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PhosphocreatineMagnetic Resonance SpectroscopyCreatineAdenosine TriphosphateEnergy MetabolismPhosphatesPhosphorus IsotopesCreatine KinasePhosphorusMuscle, SkeletalCreatine Kinase, BB FormAdenosine DiphosphateLactatesCreatine Kinase, MM FormLactic AcidOxygen ConsumptionCreatine Kinase, Mitochondrial FormHydrogen-Ion ConcentrationOxidative PhosphorylationGlycolysisMitochondria, MuscleMusclesMyocardiumExerciseMuscle ContractionGuanidinoacetate N-MethyltransferaseGlycogenAdenine NucleotidesAspartic AcidHypoxia, BrainBrainMuscle FatigueAdenosine MonophosphateInosine MonophosphateDichloroacetic AcidPhysical ExertionPhosphorus CompoundsErgometryKineticsPerfusionPhysical Conditioning, HumanCholineIodoacetic AcidRats, Inbred StrainsOxygenBrain ChemistryAcetylcarnitineMyocardial ContractionAcidosisGlycerylphosphorylcholineIodoacetatesIsometric ContractionPerhexilineGlucoseHeartPyruvate Dehydrogenase ComplexRestDinitrofluorobenzeneProtonsPyruvic AcidTime FactorsPropionatesMitochondria, HeartLegMagnetic Resonance ImagingPhysical EnduranceAmidinotransferasesPyruvatesAdenylate KinaseAnoxiaBrain IschemiaQuadriceps MuscleRats, Wistar

Form of phosphocreatineKnown as creatine phosphateMusclesCreatine kinasePhosphorylationAdenosine triphosphateMusclePhosphate groupCompoundHigh-intensity exerciseFatsReplenishPancreasEnergyBrainBody weightProduction of phosphocreatineMagnetic Resonance SpGlycogenMyocardiumResynthesisControlled substanceSkeletalPhosphateRegenerationMoleculeBoostsAdenosineEnzymeTissuesConvertBodySystemRoleLevelsExercise

Form of phosphocreatine3

• Creatine is a substance that is found naturally in muscle cells (about 95% of your body's creatine is stored in muscles in the form of phosphocreatine). (nutrition-nation.com)
• It stores high-energy phosphate groups in the form of phosphocreatine. (beforethemusicdies.com)
• Muscles store ATP in the form of phosphocreatine. (beforethemusicdies.com)

Known as creatine phosphate2

• Phosphocreatine, also known as creatine phosphate (CP) or PCr (Pcr), is a phosphorylated form of creatine that serves as a rapidly mobilizable reserve of high-energy phosphates in skeletal muscle, myocardium and the brain to recycle adenosine triphosphate, the energy currency of the cell. (wikipedia.org)
• The researchers were interested in measuring phosphocreatine, also known as creatine phosphate (Pcr), as this provides a rapidly mobilised reserve of high-energy phosphates released during exercise. (mynewsdesk.com)

Muscles9

• It works by increasing phosphocreatine stores in your muscles. (healthline.com)
• Most creatine goes to your skeletal muscles, which convert creatine into a compound of creatine and phosphoric acid (phosphocreatine or creatine phosphate). (runningahead.com)
• Your muscles add a phosphate group to creatine to create phosphocreatine and charge it with energy. (livestrong.com)
• During exercise, phosphocreatine recharges ATP, adenosine triphosphate, the primary source of energy in your muscles. (livestrong.com)
• During exercise, phosphocreatine is used as an energy source, lowering its concentration in the muscles, and vO2 is increased as the lungs take in more oxygen. (mynewsdesk.com)
• When it combines with phosphate in your muscles, it becomes phosphocreatine, fuel for cellular metabolism. (greatist.com)
• Once ingested, the creatine is transported to your muscles where it is converted into phosphocreatine. (wowio.com)
• The phosphocreatine is then stored in our muscles where it is used to create energy. (wowio.com)
• Once it reaches the muscles, it is converted into phosphocreatine (creatine phosphate). (a1supplements.com)

Creatine kinase3

• Once inside the cells it is transformed into phosphocreatine by the enzyme complex creatine kinase. (wikipedia.org)
• By increasing intracellular creatine content, oral creatine ingestion conceivably stimulates operation of the creatine kinase (CK)/phosphocreatine (PCr) system, which in turn facilitates muscle relaxation. (nih.gov)
• Our range of Phosphocreatine Kinase antibodies (also known as Creatine Kinase (CK) or Creatine Phosphokinase (CPK)) come in a selection of different formats and can be used for applications including western blotting and ELISA . (bio-rad-antibodies.com)

