• gene
  • Whether the observed association results from linkage imbalance with other loci on chromosome 2 or other polymorphisms of the CTLA-4 gene or even from a preferential transfer and/or expression of one allele from a heterozygous mother to the fetus will be the subject of future investigations. (biomedsearch.com)
  • The gene is located in the Watson (plus) strand and is 68,968 bases in length. (wikipedia.org)
  • Commonly made in the laboratory by solid-phase chemical synthesis, these small bits of nucleic acids can be manufactured as single-stranded molecules with any user-specified sequence, and so are vital for artificial gene synthesis, polymerase chain reaction (PCR), DNA sequencing, library construction and as molecular probes. (wikipedia.org)
  • Gene polymorphism between species is much more diverse than the intraspecific polymorphism of lactoferrin. (wikipedia.org)
  • The endonuclease domain of FokI has been used in several studies, after combination with a variety of DNA-binding domains such as the zinc finger (see zinc finger nuclease), or inactive Cas9 One of several human vitamin D receptor gene variants is caused by a single nucleotide polymorphism in the start codon of the gene which can be distinguished through the use of the FokI enzyme. (wikipedia.org)
  • specificity
  • Several such enzymes have been discovered (including CEL I, T4 endonuclease VII, Endonuclease V, T7 endonuclease I). One of the commonly used enzymes is Surveyor nuclease (CEL II), which cleaves the 3′ side of both DNA strands with high specificity at sites of base substitution or insertion/deletion. (wikipedia.org)
  • temperature
  • xDNA is more stable when compared to regular DNA when subjected to higher temperature, and while entire strands of xDNA, yDNA, xxDNA and yyDNA exist, they are currently difficult to synthesize and maintain.Experiments with xDNA provide new insight into the behavior of natural B-DNA. (wikipedia.org)
  • structures
  • They are helical structures containing quandine tetrads that can form from one, two or four strands. (wikipedia.org)
  • Depending on the direction of the strands or parts of a strand that form the tetrads, structures may be described as parallel or antiparallel. (wikipedia.org)
  • These structures, formed from two separate G-rich strands, are termed bimolecular quadruplexes. (wikipedia.org)
  • change
  • This conformational change permits the fluorophore and quencher to be free of their tight proximity due to the hairpin association, allowing the molecule to fluoresce. (wikipedia.org)
  • When the nuclease is unbound to DNA, the endonuclease domain is sequestered by the DNA-binding domain and is released through a conformational change in the DNA-binding domain upon binding to its recognition site. (wikipedia.org)
  • common
  • They may have common ancestry with plant positive strand RNA viruses in supergroup 1 with potyvirus lineages, respectively A new clade (as yet unnamed) of six viruses infecting filamentous fungi has been reported. (wikipedia.org)
  • specific
  • This entry represents various uracil-DNA glycosylases and related DNA glycosylases (EC), such as uracil-DNA glycosylase, thermophilic uracil-DNA glycosylase, G:T/U mismatch-specific DNA glycosylase (Mug), and single-strand selective monofunctional uracil-DNA glycosylase (SMUG1). (wikipedia.org)
  • TDG and MBD4 are strictly specific for double-stranded DNA. (wikipedia.org)
  • members
  • It is a double-stranded RNA non-enveloped virus The members of genus Orbivirus within the Reoviridae family are arthropod borne viruses and are responsible for high morbidity and mortality in ruminants. (wikipedia.org)
  • women
  • One study suggested that TP53 codon 72 polymorphisms, MDM2 SNP309, and A2164G may collectively be associated with non-oropharyngeal cancer susceptibility and that MDM2 SNP309 in combination with TP53 codon 72 may accelerate the development of non-oropharyngeal cancer in women. (wikipedia.org)
  • remove
  • In the second step, the amplified product is attached to a streptavidin column and washed with NaOH to remove the unbiotinylated strand. (wikipedia.org)