The alternatively spliced sequences encode the cysteine-rich globular domain in the NH2-propeptide of the type II procollagen chain. (rupress.org)
Enzyme2
In enzymology, a procollagen glucosyltransferase (EC 2.4.1.66) is an enzyme that catalyzes the chemical reaction UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen ⇌ {\displaystyle \rightleftharpoons } UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen Thus, the two substrates of this enzyme are UDP-glucose and 5-(D-galactosyloxy)-L-lysine-procollagen, whereas its two products are UDP and 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen. (wikipedia.org)
The systematic name of this enzyme class is UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase. (wikipedia.org)
PLOD11
We further demonstrate that the procollagen lysyl hydroxylase ( PLOD1) promoter is regulated by Nkx2.5. (lu.se)
Proteinase6
Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1. (nih.gov)
Identification and expression of a novel type I procollagen C-proteinase enhancer protein gene from the glaucoma candidate region on 3q21-q24. (nih.gov)
Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer protein 2, to chromosome 9 and localization of PCOLCE2 to human chromosome 3q23. (nih.gov)
PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1. (nih.gov)
The procollagen C-proteinase is a member of the subfamily Astacin of the family M12 (Astacin) of clan MB of metalloproteinases that specifically cleaves an Ala-Asp bond in type I/II procollagens, a Gly-Asp bond in type III procollage, and similar bonds in a precursor of lysyloxidase as well as in laminin 5. (apexbt.com)
Three procollagen C-proteinase proteins encoded by different open reading frames (ORFs) of the same gene have been identified, including a 70 kDa polypeptide referred to as bone morphogenetic protein/C-proteinase (BMP-1/C-proteinase) or pCP1, an 80 kDa polypeptide referred to as bone morphogenetic protein/His (BMP-1/His) and a 100 kDa polypeptide referred to as mammalian tolloid (mTld) or pCP-2. (apexbt.com)
Genes6
BL treatment increased the lung procollagen I and III gene expressions in the BL + CD groups by several-fold at varying times compared with the corresponding SA + CD, and treatment with PD in the BL + PD groups significantly down-regulated the BL-induced overexpression of these genes. (aspetjournals.org)
Our results indicate that the antifibrotic effect of PD was partly due to suppression of the BL-induced inflammatory events and partly due to down-regulation of BL-induced overexpression of lung procollagen I and III genes. (aspetjournals.org)
Expression of two nonallelic type II procollagen genes during Xenopus laevis embryogenesis is characterized by stage-specific production of alternatively spliced transcripts. (rupress.org)
At later times and coincident with the appearance of chondrogenic tissues in the developing embryo, expression of the procollagen genes is characterized by the production of an additional, alternatively spliced transcript. (rupress.org)
Ninety percent of people who have one of these main types have mutations in the genes encoding the pro-alpha chains of type I procollagen (a structural component of bones, ligaments, and tendons), COL1A1 or COL1A2 . (msdmanuals.com)
Analysis of type I procollagen from cultured fibroblasts (from a skin biopsy) or sequence analysis of the COL1A1 and COL1A2 genes can be used when clinical diagnosis is unclear. (msdmanuals.com)
Type3
Does not cleave type III procollagen. (expasy.org)
Evidence is presented suggesting that in X. laevis there are two transcriptionally active copies of the type II procollagen gene. (rupress.org)
It has been postulated that nonablative lasers cause an increase in the production of type I procollagen mRNA associated with the tissue response occurring within the dermal matrix. (medscape.com)
Aminoterminal propeptide of type III procollagen14
Twenty-four psoriatic patients on methotrexate were studied with liver biopsies and serum measurements of aminoterminal propeptide of type III procollagen (PIII NP). (nih.gov)
The study indicates that aminoterminal propeptide of type III procollagen can be utilized as a valuable non-invasive marker of fibrogenesis in the liver. (nih.gov)
Serum aminoterminal propeptide of type III procollagen in psoriasis and psoriatic arthritis: relation to liver fibrosis and arthritis. (nih.gov)
Serum aminoterminal propeptide of type III procollagen. (nih.gov)
1. Collagen metabolism in gynecologic patients: changes in the concentration of the aminoterminal propeptide of type III procollagen in serum. (nih.gov)
3. Aminoterminal propeptide of type III procollagen in ovarian cancer. (nih.gov)
4. Aminoterminal propeptide of type-III procollagen in serum--an indicator of clinical behavior of advanced ovarian carcinoma? (nih.gov)
7. Effect of gynecological operations on the serum concentration of the aminoterminal propeptide of type III procollagen. (nih.gov)
8. Collagen metabolism in normal and complicated pregnancy: changes in the aminoterminal propeptide of type III procollagen in serum. (nih.gov)
11. Aminoterminal propeptide of type III procollagen: a marker of disease activity in schistosomal patients. (nih.gov)
12. Clinical evaluation of serum aminoterminal propeptide of type III procollagen as tumor marker in gynecologic malignancies. (nih.gov)
