ThrombosisAdhesionFibrinogenThrombusProteinsWillebrandCoagulation factorsActivationHemostasisAlpha-granuleNicotineCollagenIntegrinDecreasesVitroPeripheralIncreasesHaemostasisProthromboticEndothelialInhibitionHemorrhageCholesterolIncreaseInteractionsFunctionVitaminProteinBleeding timeCellFlowResultBlood cellsRoleLevelsPlasmaModelsFormTerm
Thrombosis5
- Overall, the parallelized multiscale framework described here is demonstrated to be a promising approach for studying single-platelet resolved thrombosis at length scales that are sufficiently large to directly simulate coronary blood vessels. (frontiersin.org)
- Platelets are the primary cellular components involved in arterial thrombosis. (frontiersin.org)
- Our objective in this study was to determine the extent to which tocotrienols inhibit platelet aggregation and reduce coronary thrombosis, a major risk factor for stroke in humans. (biomedcentral.com)
- a mixture of α- + γ- + δ-tocotrienols) on in vivo platelet thrombosis and ex vivo platelet aggregation (PA) after intravenous injection in anesthetized dogs, by using a mechanically stenosed circumflex coronary artery model (Folts' cyclic flow model). (biomedcentral.com)
- Physiologically, upon platelet activation, uncontrolled propagation of thrombosis is prevented by regulating mechanisms which affect the expression and function of either platelet adhesion receptors or integrins. (biomedcentral.com)
Adhesion12
- Platelet adhesiveness is the adhesion of platelets to other structures. (wikipedia.org)
- It can be contrasted with platelet aggregation,[citation needed] which refers to the processes or factors which lead to the adhesion of platelets to other platelets. (wikipedia.org)
- METHODOLOGY/PRINCIPAL FINDINGS: In the present study we assessed static adhesion, cell spreading, granule secretion, integrin alpha(IIb)beta(3) activation and platelet aggregation in washed mouse platelets lacking PKCtheta. (cam.ac.uk)
- PKCtheta(-/-) platelets exhibited reduced static adhesion and filopodia generation on fibrinogen, suggesting that PKCtheta positively regulates outside-in signalling, in agreement with a previous report. (cam.ac.uk)
- Diagram of platelet, coagulation, and vessel- related mechanisms involved in platelet adhesion, activation and further aggregation. (web.app)
- While the expression and shedding of pro-inflammatory molecules can induce post-transfusion adverse effects, stored-dependent loss of adhesion receptors by ectodomain shedding or microvesiculation may attenuate post-transfusion adhesive functions of platelets causing their premature clearance from circulation. (biomedcentral.com)
- In its first part, the review presented here aims to describe the mechanisms involved in down-regulation of platelet adhesion receptors. (biomedcentral.com)
- The firm adhesion of platelets to the site of injury forms a monolayer which serves as a reactive site for further recruitment of free-flowing platelets. (biomedcentral.com)
- Figure 1 demonstrates different steps of platelet tethering, adhesion, aggregation and thrombus formation. (biomedcentral.com)
- a Different Stages of Platelet Adhesion to the Site of Vascular Injury. (biomedcentral.com)
- Platelets firmly adhere to the sub-endothelial matrix through the engagement of collagen receptors α2β1 and GPVI (Adhesion) . (biomedcentral.com)
- Novel integrin-dependent platelet malfunction in siblings with leukocyte adhesion deficiency-III (LAD-III) caused by a point mutation in FERMT3. (lu.se)
Fibrinogen1
- Also Read: Blood Coagulation Platelet activation in turn degranulates and releases factor V and fibrinogen, potentiating the coagulation cascade. (web.app)
Thrombus8
- Thrombus growth is a complex and multiscale process involving interactions spanning length scales from individual micron-sized platelets to macroscopic clots at the millimeter scale. (frontiersin.org)
- Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation. (cam.ac.uk)
- So, in reality, the process of platelet plugging and coagulation are occurring simultaneously rather than sequentially, with each inducing the other to form the final fibrin-crosslinked thrombus. (web.app)
- These results also indicate that intravenously administered tocotrienols were significantly better than tocopherols in inhibiting cyclic flow reductions (CFRs), a measure of the acute platelet-mediated thrombus formation. (biomedcentral.com)
- The present results indicate that intravenously administered tocotrienols inhibited acute platelet-mediated thrombus formation, and collagen and ADP-induced platelet aggregation. (biomedcentral.com)
- Tocotrienols, given intravenously, could potentially prevent pathological platelet thrombus formation and thus provide a therapeutic benefit in conditions such as stroke and myocardial infarction. (biomedcentral.com)
- Of note, in a developing thrombus further activation converts platelets from a proaggregatory to a to pro-coagulant phenotype which enables the assembly of the coagulation reaction complexes (the Tenase and Prothrombinase complex) on the cell surface, necessary for thrombin and fibrin generation. (biomedcentral.com)
