Platelet function tests. Medical search. Frequent questions

The platelet GP IIb/IIIa complex mediates platelet-to-platelet interactions (platelet aggregation). (medscape.com)
Platelet aggregation testing often requires a coagulation consult with a pathologist prior to scheduling specimen collection. (unboundmedicine.com)
Functional platelet disorders affect the adhesion, activation, or aggregation of platelets and are frequently associated with excessive bleeding, often following trauma or surgery. (arupconsult.com)
further testing may include platelet aggregation tests, platelet flow cytometry, and in some cases, genetic testing. (arupconsult.com)
Bernard-Soulier syndrome (an adhesion disorder) and Glanzmann thrombasthenia (an aggregation disorder) are among the most well-recognized inherited disorders of platelet function and are severe clinical conditions. (arupconsult.com)
This interrupts one of the key steps in the pathway of platelet aggregation. (the-hospitalist.org)
The primary endpoint was assessment of platelet aggregation after stimulation with adenosine diphosphate 20 μM at 12-month follow-up. (revespcardiol.org)
A number of bleeding disorders arise as a result of mutations in the genes for proteins involved in platelet aggregation. (hindawi.com)
However, diabetic patients have significantly higher platelet aggregation and activation than non-diabetic patients, including those undergoing dual antiplatelet therapy [ 4 - 6 ]. (aging-us.com)
However, the ultimate common pathway of platelet aggregation is the activation of glycoprotein (GP) IIb/IIIa receptors present on platelet surface [ 7 - 9 ]. (aging-us.com)
Patients referred for evaluation of bleeding symptoms occasionally have a prolonged platelet function analyser (PFA) closure time , without evidence for von Willebrand disease or impaired platelet aggregation . (bvsalud.org)
Principal components analysis indicated VWF as primary explaining variable of PFA prolongation, whereas conventional platelet aggregation primarily explained the reduced thrombus parameters under shear. (bvsalud.org)
In five patients with severe microfluidic abnormalities , conventional platelet aggregation was in the lowest range of normal. (bvsalud.org)
Multiparameter assessment of whole- blood thrombus formation under shear indicates single or combined effects of low-normal VWF and low-normal platelet aggregation in these patients , suggesting a shear-dependent platelet function defect, not detected by static conventional haemostatic tests. (bvsalud.org)
Fibrinogen is an essential blood-clotting factor and is involved in a range of other functions, including platelet aggregation and smooth muscle proliferation. (cdc.gov)

We do know that if you have high platelet reactivity, you do worse. (medscape.com)
The test (or variables) used to define high platelet reactivity during treatment doesn't accurately reflect platelet function or predict clinical outcome. (jwatch.org)
No, I think the test detects the right patients - those with high platelet reactivity, who are known to have a worse prognosis. (jwatch.org)
The additional antiplatelet treatment didn't adequately correct the high platelet reactivity noted in some subjects. (jwatch.org)
We used the most potent agents available to correct the anomaly of high platelet reactivity: glycoprotein IIb/IIIa inhibitors and high doses of clopidogrel, aspirin, and (when it became available) prasugrel. (jwatch.org)
Those with high platelet reactivity using the VerifyNow assay - despite clopidogrel therapy - were randomised to either high-dose (600mg followed by daily 150mg) or standard-dose (75mg daily) clopidogrel. (bmj.com)
Translational platelet function investigations performed in the percutaneous coronary intervention (PCI)-treated population receiving clopidogrel have identified high platelet reactivity to ADP (HPR) as a major risk factor for both acute as well as long-term ischaemic event occurrence, including stent thrombosis. (lu.se)
article{583d315e-97a9-42ca-afc7-d0a569800561, abstract = {{Translational platelet function investigations performed in the percutaneous coronary intervention (PCI)-treated population receiving clopidogrel have identified high platelet reactivity to ADP (HPR) as a major risk factor for both acute as well as long-term ischaemic event occurrence, including stent thrombosis. (lu.se)

