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  • Probenecid-AFT tablets 500mg are used to treat gout and gouty arthritis to relieve painful symptoms at all stages of the condition, also to prevent attacks of gout in people at risk of developing gout. (inhousepharmacy.vu)
  • Probenecid-AFT 500mg is also used to prevent hyperuricaemia which can be induced or aggravated by some diuretics that are used to treat oedema and hypertension. (inhousepharmacy.vu)
  • Probenecid-AFT tablets 500mg also have another use in increasing the effectiveness of penicillin antibiotics by prolonging the length of time the antibiotic remains in the blood before it is excreted into the urine. (inhousepharmacy.vu)
  • Probenecid-AFT tablets 500mg contain probenecid, which is a uricosuric drug that promotes the excretion of uric acid in the urine and this reduces the concentration of uric acid in the blood. (inhousepharmacy.vu)
  • Probenecid-AFT tablets 500mg also increase and prolong the blood concentration of beta-lactam antibiotics like penicillin, by inhibiting the secretion of penicillin by the kidneys into the urine, which means it stays in the blood for longer and is therefore more effective. (inhousepharmacy.vu)
  • Probenecid-AFT tablets 500mg contain probenecid, which is a uricosuric drug that in that promotes the excretion of uric acid in the urine. (inhousepharmacy.vu)
  • Probenecid-AFT 500mg acts on the tubules of the kidneys and blocks the reabsorption of uric acid by preventing its uptake into the tubules and this reduces the concentration of uric acid in the blood. (inhousepharmacy.vu)
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  • Pill with imprint Z 2193 is White, Oval and has been identified as Colchicine and Probenecid 0.5 mg / 500 mg. (drugs.com)
  • Colchicine/probenecid is used in the treatment of Gouty Arthritis and belongs to the drug class antigout agents . (drugs.com)
  • Colchicine/probenecid 0.5 mg / 500 mg is not a controlled substance under the Controlled Substances Act (CSA). (drugs.com)
  • Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine. (wikipedia.org)
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  • Probalan (Probenecid) is used in the treatment of chronic gout or gouty arthritis. (vespharmacy.com)
  • Each tablet contains 500 mg of probenecid. (phebra.com)
  • Probenecid is primarily used to treat gout and hyperuricemia. (wikipedia.org)
  • In gout, probenecid competitively inhibits the reabsorption of uric acid through the organic anion transporter (OAT) at the proximal tubules. (wikipedia.org)
  • Probenecid tablets are indicated for the treatment of the hyperuricemia associated with gout and gouty arthritis. (nih.gov)
  • Theoretically probenecid can increase the risk of uric acid kidney stones. (wikipedia.org)
  • Probenecid is a uricosuric and renal tubular transport blocking agent. (nih.gov)
  • Probenecid inhibits the tubular secretion of penicillin and usually increases penicillin plasma levels by any route the antibiotic is given. (nih.gov)
  • aspirin decreases effects of probenecid by acidic (anionic) drug competition for renal tubular clearance. (medscape.com)
  • Probenecid competes withe meropenem for active tubular secretion. (medscape.com)
  • probenecid increases levels of methotrexate by acidic (anionic) drug competition for renal tubular clearance. (medscape.com)
  • aceclofenac will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. (medscape.com)
  • These data are consistent with inhibition of tubular secretion of cidofovir by probenecid. (aspetjournals.org)
  • Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. (jairadhesales.co.in)
  • In all these interactions, the excretion of these drugs is reduced due to probenecid, which in turn can lead to increased concentrations of these. (wikipedia.org)
  • Drug interactions with Ceftin include vaccines (for example, typhoid vaccine) and probenecid. (rxlist.com)
  • 4.Brown GR. Cephalosporin-probenecid drug interactions. (webmd.com)
  • Probenecid increases plasma concentrations of methotrexate in both animals and humans. (nih.gov)
  • Probenecid can raise the concentrations of many common antibiotics like penicillins and cephalosporins. (reallifepharmacology.com)
  • 1.Hoffstedt B, Haidl S, Walder M. Influence of probenecid on serum and subcutaneous tissue fluid concentrations of benzylpenicillin and ceftazidime in human volunteers. (webmd.com)
  • 10.Spina SP, Dillon EC Jr. Effect of chronic probenecid therapy on cefazolin serum concentrations. (webmd.com)
  • 11.Brown G, Zemcov SJ, Clarke AM. Effect of probenecid on cefazolin serum concentrations. (webmd.com)
  • Apparent effect of probenecid on the distribution of penicillins in man. (webmd.com)
  • The chemical name for probenecid is 4-[(dipropylamino) sulfony1] benzoic acid. (nih.gov)
  • Probenecid is the generic name for 4-[(dipropyl-amino)sulfonyl] benzoic acid. (nih.gov)
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  • This leads to preferential reabsorption of probenecid back into plasma and excretion of uric acid in urine, thus reducing blood uric acid levels and reducing its deposition in various tissues. (wikipedia.org)
  • Probenecid-AFT acts on the tubules of the kidneys and blocks the reabsorption of uric acid by competing with the membrane transporter for uric acid and preventing its uptake. (inhousepharmacy.vu)
  • Probenecid is sometimes used to increase the concentration of some antibiotics and to protect the kidneys when given with cidofovir. (wikipedia.org)
  • In the kidneys, probenecid is filtered at the glomerulus, secreted in the proximal tubule and reabsorbed in the distal tubule. (wikipedia.org)