- Nonetheless, physiological thrombus formation (mural thrombi) is tightly regulated to avoid excessive platelet accumulation at the injury site and vascular obstruction, the principal pathological process causing heart attacks and ischaemic stroke [ 5 ]. (biomedcentral.com)
Proteins2
- Alpha-granules are the most abundant vesicles in platelets and store proteins that promote platelet adhesiveness and wound healing when secreted during platelet activation. (orpha.net)
- Likewise, it generates pemphigus, and pemphigus foliaceus, a loss of adhesiveness between epidermal according to their clinical and histo- cells, histologically characterized by the logical manifestations and the type formation of intraepidermal blisters, a process of proteins involved5,6. (bvsalud.org)
Willebrand3
- Is the Pro-Adhesive Activity of Plasma Von Willebrand Factor Counteracted by a Physiological Inhibitor of Platelet Adhesiveness? (portlandpress.com)
- 1. Abnormal plasma levels of von Willebrand factor are accompanied by abnormal platelet function in some disease states. (portlandpress.com)
- 2. Platelet retention in glass bead columns, platelet aggregation in vitro , β-thromboglobulin and 6-oxo-prostaglandin F 1α were monitored in six normal male volunteers before and after an acute rise of von Willebrand factor, as induced by the intravenous administration of 1-deamino-8-d-arginine vasopressin (DDAVP). (portlandpress.com)
Coagulation factors3
- Several of these models make use of a continuum approach where platelets, platelet agonists, and coagulation factors are treated as chemical species that obey the convection-diffusion-reaction equation for species transport [ 11 - 15 ]. (frontiersin.org)
- When there is an injury to a blood 15 Feb 2020 The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (web.app)
- At the same time, coagulation factors aggregate on the procoagulant surface of activated platelets to consolidate the platelet plug by forming a mesh of cross-linked fibrin. (web.app)
Activation8
- Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (nih.gov)
- Platelet activation and aggregation are complex processes that depend on a variety of factors, including local blood flow conditions and the surrounding biochemical environment. (frontiersin.org)
- In turn, the structure and size of platelet aggregates affect blood flow as well as the release and transport of various biochemical species that couple back to platelet activation. (frontiersin.org)
- Although it has recently been shown that PKCtheta positively regulates outside-in signalling through integrin alpha(IIb)beta(3) in platelets, the role of PKCtheta in GPVI-dependent signalling and functional activation of platelets has not been assessed. (cam.ac.uk)
- They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. (lookformedical.com)
- Damage to vessel walls can result in hemorrhage and/or activation of platelets and coagulation. (web.app)
- Alternatively, further activation of platelets is associated with microvesiculation as a none-selective mechanism which leads to the loss of membrane- bearing receptors. (biomedcentral.com)
- In a non-physiological condition, the storage of therapeutic platelets has also shown to be associated with the unwilling activation of platelets which triggers receptors down-regulation via aforementioned different mechanisms. (biomedcentral.com)
Hemostasis1
- Coagulation and Platelet Disorders Hemostasis depends on vascular integrity, platelet numbers and function, and coagulation. (web.app)
Alpha-granule1
- In contrast, PKCtheta(-/-) platelets also exhibited markedly enhanced GPVI-dependent alpha-granule secretion, although dense granule secretion was unaffected, suggesting that PKCtheta differentially regulates these two granules. (cam.ac.uk)
Nicotine2
- Prothrombotic effects: Nicotine increases platelet adhesiveness by inhibiting prostacyclin, leading to microvascular occlusion and tissue ischemia. (medscape.com)
- Its products like nicotine increase platelet adhesiveness. (parkdentalclinics.in)
Collagen1
- Collagen is a major agonist for platelets, operating through an immunoreceptor-like signalling pathway from its receptor GPVI. (cam.ac.uk)
Integrin2
- Platelet integrin α IIb β 3 can also be modulated with a calpain-dependent proteolytic cleavage. (biomedcentral.com)
- This triggers potent inside out signals inducing ADP release from dense bodies ( Shape change & agonist release ) as well as activating platelet major integrin α IIb β 3 . (biomedcentral.com)
Decreases1
- It also decreases the adhesiveness of the blood platelets and thus breaks down blood clot. (findhealthtips.com)
Vitro1
- The inhibitory effects of α-tocopherol on platelet function in vivo and ex vivo have been well established [ 14 - 18 ], but inhibition of platelet aggregation by α-tocopherol in vitro requires non-physiologically high levels of α-tocopherol [ 14 ]. (biomedcentral.com)
Peripheral2
Increases1
- α-Tocotrienols treatment induced increases in α-tocopherol levels of 4-fold and 6-fold in plasma and platelets, respectively. (biomedcentral.com)
