- Phosphorylcholine (abbreviated ChoP) is the hydrophilic polar head group of some phospholipids, which is composed of a negatively charged phosphate bonded to a small, positively charged choline group. (wikipedia.org)
- Choline kinase (ChoK), the enzyme responsible for the generation of phosphorylcholine (PCho) from its precursor choline, is the first enzyme in the Kennedy pathway that renders phosphatidylcholine as its final product. (aacrjournals.org)
- Antibodies against phosphorylcholine are naturally occurring autoantibodies that are created by CD5+/B-1 B cells and are referred to as non-pathogenic autoantibodies. (wikipedia.org)
- In interventional cardiology, phosphorylcholine is used as a synthetic polymer-based coating, applied to drug-eluting stents, to prevent the occurrence of coronary artery restenosis. (wikipedia.org)
- Phosphorylcholine is used as the polymer-based coating of a DES because its molecular design improves surface biocompatibility and lowers the risk of causing inflammation or thrombosis. (wikipedia.org)
- https://doi.org/10.1016/0142-9612(84)90047-4 Retrieved on 2009-02-09 A.L. Lewis, L.A. Tolhurst and P.W. Stratford, Analysis of a phosphorylcholine-based polymer coating on a coronary stent pre- and post-implantation, Biomaterials 23 (2002), pp. 1697-1706. (wikipedia.org)
- The purpose of this clinical study was to analyse the bacterial composition of the denture plaque and to evaluate the changes in bacterial composition of the denture plaque before and after 2- methacryloyloxyethyl phosphorylcholine (MPC) polymer coating. (biomedres.info)
- It is coated with a phosphorylcholine containing polymer and is premounted on a 3.5 mm balloon. (bmj.com)
- Recently, a polymer containing a 2-methacryloyloxyethyl phosphorylcholine (MPC) unit was created that mimics the surface of the cornea. (news-medical.net)
- Additionally, ceramide is also converted to sphingomyelin by the addition of a phosphorylcholine headgroup by sphingomyelin synthase (SMS). (frontiersin.org)
- an inherited disorder of metabolism, caused by deficient sphingomyelinase activity, resulting in accumulation of sphingomyelin (ceramide phosphorylcholine) in reticuloendothelial cells. (msdmanuals.com)
- ABSTRACT A placebo-controlled trial compared 6% hexadecyl-phosphorylcholine (HePC) and 12% benzethonium chloride ointment with placebo ointment for treatment of cutaneous leishmaniasis. (who.int)
- 2-Methacryloyloxyethyl phosphorylcholine (MPC) is commonly used to prepare biocompatible copolymers that have delivered clinically proven benefits in various biomedical applications. (brighton.ac.uk)
- Objectives The biocompatible 2-methacryloyloxyethyl phosphorylcholine (MPC)-polymers, which mimic a biomembrane, reduce protein adsorption and bacterial adhesion and inhibit cell attachment. (tokushima-u.ac.jp)
- Hexadecyl-phosphorylcholine (HePC), an alkylphosphorylcholine compound, is the most promising of the new class of anti-tumour agent. (who.int)
- We have previously shown that excretory-secretory product-62 (ES-62), a homologue of phosphorylcholine-containing molecules that are secreted by human parasites and which is active in rodent models of filarial infection, is able to polyclonally activate certain protein tyrosine kinase and mitogen-activating protein kinase signal transduction elements in B lymphocytes. (eurekamag.com)
- The antibody responses to the T-independent type 2 antigen, phosphorylcholine (PC) and the T-dependent antigen, pneumococcal surface protein A (PspA) were characterized in C57BL/6 mice after heat-killed Streptococcus pneumoniae (HKSP) immunization and single or mixture herbicide exposure. (cdc.gov)
- PC Technology allows contact lenses to incorporate phosphorylcholine (PC), a water-loving molecule naturally found on the outside of every cell, including cells of the human eye. (lens.com)
- who showed that the phosphorylcholine component of the outer surface of the erythrocyte bilayer was non-thrombogenic. (wikipedia.org)
- Phosphorylcholine surface modified flow diverter associated with reduced intimal hyperplasia. (umassmed.edu)
- We tested the capacity for cell-free biosynthetic implants made from recombinant human collagen type III and 2-methacryloyloxyethyl phosphorylcholine (RHCIII-MPC) to suppress inflammation and promote tissue regeneration in the damaged corneas. (diva-portal.org)
- The material includes a substance that is part of human cell membranes, called phosphorylcholine (PC). (lensshopper.com)
- For targeted local delivery of Zotarolimus to the artery, the drug is incorporated into a methacrylate-based copolymer that includes a synthetic form of phosphorylcholine. (wikipedia.org)
- Until 2002, over 120,000 phosphorylcholine-coated stents have been implanted in patients with no apparent deleterious effect in the long term compared to bare metal stent technologies. (wikipedia.org)
- Treatment of cell membranes, like those of RBCs, by certain enzymes, like some phospholipase A2, renders the phosphorylcholine moiety exposed to the external aqueous phase, and thus accessible for recognition by the immune system. (wikipedia.org)
- It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. (hmdb.ca)
- For example, ENPP7 also known as alkaline sphingomyelinase (Alk-SMase) is responsible for the digestion of dietary sphingomyelin by hydrolyzing sphingomyelin into ceramide and phosphorylcholine. (rndsystems.com)
- an inherited disorder of metabolism, caused by deficient sphingomyelinase activity, resulting in accumulation of sphingomyelin (ceramide phosphorylcholine) in reticuloendothelial cells. (msdmanuals.com)
- Phosphorylcholine (abbreviated ChoP) is the hydrophilic polar head group of some phospholipids, which is composed of a negatively charged phosphate bonded to a small, positively charged choline group. (wikipedia.org)
- Using mass spectrometry and murine upper airway infection models, we demonstrated that phosphorylcholine (ChoP) moieties that are shared by PAF and the bacterial cell wall allow S. pneumoniae to leverage a ChoP-remodeling enzyme (Pce) to remove PAF from the airway. (nih.gov)
- OxPAPC is generated by the oxidation of 1-palmitoyl-2-arachidonyl-sn-glycero- 3-phosphorylcholine (PAPC), a major component of mammalian cell membranes that becomes oxidized by reactive oxygen species (ROS) released from dead or dying cells [2]. (invivogen.com)
- For targeted local delivery of Zotarolimus to the artery, the drug is incorporated into a methacrylate-based copolymer that includes a synthetic form of phosphorylcholine. (wikipedia.org)
- 15. Cell adhesion on phase-separated surface of block copolymer composed of poly(2-methacryloyloxyethyl phosphorylcholine) and poly(dimethylsiloxane). (nih.gov)
- PC Technologyâ„¢ allows lenses to incorporate phosphorylcholine (PC), a highly hydrophilic compound naturally found in the cells of the eye and through the body. (coopervision.com)
- 16. Superlubricious surface mimicking articular cartilage by grafting poly(2-methacryloyloxyethyl phosphorylcholine) on orthopaedic metal bearings. (nih.gov)
- The innovative construction of the lenses utilizes advanced PC Technology, which is composed of molecules of phosphorylcholine. (lens.com)