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  • NEUTROPHILS
  • Up-regulation of ALOX5 may occur during the maturation of leukocytes and in human neutrophils treated with granulocyte macrophage colony-stimulating factor and then stimulated with physiological agents. (wikipedia.org)
  • histamine
  • Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions," The Journal of Allergy and Clinical Immunology , vol. 124, no. 2, pp. 307-314.e2, 2009. (hindawi.com)
  • analogs
  • Synthetic analogs of TXA2 that activate TP but are relatively resistant to spontaneous and metabolic degradation include SQ 26655, AGN192093, and EP 171, all of which have binding and activating potencies for TP similar to I-BOP. (wikipedia.org)
  • tissue
  • In 12 rabbits, we found tissue levels of platelet-activating factor measured by the release of serotonin from washed platelets to be elevated by approximately 20-fold in spinal cord injured by 25 minutes of ischemia and 2 hours of reperfusion (2.80 +/- 0.98 ng/g) compared with that in normal spinal cord (0.15 +/- 0.06 ng/g, p less than 0.01). (ahajournals.org)
  • 1993
  • Liou, H. C. and Baltimore, D. (1993) Regulation of the NF-KB/rel transcription factor and IKB inhibitor system. (springer.com)
  • human
  • In animal models and human tissues, they act through TP to promote platelet responses and stimulate blood vessel contraction. (wikipedia.org)
  • IIIa
  • Drugs that inhibit the GPIIb/IIIa receptor, e.g. eptifibatide, can also reduce or eliminate the ADP-induced platelet response. (wikipedia.org)
  • site
  • These results are the first to indicate (1) that a functional blocking anti-P-selectin mAb binds to SCR 4, a site other than the lectin-like/epidermal growth factor-like domain, and (2) that SCR domain 4 has a functional role in P-selectin-leucocyte interactions. (biochemj.org)
  • enzyme
  • As the enzyme is quite specific for monocytes and macrophages, determination of the presence of factor XIII may be used to identify and classify malignant diseases involving these cells. (wikipedia.org)
  • Adhesion
  • Both morphological changes and cytoskeletal reorganization, together with the focal adhesion development observed in HOB osteoblasts, significantly related to TiO 2 treated PLGA in which the Ti deposition method described has revealed to be a valuable tool to increase bioactivity of PLGA membranes, by combining cell nanotopography cues with the incorporation of bioactive factors. (mdpi.com)
  • protein
  • 18.Shu-Lan Qiu, Zhi-Cheng Xiao, Chun-Mei Piao, Ying-Lin Xian, Li-Xin Jia, Young-Fen Qi, Jiahuai Han, You-Yi Zhang, Jie Du: AMP-Activated Protein Kinase α2 Protects Against Liver Injury from Metastasized Tumors via Reduced Glucose Deprivation-Induced Oxidative Stress. (54doctor.net)
  • This provides a molecular tool to simultaneously track both the movement of the activated protein and its replacement with the non-activated form. (clontech.com)
  • These include enzymes called ceramide-activated Ser-Thr phosphatases (CAPPs), such as protein phosphatase 1 and 2A (PP1 and PP2A), which were found to interact with ceramide in studies done in a controlled environment outside of a living organism (in vitro). (wikipedia.org)
  • On the other hand, studies in cells have shown that ceramide-inducing agents such as tumor necrosis factor-alpha α (TNFα) and palmitate induce the ceramide-dependent removal of a phosphate group (dephosphorylation) of the retinoblastoma gene product RB and the enzymes, protein kinases B (AKT protein family) and C α (PKB and PKCα). (wikipedia.org)
  • also termed Pre-mRNA 3'-end-processing factor FIP1) is a protein that in humans is encoded by the FIP1L1 gene (also known as Rhe, FIP1, and hFip1). (wikipedia.org)
  • In APS there are also antibodies binding to Protein S, which is a co-factor of protein C. Thus, anti-protein S antibodies decrease protein C efficiency. (wikipedia.org)
  • Factor IXa, in turn, activates factor X. Inhibitors of factor XIa include protein Z-dependent protease inhibitor (ZPI, a member of the serine protease inhibitor/serpin class of proteins), which is independent of protein Z (its action on factor X, however, is protein Z-dependent, hence its name). (wikipedia.org)
  • Inflammation
  • 13.Yina Wu, Yulin Li, Congcong Zhang, Xi A, Yueli Wang, Wei Cui, Huihua Li, Jie Du: S100a8/a9 Released by CD11b+Gr1+ Neutrophils Activates Cardiac Fibroblasts to Initiate Angiotensin II-Induced Cardiac Inflammation and Injury. (54doctor.net)
  • Besides reducing pain and inflammation, aspirin and, to a lesser extent, other NSAIDs interfere with cells in the blood called platelets, which facilitate clotting. (oakhillhospital.com)