Haemostasis2
- Specific medical reason or under why equipoise is less androgenic and less estrogenic than haemostasis: the relation between haematocrit, bleeding time and platelet adhesiveness. (ncfy.com)
- Platelets and coagulation mutually influence each other and there are strong indications that, thanks to the interplay between platelets and coagulation, haemostasis is far more effective than the two processes separately. (web.app)
Prothrombotic1
- Moreover, tobacco smoking has been found to be associated with heightened platelet (PLT)-dependent thrombin level which will induce a prothrombotic state. (biomedcentral.com)
Endothelial1
- To investigate whether the endothelial cells of Schlemm's canal ( ECSCs) are connected to lymphatic vessels or are involved in platelet coagulation Platelet aggregation is the property of platelets to clump with each other to form a platelet plug. (web.app)
Inhibition1
- At first, platelet aggregation was considered to be the cause of the clogging, but even plasmin, which was assumed to decompose platelet aggregations, did not show obvious inhibition of the clogging. (fujipress.jp)
Hemorrhage1
- GPS may result in fatal hemorrhage especially in adulthood when platelet counts are further decreased. (orpha.net)
Cholesterol1
- Other benefits of regular exercises include maintaining healthy body weight, anti-thrombotic effects decreasing platelet adhesiveness, increased HDL cholesterol, lower risks of NIDDM as well as reduced risks of other diseases such as diabetes, heart conditions, hypertension, and osteoporosis. (madoupt.com)
Increase2
- Interestingly, tocotrienols (TRF) treatment induced a less pronounced increase in the levels of tocotrienols in plasma and platelets, suggesting that intravenously administered tocotrienols may be converted to tocopherols. (biomedcentral.com)
- Too much sugar can increase something called platelet adhesiveness, which means the ability of red blood cells to form clots. (nutracraft.com)
Interactions1
- Platelet-coagulation interactions. (web.app)
Function2
- Artikel i vetenskaplig tidskrift, Titel: Monitoring of coagulation and platelet function in paediatric cardiac surgery. (web.app)
- Platelets typically circulate in the bloodstream for 7-10 days and their principal function is to survey the inner lining of blood vessels to detect and seal any breaches in the vasculature by the creation of thrombi. (biomedcentral.com)
Vitamin1
- Effect of vitamin E on platelet aggregation in diabetic retinopathy. (vitalraadet.dk)
Protein1
- BACKGROUND: PKCtheta is a novel protein kinase C isozyme, predominately expressed in T cells and platelets. (cam.ac.uk)
Bleeding time1
- Desmopressin virtually immediately reduced bleeding time, enhanced platelet adhesiveness, and significantly increased plasma concentrations of FVIII and vWF. (lu.se)
Cell1
- Platelets are a type of blood cell. (web.app)
Flow2
- To overcome this limitation, we developed a fully three-dimensional multiscale model for platelet aggregation under flow and validated model predictions against experimental observations in prior work [ 9 ]. (frontiersin.org)
- Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions. (lu.se)
Result1
- As a result, the model has the ability to predict the structure of the clot at the resolution of an individual platelet. (frontiersin.org)
Blood cells1
- Platelets are tiny blood cells that help your body form clots to stop bleeding. (web.app)
Role1
- It then highlights the crucial role of ectodomain shedding and microvesiculation in the propagation of "platelet storage lesion" which may affect the post-transfusion efficacy of platelet components. (biomedcentral.com)
Levels3
- Next, pharmacokinetic studies were carried out and tocol levels in canine plasma and platelets were measured. (biomedcentral.com)
- As expected, α-Tocopherol treatment increased levels of total tocopherols in post- vs pre-treatment specimens (57 vs 18 μg/mL in plasma, and 42 vs 10 μg/mL in platelets). (biomedcentral.com)
- However, treatment with α-tocopherol resulted in slightly decreased levels of tocotrienols in post- vs pre-treatment samples (1.4 vs 2.9 μg/mL in plasma and 2.3 vs 2.8 μg/mL in platelets). (biomedcentral.com)
Plasma2
- tocotrienols, 2.8 vs 0.9 μg/mL in plasma and 1.28 vs 1.02 μg/mL in platelets). (biomedcentral.com)
- tocotrienols, 8.6 vs 1.7 μg/mL in plasma and 3.8 vs 3.9 μg/mL in platelets). (biomedcentral.com)
Models1
- This model falls under the class of hybrid multiscale models where blood velocity and platelet agonists are treated as continuum fields while platelets are resolved explicitly [ 2 - 10 ]. (frontiersin.org)
Form1
- If one of your blood vessels gets damaged, it sends out signals Platelet Aggregation Test A platelet aggregation test checks how well your platelets clump together to form blood clots. (web.app)
Term1
- Electron microscopy of platelets differentiates GPS from the autosomal dominant variant and from the X-linked variant described as X-linked thrombocytopenia with thalassemia, caused by mutations in GATA1 gene (see this term). (orpha.net)