AnticoagulantsClopidogrelAspirinCoagulationAntiplatelet AgentsAntagonistExclPercutaneous Coronary IntReceptorTherapeuticIIIaInhibitory effectProteaseThrombinDrugsEndothelialSynthesisVascularMedicationsPlasmaSignificantlyEptifibatideDependentCompoundsSerumEnzymesWillebrandBlood cellsOralBleedingMechanismsPatientsFactorsFactorActivation
Anticoagulants2
- Bleeding with concomitant NSAIDs, anticoagulants, or platelet aggregation inhibitors. (empr.com)
- Preventive drugs-including antihypertensives, platelet aggregation inhibitors, anticoagulants, statins, and oral antidiabetics-were frequently continued until the final month of life. (ascopost.com)
Clopidogrel9
- Clopidogrel inhibits ADP mediated platelet aggregation through inhibition of the P2Y12 receptor by its active metabolite. (nih.gov)
- Thrombin induces platelet aggregation by binding to protease activated receptor-1 (PAR-1), and inhibition of PAR-1 has been evaluated in patients treated with clopidogrel to reduce ischemic events after acute coronary syndromes. (nih.gov)
- Residual PAR-1 mediated platelet aggregation may be dependent on extent of clopidogrel response. (nih.gov)
- Platelet aggregation was measured in 55 patients undergoing elective PCI at 16-24 hours after 600 mg clopidogrel loading dose by light transmittance aggregometry using ADP 20 μM and thrombin receptor agonist peptide (TRAP) at 15 μM and 25 μM as agonists. (nih.gov)
- Increasing quartiles of 20 μM ADP induced platelet aggregation after clopidogrel loading were associated with increasing levels of TRAP mediated platelet aggregation. (nih.gov)
- Non-responders to clopidogrel show increased residual platelet aggregation induced by TRAP, whereas clopidogrel responders exhibit attenuated response to TRAP. (nih.gov)
- Addition of PAR-1 antiplatelet drugs may be most effective in patients with reduced clopidogrel response and high residual TRAP mediated platelet aggregation. (nih.gov)
- Antiplatelets, such as aspirin and clopidogrel, prevent blood cells called platelets from clumping together to form a clot. (medlineplus.gov)
- Aspirin, glycoprotein (GP) IIb/IIIa inhibitors, and clopidogrel have an inhibitory effect on platelet activation and aggregation. (medscape.com)
Aspirin4
- Aspirin/dipyridamole is used in the treatment of Ischemic Stroke, Prophylaxis and belongs to the drug class platelet aggregation inhibitors . (drugs.com)
- The American Heart Association (AHA) has promulgated its Get With the Guidelines program, which involves an Internet-based checklist of discharge medications to ensure that coronary artery disease (CAD) patients are started on aspirin, beta-blockers, ACE inhibitors, and statins (if needed) in the hospital. (medscape.com)
- Aspirin and HMG-CoA reductase inhibitors may reduce plaque inflammation. (medscape.com)
- A drug combination of aspirin and dipyridamole that functions as a PLATELET AGGREGATION INHIBITOR, used to prevent THROMBOSIS and STROKE in TRANSIENT ISCHEMIC ATTACK patients. (bvsalud.org)
Coagulation5
- 70%. Severe cases exhibit abnormal coagulation, endothelial barrier disruption, and dysfunctional platelet aggregation but the underlying mechanisms remain poorly understood. (cdc.gov)
- In Sierra Leone during 2015-2018, we assessed LF patients' day-of-admission plasma samples for levels of proteins necessary for coagulation, fibrinolysis, and platelet function. (cdc.gov)
- Both hemostasis and thrombosis depend on the coagulation cascade, vascular wall integrity, and platelet response. (medscape.com)
- The patient receives nonsteroidal anti-inflammatory drugs and coagulation and platelet aggregation inhibitors drugs. (bvsalud.org)
- During the process, increased platelet aggregation and coagulation. (msdmanuals.com)
Antiplatelet Agents1
- Evidence shows that antiplatelet agents, antioxidant therapies, amino acid supplementation, angiotensin converting enzyme (ACE) inhibitors, and angiotensin-receptor blockers may be able to prevent or slow the progression of atherosclerosis. (medscape.com)
Antagonist2
- Nifedipine is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) which inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. (nih.gov)
- Magnesium is a powerful antagonist of platelet adhesion. (digitalnaturopath.com)
Excl1
- Platelet aggregation inhibitors excl. (rxwiki.com)
Percutaneous Coronary Int1