We're chasing the wrong car (i.e., treating platelet reactivity doesn't really matter). (jwatch.org)
Platelet reactivity has been used as a surrogate endpoint in many intervention studies with antiplatelet agents, and we know the limits of surrogate endpoints. (jwatch.org)
Was bedside monitoring of platelet reactivity helpful in this group? (jwatch.org)
Platelet reactivity climbed to near normal levels within 10 minutes of administration, and peak effects were sustained through the first 24 hours after administration. (the-hospitalist.org)
While Dr. Bhatt acknowledged that the number of patients in the major-bleeding subgroup was small, he noted that the reduction in platelet reactivity relative to baseline was still significant. (the-hospitalist.org)
The GRAVITAS (Gauging Responsiveness with A VerifyNow assay - Impact on Thrombosis and Safety) aimed to investigate the effect of high-dose vs standard-dose clopidogrel in patients with high on-treatment platelet reactivity after PCI. (bmj.com)
Bleeding and platelet reactivity outcomes were also analysed. (bmj.com)
The use of high-dose clopidogrel in patients with high on-treatment platelet reactivity after PCI was not associated with any improvement in clinical outcomes, despite an overall lowering in platelet reactivity. (bmj.com)
Intensive glucose control with insulin in patients with an acute coronary syndrome reduces platelet reactivity during hospitalization, compared to conventional control. (revespcardiol.org)
However, the effect of strict, long-term glucose control on platelet reactivity in these patients remains uncertain. (revespcardiol.org)
180 mg/dL), on platelet reactivity after hospital discharge in patients with an acute coronary syndrome and hyperglycemia. (revespcardiol.org)
Additionally, few studies have included longitudinal assessment of platelet function to assess a potential time-dependent relation to ischaemic event occurrence and no phase-III antiplatelet-therapy trial has included a large enough platelet function sub-study to examine the relation between on-treatment platelet reactivity, bleeding, and ischaemic event occurrence. (lu.se)

The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)
Under physiological circumstances, the resistance of the endothelial cell lining to interactions with platelets and coagulation factors prevents thrombosis. (medscape.com)
Platelet disorders lead to defects in primary hemostasis and produce signs and symptoms different from coagulation factor deficiencies (disorders of secondary hemostasis). (medscape.com)
Roche will expand its coagulation testing product line with the development of a full line of coagulation analyzers for hospital and reference laboratories. (clpmag.com)
Dade Behring Inc has signed a license agreement with Radboud University Nijmegen Medical Centre (RUNMC), giving Dade Behring the exclusive rights for a new coagulation test called the Nijmegen Hemostasis Assay (NHA). (clpmag.com)

This makes it difficult to assess platelet dysfunction in healthy or sick dogs that also have low platelet counts. (akcchf.org)
This test is commonly performed in people and there has been a much research into interpreting results from human patients with different diseases, including low platelet counts. (akcchf.org)
Reference intervals exist for healthy dogs but there is no available data on its use in dogs with decreased platelet counts. (akcchf.org)
This study is important because the effect of low platelet counts on the reliability of this platelet function test has not been studied in dogs. (akcchf.org)
This project will result in important information to help veterinary clinicians accurately assess platelet function in dogs with low platelet counts, thus ensuring proper treatment of canine patients. (akcchf.org)
Platelet counts may decrease slightly with age. (unboundmedicine.com)
Conventional units.MPV = mean platelet volume.Care must be taken when reviewing platelet counts after a blood product transfusion-documentation should clearly reflect the time and date of the last transfusion with respect to the collection time of the study. (unboundmedicine.com)
Timely identification of other more likely pathogens and access to routine laboratory testing, such as blood counts and chemistries, is essential for providing appropriate patient care. (cdc.gov)
Background: Inherited platelet disorders (IPDs) are rare diseases characterized by reduced blood platelet counts and/or impaired platelet function. (lu.se)
Platelet counts may be low. (mountsinai.org)
to reduce the risks of alloimmunization and infection, avoid platelet transfusion in older individuals whose platelet counts exceed a particular threshold (10 platelets/nL). (nih.gov)
Any history of liver or kidney disease, blood or bone marrow disease, or high or low blood platelet counts. (hoacny.com)
Laboratory findings include low white blood cell and platelet counts and elevated liver enzymes. (who.int)

We really are in a data-free zone with regard to the role of platelet-function testing in the ACS population," she said. (medscape.com)
Therefore, futher studies are needed to delineate the role of platelet function testing across the spectrum of symptomatic coronary artery disease. (lu.se)

