• coronary
  • Pravastatin is also used to lower the risk of stroke, heart attack, and other heart complications in people with or without coronary heart disease or other risk factors. (peacehealth.org)
  • Recently completed regression studies (PLAC I, PLACII, KAPS and REGRESS) show that pravastatin slows progression of atherosclerosis and lowers the incidence of coronary events in patients with mild to moderately severe hypercholesterolaemia and known coronary heart disease. (springer.com)
  • Large scale primary (WOSCOPS) and secondary (CARE) prevention studies, moreover, demonstrate that pravastatin has beneficial effects on coronary morbidity and mortality. (springer.com)
  • Methods and Results Clinical data from four atherosclerosis regression trials that evaluated pravastatin were pooled for a predetermined analysis of the effect of that agent on the risk of coronary events. (ahajournals.org)
  • The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT), failed to demonstrate a difference in all-cause mortality or nonfatal myocardial infarction/fatal coronary heart disease rates between patients receiving pravastatin 40 mg daily (a common starting dose) and those receiving usual care. (wikipedia.org)
  • atherosclerosis
  • Pravastatin may help prevent or slow down medical problems, like atherosclerosis (hardening of the arteries), that are caused by fats clogging the blood vessels. (drugs.com)
  • Pravastatin slows the progression of atherosclerosis in humans and may have beneficial effects in stabilising plaques, improving endothelial dysfunction, decreasing platelet thrombus formation, improving fibrinolytic activity and reducing the incidence of transient myocardial ischaemia. (springer.com)
  • therapy
  • Pravastatin therapy was associated with an increasing risk of cancer as age increases. (greenmedinfo.com)
  • Combination therapy with other antihyperlipidaemic agents such as cholestyramine further enhances the efficacy of pravastatin in patients with severe dyslipidaemias. (springer.com)
  • Generic
  • The U.S. Food and Drug Administration approved generic pravastatin for sale in the United States for the first time on April 24, 2006. (wikipedia.org)
  • drugs
  • Using pravastatin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. (drugs.com)
  • elderly
  • Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pravastatin in the elderly. (drugs.com)
  • However, elderly patients are more likely to have age-related muscle problems, which may require caution in patients receiving pravastatin. (drugs.com)
  • Available data suggest that pravastatin is effective in elderly patients and in patients with hypercholesterolaemia secondary to diabetes mellitus or renal disease. (springer.com)
  • Pravastatin is generally well tolerated by most patients (including the elderly), as evidenced by data from studies of up to 5 years in duration. (springer.com)
  • risk
  • Pravastatin is used with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. (empowher.com)
  • you should know that the risk that you will develop serious muscle and kidney problems during your treatment with pravastatin is higher if you are 65 years of age or older. (empowher.com)
  • Pravastatin works by reducing the amount of cholesterol that is made in the liver, lowering bad cholesterol and triglycerides, decreasing the risk of heart disease, preventing strokes and heart attacks. (euroclinix.net)
  • liver
  • Your doctor will probably tell you not to take pravastatin if you have liver disease or if the tests show that you may be developing liver disease. (empowher.com)
  • Drug
  • Pravastatin should be considered as a potential cause of cholestatic hepatitis with favorable clinical outcome after drug withdrawal. (ebscohost.com)
  • dose
  • Your doctor may start you on a low dose of pravastatin and gradually increase your dose, not more than once every 4 weeks. (empowher.com)
  • Studies
  • Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of pravastatin in children 8 to 18 years of age. (drugs.com)