Phosphoribosyl pyrophosphate (PRPP) is a pentose phosphate. (wikipedia.org)
Decreased levels of hypoxanthine guanine phosphoribosyl transferase (HGPRT) causes this accumulation, as PRPP is a substrate used by HGPRT during purine salvage. (wikipedia.org)
The PRPS1 gene provides instructions for making an enzyme called phosphoribosyl pyrophosphate synthetase 1, or PRPP synthetase 1. (medlineplus.gov)
This enzyme helps produce a molecule called phosphoribosyl pyrophosphate (PRPP). (medlineplus.gov)
An improved method for the determination of 5-phosphoribosyl-1-pyrophosphate (PRPP) in red blood cells is presented. (tau.ac.il)
Adenine phosphoribosyltransferase from the protozoan parasite Leishmania donovani has been crystallized in the presence of the substrate Mg 2+ -α- D-5-phosphoribosyl-1-pyrophosphate (PRPP) or the product adenosine-5- monophosphate, as well as in the absence of ligand. (elsevierpure.com)
abstract = "Adenine phosphoribosyltransferase from the protozoan parasite Leishmania donovani has been crystallized in the presence of the substrate Mg2+ -α- D-5-phosphoribosyl-1-pyrophosphate (PRPP) or the product adenosine-5- monophosphate, as well as in the absence of ligand. (elsevierpure.com)
Purine2
The genetic and functional basis of purine nucleotide feedback-resistant phosphoribosylpyrophosphate synthetase superactivity. (medlineplus.gov)
Chick liver, in comparison with rat liver, was found to contain a high activity of purine synthesis de novo, a high content and availability of 5-phosphoribosyl 1-pyrophosphate (PP-rib-P), comparable activity of PP-rib-P synthetase, and low activity of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and of adenine phosphoribosyltransferase (APRT). (tau.ac.il)
PRPS13
Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1). (nih.gov)
At least seven mutations in the PRPS1 gene that cause a severe form of phosphoribosylpyrophosphate synthetase superactivity (PRS superactivity) have been identified. (medlineplus.gov)
Accelerated transcription of PRPS1 in X-linked overactivity of normal human phosphoribosylpyrophosphate synthetase. (medlineplus.gov)
Synthetase13
Phosphoribosylpyrophosphate synthetase superactivity (PRS superactivity) is characterized by the overproduction and accumulation of uric acid (a waste product of normal chemical processes) in the blood and urine. (medlineplus.gov)
The PRPS1 gene provides instructions for making an enzyme called phosphoribosyl pyrophosphate synthetase 1, or PRPP synthetase 1. (medlineplus.gov)
This intronless gene is specifically expressed in the testis, and encodes a protein that is highly homologous to the two subunits of phosphoribosylpyrophosphate synthetase encoded by human X-linked genes, PRPS1 and PRPS2. (nih.gov)
A human testis-specific mRNA for phosphoribosylpyrophosphate synthetase that initiates from a non-AUG codon. (nih.gov)
Promoter regions of the human X-linked housekeeping genes PRPS1 and PRPS2 encoding phosphoribosylpyrophosphate synthetase subunit I and II isoforms. (nih.gov)
Phosphoribosylpyrophosphate synthetase (PRS) superactivity comprises two phenotypes, both characterized by hyperuricemia and hyperuricosuria. (nih.gov)
Here we report the first three-dimensional structure of a phosphoribosylpyrophosphate (PRPP) synthetase. (rcsb.org)
17. Mutant feedback-resistant phosphoribosylpyrophosphate synthetase associated with purine overproduction and gout. (nih.gov)
In a series of experiments in both the lab and in mice, the researchers were able to determine that there is an important enzyme involved in nucleotide synthesis, called phosphoribosyl pyrophosphate synthetase 1 (PRPS1), that is modified by O -G1cNAc. (eurekalert.org)
We also found that, among the differentially expressed kinases, phosphoribosyl pyrophosphate synthetase 2 (PRPS2) promotes the migration and invasion of cultured CRC cells through regulating the activity of matrix metalloproteinase 9 (MMP-9) and the expression of E-cadherin. (nih.gov)
Phosphoribosyl pyrophosphate synthetase (PRPS) is a key enzyme of this pathway and plays a central role in the synthesis of purines and pyrimidines. (ukrbiochemjournal.org)
Mutations in the 5'-phosphoribosyl-1-pyrophosphate (PRPP) synthetase genes can result in overactivity of the pathway, leading ultimately to increased urate production. (sagepub.com)
Transferase5
similar effects on phosphoribosyl-pyrophosphate amido transferase, orotidine-monophosphate decarboxylase, and both nucleoside and nucleotide kinases were observed. (nih.gov)
The third and fifth genes involved in this pathway showed high up-regulation during biotrophic stages and down-regulation during necrotrophy, whereas the uracil phosphoribosyl transferase gene involved in pyrimidine salvage showed the inverse behavior. (unboundmedicine.com)
APRT means Adenosyl Phosphoribosyl Transferase (APRTase). (tripoeste.com.br)
The origin of the enzyme amino phosphoribosyl transferase is inhibited by its product. (tripoeste.com.br)
Two major genetic mutations lead to gout, urolithiasis, and related problems: Mutations in the gene that encodes hypoxanthine-guanine phosphoribosyl transferase are associated with a spectrum of diseases in children, which ranges from the Lesch-Nyhan syndrome at the severe end of the spectrum to simple hyperuricemia at the mild end. (sagepub.com)
Enzyme1
An enzyme that catalyzes the formation of phosphoribosyl pyrophosphate from ATP and ribose-5-phosphate. (bvsalud.org)
Nucleotide synthesis1
They found that UBR7 interacts with a group of phosphoribosyl pyrophosphate synthetases (PRPSs), essential enzymes for nucleotide synthesis. (northwestern.edu)
Pathway engineering in vitro from HMP pathway form 5-phosphoribosyl-1-amine ( PRA ) is condensed with it. (tripoeste.com.br)
PRRP though becomes committed particularly to purine biosynthesis when PRRP is converted into 5-phosphoribosyl amine by having the pyrophosphate of PRRP replaced by the amide group of glutamine. (biologyonline.com)
Biosynthesis1
One includes the part it plays in the nicotinamide adenine dinucleotide biosynthesis process , catalyzing the nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide. (prospecbio.com)