Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. (musc.edu)
PHOSPHATE2
A group of enzymes that catalyzes the transfer of a phosphate group onto a phosphate group acceptor. (bvsalud.org)
A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. (wakehealth.edu)
MeSH1
Phosphotransferases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
Phosphoryl3
The resultant structures of the active site at TS in both reactions have compact geometries but a less electron density of the phosphoryl group. (riken.jp)
Structure and literature database searches on phosphotransferases suggest that such a hybrid TS is consistent with many structures and physical organic studies and likely holds for most enzymes catalyzing phosphoryl transfer. (riken.jp)
The critical question that needed to be answered was to what extent the functionality required for the catalysis of phosphoryl transfer is conserved within the 25 families or 12 fold-groups. (biomedcentral.com)
Phosphate groups2
A class of enzymes that transfers phosphate groups and has a carboxyl group as an acceptor. (bvsalud.org)
A group of enzymes that transfers two phosphate groups from a donor such as ATP to two different acceptors. (ucdenver.edu)
Amino4
To gain an insight into the molecular mechanisms of the recognition of lipid molecules by membrane proteins, we investigated amino acid propensities in membrane proteins for interacting with the head and tail groups of lipid molecules. (riken.jp)
We also found that membrane and water-soluble proteins utilize essentially an identical set of amino acids for interacting with lipid head and tail groups. (riken.jp)
We showed that the lipophilicity of amino acid residues determines the amino acid preferences for lipid tail groups in both membrane and water-soluble proteins, suggesting that tightly-bound lipid molecules and lipids in the annular shell interact with membrane proteins in a similar manner. (riken.jp)
In contrast, interactions between lipid head groups and amino acids showed a more variable pattern, apparently constrained by each protein's specific molecular function. (riken.jp)
Residues2
A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. (nih.gov)
To this end, the putative mechanistic role of the C8 proton in the catalysis of the 22 families within the 10-fold groups was also investigated in the context of the conserved catalytic residues of each group of kinases. (biomedcentral.com)
Gene1
homeobox-containing gene with an unusual feature: a leucine zipper motif adjacent to the carboxyl-terminal of the homeodomain structure. (or.jp)
General1
These interactions are largely explained by general lipophilicity, whereas the preferences for lipid head groups vary among individual proteins. (riken.jp)
Data1
We perform QM/MM simulations for the reversible phosphorylation of phosphoserine phosphatase (PSP), which belongs to one of the largest phosphotransferase families characterized to data. (riken.jp)