID NO: 158, 162 and 395, respectively. (managingip.com)
Prohormone convertase 1 (PC1), mediating the proteolytic processing of neural and endocrine precursors, is thought to be regulated by the neuroendocrine protein proSAAS. (elsevierpure.com)
LDLRAP1, LDL receptor adaptor protein 1 (i.e. (endotext.org)
Prohormone convertase4
Another prohormone convertase, proprotein convertase 2 plays a more minor role in the first step of insulin biosynthesis, but a greater role in the first step of glucagon biosynthesis. (wikipedia.org)
Neuroendocrine-specific expression of the human prohormone convertase 1 gene. (wikipedia.org)
Using stem cell-derived hypothalamic neurons to investigate the neurophysiology of obesity caused by prohormone convertase 1/3 deficiency (Chapter 3). (columbia.edu)
Although the mechanisms underlying these effects are still enigmatic, glucagon-like peptide-1 (GLP-1) appearstobe involved.Inadditiontoafew reported mechanisms, we propose prohormone convertase 1β (PC1β), an essential enzyme of GLP-1 production, as a potent molecule in the GLP-1 release induced by BABRs. (elsevierpure.com)
Post-Translational1
Therefore, these precursor proteins require post-translational cleavage by proprotein convertases (PCs) to become fully functional. (molcells.org)
Enzyme3
Proprotein convertase 1 is the enzyme largely responsible for the first step in the biosynthesis of insulin. (wikipedia.org)
It is the major processing enzyme of the secretory pathway and is localized in the trans-golgi network (1,2). (neb.com)
1 unit is defined as the amount of enzyme required to cleave 25 µg of a MBP-FN-paramyosin-ΔSal substrate to 95% completion in 6 hours at 25°C in a total reaction volume of 25 µl. (neb.com)
Type4
In patients with type 2 diabetes mellitus who are overweight or obese, antidiabetic medications that have additional actions to promote weight loss (such as glucagonlike peptide-1 [GLP-1] analogs or sodium-glucose-linked transporter-2 [SGLT-2] inhibitors) are suggested, in addition to the first-line agent for type 2 diabetes mellitus and obesity, metformin. (medscape.com)
In obese patients with type 2 diabetes mellitus who require insulin therapy, at least one of the following is suggested: metformin, pramlintide, or GLP-1 agonists to mitigate associated weight gain due to insulin. (medscape.com)
Glucagon-like peptide-1 (GLP-1) agonists have been shown to promote weight loss in patients with or without type 2 diabetes and are the Food and Drug Administration (FDA)-approved for chronic weight management . (medscape.com)
it turns into upregulated by T-cell-receptor-mediated signaling and through 951695-85-5 the IL-12/STAT4 pathway 951695-85-5 in T helper type 1 cells [11, 12]. (woofahs.com)
Mammalian2
The subtilisin-like proprotein convertases are expressed extensively in mammalian neural and endocrine cells and play a major role in the proteolytic processing of both neuropeptide and peptide hormone precursors. (eu.org)
HE BIOSYNTHESIS OF mammalian neuropeptide hormones follows the principles of the prohormone theory, which begins with an mRNA translation process into a large, inactive precursor polypeptide, followed by a limited posttranslational proteolysis to release different products of processing (1). (moam.info)
Obesity3
Recently, the FDA approved tirzepatide , glucose-dependent insulinotropic polypeptide (GIP) receptor and GLP-1 receptor agonist, for chronic weight maintenance in adults with obesity. (medscape.com)
Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. (utsouthwestern.edu)
Minireview: Regulation of Prohormone Convertases in Hypothalamic Neurons: Implications for ProThyrotropin-Releasing Hormone and Proopiomelanocortin Eduardo A. Nillni Division of Endocrinology, Department of Medicine, Brown Medical School/Rhode Island Hospital, and Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02903 Recent evidence demonstrated that posttranslational processing of neuropeptides is critical in the pathogenesis of obesity. (moam.info)
Precursor proteins1
The members of the subtilisin-like family are proprotein convertases that process latent precursor proteins into their biologically active products. (eu.org)