Jobe SM, Di Paola J. Congenital and acquired disorders of platelet function and number. (medlineplus.gov)

platelet function testing is used to assist in identification of inherited or acquired platelet dysfunction or to evaluate therapeutic response to platelet-inhibiting drugs. (unboundmedicine.com)
The workup of a patient with a platelet-type bleeding pattern typically includes correlation with platelet count ( thrombocytopenia ), evaluation of platelet morphology on peripheral smear, exclusion of acquired causes of platelet dysfunction, and testing for von Willebrand disease (VWD) . (arupconsult.com)
The effect was also consistent across a broad array of prespecified subgroups, including stratifications by age, renal function, time from last dose of ticagrelor, race, and the presence of comorbidities, such as diabetes, renal dysfunction, hypertension, and history of MI. (the-hospitalist.org)
The technology has the potential to provide a more sensitive and biologically relevant readout of platelet dysfunction than traditional diagnostic methodologies. (clpmag.com)

In this case study, scientists used flow cytometry as a means of determining platelet function in neonates. (news-medical.net)

Platelet inhibition is a prerequisite for the prevention of acute or subacute thrombosis in various neurointerventional procedures such as stent placement in atherosclerotic lesions or stent-assisted coiling of aneurysms. (ajnr.org)
Platelets are anucleate cells that are important for haemostasis, thrombosis, and atherosclerotic disease. (hindawi.com)
Results Our findings indicate that the platelets in HD are dysfunctional with respect to the release of angiogenic factors and functions including thrombosis, angiogenesis and vascular haemostasis. (bmj.com)
In thrombosis, platelet activation serves as the initiation factor. (aging-us.com)

Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
Pseudo , or platelet-type , Von Willebrand disease is similar to type 2B, but the defect is in the platelets instead of in the factor. (kidshealth.org)
This test measures the amount of von Willebrand factor in your blood. (hoacny.com)
This test shows how well your von Willebrand factor works. (hoacny.com)
Common tests of von Willebrand factor (VWF) and platelet function and exome sequencing were performed. (bvsalud.org)

Testing is also warranted in infants and children with unexplained thrombocytopenia . (arupconsult.com)
Immune-mediated thrombocytopenia (ITP) in dogs is a blood disease in which the dog's immune system attacks and destroys the body's platelets. (petmd.com)

This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with other agonists in the vicinity of vessel injury, such as adenosine 5'-diphosphate (ADP), subendothelial collagen, and thrombin. (medscape.com)
The body's reaction to vessel wall injury is rapid adhesion of platelets to the subendothelium. (medscape.com)
Over 300 proteins were identified in the releasate, with a wide range of annotated biophysical and biochemical properties, in particular platelet activation, adhesion, and wound healing. (hindawi.com)
Following activation by agonists such as thrombin, platelets release storage granules and membrane vesicles that contain prothrombotic (e.g., fibrinogen), mitogenic (e.g., platelet derived growth factor), immunomodulatory (e.g., neutrophil-activating peptide 2), and adhesive (e.g., platelet endothelial cell adhesion molecule) proteins. (hindawi.com)
This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with each other to form an aggregate (see image below). (medscape.com)
In 14 PFA-only patients , compared to healthy volunteers , microfluidic tests showed significantly lower platelet adhesion and thrombus formation parameters . (bvsalud.org)

