• PSDs
  • PSDs were originally identified by electron microscopy as an electron-dense region at the membrane of a postsynaptic neuron. (wikipedia.org)
  • The results show that all PSDs contain a central mesh immediately underlying the postsynaptic membrane. (jneurosci.org)
  • The immunogold labeling of isolated PSDs makes it possible to compare the composition of different individual PSDs, permitting detection of any substantial synapse-to-synapse variation in the density of labeled molecules. (jneurosci.org)
  • regulate
  • In this review, we are discussing key factors that regulate the structure and dynamics of the actin cytoskeleton, the major cytoskeletal building block that supports the postsynaptic compartment. (hindawi.com)
  • potentiation
  • In nondeprived animals, PSD-95-GFP produces no additional potentiation, indicating common mechanisms between PSD-95-mediated potentiation and experience-driven synaptic strengthening. (jneurosci.org)
  • mechanisms
  • Somatodendritically released peptides alter synaptic function through a variety of mechanisms, including autocrine actions that liberate retrograde transmitters. (jneurosci.org)
  • Such tools provide insight into regulation mechanisms and will likely be instrumental for identifying novel modulators of postsynaptic receptor transport. (jneurosci.org)
  • CaMKII
  • There appears to be a local organization of CaMKII, as judged by fact that the nearest-neighbor distances are nearly invariant over a wide range of labeling density for CaMKII. (jneurosci.org)
  • The average density of CaMKII holoenzymes is highly variable, ranging from zero to values approaching a tightly packed state. (jneurosci.org)
  • Her laboratory purified and characterized the synaptic signaling protein Calcium/calmodulin-dependent protein kinase II (CaMKII) in 1983 and showed that it is 1-2% of forebrain protein, is a major constituent of the postsynaptic density, and is regulated by autophosphorylation following activation by synaptic activity. (wikipedia.org)
  • It has been shown that there is an increase in CaMKII activity directly in the post synaptic density of dendrites after LTP induction, suggesting that activation is a direct result of stimulation. (wikipedia.org)
  • After LTP induction, CaMKII moves to the postsynaptic density (PSD). (wikipedia.org)
  • endogenous
  • There are clear demonstrations that exogenous CCK modulates food intake and neuropeptide expression in the DMH, but there is no information on how endogenous CCK alters synaptic properties. (jneurosci.org)
  • Endogenous phosphorylated Mad was found in both the postsynaptic density and the nuclei of the muscles, and expression of a constitutively active Tkv increased the abundance of a green fluorescent protein (GFP)-Mad fusion protein in the nuclei. (sciencemag.org)
  • exert
  • The size of terminals was correlated with the number of mitochondria and with the number of active zones, which was highly correlated with the number of postsynaptic densities, suggesting that larger terminals exert more powerful influence on the cell than smaller terminals. (frontiersin.org)