TumorHyperprolactinemiaBenignTreat prolactinomaAdenomaTumorsCabergolineAcromegalyDopamineMacroprolactinomasEndoscopic surgeryAdenomasClinicalSerumDiagnosisPregnancyInfarctionTranssphenoidalSubsetPrevalenceTreatmentPatientsAmyloidGiantCommonlyOccurProliferationEstrogenHumansSymptoms dueCommonGrowthPatientSurgery
Tumor11
- A prolactinoma is a tumor (adenoma) of the pituitary gland that produces the hormone prolactin. (wikipedia.org)
- Symptoms of prolactinoma are due to abnormally high levels of prolactin in the blood (hyperprolactinemia), or due to pressure of the tumor on surrounding tissues. (wikipedia.org)
- A prolactinoma is a noncancerous (benign) pituitary tumor that produces a hormone called prolactin. (medlineplus.gov)
- We present a case of prolactinoma in a 54-year old male patient who presented with pressure effects because of the tumor, as head ache and bi-temporal hemianopsia. (scirp.org)
- Here, we report a patient with an highly aggressive, dopamine-resistant prolactinoma, who only achieved biochemical and tumor control during pasireotide long-acting release (PAS-LAR) therapy, a second-generation somatostatin receptor ligand (SRL). (prinsesmaximacentrum.nl)
- In addition, PAS-LAR therapy may induce cystic degeneration, tumor cell necrosis or both in prolactinomas. (prinsesmaximacentrum.nl)
- Differences in prolactinoma incidence tumor size and behavior have been described among genders. (cell-metabolism.com)
- Prolactinoma treatment The major goals of treatment in patients with prolactinomas are to normalize serum PRL levels to restore gonadal function to reduce tumor size and to preserve or improve residual pituitary function. (cell-metabolism.com)
- A rare but important cause of HSDD is a functioning prolactin-secreting tumor of the pituitary gland, a prolactinoma. (minddisorders.com)
- The most common pituitary tumor, a prolactinoma, causes an overproduction of the hormone that helps control sexual function. (mayfieldclinic.com)
- Often, the cause of raised levels of this hormone is due to a small prolactin-producing tumor sitting on the pituitary gland called a prolactinoma. (sharedjourney.com)
Hyperprolactinemia6
- [ 1 ] Causing hyperprolactinemia, prolactinomas can reduce estrogen levels in women and testosterone concentrations in men and may result in infertility. (medscape.com)
- In those patients with DA agonist-resistant prolactinomas (DARPs) having persistent hyperprolactinemia despite surgical debulking, with or without radiotherapy, temozolomide, a chemotherapeutic alkylating agent, has been recommended. (medscape.com)
- Prolactinomas cause the overproduction of the hormone prolactin (hyperprolactinemia) by the pituitary gland. (msdmanuals.com)
- This report emphasizes the need to exclude other causes of hyperprolactinemia including prolactinoma, in patients who are compliant with optimized L-Dopa treatment and their prolactin levels remain significantly high. (rarediseasesjournal.com)
- These include evidence-based approaches to assessing the cause of hyperprolactinemia, treating drug-induced hyperprolactinemia, and managing prolactinomas in nonpregnant and pregnant subjects. (nih.gov)
- Hyperprolactinemia is associated primarily with prolactin-secreting pituitary tumors (prolactinoma). (medscape.com)
Benign4
- Prolactinomas, benign lesions that produce the hormone prolactin, are the most common hormone-secreting pituitary tumors. (medscape.com)
- Prolactinomas are the most common benign pituitary neoplasms and the common cause of hyper- prolactinemia. (scirp.org)
- There has been a good deal of concern and confusion about prolactinomas (benign tumours of the pituitary gland) since the sad death of Tara Palmer Tomkinson in February 2017. (markvanderpump.co.uk)
- Prolactinomas are usually benign and although some tumors show invasion into the parasellar compartment and/or sphenoid sinuses malignant transformation and metastatic spread are extremely rare. (cell-metabolism.com)
Treat prolactinoma3