- The inhibitor is also indicated for the treatment of patients undergoing percutaneous coronary intervention (PCI), in which physicians insert a catheter to visualize and open blocked coronary arteries and may, if needed, implant a mesh tube, called a stent, to keep the artery open. (manufacturingchemist.com)
Receptor7
- P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
- Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)
- We tested a monoclonal antibody Fab fragment (c7E3) directed against the platelet glycoprotein IIb/IIIa integrin, the receptor mediating the final common pathway of platelet aggregation, to see whether it reduced the frequency of clinical restenosis. (duke.edu)
- Blockade of the platelet Fc-receptor or enzymatic cleavage of IgG abolished platelet activation and aggregation. (lu.se)
- SBSEC mediates platelet aggregation in an IgG and IgG-Fc-receptor dependent manner. (lu.se)
- The Fc-IgG-receptor pathway was shown essential for platelet activation and aggregation. (lu.se)
- It adds SBSEC to a group of bacteria that activate and aggregate platelets via the platelet Fc-receptor. (lu.se)
Therapeutic1
- Bacterial activation of platelets through this pathway is common for many bacteria causing IE and could be a potential therapeutic target for the prevention and treatment of this infection. (lu.se)
IIIa2
- Current or planned administration of another parenteral GP IIb/IIIa inhibitor. (globalrph.com)
- Scholars@Duke publication: Randomised trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of clinical restenosis: results at six months. (duke.edu)
Inhibitory effect1
- Effects of betel nut crude and pure compounds on human platelet aggregation Concentration-response curves show the inhibitory effect of (A) betel nut 70% aqueous-methanolic extract and (B) (+)-catechin, against platelet aggregation induced by agonists such as arachidonic acid (AA, 1.7 mmol/L), adenosine diphosphate (ADP, 4.3 μmol/L), platelet-activating factor (PAF, 8 nmol/L), epinephrine (20 μmol/L) and Ca2+-ionophore (10 μmol/L) in human venous blood. (jcimjournal.com)
Protease4
- Prezcobix (darunavir and cobicistat) is a combination of a human immunodeficiency virus ( HIV -1) protease inhibitor and a CYP3A inhibitor and is indicated for the treatment of HIV-1 infection in adult patients. (rxlist.com)
- Darunavir is an inhibitor of the human immunodeficiency virus ( HIV -1) protease . (rxlist.com)
- HA719 trade name] is used for protease inhibitor-experienced patients when HIV-1 genotype testing is available. (who.int)
- See section 4.4 for advice on darunavir/ritonavir treatment in protease inhibitor-experienced patients when genotype testing is not available. (who.int)
Thrombin1
- During thrombus formation, circulating prothrombin is activated to the active clotting factor, thrombin, by activated platelets. (medscape.com)
Drugs1
- Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (online-medical-dictionary.org)
Endothelial2
- Potential cellular targets include vascular smooth muscle cells, monocyte/macrophage cell lines, platelets, and endothelial cells. (medscape.com)
- The impaired homeostasis and platelet dysfunction implicate alterations in the protein C pathway, which might contribute to the loss of endothelial barrier function in fatal infections. (cdc.gov)
Synthesis1
- He and his colleagues used the upgraded software to plan the synthesis of the platelet aggregation inhibitor imperanene and were able to shorten the synthetic route from eight steps to just three and two protections by choosing a tactical combination that included an addition and a reduction reaction. (chemistryworld.com)
Vascular2
- Thrombocytopenia is a common feature of hemorrhagic fevers and vascular permeability disorders ( 8 ), but the decrease in platelet counts in acute LF is not low enough to cause spontaneous hemorrhage. (cdc.gov)
- NO have many physilogical roles, e.g., it acts as a vascular relaxing agent a nurotransmiter and an inhibitor of platelet aggregation. (conicet.gov.ar)
Medications1
- Treprostinil is in a class of medications called vasodilators and platelet-aggregation inhibitors. (safemedication.com)
Plasma6
- Antiplatelet activity was measured in human platelet-rich plasma by using a Lumi-aggregometer while anti-AChE activity was measured spectrophotometrically in vitro. (jcimjournal.com)