SAN FRANCISCO, CA - Physicians are far more likely to order a VerifyNow (Accumetrics) platelet-function test for their patients with acute MI if the point-of-care assay is offered to them for free, but it only modestly influences their choice of antiplatelet agent and doesn't have any effect on 30-day risk of events, including bleeding. (medscape.com)
The trial evenly randomized 100 hospitals across the US, centers that did not already routinely perform platelet-function testing for ACS patients (routinely defined as at least 30% of the time) to have the VerifyNow test provided free of charge (with encouragement to use it at least 12 hours after PCI for STEMI or NSTEMI) or to perform their usual care. (medscape.com)
Usual care, which involved 1853 patients at 50 centers, could include platelet-function testing if physicians independently chose to use it, but the study did not provide it to them free or otherwise. (medscape.com)
There were 2013 patients participating at the 50 free-testing centers. (medscape.com)
Testing was ordered for only 26 patients (1.4%) in the usual-care group but for 1336 patients (66.4%) in the free-access group. (medscape.com)
15 This study analyzed our initial experiences with this test in the management of patients undergoing various neurointerventional stent-placement procedures. (ajnr.org)
For a period of 10 months since the availability of the test in our neurovascular angiographic suite (July 2006-April 2007), 106 patients were identified, of whom 98 met inclusion criteria. (ajnr.org)
CardioExchange editors Richard Lange and David Hillis ask an ARCTIC trial investigator to discuss possible reasons why antiplatelet-drug and dosing adjustments, guided by platelet-function testing, did not improve clinical outcomes for stented patients. (jwatch.org)
A) a monitoring-guided approach of platelet-function testing in the catheterization lab with the VerifyNow assay (Accumetrics), followed by antiplatelet-drug (aspirin, clopidogrel, or prasugrel) and dosage adjustment for patients with inadequate inhibition. (jwatch.org)
aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) are common causes of abnormal platelet function, and platelet function testing may need to be deferred if patients have been taking these medications. (arupconsult.com)
On the primary reversal endpoint, which was restoration of activity on the proprietary platelet function assays Verify Now and PRUTest, a rapid restoration of platelet function was achieved in both surgical and major-bleeding patients. (the-hospitalist.org)
On the basis of the platelet function assays, the pattern of response to bentracimab was "very similar in the surgical and bleeding patients," reported Dr. Bhatt, executive director of interventional cardiovascular programs at Brigham and Women's Health, Boston. (the-hospitalist.org)
This document provides guidance for hospitals and clinical laboratories on performing routine diagnostic (non-ebolavirus) testing necessary for management and care of patients with suspected ebolavirus infection, while minimizing risk to laboratory personnel. (cdc.gov)
These patients should be isolated at a healthcare facility, in a private room and continue to undergo appropriate clinical assessment and management while determining whether ebolavirus testing is indicated. (cdc.gov)
Translational platelet research in patients with coronary artery disease: hat are the rnalor knowledge gaps? (lu.se)
However, there is no information regarding the utility of platelet function testing to predict outcomes in patients with stable coronary artery disease and in medically managed patients with acute coronary syndromes. (lu.se)
Methods We assessed the functional status of platelets by performing ELISA, western blot and RNA sequencing in a cohort of 71 patients and 68 age- and sex-matched healthy control subjects. (bmj.com)
HIV testing should be considered in the management of patients with genital ulcers, especially for those with syphilis or chancroid. (cdc.gov)
A health-care provider often must treat a patient before test results are available (even after complete testing, at least one quarter of patients with genital ulcers have no laboratory-confirmed diagnosis). (cdc.gov)
Pathological events in platelets of Wiskott-Aldrich syndrome patients. (msdmanuals.com)
The antigenic target in most patients appears to be the platelet GP IIb/IIIa complex. (medscape.com)
Multiparameter platelet function analysis of bleeding patients with a prolonged platelet function analyser closure time. (bvsalud.org)
The aim of this study was to establish a shear-dependent platelet function defect in these patients . (bvsalud.org)

Exclusion criteria were the following: 1) unclear antiplatelet medication history, 2) platelet count lower than 150 × 10 3 /μL, and/or 3) hematocrit level lower than 33% at the time of admission. (ajnr.org)
Platelet count is part of a CBC, one of the most requested laboratory studies, and is included in the Anemia profile, Complete Blood Count, General Health panel, and Obstetric panel. (unboundmedicine.com)
There are no food, fluid, activity, or medication restrictions unless by medical direction for platelet count. (unboundmedicine.com)
Initial laboratory testing for a functional platelet disorder includes a CBC with platelet count and a peripheral smear. (arupconsult.com)
Many tests are designed to determine the number of erythrocytes and leukocytes in the blood, together with the volume, sedimentation rate, and hemoglobin concentration of the red blood cells ( blood count ). (britannica.com)
Platelet count when evidence of increased bleeding tendency (bruising, petechiae) occurs. (nih.gov)
Laboratory results showed an erythrocyte sedimentation rate of 99 mm/h, a leukocyte count of 9480 /mm3 with 49% neutrophils and 32% lymphocytes, a haemoglobin level of 11.8 g/dL and a platelet count of 348 000 /mm3. (who.int)

We further performed haemostasis and platelet depletion tests in the R6/2 HD mouse model. (bmj.com)

