Pichinde virus Pichinde virus - 3739 [S segment: K02734, L segment: AF427517] (PICV-3739) Oryzomys albigularis, Colombia[dead link] Mahy, Brian W J (2001). (wikipedia.org)
another vector is based on Pichinde virus (PICV). (khon2.com)
The authors, which include researchers from the University of Texas Medical Branch, also reference a previous animal study which shows genistein's ability to reduce harm from Pichinde Ěvirus (PICV), an Ebola-like virus that also causes hemorrhagic fever. (beforeitsnews.com)
We have previously shown that the small matrix Z protein of LASV, but not of a nonpathogenic arenavirusPichinde virus (PICV), can inhibit the cellular RIG-I-like receptors (RLRs), but its biological significance has not been evaluated in an infectious virus due to the multiple essential functions of the Z protein required for the viral life cycle. (bvsalud.org)
IMPORTANCE Lassa virus (LASV) can cause lethal hemorrhagic fever disease in humans but other arenaviruses, such as Pichinde virus (PICV), do not cause obvious disease. (bvsalud.org)
HB-300 uses the lymphocytic choriomeningitis virus (LCMV) and pichinde virus (PICV) as arenaviral backbones, with each expressing two well-defined antigens of prostate cancer, prostatic acid phosphatase (PAP) and prostate-specific antigen (PSA). (decaturdailydemocrat.com)
Arenaviruses12
In view of reported high frequency of laboratory aerosol infection that occurred in workers manipulating high concentrations of Pichinde virus, it is strongly recommended that work with high concentrations of Level 2 arenaviruses be done at Level 3. (cdc.gov)
The arenaviruses are a large group of viruses that typically affect rodents. (medscape.com)
Arenaviruses are single-stranded ribonucleic acid (RNA) viruses that cause chronic asymptomatic infections in rodents and zoonotically acquired disease in humans through rodent excreta, especially urine. (medscape.com)
Arenaviruses have been divided into 2 groups based on whether the virus is found to infect Old World (ie, Eastern Hemisphere) rodents (family Muridae, subfamily Murinae) or New World (ie, Western Hemisphere) rodents (family Muridae, subfamily Sigmodontinae). (medscape.com)
The New World arenaviruses are further divided into 3 lineages designated clades: A, B, C. LCMV is the only arenavirus to exist in both areas but is classified as an Old World virus. (medscape.com)
Monoclonal antibodies prepared against Tacaribe and Junin viruses have been used to define further the serological relationships between arenaviruses of the Tacaribe complex. (microbiologyresearch.org)
We use several virus systems, but focus on lymphocytic chorimeningitis (LCMV) and Pichinde (PV) viruses, distantly related arenaviruses whose T cell responses are well defined, and on the poxvirus vaccinia (VV), which is used as a vaccine for smallpox and as a recombinant vaccine and vector for many antigens. (umassmed.edu)
A single inoculation of a plasmid encoding full-length Lassa nucleoprotein (LNP) can induce CD8 (+) T cell responses in mice and protect them against infection with two arenaviruses, LCMV and Pichinde virus (PV). (helixbiogeninstitute.org)
Like other arenaviruses, Lassa virus lacks a ogy and clinical presentation, treatment, prevention conventional negative-strand coding arrangement and control as well as the current theories of its patho- and the isolates of the virus differ in their genetic, genesis and efforts in vaccine development. (folkhalsomyndigheten.se)
LCMV2
This article divides the discussion of these viruses by clinical relevance and manifestations: Old World (Lassa virus, LCMV) and New World (South American hemorrhagic fevers). (medscape.com)
In 1934, the prototypic arenavirus, lymphocytic choriomeningitis virus (LCMV), was first isolated during serial monkey passage of human material that was obtained from a fatal infection in the first documented epidemic of St. Louis encephalitis, a totally unrelated virus. (medscape.com)
Parana1
A close relationship was found between these two viruses and the heterologous Amapari and Machupo viruses, with Pichinde virus and Parana virus being more distantly related. (microbiologyresearch.org)
