Loading...
  • inhibitor
  • With readily access to key intermediates, we utilized a solution phase parallel synthesis approach and rapidly identified a highly potent PTP1B inhibitor (19, K(i)=76 nM) with moderate selectivity (5-fold) over T-cell PTPase (TCPTP) through interacting with a second phosphotyrosine binding site (site 2) in the close proximity to the catalytic site. (rcsb.org)
  • The effect of orthovanadate (phosphatase inhibitor, 10,7,10,5 m) on somatostatin's (10,5 m) actions was examined, and western blot analysis was employed to determine the presence of ssts and phosphotyrosine phosphatase SHP-1 in human RPE cells. (academicconcepts.net)