Eligibility level for platelets may not be reached by transfusion. (knowcancer.com)

Platelet surface glycoprotein (GP) receptor expression. (unboundmedicine.com)
Platelet surface glycoprotein expression = Normal (Some laboratories report Greater Than or Equal to 70.0%) Abnormal findings may be supplemented with an interpretation by a pathologist. (unboundmedicine.com)
In conclusion, EMP-PDI promotes early platelet activation through glycoprotein (GP) IIb/IIIa receptors present on platelet surface in the diabetic state. (aging-us.com)

A previous study from our laboratory using a MuDPIT (multidimensional protein identification technology) approach identified over 300 proteins secreted by platelets upon thrombin activation [ 1 ]. (hindawi.com)
This test method involves measuring the rate of fibrinogen to fibrin conversion in diluted sample under the influence of excess thrombin. (cdc.gov)

The test results were reported as aspirin-reaction unit (ARU) for aspirin and P2Y 12 reaction units (PRU), baseline (BASE), and percentage inhibition for the P2Y 12 assay and were summarized as mean ± SD of the values. (ajnr.org)
The risk of bleeding due to an overlap if a new loading dose is given should be weighed against the higher risk of a serious gap in adequate anti-platelet inhibition if just a new maintenance dose is used. (scai.org)
An acceptable P2Y12 switching strategy, in nearly all clinical situations, would consist of a loading dose of the new P2Y12 agent followed by a maintenance dose regimen to avoid any gap in adequate anti-platelet inhibition [2]. (scai.org)

We present our initial experience with a new point-of-care antiplatelet-function test (VerifyNow assay) in neurointerventional procedures. (ajnr.org)

On resting platelets, GP IIb/IIIa is unable to bind fibrinogen or vWf. (medscape.com)
The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
Fibrinogen Participants aged 40-69 years were tested. (cdc.gov)

Those observations were from a novel study presented here at TCT 2013 that gauged physicians' inclination to use the test, not just whether the test performed as advertised and made a clinical impact. (medscape.com)
The study's lead investigator, Dr Tracy Wang (Duke Clinical Research Institute, Durham, NC), told heart wire that most likely ordering the test didn't change antiplatelet therapy much because "up front, there was already a higher use of the more potent antiplatelet agents, prasugrel or ticagrelor, than clopidogrel. (medscape.com)
Do you think the results (i.e., no significant improvement in clinical outcomes with platelet-function monitoring and treatment adjustment) would be similar for the newer antiplatelet agents? (jwatch.org)
The clinical features of functional platelet disorders vary. (arupconsult.com)
Clinical teams should coordinate with STLT public health officials and CDC to assess the risk of Ebola disease based on the clinical presentation and epidemiologic risk factors to determine if ebolavirus testing is needed, and if other causes of illness should be considered (e.g., malaria). (cdc.gov)
Routine testing to monitor the patient's clinical status and diagnostic testing for other potential causes of the patient's illness should be pursued while ebolavirus testing is underway. (cdc.gov)
If a hospital facility is unable to provide appropriate clinical care and laboratory diagnostic testing for a suspect case of Ebola disease, the patient should be transferred to a facility that is able to provide appropriate management until ebolavirus testing is completed. (cdc.gov)
The diagnostic tools include clinical evaluation, platelet function tests, and molecular analyses. (lu.se)
1) describe the epidemiology, clinical manifestation, management and prevention of Zika virus disease, 2) discuss diagnostic testing for Zika virus infection and interpretation of test results, 3) articulate the importance of early recognition and reporting of cases, 4) state the recommendations for pregnant women and possible Zika virus exposure, and 5) discuss evaluation of infants with microcephaly and relationship of Zika in microcephaly. (cdc.gov)
Although ideally all of these tests should be conducted for each patient with a genital ulcer, use of such tests (other than a serologic test for syphilis) may be based on test availability and clinical or epidemiologic suspicion. (cdc.gov)

Standard- vs High-Does Clopidogrel Based on Platelet Function Testing After Percutaneous Coronary Intervention. (bmj.com)