- Dopamine is the chemical that normally inhibits prolactin secretion, so clinicians may treat prolactinoma with drugs that act like dopamine such as bromocriptine and cabergoline. (wikipedia.org)
- How long should I treat prolactinoma? (endocrine-abstracts.org)
- CONCLUSIONS: We found no evidence of increased mitral valve tenting area/height, valvular thickening or significant regurgitation with the long-term administration of the commonly used doses of cabergoline to treat prolactinoma. (ox.ac.uk)
Adenoma4
- In prolactinomas, for instance, endocrinologists can utilize dopamine agonists to treat any residual adenoma that might persist after resection. (cap.org)
- Lactotroph adenoma (prolactinoma) typically exhibits strong cytoplasmic prolactin immunoreactivity. (cap.org)
- The most frequently encountered adenoma in children is the prolactinoma, followed by corticotropinoma and somatotropinoma. (medscape.com)
- Overall, prolactinoma is the most common pituitary adenoma encountered in childhood. (medscape.com)
Tumors3
- Prolactinomas are noncancerous tumors made up from special cells (lactotrophs) in the pituitary gland. (msdmanuals.com)
- Male prolactinoma patients tend to have more invasive and larger tumors. (dergipark.org.tr)
- Prolactinomas Among functioning pituitary tumors prolactinomas are the most frequently observed in the clinic (40%) (Ciccarelli 2005). (cell-metabolism.com)
Cabergoline6
- The objective of this study was to determine demographic profile of patients with prolactinomas, and to compare the outcomes in patients treated with Cabergoline versus those receiving Bromocriptine treatment. (aku.edu)
- Valvular heart disease and the use of cabergoline for the treatment of prolactinoma. (ox.ac.uk)
- Rapid improvement in visual loss with cabergoline treatment in a giant prolactinoma case: 5 years survey. (nel.edu)
- Our findings suggest that, cabergoline can be used as a first-line therapy in giant prolactinomas because tumoral shrinkage without a surgical procedure and rapid improvement in visual field defect is achieved with this medical treatment. (nel.edu)
- Tasan E, Hanimoglu H, Turgut S, Ilhan M, Evran S, Kaynar M. Rapid improvement in visual loss with cabergoline treatment in a giant prolactinoma case: 5 years survey. (nel.edu)
- Impressive shrinkage of a giant prolactinoma treated with cabergoline in a prepubescent girl. (bvsalud.org)
Acromegaly1
- A recap of long-term follow-up practices for pituitary diseases including acromegaly, Cushing's, prolactinoma, Rathke's Cleft Cyst, and nonfunctional pituitary adenomas. (pituitaryworldnews.org)
Dopamine6
- While most can be controlled by dopamine agonists, a subset of prolactinomas are dopamine-resistant and very aggressive. (prinsesmaximacentrum.nl)
- This case shows that PAS-LAR therapy holds clinical potential in selective aggressive, dopamine-resistant prolactinomas that express somatostatin (SST) receptor subtype 5 and appears to be a potential new treatment option before starting temozolomide. (prinsesmaximacentrum.nl)
- Dopamine agonist therapy for prolactinomas: do we need to rethink the place of surgery in prolactinoma management? (dergipark.org.tr)
- The combination of dopamine agonist treatment and surgery may be the best option in challenging prolactinoma cases: a single-centre experience. (dergipark.org.tr)
- Prolactinomas are the most frequently observed pituitary adenomas and most of them respond well to conventional treatment with dopamine agonists. (cell-metabolism.com)
- The majority of prolactinomas retain an intact response to dopamine inhibition therefore medical treatment with dopamine agonists (DAs) such. (cell-metabolism.com)
Macroprolactinomas1
- Results of the tumour size on initial MRI showed macroprolactinomas 52.9% (36), microprolactinomas in 33.8% (23), and giant prolactinomas in 13.3 % (9) patients. (aku.edu)
Endoscopic surgery2
- 10. Akin S, Isikay I, Soylemezoglu F, Yucel T, Gurlek A, Berker M. Reasons and results of endoscopic surgery for prolactinomas: 142 surgical cases. (dergipark.org.tr)