Protein structure of lymphocytic choriomeningitis virus: identification of the virus structural and cell associated polypeptides. (microbiologyresearch.org)
Tacaribe2
Variants of Tacaribe virus resistant to neutralization by antibody 2.25.4 were obtained by growth in the presence of this antibody and neutralization kinetics were reexamined using the heterologous monoclonal neutralizing antibodies. (microbiologyresearch.org)
Lassa fever is an acute viral zoonotic illness caused by Lassa virus, an arenavirus known to be responsible for a severe haemorrhagic fever characterised by fever, muscle aches, sore throat, nausea, vomiting and, chest and abdominal pain. (folkhalsomyndigheten.se)
Archives of Virology1
A 2011 research paper in the journal Archives of Virology entitled , "Inhibition of Lassa virus and Ebola virus infection in host cells treated with the kinase inhibitors genistein and tyrphostin," details the pair's therapeutic role in reducing the severity of hemorrhagic fever. (beforeitsnews.com)
Lassa virus (LASV) is a mammarenavirus that can cause lethal Lassa fever disease with no FDA-approved vaccine and limited treatment options. (bvsalud.org)
Lassa virus (LASV) is a human pathogen, causing substantial morbidity and mortality1,2. (bvsalud.org)
Lassa virus infections can respond to antiviral treatment in some cases, but there is no vaccine available. (helixbiogeninstitute.org)
Helix Biogen Institute is working on a Lassa virus vaccine containing both nucleoprotein and surface glycoprotein component of the Lassa virus for endemic region. (helixbiogeninstitute.org)
The Institute is ideally placed to develop this new conjugate sub-unit vaccine to help prevent and ultimately eliminate Lassa virus in African countries where they are most needed. (helixbiogeninstitute.org)
Antibodies with broad neutralizing activity are induced by adjuvant-formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein. (helixbiogeninstitute.org)
Helix Biogen Institute is working on the development of a Lassa virus vaccine (candidate 2) which contain the surface glycoprotein component of the Lassa virus. (helixbiogeninstitute.org)
Lassa virus (LV), for example, is a common cause of disease in Africa, and survivors frequently suffer from significant neurological damage. (helixbiogeninstitute.org)
Lassa virus vaccine (candidate 3) that contains only nucleotide proteins is under development at Helix Biogen Institute. (helixbiogeninstitute.org)
Lassa fe- Lassa virus in many more districts and states in en- ver is endemic in West Africa and has been reported demic countries of the West African sub-region and from Sierra Leone, Guinea, Liberia, and Nigeria4-7. (folkhalsomyndigheten.se)
Epidemics of Lassa fever were have comprehensive information about the virus and also documented in other West African countries in- the disease it causes. (folkhalsomyndigheten.se)
Furthermore, Lassa virus has cluding Liberia, Sierra Leone, Guinea, Mali and been associated with nosocomial outbreaks with high Senegal5-7. (folkhalsomyndigheten.se)
A few cases of the importation of Lassa mortality10,11, hence, early identification of infected virus into other parts of the world for example by individuals is important for prompt implementation travellers were documented17-20. (folkhalsomyndigheten.se)
Lassa reported in English, that investigated Lassa fever with virus is spherical in shape and measures between 70 reference to West Africa were identified using the and 150 nm in diameter (Fig. 1). (folkhalsomyndigheten.se)
The following are the major viruses and the other recognized Arenaviridae listed in relationship to their rodent reservoirs. (medscape.com)
West African sub-region with consideration of the mented RNA virus belonging to the Arenaviridae origin of the virus, its properties/strains, epidemiol- family. (folkhalsomyndigheten.se)
Antibody3
The kinetics of reaction between antibody and virus were examined for all five neutralizing antibodies. (microbiologyresearch.org)
Evaluation of plaque size reduction as a method for the detection of Pichinde virus antibody. (microbiologyresearch.org)
Infection5
Memory T cells laid down as a consequence of one infection can influence protective immunity and immunopathology associated with a second unrelated virus. (umassmed.edu)