12 , 13 Monitoring platelet function, however, has not been part of our daily practice, due to the difficulty and impracticality of laboratory testing. (ajnr.org)
Refer to the table, Laboratory Findings in Selected Inherited Functional Platelet Disorders , for additional information and a more comprehensive list of inherited functional platelet disorders. (arupconsult.com)
Laboratory testing for functional platelet disorders is appropriate in individuals with bleeding manifestations that suggest a functional platelet disorder (eg, easy bruising, prolonged bleeding following dental work or surgery, menorrhagia), particularly those with a family history of a bleeding disorder and in whom VWD has been previously excluded. (arupconsult.com)
Following consultation with local/state health departments and CDC, presumptive testing for Ebola virus (species Zaire ebolavirus) or Sudan virus (species Sudan ebolavirus) is available at select public health laboratories within the Laboratory Response Network (LRN). (cdc.gov)
Some doctors also order laboratory tests to check kidney and liver function. (healthline.com)
The laboratory tests on her discharge were normal, including erythrocyte sedimentation rate and liver function tests. (who.int)
Three months after discharge the patient remained free of symptoms, neurological examination was normal and complete laboratory tests were within normal limits with a decrease in the anti-Brucella IgM antibody titre to 50 IU/mL. (who.int)
If vitamin K deficiency is suspected in a patient with unexpected or excessive bleeding, PT is the main laboratory test indicated. (medscape.com)

What is the general diagnostic testing approach to a patient with a platelet-type bleeding pattern? (arupconsult.com)
Prior travel to an Ebola disease-affected region should not be a reason to defer diagnostic testing needed for patient care. (cdc.gov)
Your doctor may do a variety of diagnostic tests. (healthline.com)
We established a method to assess the platelet phenotype on blood smears using immunofluorescence microscopy as a diagnostic tool for IPDs. (lu.se)
Your vet will then perform a physical examination and likely recommend diagnostic testing. (petmd.com)
A range of diagnostic tests have been developed to confirm the presence of the virus. (who.int)

These tests can be used to assess liver functions or liver injury. (medicinenet.com)
Serum electrolytes, blood urea nitrogen, and creatinine to assess kidney function per nephrologist. (nih.gov)
Additional testing, such as a bone marrow biopsy and imaging techniques, including X-rays and ultrasound, can assess for other underlying causes of ITP. (petmd.com)

If lab tests don't find any abnormalities, and if you've also been under extreme stress, your doctor may suggest treatment to help you cope with fear, stress, and other emotions. (healthline.com)
Objectives Seeking to elucidate the origin of these vascular and BBB abnormalities, we studied platelets that are known to play a role in maintaining the integrity of the vasculature and thrombotic pathways linked to this, given they surprisingly contain the highest concentration of mHtt of all blood cells. (bmj.com)

Acquired platelet function defects are conditions that prevent clotting elements in the blood called platelets from working as they should. (medlineplus.gov)
Platelet function defects caused by kidney failure are treated with dialysis or medicines. (medlineplus.gov)
Using medicines as directed can reduce the risk for drug-related acquired platelet function defects. (medlineplus.gov)

This may have tempered our clinicians' response to the test results. (medscape.com)

Upon administration, bentracimab binds to free ticagrelor so that ticagrelor cannot bind to the P2Y12 platelet receptor. (the-hospitalist.org)
Whereas ticagrelor is a cyclopentyltriazolopyrimidine that directly and reversibly inhibits through allosteric modulation the platelet ADP P2Y12 receptor [1]. (scai.org)

The blood cells- erythrocytes (red blood cells), leukocytes (white blood cells), and thrombocytes ( platelets )-are suspended in the plasma with other particulate matter. (britannica.com)

When physicians did order the test, which measures the aggressiveness of platelets and can help guide the choice of an ADP-receptor inhibitor, it was usually to switch the patient from clopidogrel to a more potent drug like prasugrel (Effient, Lilly/Daiichi-Sanyo) or, sometimes, ticagrelor (Brilinta, AstraZeneca). (medscape.com)
Clopidogrel is a prodrug that needs to be converted into an active metabolite in order to be active, however wide interindividual variability has been noted both in the concentration of active metabolite and also platelet responsiveness. (bmj.com)
Platelet function was assessed with remote measurement of surface expression of P-selectin (CD62P) using commercial kits sensitive to aspirin or clopidogrel. (bmj.com)
those with an ischaemic stroke had a non-significantly higher baseline P-selectin using the clopidogrel test as compared with those with no recurrence: 626 [380, 801] versus 406 [265, 609], p=0.08. (bmj.com)