  • Probenecid may decrease the ability of your kidneys to remove some antibiotics. (webmd.com)
  • Probenecid competes with penicillin for excretion at the OAT, which in turn increases the plasma concentration of penicillin. (wikipedia.org)
  • 14. Requirement for concomitant use of valproic acid, divalproex sodium, or probenecid between randomization and EOT. (who.int)
  • Patients with G6PD deficiency who are taking probenecid are at increased risk for hemolytic anemia. (reallifepharmacology.com)
  • Probenecid was developed as an alternative to caronamide to competitively inhibit renal excretion of some drugs, thereby increasing their plasma concentration and prolonging their effects. (wikipedia.org)
  • Probenecid decreases both hepatic and renal excretion of sulfobromophtalein (BSP). (nih.gov)
  • Probenecid decreases both hepatic and renal excretion of sulfobromophthalein (BSP). (nih.gov)
  • Effect of probenecid on the distribution, metabolism, and excretion of cidofovir in rabbits. (aspetjournals.org)
  • The effect of concomitant probenecid on the tissue distribution, metabolism, and urinary excretion of cidofovir was examined in New Zealand white rabbits. (aspetjournals.org)
  • Pharmaceutical grade Probenecid is a medication that increases uric acid excretion in the urine. (ecplaza.net)
  • Probenecid also has been reported to inhibit the renal transport of many other compounds including aminohippuric acid (PAH), aminosalicylic acid (PAS), indomethacin, sodium iodomethamate and related iodinated organic acids, 17 -ketosteroids, pantothenic acid, phenolsulfonphthalein (PSP), sulfonamides, and sulfonylureas. (nih.gov)
  • I see you offer a probenecid 25 mM stabilized aqueous solution and a water soluble probenecid sodium salt. (aatbio.com)
  • Aspirin decreases uricosuric action of probenecid. (medscape.com)
  • Historically, probenecid has been used to increase the duration of action of drugs such as penicillin and other beta-lactam antibiotics. (wikipedia.org)
  • During World War II, probenecid was used to extend limited supplies of penicillin. (wikipedia.org)
  • Because of its mechanism of action, probenecid is not recommended in conjunction with a penicillin in the presence of known renal impairment. (nih.gov)
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  • probenecid increases levels of meropenem/vaborbactam by decreasing elimination. (medscape.com)
  • Two groups of six male rabbits received intravenous [3H]cidofovir (5 mg/kg, 20 mu Ci/kg) alone or with concomitant intravenous probenecid (90 mg/kg). (aspetjournals.org)
  • If probenecid is given with methotrexate, the dosage of methotrexate should be reduced and serum levels may need to be monitored. (nih.gov)
  • 5.Welling PG, Dean S, Selen A, Kendall MJ, Wise R. Probenecid: an unexplained effect on cephalosporin pharmacology. (webmd.com)
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  • probenecid increases levels of imipenem/cilastatin by decreasing renal clearance. (medscape.com)
  • Two additional groups of six rabbits received intravenous [14C]cidofovir (15 mg/kg, 100 mu Ci/kg) alone or 1 hr after oral administration of probenecid (90 mg/kg). (aspetjournals.org)
  • Single-dose oral treatment of gonorrhea in men and women, using ampicillin alone and combined with probenecid. (bmj.com)
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  • Specifically, a small amount of evidence supports the use of intravenous cefazolin once rather than three times a day when it is combined with probenecid. (wikipedia.org)
  • Probenecid has been used in patients with some renal impairment, but dosage requirements may be increased. (nih.gov)
  • Probenecid may not be effective in chronic renal insufficiency particularly when the glomerular filtration rate is 30 mL/minute or less. (nih.gov)
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  • In patients on probenecid the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (nih.gov)
  • In patients on probenecid who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (nih.gov)
  • The brain interstitial fluid (ISF)-to-plasma cerebrospinal fluid (CSF)-to-plasma and brain tissue-to-plasma unbound concentration ratios of probenecid at steady state were less than unity, which suggests restricted distribution in the brain. (aspetjournals.org)
  • The ratio of the ISF concentration (C isf ) to the plasma unbound concentration (C p,f ) of probenecid was increased 2- to 3-fold by salicylate (3.7 mM) and benzoate (3.6 mM), which are accepted as substrates of the monocarboxylic acid transport system, compared with the same ratio for the control. (aspetjournals.org)
  • These data suggest that the restricted distribution of probenecid in the brain may be ascribed to efficient efflux from the brain ISF, which may be regulated by the monocarboxylic acid transport system at a relatively high ISF concentration. (aspetjournals.org)
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  • Therapy with probenecid should not be started until an acute gouty attack has subsided. (nih.gov)
  • Remember that there are many medications that can oppose the beneficial effects of probenecid. (reallifepharmacology.com)
  • What are the side effects of Probenecid-AFT? (inhousepharmacy.vu)
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  • In a patient taking probenecid, they need to have adequate kidney function for the drug to work. (reallifepharmacology.com)
  • The appearance of hypersensitivity reactions requires cessation of therapy with probenecid. (nih.gov)
  • plasma levels at 15 min postdose were increased 65% by probenecid. (aspetjournals.org)