- Cho D-Y, Liau W-R. Comparison of endonasal endoscopic surgery and sublabial microsurgery for prolactinomas. (scielo.br)
Adenomas6
- They are relatively common in prolactinomas and less common, but can occur in growth hormone (GH)―and corticotrophin (ACTH)―secreting or nonfunctional adenomas. (scirp.org)
- Linkage to aryl hydrocarbon-interacting protein gene (AIP) mutation has been identified in some families with prolactinoma and in childhood-onset pituitary adenomas. (medscape.com)
- Prolactinomas are the most commonly encountered pituitary adenomas in the clinical setting. (prinsesmaximacentrum.nl)
- já os adenomas hipofisários funcionantes (por exemplo, acromegalia, síndrome de Cushing, prolactinoma) são tratados separadamente. (bmj.com)
- Os ACNF hipofisários e prolactinomas são os 2 adenomas hipofisários mais prevalentes. (bmj.com)
- Os adenomas hipofisários funcionantes (por exemplo, acromegalia, síndrome de Cushing e prolactinoma) não são abordados. (bmj.com)
Clinical3
- In principle patients should be treated for a prolactinoma for as long as they are deriving a clinical benefit from treatment. (endocrine-abstracts.org)
- 15. Delgrange E, Trouillas J, Maiter D, Donckier J, Tourniaire J. Sex-related difference in the growth of prolactinomas: a clinical and proliferation marker study. (dergipark.org.tr)
- 18. Delgrange E, Sassolas G, Perrin G, Jan M, Trouillas J. Clinical and histological correlations in prolactinomas, with special reference to bromocriptine resistance. (dergipark.org.tr)
Serum1
- In the presence of prolactinoma, serum prolactin is an unreliable tool for treatment monitoring in these patients. (rarediseasesjournal.com)
Diagnosis3
- As mentioned above, the impact of stress should be ruled out before the diagnosis of prolactinoma is given. (wikipedia.org)
- In considering whether to stop treatment of a prolactinoma, it is helpful first to review the diagnosis and clarify whether the patient has a prolactinoma. (endocrine-abstracts.org)
- Hyperprolactinaemia has many causes, and some patients are treated without a secure diagnosis of prolactinoma. (endocrine-abstracts.org)
Pregnancy3
- A large prolactinoma can sometimes get larger during pregnancy. (medlineplus.gov)
- Women with prolactinomas should be followed closely during pregnancy. (medlineplus.gov)
- The most common symptom of a prolactinoma is galactorrhea, which is the production of breast milk in men or in women other than during and following pregnancy. (msdmanuals.com)
Infarction1
- However, in some cases it is possible to reduce or stop treatment without a new threat to vision, for example after an episode of pituitary apoplexy causing infarction of the prolactinoma. (endocrine-abstracts.org)
Transsphenoidal1
- Prolactinoma patients who underwent endoscopic transsphenoidal surgery at Istanbul University-Cerrahpasa, Neurosurgery clinics between 2013-2023 were included in this study. (dergipark.org.tr)
Subset1
- Giant prolactinoma is a rare subset of macroadenomas. (nel.edu)
Prevalence1
- RESULTS: No significant valvular thickening or regurgitation of any valve was detected in the prolactinoma group and the prevalence of mild valvular regurgitation was not higher than in the case-control group. (ox.ac.uk)
Treatment10
- Treatment for prolactinoma may change the levels of other hormones in the body, especially if surgery or radiation is performed. (medlineplus.gov)
- Bromocriptine (BEC) is generally considered to be the agent of choice in the treatment of prolactinoma. (medscape.com)
- [ 10 ] Bromocriptine (BEC) is generally considered to be the agent of choice in the treatment of prolactinomas because of its long track record and safety. (medscape.com)
- Many patients taking medical therapy for a prolactinoma may assume that they need treatment for life. (endocrine-abstracts.org)
