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  • CaMKII
  • There appears to be a local organization of CaMKII, as judged by fact that the nearest-neighbor distances are nearly invariant over a wide range of labeling density for CaMKII. (jneurosci.org)
  • The average density of CaMKII holoenzymes is highly variable, ranging from zero to values approaching a tightly packed state. (jneurosci.org)
  • It has been shown that there is an increase in CaMKII activity directly in the post synaptic density of dendrites after LTP induction, suggesting that activation is a direct result of stimulation. (wikipedia.org)
  • After LTP induction, CaMKII moves to the postsynaptic density (PSD). (wikipedia.org)
  • potentiation
  • In nondeprived animals, PSD-95-GFP produces no additional potentiation, indicating common mechanisms between PSD-95-mediated potentiation and experience-driven synaptic strengthening. (jneurosci.org)
  • dendritic
  • These results indicated that CSPs exhibit area-specific modifications on an otherwise conserved synaptic organization, and that different afferents innervate M1-CSP dendritic domains in a source-specific manner. (jneurosci.org)
  • Some changes in functional state may involve rapid changes of structural connectivity at the synaptic level, as has been elucidated by two-photon imaging experiments showing the rapid appearance and disappearance of dendritic spines (Bonhoeffer and Yuste, 2002). (wikipedia.org)
  • Generally, excitatory postsynaptic potentials (EPSPs) from synaptic activation are not large enough to activate the dendritic voltage-gated calcium channels (usually on the order of a couple milliamperes each) so backpropagation is typically believed to happen only when the cell is activated to fire an action potential. (wikipedia.org)
  • presynaptic
  • This can lead to changes in the synapse's excitability, for example by presynaptic inhibition of neurotransmission, or modulation and even induction of postsynaptic responses. (wikipedia.org)
  • Their action can be excitatory, increasing conductance, causing more glutamate to be released from the presynaptic cell, but they also increase inhibitory postsynaptic potentials, or IPSPs. (wikipedia.org)
  • For example, one study found that Group I mGluRs are located mostly on postsynaptic parts of cells, while groups II and III are mostly located on presynaptic elements, though they have been found on both pre- and postsynaptic membranes. (wikipedia.org)
  • N-cadherins are most commonly expressed on both the presynaptic active zone and postsynaptic density (PSD) regions, and contain both extracellular Ca2+ binding domains as well as intracellular domains for binding their protein partners. (wikipedia.org)
  • This includes spike generation, a product of nonsynaptic regulation of potassium and other presynaptic ion channels, which increase the response of the excitatory postsynaptic potential through neurotransmitter release and augmentation of the action potential. (wikipedia.org)
  • brain
  • Found to be densely associated to the postsynaptic density (PSD), it has been characterised as a 188 kDa (originally thought to be 180 kDa, hence nomenclature), 1495 residues long, brain-specific protein containing 16 leucine-rich repeats (LRRs) within the 500 N-terminal residues, and one Psd95/Discs large/Zona occludens (PDZ) domain within the 200 C-terminal residues. (wikipedia.org)
  • channels
  • Results have indicated a linear increase in the density of A-type channels with increasing distance into the dendrite away from the soma. (wikipedia.org)
  • work
  • She discusses the work of Boroditsky mentioned in my Feb. 22 post , and work showing that in giving us symbols for spatial patterns, spatial language helps us carve up the world in specific ways. (dericbownds.net)