- Twenty-six isolates of the four most common species and subspecies of SBSEC identified in bacteremia were collected, and interactions with platelets were investigated in platelet rich plasma (PRP) from three donors. (lu.se)
- The collagen-induced platelet aggregation of platelet-rich plasma samples from 14 healthy rabbits was measured turbidometrically using a platelet aggregometer, before and 1 hour after intravenous injection of alum. (who.int)
- L'agrégation plaquettaire induite par le collagène dans des échantillons de plasma riche en plaquettes de 14 lapins sains a été mesurée par turbidimétrie en utilisant un agrégomètre, avant et une heure après une injection intra- veineuse d'alun. (who.int)
- Washed RBCs are free of almost all traces of plasma, most white blood cells, and platelets. (msdmanuals.com)
- Fresh frozen plasma (FFP) is an unconcentrated source of all clotting factors without platelets. (msdmanuals.com)
Significantly1
- Collagen-induced platelet aggregation was significantly reduced after alum injection. (who.int)
Eptifibatide1
- Eptifibatide is a platelet aggregation inhibitor that prevents platelets from sticking together and clotting. (manufacturingchemist.com)
Dependent1
- This study reports that 22 of 26 tested isolates of different subspecies within SBSEC can induce aggregation, and that aggregation is host dependent. (lu.se)
Compounds2
- Herein, a straightforward synthetic strategy mediated by Ugi reaction was developed to synthesize novel series of compounds as tyrosinase inhibitors. (researchgate.net)
- Out of the tested compounds, none of the compounds in betel nut showed any antiplatelet effect except for catechin that was the most potent against epinephrine-induced aggregation. (jcimjournal.com)
Serum2
- Platelets and serum were treated with different inhibitors to determine mechanisms involved in platelet aggregation and activation. (lu.se)
- The capacity for bacteria-induced platelet aggregation was also shown to be transferable between donors through serum. (lu.se)
Enzymes1
- Cobicistat is a mechanism-based inhibitor of cytochrome P450 (CYP) enzymes of the CYP3A family. (rxlist.com)
Willebrand1
- Comprehensive re-evaluation of historical von Willebrand disease diagnosis in association with whole blood platelet aggregation and function. (cdc.gov)
Blood cells1
- It works by preventing certain types of blood cells, called platelets, from sticking together. (medbroadcast.com)
Oral1
- Ces résultats semblent indiquer que l'utilisation de l'alun en tant qu'antiplaquettaire oral pourrait faire l'objet d'études complémentaires, en tenant compte des effets secondaires éventuels notamment chez les patients dont la fonction rénale est altérée. (who.int)
Bleeding3
- This study investigated the in vivo effect of alum on platelet aggregation and bleeding time in rabbits. (who.int)
- contradiction in the mechanism of action of alum, we evaluated the in vivo effect of Alum (aluminium potassium sulfate) is a alum in terms of collagen-induced platelet food additive and traditional remedy used to aggregation and bleeding time. (who.int)
- FFP is ineffective in managing bleeding due to direct factor Xa inhibitors. (msdmanuals.com)
Mechanisms1
- To the best of our knowledge, this is the first study that reports on platelet interactions of SBSEC-isolates other than Streptococcus gallolyticus subspecies gallolyticus as well as the first study to report of mechanisms of platelet interaction of SBSEC-isolates. (lu.se)
Patients1
- for exchange transfusions, for patients who require cytomegalovirus-negative blood that is unavailable, and possibly for the prevention of human leukocyte antigen (HLA) alloimmunization to help prevent refractoriness to platelet transfusion (failure to achieve the target level of blood platelets after platelet transfusion). (msdmanuals.com)
Factors1
- Platelets migrate to the area of injury, where they secrete several cellular factors and mediators. (medscape.com)
Factor1
- Ac.Cr inhibited platelet aggregation induced by arachidonic acid (AA), adenosine diphosphate (ADP), platelet-activating factor (PAF), epinephrine and Ca 2+ -ionophore. (jcimjournal.com)
Activation2
- Aggregation was studied using light-transmission aggregometry and platelet activation using flow cytometry detecting. (lu.se)
- Aggregation was studied using light-transmission aggregometry and platelet activation using flow cytometry detecting surface upregulation of CD62P. (lu.se)