• PDE4
  • PDE4 inhibitors may have antidepressive effects and have also recently been proposed for use as antipsychotics. (wikipedia.org)
  • Treatment with a PDE4 inhibitor raised the deficient cAMP levels and restored some functionality to Hippocampus-based memory functions. (wikipedia.org)
  • Here, we review a decade-long exploration of the contribution of cyclic-AMP and PDE4 to the pathogenesis of B-cell lymphoma, 5 ⇓ ⇓ ⇓ - 9 culminating with the first-in-cancer clinical trial of a PDE4 inhibitor in advanced B-cell malignancies. (bloodjournal.org)
  • PDE4 also regulates the D1/PKA/DARPP-32 signalling cascade in the frontal cortex, which may contribute to the antipsychotic and procognitive effects of PDE4 inhibitors. (wikipedia.org)
  • Nausea, vomiting, and related general gastrointestinal side effects are the most commonly implicated side effects of PDE4 inhibitors. (wikipedia.org)
  • isoenzymes
  • 11, 150-155, 1990) these are the phosphodiesterase isoenzymes PDE-I, PDE-II and PDE-V. An increase of the cGMP concentration can lead to beneficial antiaggregatory, antithrombotic, antiprolific, antivasospastic, vasodilative, natriuretic and diuretic effects. (patentsencyclopedia.com)
  • theophylline
  • Bronchodilatory substances such as the phosphodisterase inhibitor (PDE-I) theophylline stimulate mucociliary activity. (lu.se)
  • subtypes
  • The different forms or subtypes of phosphodiesterase were initially isolated from rat brains by Uzunov and Weiss in 1972 and were soon afterward shown to be selectively inhibited in the brain and in other tissues by a variety of drugs. (wikipedia.org)
  • These multiple forms (isoforms or subtypes) of phosphodiesterase were isolated from rat brain using polyacrylamide gel electrophoresis in the early 1970s, and were soon afterward shown to be selectively inhibited by a variety of drugs in brain and other tissues. (wikipedia.org)
  • therapeutics
  • However, notably absent from these efforts is a detailed examination of PDE inhibitors in cancer therapeutics. (bloodjournal.org)
  • PDE inhibitors have been identified as new potential therapeutics in areas such as pulmonary arterial hypertension, coronary heart disease, dementia, depression, asthma, COPD, protozoal infections (including malaria) and schizophrenia. (wikipedia.org)
  • effect
  • In addition, using of a PDE inhibitor (pentoxifylline) in pentylenetetrazole-induced seizure indicated the antiepileptic effect by increasing the time latency to seizure incidence and decreasing the seizure duration in vivo. (wikipedia.org)