Further, it cannot be said that there is a description in each of the specifications indicating that each of the inventions is specified only by a function to compete with reference antibody 1 or 2. (managingip.com)
Data on antibody formation and LDL-cholesterol-lowering effects from six trials of bococizumab in a total of 4300 patients, as well as final outcome results from the SPIRE 1 and 2 trials, were presented today at the American College of Cardiology (ACC) 2017 Scientific Sessions and simultaneously published online in the New England Journal of Medicine . (medscape.com)
Lead investigator of the SPIRE 1 and 2 studies and lead author of both papers on bococizumab, Dr Paul Ridker (Harvard Medical School, Boston, MA) commented to heart wire from Medscape: "Despite antidrug antibody development, bococizumab nonetheless significantly reduced vascular events by 21% among those with higher risk and higher LDL levels. (medscape.com)
Receptor1
GLP-1 is a physiologic regulator of appetite and calorie intake, and the GLP-1 receptor is present in several areas of the brain involved in appetite regulation. (medscape.com)
Endoprotease1
citation needed] Proprotein convertase 1 is a calcium (Ca2+) activated serine endoprotease (meaning that a serine residue is part of the active site that hydrolyzes the peptide bond within the substrate). (wikipedia.org)
Inhibitor2
We also propose a combination of BABR and dipeptidyl peptidase-4 inhibitor in the context of GLP-1-based antidiabetic therapy. (elsevierpure.com)
We compared the HCV anti- viral effect of the most potent SKI-1/S1P small molecule inhibitor (PF-429242) with a set of two statins on different steps of the viral life cycle, and showed that SKI-1/S1P inhibitor blocked HCVcc (strain JFH-1) RNA replication (EC50 = 5.8 lM) more efficiently than statins. (cp-673451inhibitor.com)
Biosynthesis1
Leptin or other physiological changes affects the biosynthesis and processing of many peptides hormones as well as the regulation of the family of prohormone convertases responsible for the maturation of these hormones. (moam.info)
Proteolytic1
These proneuropeptide precursors require for their maturation proteolytic cleavage by the prohormone convertases 1 and 2 (PC1/3 and PC2). (moam.info)
P632391
Proprotein+Convertase+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview of all the structural information available in the PDB for UniProt: P63239 (Mouse Neuroendocrine convertase 1) at the PDBe-KB. (wikipedia.org)
Bioactive2
Following the action of proprotein convertase 1, a carboxypeptidase is required to remove the basic residues from the processing intermediate and generate the bioactive form of insulin. (wikipedia.org)
Congenital hypomorphism for this gene causes a rare autosomal disorder that impairs the processing of specific proproteins to their more bioactive derivatives, affecting, for example, the processing of POMC, proinsulin and proglucagon. (columbia.edu)
Mice3
The knockout of proprotein convertase 1 is not lethal in mice or humans, most likely due to the presence of the second convertase, although mice lacking proprotein convertase 1 activity show a number of defects including slow growth. (wikipedia.org)
Fig. 1: Identification of an siRNA with durable Lp(a) gene silencing activity in Lp(a) double transgenic mice and in cynomolgus monkeys. (nature.com)
Instead, LysMCre- fur (fl/fl) mice had elevated serum IL-1β levels and reduced numbers of splenocytes. (oncotarget.com)
Gene expression1
Altogether, our data indicate that the TGR5-dependent intestinal PC1/3 gene expression supports the BABR-stimulated GLP-1 release. (elsevierpure.com)
Disorder1
1] It can be thought of as a degenerative disorder arising from the biochemical breakdown of articular (hyaline) cartilage in the synovial joints. (medscape.com)
20221
As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)
Expression of each cluster's gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq. (stowers.org)
Cells1
We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. (stowers.org)