• Our lab has demonstrated an important role of the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) in stress and emotional behavior. (uvm.edu)
  • PACAP is important in the control of endocrine and homeostatic processes, such as secretion of pituitary and gut hormones and food intake. (childrensmercy.org)
  • Pituitary adenylate cyclase-activating polypeptide (PACAP) is a naturally occurring peptide found in the central nervous system that plays a role in somatosensory processing and activation of protein kinase A (PKA) and protein kinase C (PKC). (uky.edu)
  • Pituitary adenylate cyclase activating polypeptide (PACAP) is a multifunctional peptide having neuroprotective, antiapoptotic, antioxidant, cytoprotective and cardioprotective effects. (hungarica.eu)
  • Pituitary adenylate cyclase-activating polypeptide ( PACAP ) is a neuropeptide with widespread occurrence and diverse functions. (bvsalud.org)
  • The primary structure of frog pituitary adenylate cyclase‐activating polypeptide (PACAP) has recently been determined and the results show that the sequence of PACAP has been highly conserved during evolution. (uaeu.ac.ae)
  • The adenylate cyclase‐stimulating activity of PACAP was tested by using a static incubation technique for hypothalamic slices. (uaeu.ac.ae)
  • The discrete localization of PACAP immunoreactivity in the brain and the adenylate cyclase‐stimulating activity of PACAP27 on frog hypothalamic slices suggest that PACAP acts as a neurotransmitter or neuromodulator in the brain of amphibians. (uaeu.ac.ae)
  • Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the vasoactive intestinal peptide/secretin/glucagon family , has an amino acid sequence identity of 68% with vasoactive intestinal polypeptide (VIP). (eurogentec.com)
  • The pituitary adenylate cyclase-activating polypeptide/adenylate cyclase-activating polypeptide 1 (pituitary) ( PACAP/ADCYAP1 ) gene maps to this region. (lww.com)
  • PACAP is pituitary adenylate cyclase-activating polypeptide, which has similar biological actions as CGRP but with additional actions. (medscape.com)
  • The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) and their receptors are linked to migraine neurobiology. (iasp-pain.org)
  • At one time, investigators had analyzed compounds called pituitary adenylate cyclase activating polypeptide (PACAP) analogs for their potential anti-cancer effects. (ichelp.org)
  • A hormone known as pituitary adenylate cyclase-activating polypeptide (PACAP) could be responsible for women succumbing to PTSD more often than men. (recoveryranch.com)
  • Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide, which was originally isolated from the ovine hypothalamus and reportedly has diverse biological functions. (scite.ai)
  • Bi-directional effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on fear-related behavior and c-Fos expression after fear conditioning in rats. (ucsf.edu)
  • Pituitary adenylate cyclase-activating polypeptide (PACAP) promotes both survival and neuritogenesis in PC12 cells through activation of nuclear factor ?B (NF-?B) pathway: involvement of extracellular signal-regulated kinase (ERK), calcium, and c-REL. (genscript.com)
  • PACAP promotes both survival and neuritogenesis in PC12 cells by activating NF-kappaB pathway, most likely via classical and alternative signaling cascades involving ERK1/2 kinases, Ca(2+), and c-Rel/p52 dimers. (genscript.com)
  • Here, we present structures of peptide and Gs-bound pituitary adenylate cyclase-activating peptide, PAC1 receptor, and corticotropin-releasing factor (CRF), (CRF1) receptor. (nih.gov)
  • The human receptor protein is encoded by the FPR2 gene and is activated to regulate cell function by binding any one of a wide variety of ligands including not only certain N-Formylmethionine-containing oligopeptides such as N-Formylmethionine-leucyl-phenylalanine (FMLP) but also the polyunsaturated fatty acid metabolite of arachidonic acid, lipoxin A4 (LXA4). (wikipedia.org)
  • Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7. (uchicago.edu)
  • We found that LPBn neurons are activated following both acute and chronic stressor exposure and that a portion of those neuron project to the BNST. (uvm.edu)
  • Evans and associates identify a crucial role for leptin in controlling the onset of female puberty in pituitary adenylate cyclase-activating polypeptide-expressing neurons. (endocrine.org)
  • Ergotamine and its derivatives work by activating the 5-HT1D receptors, causing vasoconstriction of intracranial blood vessels and inhibiting the release of inflammatory neuropeptides. (pharmacytimes.com)
  • Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
  • This graph shows the total number of publications written about "Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide" by people in this website by year, and whether "Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide" was a major or minor topic of these publications. (ouhsc.edu)
  • Below are the most recent publications written about "Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide" by people in Profiles. (ouhsc.edu)
  • This is a "connection" page, showing publications Graeme Bell has written about Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I. (uchicago.edu)
  • Although first isolated from hypothalamic extracts and named for its action on the pituitary, it is widely distributed in the central and peripheral nervous systems. (childrensmercy.org)
  • describe second generation programming of the hypothalamic - pituitary - adrenal axis of male rat offspring by a maternal high-fat diet. (endocrine.org)
  • However, FPR2 also mediates responses to a wide range of polypeptides and proteins which may serve to promote inflammation or regulate activities not directly involving inflammation. (wikipedia.org)
  • For example, in response to a stressful situation, the pituitary gland may release beta endorphin and ACTH, which, in turn, prompt the suprarenal cortex to release hormones. (medscape.com)
