• Amyloid deposits in pituitary adenomas. (nih.gov)
  • Two different types of amyloid deposits in pituitary adenomas are described herein. (nih.gov)
  • Pituitary adenomas (PA) are commonly occurring benign neoplasms. (cancerindex.org)
  • Despite the advancement of microsurgical and endoscopic techniques, some nonfunctioning pituitary adenomas (NFPAs) can be difficult to cure. (cns.org)
  • Should patients with recurrent or residual nonfunctioning pituitary adenomas (NFPAs) undergo stereotactic radiosurgery (SRS), fractionated radiation therapy (eg, XRT, fractionated stereotactic radiotherapy [SRT], or intensity modulated radiotherapy[IMRT]), or repeat resection? (cns.org)
  • These recommendations apply to adult patients with recurrent or residual nonfunctioning pituitary adenomas (NFPAs). (cns.org)
  • Approximately 85% of masses from this region are pituitary adenomas, followed in incidence by craniopharyngioma, Rathke cleft cyst, meningioma, and metastasis. (cap.org)
  • In the 2017 World Health Organization Classification of Tumours of Endocrine Organs , pituitary adenomas remain classified by hormone expression as assessed by IHC staining. (cap.org)
  • A third transcription factor, pituitary cell-restricted T box factor (Tpit), drives corticotroph adenomas but its antibody is not yet commercially available as an IHC marker. (cap.org)
  • Why should the pathologist subtype pituitary adenomas? (cap.org)
  • The microscopic technique is a traditional and well-established procedure that has been successfully applied for removal of pituitary adenomas. (scielo.br)
  • The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. (embl.de)
  • Most astrocytomas (9/13), ependymomas (5/5), glioblastoma multiforme (GBM) (11/12), schwannomas (19/21), meningiomas (22/23) and breast carcinoma metastases (Br-Mt) (9/10), and some medulloblastomas (5/15), primitive neuroectodermal tumors (PNETs) (5/11), pituitary adenomas (4/7) and lung carcinoma metastases (6/11), but none of 10 oligodendrogliomas had tumor cells that expressed one or more (up to five) srp's. (elsevierpure.com)
  • The mean PCNA-labeling index (LI) also varied, ranging from 1.2% in the group of pituitary adenomas to 24.5% in Br-Mts, with GBMs (20.4%) and medulloblastomas (18.4%) approaching the latter value. (elsevierpure.com)
  • The molecular mechanisms governing the pathogenesis of ACTH-secreting pituitary adenomas are still obscure. (unisr.it)
  • A recent study from investigators at Chongqing University in China explored the involvement of three viruses in the progression of pituitary adenomas (PA). (hhv-6foundation.org)
  • The authors suggest that the HPV-16 and HHV-6 viruses activate the TLR3/ NF-kB signaling pathway which in turn contributes to the progression and proliferation of invasive pituitary adenomas. (hhv-6foundation.org)
  • Pituitary adenomas are neoplasms in the anterior pituitary and are associated with conditions such as acromegaly (an overproduction of growth hormone), Cushing's syndrome (excessive production of cortisol), and diabetes insipidus (a reduction in the production of antidiuretic hormone). (hhv-6foundation.org)
  • Fractionated radiotherapy (FRT) and gamma knife stereotactic radiosurgery (GKSRS) are used as adjuvant therapies to surgical resection for functional and non-functional pituitary adenomas, although their optimum role in the treatment algorithm, as well as long-term safety and efficacy, still awaits further study. (elsevierpure.com)
  • These results are presented with a review of the relevant literature on the differential characteristics of FRT versus SRS in the treatment of functional and non-functional pituitary adenomas and validate postoperative irradiation as a potentially safe and effective means for tumor control. (elsevierpure.com)
  • We used bilateral inferior petrosal sinus sampling (BIPSS), the gold standard in diagnosing pituitary sources of CD, to obtain central blood samples for in vivo metabolomic analysis of pathways involved in pituitary adenomas. (broadinstitute.org)
  • Following Bonferroni correction for multiple comparisons, three small compound biomarkers of CD (pyridoxate, deoxycholic acid, and 3-methyladipate) were identified to be significantly altered in pituitary adenomas. (broadinstitute.org)
  • Exploiting the BIPSS technique, we showed a complete metabolite and lipid profile of pituitary adenomas in CD. (broadinstitute.org)
  • Headache is very common in pituitary disease and is reported to be present in more than a third of all patients with pituitary adenomas. (medscape.com)
  • [ 1 ] Headaches are frequently linked to pituitary disease, and it is generally accepted that headache is a common presenting feature of pituitary adenomas and other sellar pathologies. (medscape.com)
  • Seventeen patients with a TSH-secreting adenoma, diagnosed on the basis of detectable TSH levels in the face of high free thyroid hormone concentrations and pituitary lesion at neuroimaging, underwent pituitary surgery. (nih.gov)
  • MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7. (cancerindex.org)
  • NFPA = nonfunctioning pituitary adenoma, SRS = stereotactic radiosurgery, XRT = fractionated radiation therapy. (cns.org)
