Chemicals and Drugs
Potassium IonophoresIonophoresPotassiumLasalocid
InhibitorsMembraneChelatorsSelectiveCalcimycinAntibioticChannelsInhibitBiological membranesPolyetherIonsA23187NigericinSodiumStreptomycesIntracellularSelectivityMicroorganismsPermeabilityDegenerationConcentrationSubstanceToxicMagnesiumSpeciesProteinsTransportsMechanismSyntheticAffectsChannelHighChelating agentsMechanismsImproveProductSaltFunctionCenterClose
Inhibitors4
  • Sodium Potassium Chloride Symporter Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Sodium Potassium Chloride Symporter Inhibitors" by people in this website by year, and whether "Sodium Potassium Chloride Symporter Inhibitors" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Sodium Potassium Chloride Symporter Inhibitors" by people in Profiles. (umassmed.edu)
  • Regardless of the inability of the inhibitors to cause efflux of intracellular Angelicin potassium, the addition of high extracellular potassium suppressed activation from the NLRP3 inflammasome. (euromedh2020.com)
Membrane11
  • Many ionophores are lipid-soluble entities that transport ions across the cell membrane. (wikipedia.org)
  • Structurally, an ionophore contains a hydrophilic center and a hydrophobic portion that interacts with the membrane. (wikipedia.org)
  • Multiple synthetic membrane-spanning ionophores have also been synthesized. (wikipedia.org)
  • Ionophores that transport hydrogen ions (H+, i.e. protons) across the cell membrane are called protonophores. (wikipedia.org)
  • A plasticised poly(vinyl chloride) optode membrane incorporated with a calix[6]arene hexaester, a H + -selective chromoionophore (3,3′,5,5′-tetramethyl-N,N-dibenzylbenzidine, a novel synthetic cationic dye) and a lipophilic potassium tetrakis(4-chlorophenyl)borate was used as a sensing device for the indirect optical determination of potassium ions. (edu.hk)
  • The selectivity of the potassium-selective membrane allows its application for the detection of the potassium concentration in real sample analysis. (edu.hk)
  • Ionophores usually have a polar inner moiety, and a non-polar outer moiety which can span or cross the hydrophobic interior of the membrane. (fermentek.com)
  • An ionophore is a substance that transports ions across a lipid membrane in a cell by combining with the ion, or by increasing the absorptivity or sponginess of the membrane. (siouxnationag.com)
  • Potassium-Selective Membrane S. (uitm.edu.my)
  • Two poly(oxyethylene) derivatives 1.10-bis(2'-benzoic acid)-1,4,7,1-tetradecane (L1) and 1,7-bis(2'-benzoic acid)-1,4,7-trioxaheptane (L2) were used as suitable ionophores for the preparation of potassium-selective PVC-membrane electrodes. (uitm.edu.my)
  • Design of a Selective and Sensitive PVC-Membrane Potentiometric Sensor for Strontium Ion Based on 1,10-Diaza-5,6-benzo-4,7-dioxacyclohexadecane-2,9-dioneas a Neutral Ionophore by: Hashem Sharghi, et al. (uitm.edu.my)
Chelators1
  • Use this guide to find the optimal Ca 2+ indicator, chelators, and ionophores for your experiments. (abcam.com)
Selective4
  • Ionophores catalyze ion transport across hydrophobic membranes, such as liquid polymeric membranes (carrier-based ion selective electrodes) or lipid bilayers found in the living cells or synthetic vesicles (liposomes). (wikipedia.org)
  • Ionophores selective for cations and anions have found many applications in analysis. (wikipedia.org)
  • Ionophores can be selective to a particular ion but may not be exclusive to it. (wikipedia.org)
  • TD19C6 is an ammonium ion selective ionophore. (dojindo.com)
Calcimycin1
  • However, these agents failed to modify the secretion elicited by high Ca2ϩ in nanomolar concentrations of the antiestrogen ICI 182,780 glands treated with the ionophore A-23187 (calcimycin), sug- (fulvestrant). (drugstodaypdf.com)
Antibiotic4
  • The term ionophore (from Greek ion carrier or ion bearer) was proposed by Berton Pressman in 1967 when he and his colleagues were investigating the antibiotic mechanisms of valinomycin and nigericin. (wikipedia.org)
  • A23187 is an ionophore antibiotic that forms dimeric. (fermentek.com)
  • Valinomycin is a cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus. (fermentek.com)
  • Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling. (targetmol.com)
Channels1
Inhibit5
  • Although both ketamine and halothane inhibit potassium currents through the Kv2.1 channel, their mechanisms of action at this potential target may be different. (silverchair.com)
  • Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. (umassmed.edu)
  • The ability of 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one potassium salt (TBX) to inhibit histamine release from both peritoneal exudate cells (PEC) containing mast cells and lung fragments of rats was investigated in vitro. (unboundmedicine.com)
  • For agencies that inhibit translation Angelicin through reduced cellular potassium, the use of high extracellular potassium restores protein suppresses and translation activation from the NLRP inflammasome. (euromedh2020.com)
  • For agencies that inhibit translation through systems that usually do not involve lack of potassium, high extracellular potassium suppresses IL-1? (euromedh2020.com)
Biological membranes3
  • Ionophores are chemical compounds that reversibly bind and transport ions through biological membranes in the absence of a protein pore. (wikipedia.org)
  • Ionophores modify the permeability of biological membranes toward certain ions to which they show affinity and selectivity. (wikipedia.org)
  • Ionophores are compounds which can facilitate the migration of ions across biological membranes. (fermentek.com)
Polyether2
Ions5
  • In chemistry, an ionophore (from Greek ion and -phore 'ion carrier') is a chemical species that reversibly binds ions. (wikipedia.org)
  • Some ionophores are synthesized by microorganisms to import ions into their cells. (wikipedia.org)
  • However, these ionophores become unable to transport ions under very low temperatures. (wikipedia.org)
  • This type of ionophores can maintain their ability to transfer ions at low temperatures, unlike carrier ionophores. (wikipedia.org)
  • Ions are bound to the hydrophilic center and form an ionophore-ion complex. (wikipedia.org)
A231872
  • Cerebellin was concentrated in synaptosomal preparations of rat brain, and its subcellular distribution pattern in rat brain was identical to that of two other known synaptosomal peptides, vasoactive intestinal polypeptide and substance P. Studies with superfused cerebellar synaptosomes and slices of rat cerebellum and hypothalamus demonstrated calcium-dependent cerebellin release when stimulated by high potassium concentrations as well as the addition of the calcium ionophore A23187. (ox.ac.uk)
  • In addition, TBX inhibited compound 48/80- but not calcium ionophore A23187-induced histamine release from normal PEC. (unboundmedicine.com)
Nigericin1
  • The final outcome that reduced intracellular potassium works as another sign to cause activation from the NLRP3 inflammasome was structured initially in the observation that lack of potassium induced by nigericin, a Angelicin potassium ionophore, or by ATP leads to the robust discharge of IL-1? (euromedh2020.com)
Sodium1
  • Ionophores form lipid soluble, reversible complexes with cations and facilitate ion transport across membranes, as well as a monensin-electroneutral exchange of sodium and protons. (siouxnationag.com)
Streptomyces1
  • Ionomycin is a highly specific ionophore isolated from Streptomyces conglobatus . (agscientific.com)
Intracellular3
  • As a potassium-specific ionophore, beauvericin A increases intracellular calcium concentrations and triggers DNA fragmentation and apoptosis through a calcium dependent caspase 3-sensitive pathway. (medindex.am)
  • Lack of intracellular potassium provides emerged being a regular correlate of NLRP3 inflammasome activation and continues to be suggested to constitute one particular sign. (euromedh2020.com)
  • Nevertheless, the mechanism where lack of intracellular potassium is certainly associated with activation from the NLRP3 inflammasome is certainly unclear. (euromedh2020.com)
Selectivity1
  • The selectivity of TD19C6 for ammonium ion is about 10 times that of potassium ion, which is nearly the same selectivity of nonactin. (dojindo.com)
Microorganisms1
