• These populations include the orexigenic neuropeptide Y (NPY) and anorexigenic proopiomelanocortin (POMC) neurons that have projections to key neurons in other hypothalamic nuclei and higher brain centers in order to orchestrate the feeding responses. (researchgate.net)
  • Proopiomelanocortin (POMC) deficiency causes severe obesity through hyperphagia of hypothalamic origin. (cam.ac.uk)
  • Proopiomelanocortin (POMC) neurons are major regulators of energy balance and glucose homeostasis. (nih.gov)
  • Other groups underwent the same procedure, and also received naloxone (Na) to block μ-δ endogenous receptors, or a phosphorothioate antisense oligonucleotide (AS) directed against pro-opiomelanocortin (POMC)-mRNA [to block adrenocorticotropin (ACTH)- and POMC-derived opioid peptides]. (unicas.it)
  • Rare mutations in the proopiomelanocortin (POMC) gene cause severe early-onset childhood obesity. (ox.ac.uk)
  • Increase of energy accumulation elicits leptin release and simultaneous inhibition of orexigenic neurons expressing neuropeptide Y (NPY) and agouti-related peptide (AgRP), as well as activation of the anorexigenic proopiomelanocortin (POMC) neurons within the hypothalamic arcuate nucleus (ARC). (frontiersin.org)
  • Microglia, a type of CNS immune cell, have been shown to contribute to ethanol-activated neuronal death of the stress regulatory proopiomelanocortin (POMC) neuron-producing b-endorphin peptides in the hypothalamus in a postnatal rat model of fetal alcohol spectrum disorders. (researchwithrutgers.com)
  • To attempt to provide balance, the pituitary gland overcompensates by making more ACTH, beta-endorphin, and melanocyte-stimulating hormone (MSH) from the protein pro-opiomelanocortin (POMC). (news-medical.net)
  • The other neuronal population releases the anorexigenic cocaine- and amphetamine-regulated transcript and pro-opiomelanocortin neurotransmitters, both of which inhibit feeding. (medscape.com)
  • CRISPR/SaCas9 mutagenesis of stromal interaction molecule 1 in proopiomelanocortin neurons increases glutamatergic excitability and protects against diet-induced obesity. (harvard.edu)
  • Post-natal stress-induced endocrine and metabolic alterations in mice at adulthood involve different pro-opiomelanocortin-derived peptides. (unicas.it)
  • Pro-opiomelanocortin converting enzyme (EC 3.4.23.17, prohormone converting enzyme, pro-opiomelanocortin-converting enzyme, proopiomelanocortin proteinase, PCE) is an enzyme. (wikipedia.org)
  • Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone. (cam.ac.uk)
  • In conclusion, the increase in β-endorphin concentration and immunoreactive ACTH 1-39 staining in the cells of origin, areas of fiber projection and terminal fields suggest that nitrous oxide stimulates the central pro-opiomelanocortin system in vivo in the rat. (elsevierpure.com)
  • Previous findings showed that pro-opiomelanocortin-containing neurons and endocrine cells synthesize multiple forms of beta-endorphin (beta E) and alpha-melanocyte-stimulating hormone (alpha-MSH), and that tissue specific post-translational processing of pro-opiomelanocortin can change ratios of the forms of secreted peptides. (aspetjournals.org)
  • Structural modifications of pro-opiomelanocortin-derived peptides alter their behavioral effects markedly. (aspetjournals.org)
  • Pro-opiomelanocortin converting enzyme (EC 3.4.23.17, prohormone converting enzyme, pro-opiomelanocortin-converting enzyme, proopiomelanocortin proteinase, PCE) is an enzyme. (wikipedia.org)
  • Carboxypeptidase E and Secretogranin III coordinately facilitate efficient sorting of pro-opiomelanocortin to the regulated secretory pathway in AtT20 cells. (nih.gov)
  • It focuses on the treatment for Prader-Willi Syndrome and Pro-Opiomelanocortin deficiency obesity. (businessinsider.com)
  • Krude H, Biebermann H, Gruters A. Mutations in the human proopiomelanocortin gene. (medlineplus.gov)
  • 5. Corticotropin-releasing hormone, proopiomelanocortin, and glucocorticoid receptor gene expression in adrenocorticotropin-producing tumors in vitro. (nih.gov)