We have identified a matrix of cross-reactive epitopes between viruses, and developed both systemic and respiratory infection model systems. (umassmed.edu)
Our studies in human viral infections on heterologous immunity and cross-reactive T cell responses during Epstein Barr virus (EBV) infection only begin to scratch the surface of the prevalence and potential impact of cross-reactive T cell responses on both vaccine development and immunopathology. (umassmed.edu)
The virus exhibits persistent, asymptomatic infection with profuse urinary virus excretion in the ubiquitous rodent vector, Mastomys natalensi s. (folkhalsomyndigheten.se)
tent, asymptomatic infection, with profuse urinary virus excretion in Mastomys natalensi s, the ubiqui- The emergence of this highly virulent and contagious tous and highly commensal rodent host2,3. (folkhalsomyndigheten.se)
Evidence from animal models shows that T cells can provide heterosubtypic protection and are crucial for immune control of influenza virus infections. (mdpi.com)
Outbreak of hepatitis B and hepatitis C virus infections associated with a cardiology clinic, West Virginia, 2012-2014. (cdc.gov)
Influenza virus2
This has provided hope for the design of a universal vaccine able to prime against diverse influenza virus strains and subtypes. (mdpi.com)
Five of 8 young adult HLA-A2+ patients experiencing IM had an increased number of influenza virus (FLU)-M1 58-66 specific CD8+ T cells in their peripheral blood as compared to healthy donors. (umassmed.edu)
Murine2
Monoclonal antibodies to murine hepatitis virus-4 (strain JHM) define the viral glycoprotein responsible for attachment and cell-cell fusion. (microbiologyresearch.org)
Our studies with viruses in murine systems have focused on virus-specific memory T cell populations, which demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. (umassmed.edu)
Ebola2
Amid the mainstream media hype surrounding Ebola, it may come as major shock to discover that for quite some time there have been major scientific breakthroughs regarding the numerous ways in which we may be able to diminish or even halt the virus at a base level. (beforeitsnews.com)
Numerous plant compounds, which also come with a host of additional medicinal benefits outside of their role in the fight against the Ebola virus, have been documented to have extreme promise in the deterrence of yet another virus epidemic. (beforeitsnews.com)
Hepatitis1
Complex genetic encoding of the hepatitis B virus on-drug persistence. (cdc.gov)
Genus1
Note the virus list is broken down to genus level classification and only contains BSL2 and BSL3 non select agent pathogens. (cdc.gov)
Encephalitis1
A mosquito-borne encephalitis caused by the Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE) occurring throughout Eastern Asia and Australia. (curehunter.com)
Aseptic1
LCM virus was the first recognized cause of aseptic meningitis in humans. (medscape.com)
Immunopathology1
Molecular studies of LCM virus-induced immunopathology: development and characterization of monoclonal antibodies to LCM virus. (microbiologyresearch.org)
Respiratory1
Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis in US Mothers and Children Aged 0-2: PREVAIL Cohort Study. (cdc.gov)
Immune1
The virus infects and kills immune cells, and without effective ongoing treatment leaves the individual increasingly immunocompromised over time. (khon2.com)
Transmission1
While effective treatments have significantly extended the lives of people living with HIV and reduced the transmission of the virus, there is no cure for HIV or AIDS. (khon2.com)
Proteins1
Although genistein and tyrophostin individually inhibited the entry of these viruses into the cells, together they were able to interfere with endocytosis (the process by which a cell pulls in a virus) and uncoating proteins (the process by which a virus alters proteins on the surface of the host cell to gain entry) while also producing a synergistic effect. (beforeitsnews.com)
Entry1
Click on the PDF icon to the left to view a copy of this virus entry in PDF format. (cdc.gov)
Study1
Most of these viruses are under continuing study. (medscape.com)