  • Inflammation is stimulated by chemical factors released by injured cells and serves to establish a physical barrier against the spread of infection, and to promote healing of any damaged tissue following the clearance of pathogens. (wikipedia.org)
  • growth
  • Proliferation of vessel-forming endothelial cells is a limiting factor for tumor growth [ 4 - 7 ]. (hindawi.com)
  • In humans, an interstitial chromosomal deletion of about 800 kilobases at 4q12 deletes the CHIC2 gene (i.e.cysteine rich hydrophobic domain 2 gene) to create an in-frame fusion of the FIP1L1 gene with the platelet-derived growth factor receptor alpha gene (PGDFRA) gene. (wikipedia.org)
  • FIP1L1 gene fusions between it and either the platelet-derived growth factor receptor, alpha (PGDFRA) or Retinoic acid receptor alpha (RARA) genes are causes of certain human diseases associated with pathologically increased levels of blood eosinophils and/or Leukemias. (wikipedia.org)
  • vascular
  • If the vascular age exceeds the patient's chronological age, it alerts us to be more aggressive at controlling those risk factors associated with heart disease for this patient. (ndnr.com)
  • It also regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion, and regulates matrix metalloproteinase-9 activity after intracerebral hemorrhage. (wikipedia.org)
  • The mechanotransduction of these physical cues to endothelial and smooth muscle cells in the vascular wall can also trigger the promotion or repression of certain genes which are responsible for vasodilation, cell alignment, and other shear stress-mitigating factors. (wikipedia.org)
  • cell
  • These factors vary by cell type and gestational age and can be affected by changes to the in utero environment and maternal immunity. (jci.org)
  • It is present in plasma, platelets, and monocytes, as well as macrophages and bone marrow precursors of these cell types. (wikipedia.org)
  • Ceramide was also shown to activate PKCζ, implicating it to the inhibition of AKT, regulation of the voltage difference between the interior and exterior of the cell (membrane potential) and signaling functions that favor apoptosis. (wikipedia.org)
  • blood
  • Factor XIII has two forms: a plasmatic form that flows freely in the blood plasma, and a cellular form carried inside platelet alpha-granules. (wikipedia.org)
  • citation needed
  • citation needed] FXIII is also known as Laki-Lorand factor, after Kalman Laki and Laszlo Lorand, the scientists who first proposed its existence in 1948. (wikipedia.org)
  • Risk factors for developing antiphospholipid syndrome include:[citation needed] Primary APS genetic marker HLA-DR7 Secondary APS SLE or other autoimmune disorders Genetic markers: HLA-B8, HLA-DR2, HLA-DR3 Race: Blacks, Hispanics, Asians, and Native Americans There is an additional elevated risk of adrenal gland bleeds leading to Waterhouse-Friderichsen syndrome (Neisseria meningitidis caused primary adrenal insufficiency). (wikipedia.org)
  • levels
  • Factor XIII levels are not measured routinely, but may be considered in patients with an unexplained bleeding tendency. (wikipedia.org)
  • Low levels of factor XI also occur in many other disease states, including Noonan syndrome. (wikipedia.org)
  • High levels of factor XI have been implicated in thrombosis, although it is uncertain what determines these levels and how serious the procoagulant state is. (wikipedia.org)
  • journal
  • Periodontal infection as a possible risk factor for preterm low birth weight," Journal of Periodontology , vol. 67, no. 10, pp. 1103-1113, 1996. (hindawi.com)
  • highly
  • The formation of a highly plastic provisional matrix facilitates leukocyte infiltration and activates infarct myofibroblasts. (jci.org)
  • expression
  • Factors that act upon the ABCA1 transporter's expression or its posttranslational modification are also molecules that are involved in its subsequent function like fatty acids, cholesterol and also cytokines and cAMP. (wikipedia.org)
  • risk
  • Assessing cardiovascular risk factors is always part of the naturopathic intake. (ndnr.com)
  • Not only do they have similar risk factors but, more importantly, the relationship between the atherosclerotic burden in a carotid artery and in a coronary artery is the same as between any two coronary arteries. (ndnr.com)
  • Early
  • Analysis of bronchoalveolar lavage (BAL) fluid from patients with ARDS has shown increased numbers of activated neutrophils in the early stages of ARDS. (bmj.com)
  • action
  • This poly-adenylyl action increases pre-mRNA's maturation and movement from the nucleus to cytoplasm while also increasing the stability of the mRNA formed from pre-mRNA: FIP1L1 is a Pre-mRNA 3'-end-processing factor. (wikipedia.org)
  • function
  • This is dictated by genetic factors and has no inherent function other than to lay down the preliminary outline of the circulatory system. (wikipedia.org)