In vivo, polyanhydrides degrade into non-toxic diacid monomers that can be metabolized and eliminated from the body. (wikipedia.org)
Polymers4
Polyanhydrides are a class of biodegradable polymers characterized by anhydride bonds that connect repeat units of the polymer backbone chain. (wikipedia.org)
Biodegradable polymers, such as polyanhydrides, are capable of releasing physically entrapped or encapsulated drugs by well-defined kinetics and are a growing area of medical research. (wikipedia.org)
Traditionally, polyanhydrides have been prepared by melt condensation polymerization, which results in high molecular weight polymers. (wikipedia.org)
Polyanhydrides are a class of hydrophobic, degradable polymers used in controlled drug delivery for 30 years. (bucknell.edu)
Class2
This slow degradation rate makes aromatic polyanhydrides less suitable for drug delivery when used as homopolymers, but they can be copolymerized with the aliphatic class to achieve the desired degradation rate. (wikipedia.org)
Polyanhydrides are a class of biomaterials that have demonstrated biocompatibility, controlled antigen release kinetics, antigen stabilization, and immune modulation, making them excellent vaccine delivery vehicles. (aiche.org)
Applications1
Other applications of polyanhydrides include the use of unsaturated polyanhydrides in bone replacement, as well as polyanhydride copolymers as vehicles for vaccine delivery. (wikipedia.org)
Degradation5
Owing to their safe degradation products, polyanhydrides are considered to be biocompatible. (wikipedia.org)
The rapid degradation and limited mechanical properties of polyanhydrides render them ideal as controlled drug delivery devices. (wikipedia.org)
This slow degradation rate makes aromatic polyanhydrides less suitable for drug delivery when used as homopolymers, but they can be copolymerized with the aliphatic class to achieve the desired degradation rate. (wikipedia.org)
Two typical materials at opposite ends of the degradation kinetics spectrum are fast-degrading polyanhydrides and slow-degrading polyesters (degradation time of the latter ranges from weeks to years). (medscape.com)
Surface and bulk modifications to photocrosslinked polyanhydrides to control degradation behavior. (ucdenver.edu)
Polymer1
The characteristic anhydride bonds in polyanhydrides are water-labile (the polymer chain breaks apart at the anhydride bond). (wikipedia.org)
Degradable1
16. Burkoth A, Anseth K.A review of Photo crosslinked polyanhydrides: In situ forming degradable networks. (ajpsonline.com)
Melt2
Polyanhydrides are synthesized using either melt condensation or solution polymerization. (wikipedia.org)
Then, we talk about a hot melt used for polyanhydrides quite a lot. (alison.com)
Term1
Polyanhydrides have been investigated as an important material for the short-term release of drugs or bioactive agents. (wikipedia.org)