Qin R , Zhu H , Wang F , Song M , Lin P , Xing Y , Zhang W , Zhong M , Wang Z , . Platelet activation in diabetic mice models: the role of vascular endothelial cell-derived protein disulfide isomerase-mediated GP IIb/IIIa receptor activation. (aging-us.com)
The EMP-PDI content and GP IIb/IIIa expression of mice platelets were determined. (aging-us.com)
Compared with the normal diet group, the diabetic group had significantly increased plasma EMP-PDI content and accelerated platelet activation by increased GP IIb/IIIa expression. (aging-us.com)

For the other 11 forms of IPD, we describe alterations of platelet structure in 9 disorders and normal findings in 2 disorders. (lu.se)

Normal, abnormal, or various combinations of core lab study results can indicate that all is well, reveal a problem that requires further investigation with additional testing, signal a positive response to treatment, or suggest that the health status is as expected for the associated situation and time frame. (unboundmedicine.com)
The screening test is used to identify abnormal bleeding tendency. (unboundmedicine.com)
This test is done if one or more of the first three tests are abnormal. (hoacny.com)
Liver function tests were abnormal: alkaline phosphatase 1484 U/L, gamma-glutamyl-transpeptidase 443 U/L, serum glutamic oxaloacetic transaminase 134 U/L, serum glutamic pyruvic transaminase 324 U/L and lactate dehydrogenase 348 U/L. Blood urea, creatinine, total bilirubin and electrolyte levels were normal. (who.int)

Liver function tests (liver enzymes) may be high. (mountsinai.org)
This is followed by vomiting, diarrhoea, rash, symptoms of impaired kidney and liver function, and in some cases internal and external bleeding (e.g., oozing from the gums, blood in the stool). (who.int)

The initial hemostatic plug, composed primarily of platelets, is stabilized further by a fibrin mesh generated in secondary hemostasis. (medscape.com)

Platelet activation allows binding of these proteins, which bridges adjacent platelets. (medscape.com)
An initial step in detecting liver damage is a simple blood test to determine the level of certain liver enzymes (proteins) in the blood. (medicinenet.com)
Enzymes are proteins that are present throughout the body, each with a unique function. (medicinenet.com)
Here, we describe an experimental approach that fractionates proteins released from human platelets, linking bioassay activity to identity. (hindawi.com)
The presence of PEDF and involucrin, two proteins not previously reported in platelet releasate, was confirmed by western blotting. (hindawi.com)
Thus, altered or deregulated platelet function underpins many diseases, and platelet proteins are potential targets for novel therapeutic agents. (hindawi.com)
Previous proteomic studies of intact platelets have collectively identified hundreds of proteins using a variety of fractionation strategies including 2-dimensional electrophoresis (2DE), multidimensional chromatographic separations, membrane prefractionation techniques, and adsorption to combinatorial hexapeptide ligand libraries [ 1 - 6 ]. (hindawi.com)
These proteins may modulate the interaction of platelets with their local cellular environment. (hindawi.com)
This complex process involves platelets and proteins called clotting factors. (kidshealth.org)

Study components assessed cardiovascular health, pulmonary function and inflammation, kidney function, workplace exposures, and noise-induced hearing loss. (cdc.gov)

1-6 Unlike other secondary prevention interventions such as blood pressure and lipid lowering, antithrombotic antiplatelet agents are prescribed and administered without ongoing monitoring as there are no widely available, affordable, effective and validated tests of platelet function. (bmj.com)

There were no differences between groups in baseline characteristics or platelet function. (revespcardiol.org)

CYP2C19 loss-of-function (LoF) allele carriage has been associated with increased thrombotic risk in the PCI population. (lu.se)

If damaged blood vessels are not repaired quickly by the platelets, bleeding-ranging from a small bruise to serious internal hemorrhaging-can occur. (petmd.com)

Indeed, platelet releasate has previously been shown to induce endothelial cell permeability, endothelial cell chemotaxis, and corneal epithelial cell proliferation in cellular assays [ 7 - 9 ]. (hindawi.com)