  • The diagnosis of pituitary adenoma is usually straightforward on H&E stained sections, which readily identify the monomorphic adenoma cell population. (cap.org)
  • Table 1 summarizes the transcription factors associated with each of the pituitary adenoma subtypes. (cap.org)
  • Evidence of improved surgical outcome following endoscopy for nonfunctioning pituitary adenoma removal. (scielo.br)
  • Scholars@Duke publication: Pituitary adenoma presenting as facial pain: report of two cases and review of the literature. (duke.edu)
  • METHOD: Sex-dependent differences in prevalence, age at diagnosis, diagnostic delay, pituitary adenoma size, insulin-like growth factor 1 (IGF-I) and growth hormone (GH) concentrations were estimated. (regionh.dk)
  • IGF-ISDS was significantly lower in females compared to males, whereas neither nadir GH nor pituitary adenoma size differed between males and females. (regionh.dk)
  • Serum IGF-I levels were significantly lower in female patients, whereas nadir GH, and pituitary adenoma size were comparable. (regionh.dk)
  • Identification of small compound biomarkers of pituitary adenoma: a bilateral inferior petrosal sinus sampling study. (broadinstitute.org)
  • Finally, we screened for published case reports on pituitary adenoma, pituitary apoplexy, Rathke's cleft cyst, craniopharyngioma and hypophysitis. (medscape.com)
  • Overview of the 2022 WHO Classification of Pituitary Tumors. (nih.gov)
  • We conducted a systematic review and meta-analysis of randomized and non-randomized controlled trials that compared pure endoscopic with microscopic transsphenoidal surgery (TSS) in the resection of pituitary tumors. (scielo.br)
  • Transsphenoidal surgery (TSS) is the treatment of choice for most functioning and nonfunctioning pituitary tumors. (scielo.br)
  • In the 1990s, a distinct impulse came from the otorhinolaryngologists, with the use of the endoscope in functional endoscopic sinus surgery, disclosing the pathway to the sella turcica and the endoscopic approach for resection of pituitary tumors either alone or as an adjunct to the microneurosurgery. (scielo.br)
  • Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. (embl.de)
  • Background: Subchronic administration of the potent pharmaceutical estrogen diethylstilbestrol (DES) to female Fischer 344 (F344) rats induces growth of large, hemorrhagic pituitaries that progress to tumors. (utmb.edu)
  • Female rats had a higher incidence of pituitary tumors than males. (cdc.gov)
  • Diagnosis is augmented by reticulin staining, which allows identification of loss of normal pituitary acinar architecture. (cap.org)
  • Height of normal pituitary gland as a function of age evaluated by magnetic resonance imaging in children. (thejcdp.com)
  • In this study, we report that bone morphogenetic protein-4 (BMP-4) is expressed in the corticotrophs of human normal adenohypophysis and its expression is reduced in corticotrophinomas obtained from Cushing's patients compared with the normal pituitary. (unisr.it)
  • The empty sella syndrome is usually associated with normal pituitary function. (unboundmedicine.com)
  • AU - Coulson,C J, AU - Siddiq,M A, AU - Johnson,A P, PY - 2007/12/12/pubmed PY - 2008/5/2/medline PY - 2007/12/12/entrez SP - 623 EP - 5 JF - British journal of neurosurgery JO - Br J Neurosurg VL - 21 IS - 6 N2 - The empty sella syndrome is usually associated with normal pituitary function. (unboundmedicine.com)
  • The pituitary tumour transforming gene (PTTG), also known as securin, is a mitotic checkpoint protein which inhibits sister chromatid separation during mitosis. (birmingham.ac.uk)
  • Other specified malignant neoplasm (Other specified cancer tumour Other codes are obsolete, ie the entities have been in the previous edition). (who.int)
  • The majority (86%) of hyperthyroid patients normalized thyroid hormone concentrations and regained euthyroidism, although pituitary imaging, alpha-subunit, and alpha-subunit/TSH molar ratio normalized in only 47%, 54%, and 58% of patients, respectively. (nih.gov)
  • However, normalization of thyroid function alone does not necessarily reflect complete removal of the tumor, and more comprehensive criteria of cure based on pituitary imaging, hormone measurement, and suppression of TSH during T3 administration should be used. (nih.gov)
  • Neoplasms of the hypothalamus frequently originate from adjacent structures, including the OPTIC CHIASM , optic nerve (see OPTIC NERVE NEOPLASMS ), and pituitary gland (see PITUITARY NEOPLASMS ). (nih.gov)
  • The release of these pituitary hormones is mediated by hypothalamic neurohormones that are secreted from the median eminence (a site where axon terminals emanate from the hypothalamus) and that reach the adenohypophysis via a portal venous system. (medscape.com)
  • The infundibulum pierces the diaphragma sellae in order to connect the pituitary to the hypothalamus. (medscape.com)
  • Experience in the SEER registries has shown that using the Supplemental List increases casefinding for benign brain and CNS, hematopoietic neoplasms, and other reportable diseases. (cancer.gov)
