• prolongation
  • Very common (>10% frequency) side effects include: Akinesia Constipation Dizziness Dry mouth Hyperhidrosis Nocturia Somnolence Speech disorder Pimozide overdose presents with severe extrapyramidal symptoms, hypotension, sedation, QT interval prolongation and ventricular arrhythmias including torsades de pointes. (wikipedia.org)
  • The safety of pimozide has been questioned after case reports of arrhythmias, prolongation of the QTc (QT corrected for heart rate) interval, and sudden death. (bmj.com)
  • dose
  • Pimozide pretreatment produced a dose-dependent attenuation of acquisition of a lever-pressing habit motivated by food reward in hungry rats. (biomedsearch.com)
  • The mean dose of pimozide (16 studies) was 7.5 mg/day (range 1-70 mg/d in 26 studies). (bmj.com)
  • CR expression was counteracted by 1 mg/kg naloxone and was attenuated by pimozide (0.25, 0.33, and 0.4 mg/kg) in a dose-related manner. (uky.edu)
  • interaction
  • A dangerous interaction, possibly resulting in irregular heartbeats and/or death may occur if pimozide is taken with any of the medicines listed above. (npdpharmacy.net)
  • Pimozide can interact with grapefruit products, and the interaction may have dangerous effects. (npdpharmacy.net)
  • high
  • Studies were identified by searching electronic databases, the Cochrane Library (to April 1999), references of relevant studies, and high yield journals and by contacting authors and manufacturers of pimozide. (bmj.com)
  • known
  • It is also contraindicated in individuals being cotreated with SSRIs or in those with a known hypersensitivity to pimozide or other diphenylbutyl-piperidine derivatives. (wikipedia.org)