- In considering whether to stop treatment of a prolactinoma it is helpful to take into account the size of the prolactinoma before treatment and the response to treatment, as these factors help predict the likely outcome of stopping treatment. (endocrine-abstracts.org)
- Whether lower doses commonly used in the treatment of prolactinomas (0.25-3 mg/week) are also associated with significant valvulopathy is controversial. (ox.ac.uk)
- To investigate the differences between the characteristics of disease presentation and treatment outcomes on the basis of gender in patients with operated prolactinoma. (dergipark.org.tr)
- Surgery as a viable alternative first-line treatment for prolactinoma patients. (dergipark.org.tr)
- as well to provide recent evidence of the restoration of TGFβ1 activity as an effective treatment in experimental prolactinomas. (cell-metabolism.com)
- The present study was designed to determine the effect of treatment duration on metabolism as well as metabolic alterations after treatment in comparison with baseline in patients with prolactinoma in Iranian individuals. (jdeponline.com)
Patients8
- Other medical treatments for prolactinomas are available for patients who do not respond to BEC or for those who cannot tolerate the drug. (medscape.com)
- We reviewed the medical record of 68 patients with prolactinoma. (aku.edu)
- CONCLUSION: Most of the prolactinoma patients were females and the common the most frequent presenting complaint was headache. (aku.edu)
- Comparison of male and female prolactinoma patients requiring surgical intervention. (dergipark.org.tr)
- In a prospective and longitudinal study, 27 consecutive patients with prolactinoma were assessed during 6 months. (jdeponline.com)
- We found a significant reduction in Met.S after normalization of PRL level in patients with prolactinoma. (jdeponline.com)
- We suggest that it is important to consider the metabolic profile of patients with prolactinoma. (jdeponline.com)
- Dès le début de la pandémie, l'établissement hospitalier et universitaire d'Oran (EHUO), centre de soins de première ligne, d'une capacité 780 lits desservant environ 2 millions d'habitants s'est complètement réorganisé, en aménageant principalement des circuits pour le tri des patients « suspects Covid 19 ¼. (bvsalud.org)
Amyloid1
Giant1
- Limited studies demonstrated which therapy could be successfully used in the first-line therapy of giant prolactinoma. (nel.edu)
Commonly1
- Prolactinomas occur most commonly in people under age 40. (medlineplus.gov)
Occur1
- Prolactinoma may occur as part of an inherited condition called multiple endocrine neoplasia type 1 (MEN 1). (medlineplus.gov)
Proliferation1
Estrogen2
- High levels of estrogen or testosterone may be involved in the growth of a prolactinoma. (medlineplus.gov)
- Women with prolactinomas often have low levels of estrogen , which can lead to vaginal dryness, and thus discomfort during sexual intercourse. (msdmanuals.com)
Humans1
- Prolactinomas (animal models and humans) present reduced TGFβ1 activity as well as reduced expression of several components of the TGFβ1 system. (cell-metabolism.com)
Symptoms due1
- The symptoms due to a prolactinoma are broadly divided into those that are caused by increased prolactin levels or mass effect. (wikipedia.org)
Common1
- BACKGROUND: Prolactinomas are the most common type of functional pituitary tumours. (aku.edu)
Growth2
- The increasing and prolonged exposure of Bisphenol-A from childhood on, may contribute to the growth of a Prolactinoma. (wikipedia.org)
- Thus somatotropinomas secrete growth hormone (GH) prolactinomas secrete prolactin (PRL) thyrotropinomas secrete thyroid-stimulating hormone (TSH) and corticotropinomas secrete adrenocorticotropin hormone (ACTH). (cell-metabolism.com)
Patient1
- Your patient underwent successful surgery for a prolactinoma. (pituitaryworldnews.org)
Surgery1
- Radiation is usually only used in people with a prolactinoma that continues to grow or gets worse after both medicine and surgery have been tried. (medlineplus.gov)