14. Is the aminoterminal propeptide of type III procollagen degraded in the liver? (nih.gov)
17. Increased turnover of collagen in abdominal aortic aneurysms, demonstrated by measuring the concentration of the aminoterminal propeptide of type III procollagen in peripheral and aortal blood samples. (nih.gov)
18. Serum concentrations of CA 125 and aminoterminal propeptide of type III procollagen (PIIINP) in patients with endometrial carcinoma. (nih.gov)
PCP cleaves the carboxyl-propeptides of procollagens types I, II, and III and this initiates the self-assembly of collagen fibrils. (medchemexpress.com)
Aid your body's natural formation of collagen with cruelty-free Sugarbear® ProCollagen. (panaceaonline.co.uk)
The amino-terminal peptide of type 3 procollagen (P3NP) is formed during the synthesis of type 3 collagen. (nwlpathology.nhs.uk)
Procollagen mRNA content, expressed as a ratio of type I:III mRNAs, was consistent with the protein synthesis data and the observed ratio of collagen types being made by the lungs at the various time points evaluated. (nih.gov)
Researchers know that procollagen, a precursor to collagen, is assembled in a cellular compartment called the endoplasmic reticulum, or ER. (nih.gov)
It is later transported to the Golgi apparatus, which enables the cell to secrete procollagen and form collagen fibers. (nih.gov)
No correlation was made between procollagen I propeptide staining with collagen I levels or with observed clinical effects. (nih.gov)
Thus, the relationships between the increased collagen in rodents, increased procollagen I propeptide in humans, and the clinical effects of tretinoin have not yet been clearly defined. (nih.gov)
Propeptide4
The C-terminal region of the propeptide is required for association of the three alpha chains into a trimeric non-helical procollagen. (reactome.org)
Procollagen processing by PCP is stimulated by PCPE, a glycoprotein that binds to the C-propeptide of type I procollagen through its N-terminal CUB domains. (medchemexpress.com)
13. Splanchnic and renal extraction of circulating type III procollagen aminoterminal propeptide in patients with normal liver function and in patients with alcoholic cirrhosis. (nih.gov)
Application of 0.1% tretinoin cream to photodamaged human forearm skin was associated with an increase in antibody staining for procollagen I propeptide. (nih.gov)
Osteogenesis Imperfecta1
Knowing this quality control process will help researchers from the lab better understand how procollagen and HSP47 mutations cause osteogenesis imperfecta. (nih.gov)
Serum2
10. Serum aminoterminal type III procollagen peptide. (nih.gov)
A study of type III procollagen peptide in serum during liver transplantation in pigs. (nih.gov)
HSP475
One of the longstanding mysteries of procollagen synthesis and its transport from the ER to the Golgi is the role of a chaperone protein, HSP47. (nih.gov)
Previous research suggests that HSP47 chaperones both the assembly of procollagen and its transport to the Golgi before the protein is recycled back into the ER. (nih.gov)
Compared to prior studies that relied on still images of fixed cells, the Leikin Lab's timelapse imaging showed that procollagen is exported from the ER without HSP47 . (nih.gov)
Their work suggests a new role for HSP47 in procollagen quality control at ER exit sites. (nih.gov)
In the study, HSP47 appears to direct abnormal procollagen molecules to lysosomes for degradation rather than to the Golgi for secretion. (nih.gov)
Mutations2
Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene. (medlineplus.gov)
Ninety percent of people who have one of these main types have mutations in the genes encoding the pro-alpha chains of type I procollagen (a structural component of bones, ligaments, and tendons), COL1A1 or COL1A2 . (msdmanuals.com)
Synthesis of type1
2. Progressive ovarian carcinoma induces synthesis of type I and type III procollagens in the tumor tissue and peritoneal cavity. (nih.gov)
Protein1
The ADAMTS2 enzyme cuts a short chain of protein building blocks (amino acids) off one end of procollagens. (medlineplus.gov)
Molecules1
Procollagens are the precursors of collagens, which are complex molecules found in the spaces between cells that add strength, support, and stretchiness (elasticity) to many body tissues. (medlineplus.gov)
Fibrosis1
After 9 weeks, soft tissue around the tissue expander was excised and evaluated qualitatively and quantitatively to assess extent of inflammation (CD68 antibodies and interleukin-6 levels), degradation and fibrosis (matrix metalloproteinase-1 and procollagen-1 staining), and mechanical (tensile) strength. (medscape.com)
Disorders1
Procollagen misfolding in bone disorders / Sergey Leikin. (nih.gov)
Formation1
However, these events, when prolonged in excess and coupled with resulting excessive α-SMA and procollagens presence are also presumed to be related to the formation of capsular contracture in breast reconstruction, which is currently described as a synovia-like metaplasial cell layer that forms at the implant-capsule interface. (medscape.com)
Cell2
[ 10 , 11 ] Subsequent migration of fibroblasts and myofibroblasts to the site is accompanied by production of procollagen-1 and alpha-smooth muscle cell actin (α-SMA) followed by development of dense, fibrotic tissue. (medscape.com)
Inside the cell, the small green clusters are vesicles transporting procollagen. (nih.gov)