  • Small pituitary fossa in Cushing's syndrome due to adrenal neoplasm. (thejcdp.com)
  • The hypothalamic-pituitary-adrenal (HPA) axis is responsible for many body functions in mammals. (bvsalud.org)
  • Once excited, the PVN produces the neuropeptide corticotropin-releasing factor (CRF), which travels through the hypophyseal portal system and stimulates the adrenal and pituitary glands to produce many neurotransmitters. (bvsalud.org)
  • A condition when the SELLA TURCICA is not filled with pituitary tissue. (mcw.edu)
  • Kjær I. Sella turcica morphology and the pituitary gland-a new contribution to craniofacial diagnostics based on histology and neuroradiology. (thejcdp.com)
  • The pituitary gland is enveloped by dura and sits within the sella turcica of the sphenoid bone. (medscape.com)
  • The sella turcica is a saddle-shaped depression that surrounds the inferior, anterior, and posterior aspects of the pituitary. (medscape.com)
  • Hypersecretion of other pituitary hormones was diagnosed in 5 of 17 patients. (nih.gov)
  • Often referred to as the "master gland", the pituitary gland synthesizes and releases various hormones that affect several organs throughout the body (see the images below). (medscape.com)
  • Hormones secreted by adenohypophysis (anterior pituitary). (medscape.com)
  • Hormones secreted by neurohypophysis (posterior pituitary). (medscape.com)
  • The adenohypophysis constitutes roughly 80% of the pituitary and manufactures an array of peptide hormones. (medscape.com)
  • These hypothalamic cell bodies produce hormones that undergo axonal transport through the pituitary stalk and into terminal axons within the neurohypophysis. (medscape.com)
  • A neoplasm that arises from the anterior or posterior lobe of pituitary gland and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. (nih.gov)
  • The pituitary gland is entirely ectodermal in origin but is composed of 2 functionally distinct structures that differ in embryologic development and anatomy: the adenohypophysis (anterior pituitary) and the neurohypophysis (posterior pituitary). (medscape.com)
  • The lesions responsible for the disruption of ADH synthesis or secretion in hypophyseal diabetes insipidus include large pituitary neoplasms (endocrinologically active or inactive), a dorsally expanding cyst or inflammatory granuloma, and traumatic injury to the skull, with hemorrhage and glial proliferation in the neurohypophyseal system. (merckvetmanual.com)
  • Unspecified/other malignant neoplasm of skin of upper limb, incl. (cancer.gov)
  • The data presented in this edition of Cancer Incidence in Five The CI5 data include all invasive malignant neoplasms and Continents (CI5) are mainly organised according to anatomical some non-invasive malignant neoplasms For most morphology site However, for some sites, the histological type of cancer codes, a fifth digit /1 or /2 automatically excludes the data entry. (who.int)
  • The main structure of the histological grouping is that Morphology codes specific types of malignant neoplasms are listed as wel as Grouping of morphological codes presents several difficulties. (who.int)
  • Identification of molecular pathway resulting in pituitary tumorigenesis remains challenges in endocrine oncology. (cancerindex.org)
  • The pituitary gland is a pea-sized endocrine gland that sits at the base of the brain. (medscape.com)
  • During the course of his workup , an MRI of the brain was performed, which showed a pituitary/sellar mass. (symptoma.com)
  • In the following systematic review, we address the literature on headache and pituitary disorders with regard to prevalence, aetiology, pathophysiological mechanisms and treatment. (medscape.com)
  • Whereas in pituitary apoplexy a mechanical component explains the almost universal association of the condition with headaches, this correlation is less clear in other forms of pituitary disease and a positive impact of surgery on headaches is not guaranteed. (medscape.com)
  • Undoubtedly Goliath's great size was due to ** **acromegaly ** **secondary to a pituitary macroadenoma. (serdarbalci.com)
  • The present review attempts to systematically review the literature for any combination of headache and pituitary or hormone overproduction or deficiency. (medscape.com)
  • MEN 1 involves parathyroid, pancreatic, and pituitary neoplasms. (medscape.com)
  • The incidence of lung neoplasms was 19/59, or 32 percent, for those animals examined after 53 weeks of the study. (cdc.gov)
  • Plain film and tomographic assessment of the pituitary fossa in 140 acromegalic patients. (thejcdp.com)
  • Comparative inpatient resource utilization for patients undergoing endoscopic or microscopic transsphenoidal surgery for pituitary lesions. (scielo.br)
  • Phytoestrogens neither changed any wet organ weight (uterus, ovary, cervix, liver, and kidney) after 10 weeks of treatment, nor reversed the adverse effects of DES on pituitaries, GH and PRL levels, or body weight gain after 8 weeks of co-treatment. (utmb.edu)
  • The lateral aspects of the pituitary are adjacent to the cavernous sinuses (see the image below). (medscape.com)