  • The two broad classifications of ionophores synthesized by microorganisms are: Carrier ionophores that bind to a particular ion and shield its charge from the surrounding environment. (wikipedia.org)
Permeability1
  • intoxications with ionophores (a substance which increases cellular permeability to a specific ion, which would in turn disrupt the electrical potential of the cell), blister beetle, mercury, coffee bean (cassia) or gossypol from raw cottonseed. (endurance.net)
Degeneration1
  • It is also believed that the ionophore induces apoptotic degeneration of embryonic cortical neurons. (agscientific.com)
Concentration1
  • It exhibited a reversible response to the potassium ion in 0.05 mol/l HCl buffer media in the concentration range from 1 × 10 -6 to 1 × 10 -2 mol/l. (edu.hk)
Substance1
Toxic1
  • Ionophores can have toxic effects which are generally a result of improper use and/or mixing errors. (siouxnationag.com)
Magnesium3
  • Depending on your herd, fall may require you to pay special attention to magnesium, ionophores and breeding minerals. (southernstates.com)
  • Magnesium supplementation will help cattle avoid getting grass tetany as the cool season regrowth has the potential for high potassium and low magnesium levels. (southernstates.com)
  • As too much potassium will block magnesium absorption levels adding a supplement like Mag-o-Min or Hi Mag can do the trick to keep grass tetany worries at bay. (southernstates.com)
Species2
  • Many ionophores are produced naturally by a variety of microbes, fungi and plants, and act as a defense against competing or pathogenic species. (wikipedia.org)
  • Again, the toxicity mechanism is not yet fully understood but it is likely related to its functioning as a potassium-specific ionophore, inducing reactive oxygen species (ROS) and increasing oxidative stress which can result in apoptosis of cells. (orffa.com)
Proteins2
Transports1
  • An example of a carrier ionophore is valinomycin, a molecule that transports a single potassium cation. (wikipedia.org)
Mechanism1
  • Due to the mechanism of action, animals that are not ruminants are not able to use ionophores and can die following low levels of ionophore ingestion. (siouxnationag.com)
Synthetic1
Affects1
Channel4
  • Examples of channel-forming ionophores are gramicidin A and nystatin. (wikipedia.org)
  • Alamethicin is a channel-forming ionophore. (fermentek.com)
  • Using voltage-clamp techniques, the authors examined the effect of two general anesthetics (ketamine and halothane) on a rat brain potassium channel of known amino acid sequence, and further assessed whether the inhibition of the channel is altered by a partial deletion of the C-terminal sequence of this channel. (silverchair.com)
  • This unit of the maxi-K potassium channel (Valverde et al. (drugstodaypdf.com)
High1
  • These ef- ited at the micromolar range the catecholamine output elic- fects were reproduced with the nonpermeable drug 17␤- ited by acetylcholine or high potassium. (drugstodaypdf.com)
Chelating agents1
Mechanisms1
  • analyzed as potential mechanisms of diabetes remission after Roux-en-Y gastric sleeve and bypass gastrectomy. (acancerjourney.info)
Improve2
  • Not only will these ionophores improve your rates of gain, they will also help protect your herd from ailments such as coccidiosis, acidosis and bloat. (southernstates.com)
  • Ionophores improve the digestive process of the ruminant, reducing waste products including methane. (siouxnationag.com)
Product1
  • This is a regulated product that is required to be listed on feed tags with the rate of the ionophore in a ton of feed as well as the amount of feed that should be fed to an individual animal. (siouxnationag.com)
Salt1
  • Figure 19.8.3 A) Confocal image of a guinea pig ventricular myocyte filled with fluo-3, potassium salt ( F3715 ). (thermofisher.com)
Function1
  • Find the best indicator and ionophore for imaging Ca 2 + and cell function. (abcam.com)
Center1
  • The activity of an ionophore-metal complex depends on its geometric configuration and the coordinating sites and atoms which create coordination environment surrounding the metal center. (wikipedia.org)
Close1
  • It is difficult to separate ammonium ion and potassium ion because they are close in ion size. (dojindo.com)