The discovery of de novo gain-of-function (GOF) mutations in IL-1 activating inflammasomes (NLRP3, NLRC4, pyrin, and NLRP1) and Type-1 IFN activating viral sensors (STING, RIG-I, and IFIH1/MDA5) linked key innate immune pathways to sterile inflammation. (nature.com)
In primary, or idiopathic, ITP, there's no known reason why the immune system is destroying the body's platelets. (petmd.com)
In secondary ITP, the immune system destroys platelets in response to an underlying condition, such as cancer , infection, or toxin or drug exposure. (petmd.com)
Although dogs with ITP produce platelets normally, the platelets are destroyed by the immune system after approximately one day. (petmd.com)

Bone marrow disorders are often treated with platelet transfusions or removing platelets from the blood (platelet pheresis). (medlineplus.gov)
The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc-shaped anucleate particles for 7-10 days. (medscape.com)
Platelets are produced in the bone marrow and released into the bloodstream. (petmd.com)
This, in turn, signals the bone marrow to make new platelets. (petmd.com)
Bone alkaline phosphatase Participants aged 16-69 years were tested. (cdc.gov)

Specific tests for the evaluation of genital ulcers are listed below: -- Darkfield examination or direct immunofluorescence test for Treponema pallidum, -- Culture or antigen test for HSV, and -- Culture for Haemophilus ducreyi. (cdc.gov)
CRP present in the test sample forms an antigen-antibody complex with the latex particles. (cdc.gov)

Platelet function is somewhat impaired, suggesting that drugs such as nonsteroidal anti-inflammatory drugs or aspirin should be avoided or used with caution. (nih.gov)

The MultiplateTM platelet analyzer measures platelet function. (akcchf.org)

Diseases can affect both the number of platelets in the blood stream, as well as how well these platelets work. (akcchf.org)

The endothelial function test is noninvasive. (ucihealth.org)
The purpose of this study was to investigate the release of Endothelial microparticle (EMP)-associated protein disulfide isomerase (PDI) after endothelial cell injury induced in diabetes and the changes in platelet activation. (aging-us.com)

Functional platelet disorders are generally associated with immediate bleeding in response to surgery or trauma, whereas factor deficiencies are associated with delayed bleeding. (arupconsult.com)
The factor sticks to the platelets too well, leading to clumping of the platelets, which can cause a low platelet number. (kidshealth.org)
This test checks the clotting activity of factor VIII. (hoacny.com)
0.8 mg/L). Tests for rheumatoid factor and antinuclear antibodies, the tuberculin skin test and Wright agglutination test were all negative. (who.int)

México: hallazgo del Amblyomma cajennense influenza-like symptoms, which continued after his return naturalmente infectado en Veracruz. (cdc.gov)
Hospitals with concerns about a patient with compatible symptoms and potential epidemiologic risk factors should contact their STLT public health officials [PDF - 2 pages] as soon as possible for consultation to determine if ebolavirus testing is indicated. (cdc.gov)
Although these interactions remain to be further examined in humans, the physiological functions of taurine appear to be inconsistent with the adverse cardiovascular symptoms associated with excessive consumption of caffeine-taurine containing beverages. (researchgate.net)

Platelets contain two unique types of granules: alpha granules and dense granules. (medscape.com)

Anatomy2

Diseases4

Chemicals and Drugs24

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes8

Aggregation15

High platelet reactivity8

Reactivity12

Coagulation5

Counts13

Role of platelet-function2

Disorders of platelet function1

Dysfunction4

Flow Cytometry1

Thrombosis4

Willebrand5

Thrombocytopenia2

Adhesion6

Patients23

Count7

Haemostasis1

Transfusion1

Glycoprotein3

Thrombin2

Inhibition3

VerifyNow1

Fibrinogen3

Clinical10

Percutaneous Coronary Int1

Laboratory8

Diagnostic6

Assess3

Abnormalities2

Defects3

Clinicians1

P2Y122

Thrombocytes1

Clopidogrel4

IIIa3

Findings1

Abnormal4

Liver function2

Hemostasis1

Proteins9

Kidney function1

Antiplatelet1

Baseline1

Thrombotic1

Blood vessels1

Assays1

Immune4

Bone5

Antigen2

Aspirin1

Analyzer1

Diseases1

Endothelial2

Factor4

Symptoms3

Granules1