Phosphorylation1

• In the youngest patient, a 13 year old girl with retinitis pigmentosa, ataxia, and psychomotor retardation, there was an alteration of brain energy metabolism shown by a decreased phosphocreatine content, increased [ADP] and decreased phosphorylation potential. (nih.gov)

Adenosine triphosphate3

• Phosphocreatine is able to donate its phosphate group to convert adenosine diphosphate (ADP) into adenosine triphosphate (ATP). (wikipedia.org)
• Phosphocreatine then helps create adenosine triphosphate (ATP). (runningahead.com)
• The research team assessed neuropathology, adenosine triphosphate and phosphocreatine concentrations as well as CaM kinase IV activity. (news-medical.net)

Muscle8

• Phosphocreatine plays a particularly important role in tissues that have high, fluctuating energy demands such as muscle and brain. (wikipedia.org)
• Nongenomic effects of aldosterone on phosphocreatine levels in human calf muscle during recovery from exercise. (uni-muenchen.de)
• phosphocreatine - (= creatine phosphate) Present in high concentration (about 20mM) in striated muscle, and is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. (en-academic.com)
• The energy metabolism of her skeletal muscle was also abnormal, as shown by resting higher inorganic phosphate and lower phosphocreatine concentrations than in normal subjects. (nih.gov)
• The second method, phosphate synthesis, uses energy from phosphocreatine stored in the muscle cells. (beforethemusicdies.com)
• What Anvarol basically does, is increasing phosphocreatine formation within the muscle tissue cells. (selfgrowth.com)
• Although Phosphocreatine doesn't act as a direct muscle fuel, it's still considered a valuable factor that contributes to the improvement of strength and energy metabolism within the muscle tissue. (selfgrowth.com)
• Depletion of phosphocreatine can result in muscular fatigue and fading muscle power. (a1supplements.com)

Phosphate group1

• Phosphocreatine can anaerobically donate a phosphate group to ADP to form ATP during the first five to eight seconds of a maximal muscular effort. (wikipedia.org)

Compound1

• Phosphocreatine is a creatine compound made-up of three key amino acids: Glycine, Arginine, and Methione. (selfgrowth.com)

High-intensity exercise1

• In high-intensity exercise, its primary role is to increase phosphocreatine. (nutrition-nation.com)

Fats1

• These compounds are phosphocreatine (PCr), carbohydrates, fats and proteins. (hypertextbook.com)

Replenish1

• as ATP levels diminish with muscular exertion, the phosphoryl group of phosphocreatine can be donated to ADP to replenish ATP. (en-academic.com)

Pancreas1

• Although certain amounts of phosphocreatine are produced by the liver, kidneys and pancreas on their own, levels of the substance significantly drop with age and other factors that contribute to its natural decline. (selfgrowth.com)

Energy2

• When you supplement, your stores of phosphocreatine increase and helps your body produce more of a high-energy molecule called ATP. (nutrition-nation.com)
• It is converted to phosphocreatine which is important for short energy bursts such as sprinting and weightlifting. (a1supplements.com)

Brain2

• In the first minute after stoppage of blood flow to the brain, ATP in neurons is primarily regenerated from ADP by phosphate from PhosphoCreatine ( PCr ). (benbest.com)
• Creatine can also increase the amount of phosphocreatine in your brain, which may help with your memory. (runningahead.com)

Body weight1

• After isometric contraction of the calf (50% body weight for 3 min), phosphocreatine recovered to significantly higher levels after application of aldosterone compared with placebo. (uni-muenchen.de)

Production of phosphocreatine2

• It boosts energy by increasing the production of phosphocreatine in the muscle tissue. (slimtree.com)
• Creatine (creatine monohydrate) is a colorless, crystalline substance used in muscle tissue for the production of phosphocreatine, an important factor in the formation of adenosine triphosphate (ATP), the source of energy for muscle contraction and many other functions in the body. (modelwelt.net)

Magnetic Resonance Sp1

• Mitochodrial muscle bioenergetics was assessed as post-exercise recovery rate of phosphocreatine by phosphorus magnetic resonance spectroscopy. (nih.gov)