  • In non- reproductively active males, brain gonadotropin releasing hormone 1 (GnRH1) and pituitary β subunit of gonadotropins (GtHs) and prolactin (PRL) mRNA levels were significantly higher in males maintained in underground water. (scirp.org)
  • The pituitary gland produces the largest number of different hormones and, therefore, has the widest range of effects on the body's functions. (medscape.com)
  • The anterior pituitary, often called the "master gland," responds to chemical messages from the bloodstream to produce numerous hormones that trigger the action of other endocrine glands. (medscape.com)
  • Association analysis of the pituitary adenylate cyclase-acti. (lww.com)
  • Hyposomatotropism is a deficiency in the release of pituitary growth hormone (somatotropin), resulting in short stature. (medscape.com)
  • The parasympathetic neurotransmitters, pituitary adenylate cyclase activating peptide-38 (PACAP38) and vasoactive intestinal peptide (VIP) may be released from parasympathetic fibres and activate sensory nerve fibres during migraine attacks. (regsj.dk)
  • Pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal peptide (Part 2): biology and clinical importance in central nervous system and inflammatory disorders. (nih.gov)
  • The VPAC receptors decreased MAP when both were activated with vasoactive intestinal polypeptide or when only VPAC 1 receptors were activated. (edu.au)
  • Vasoactive intestinal polypeptide (VIP) and galanin were isolated in pure form from the stomach of the European green frog, Rana ridibunda. (nebraska.edu)
  • 9. Glucagon-stimulable adenylyl cyclase in rat liver. (nih.gov)
  • 2. Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system. (nih.gov)
  • When activated by maxadilan, PAC 1 receptors increased MAP. (edu.au)
  • These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. (nih.gov)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Adenylate Cyclase Activating Polypeptide 1, Pituitary (ADCYAP1) in serum, plasma, tissue homogenates and other biological fluids. (signetlabs.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Adenylate Cyclase Activating Polypeptide 1, Pituitary (ADCYAP1) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (signetlabs.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Adenylate Cyclase Activating Polypeptide 1, Pituitary (ADCYAP1) in samples from serum, plasma, tissue homogenates or other biological fluids. (signetlabs.com)
  • Synthetic frog VIP produced a dose-dependent increase in cAMP concentration in frog anterior pituitary fragments. (nebraska.edu)
  • 4. Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism. (nih.gov)
  • Description: A sandwich ELISA kit for detection of Adenylate Cyclase Activating Polypeptide 1, Pituitary from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (signetlabs.com)
  • However, FPR2 also mediates responses to a wide range of polypeptides and proteins which may serve to promote inflammation or regulate activities not directly involving inflammation. (wikipedia.org)
  • THs secretion is controlled by the pituitary thyroid-stimulating hormone (TSH) and the hypothalamic-pituitary-thyroid (HPT) axis. (researchgate.net)
  • Hyposomatotropism is a deficiency in the release of pituitary growth hormone (somatotropin), resulting in short stature. (medscape.com)
  • Pathogenic Escherichia coli , but not nonpathogenic E. coli , activate a p50/p65 NF-κB complex that binds to oligonucleotides corresponding to a recognition site located within the 5′ flanking region of the human GAL1R gene. (jci.org)
  • We profiled ~1 million cells, identified ~70 neuronal populations characterized by distinct neuromodulatory signatures and spatial organizations, and defined specific neuronal populations activated during social behaviors in male and female mice, providing a high-resolution framework for mechanistic investigation of behavior circuits. (cngb.org)
  • It is well established that hypothalamic-pituitary-adrenal (HPA) axis dysregulation, characterized by elevated circulating cortisol concentrations and impaired negative feedback inhibition, is associated with affective disorders. (nature.com)
  • Part II: Biochemical changes after pituitary adenylate cyclase-activating polypeptide-38 infusion in migraine patients. (cdc.gov)
  • 19. Pituitary adenylate-cyclase-activating polypeptide expression in the immune system. (nih.gov)
  • One of the most important functions of the hypothalamus is to link the nervous system to the endocrine system via the pituitary gland. (slideshare.net)
  • This year, a $25,000 grant has been awarded to Dr. Anna Di Nardo, associate professor of medicine, and colleagues at the University of California - San Diego for a new study continuing their investigations into the effects of neuropeptides on mast cells and the mechanisms by which nerve cells activate mast cells to induce rosacea signs and symptoms. (rosacea.org)
  • 3. Cannabinoid inhibition of adenylate cyclase-mediated signal transduction and interleukin 2 (IL-2) expression in the murine T-cell line, EL4.IL-2. (nih.gov)
  • Pituitary adenylate cyclase-activating polypeptide is regulated by alternative splicing of transcriptional repressor REST/NRSF in nerve injury. (atlasofscience.org)
  • 18. Hyperglucagonemia and altered responsiveness of hepatic adenylate cyclase-adenosine 3',5'-monophosphate system to hormonal stimulation during chronic ingestion of DL-ethionine. (nih.gov)
  • Caesar, I bring thee word Menecrates and Menas, famous pirates, Make the sea serve them, which esp ear and wound With keels of every kind: many hot inroads They make in Italy team fortress unlocker borders maritime Lack blood to think on't, and flush youth revolt: No vessel can peep forth but 'tis as soon Spanish abroad: en el extranjero, fuera, en el la extranjero, al extranjero. (businessopad.com)