Glycogen2

• 05) with AMPK activity were found between end-exercise muscle glycogen, exercise intensity, and muscle metabolites phosphocreatine, creatine, and free ADP. (springer.com)
• Stored fuel in your muscles (in the form of phosphocreatine and glycogen) provide immediate but limited energy for high-intensity activity. (stack.com)

Myocardium3

• Phosphocreatine, also known as creatine phosphate (CP) or PCr (Pcr), is a phosphorylated form of creatine that serves as a rapidly mobilizable reserve of high-energy phosphates in skeletal muscle, myocardium and the brain to recycle adenosine triphosphate, the energy currency of the cell. (wikipedia.org)
• Although injury of myocardium after percutaneous coronary intervention (PCI) has been reported, the mechanism and effect of exogenous phosphocreatine (PCr) supplementation on the injury are yet to be elucidated. (nih.gov)
• Phosphocreatine restores high-energy phosphates in ischemic myocardium: implication for off-pump cardiac revascularization. (cdc.gov)

Resynthesis1

• Active rest between sets may not allow complete myoglobin reoxygenation and/or phosphocreatine resynthesis. (muscleandfitness.com)

Controlled substance1

• Phosphocreatine is used intravenously in hospitals in some parts of the world for cardiovascular problems under the name Neoton, and also used by some professional athletes, as it is not a controlled substance. (wikipedia.org)

Skeletal1

• Most creatine goes to your skeletal muscles, which convert creatine into a compound of creatine and phosphoric acid (phosphocreatine or creatine phosphate). (runningahead.com)

Phosphate3

• Phosphocreatine is able to donate its phosphate group to convert adenosine diphosphate (ADP) into adenosine triphosphate (ATP). (wikipedia.org)
• Phosphocreatine can anaerobically donate a phosphate group to ADP to form ATP during the first five to eight seconds of a maximal muscular effort. (wikipedia.org)
• Creatine kinases are a small family of related genes whose protein products generate phosphocreatine, which serves as a source of high energy phosphate for rapid regeneration of ATP. (nih.gov)

Regeneration1

• The cell's ability to generate phosphocreatine from excess ATP during rest, as well as its use of phosphocreatine for quick regeneration of ATP during intense activity, provides a spatial and temporal buffer of ATP concentration. (wikipedia.org)

Molecule1

• In the body, creatine is changed into a molecule called "phosphocreatine" which serves as a storage reservoir for quick energy. (modelwelt.net)

Boosts1

• Creatine has gained popularity because it purportedly boosts intracellular phosphocreatine, a major energy source during high-intensity exercise like weight lifting. (natap.org)

Adenosine2

• Phosphocreatine then helps create adenosine triphosphate (ATP). (runningahead.com)
• In its phosphorylated form, Phosphocreatine, creatine helps rapidly resynthesize adenosine triphophate (ATP). (tigerfitness.com)

Enzyme2

• Once inside the cells it is transformed into phosphocreatine by the enzyme complex creatine kinase. (wikipedia.org)
• This enzyme is responsible for converting glucose into phosphocreatine (PCr). (phunkphenomenon.com)

Tissues1

• Creatine and phosphocreatine are intimately involved with maintenance of ATP levels and are therefore found in high concentrations in tissues that maintain high metabolic loads, like the retina. (utah.edu)

Convert2

• citation needed] Conversely, excess ATP can be used during a period of low effort to convert creatine back to phosphocreatine. (wikipedia.org)
• When you work out hard, your body can run out of phosphocreatine to convert into ATP, which causes exhaustion and fatigue. (prolab.com)

Body2

• It is converted in the body to phosphocreatine, which is important in blast sports. (nutri-mx.com)
• The body changes creatine to phosphocreatine. (wikipedia.org)

System1

• This creatine/phosphocreatine/CK system maintains the brain's ATP homeostasis, which affects neurotransmitter release, membrane potential, Ca2 + homeostasis and/or ion gradients. (jax.org)

Role1

• Magnesium also plays a role in converting creatine into phosphocreatine by activating creatine kinase. (purebulk.com)

Levels1

• Prof. Lloyd expressed concern that prolonged intake of creatine could result in increased levels of cellular creatine and phosphocreatine, as the study itself found. (medicalnewstoday.com)

Exercise1

• Interventions and Main Outcome Measures: Phosphocreatine (PCr) recovery was evaluated by 31 phosphorous-MRS after submaximal exercise. (northwestern.edu)

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