• As a polar head group, phosphatidylethanolamine creates a more viscous lipid membrane compared to phosphatidylcholine. (wikipedia.org)
  • For example, the melting temperature of di-oleoyl-phosphatidylethanolamine is -16 °C while the melting temperature of di-oleoyl-phosphatidylcholine is -20 °C. If the lipids had two palmitoyl chains, phosphatidylethanolamine would melt at 63 °C while phosphatidylcholine would melt already at 41 °C. Lower melting temperatures correspond, in a simplistic view, to more fluid membranes. (wikipedia.org)
  • The synthesis of endocannabinoid anandamide is performed from the phosphatidylethanolamine by the successive action of 2 enzymes, the N-acetyltransferase and phospholipase-D. Where phosphatidylcholine is the principal phospholipid in animals, phosphatidylethanolamine is the principal one in bacteria. (wikipedia.org)
  • Whereas the phosphate group is combined with choline in phosphatidylcholine, it is combined with ethanolamine in phosphatidylethanolamine. (wikipedia.org)
  • In a process that mirrors phosphatidylcholine synthesis, phosphatidylethanolamine is also made via the cytidine diphosphate-ethanolamine pathway, using ethanolamine as the substrate. (wikipedia.org)
  • LPA is a membrane-derived lysophospholipid from phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylethanolamine (PE) [ 7 ]. (hindawi.com)
  • Phosphatidylethanolamine is also thought to play a role in blood clotting, as it works with phosphatidylserine to increase the rate of thrombin formation by promoting binding to factor V and factor X, two proteins which catalyze the formation of thrombin from prothrombin. (wikipedia.org)
  • The phosphatidylserine decarboxylation pathway and the cytidine diphosphate-ethanolamine pathways are used to synthesize phosphatidylethanolamine. (wikipedia.org)
  • The phosphatidylserine decarboxylation pathway is the main source of synthesis for phosphatidylethanolamine in the membranes of the mitochondria. (wikipedia.org)
  • Phosphatidylethanolamine (PE) is frequently the main lipid component of microbial membranes and the second most abundant phospholipid in mammals, comprising as much as 45% of brain lipids. (matreya.com)
  • Surprisingly, bacteria in the stationary phase produced N-acyl-phosphatidylethanolamine (NAPE) and another rare lipid we tentatively name as 1-phosphatidyl-2-acyl-glycero-3-phosphoethanolamine (PAGPE) based on tandem mass spectrometry. (nature.com)
  • Its unique signature that distinguishes it from other forms of cell death is the formation and accumulation of lipid hydroperoxides, particularly oxidized forms of polyunsaturated phosphatidylethanolamines (PEs), which drives cell death. (cdc.gov)
  • Phosphatidylethanolamine (PE) is a class of phospholipids found in biological membranes. (wikipedia.org)
  • Phosphatidylethanolamines are found in all living cells, composing 25% of all phospholipids. (wikipedia.org)
  • One of the primary roles for phosphatidylethanolamine in bacterial membranes is to spread out the negative charge caused by anionic membrane phospholipids. (wikipedia.org)
  • This strain produced triglycerides (TG) as well as four common phospholipids: phosphatidylethanolamine (PE), phosphatidylglycerol (PG), cardiolipin (CL) and lysocardiolipin (LCL). (nature.com)
  • Phosphatidylethanolamines (cephalins, PtdEtn, GPEtn, or PE) belong to the group of ester phospholipids within the phospholipids. (lipotype.com)
  • The predominant phospholipids were phosphatidylethanolamine, phosphatidylglycerol and cardiolipin. (microbiologyresearch.org)
  • NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al. (novusbio.com)
  • While CL increases, the two predominant lipids phosphatidylglycerol (PG) and phosphatidylethanolamine (PE) of the exponential growth phase decrease as B. subtilis enters stationary phase 6 . (nature.com)
  • Phosphatidylethanolamine produced in the mitochondrial membrane is also transported throughout the cell to other membranes for use. (wikipedia.org)
  • Phosphatidylethanolamine is the second most abundant phospholipid in mammalian cells. (alfa-chemistry.com)
  • Phosphatidylethanolamine is a non-bilayer formed phospholipid containing small polar heads proportional to the diameter of its fatty acid chain. (alfa-chemistry.com)
  • Concurrent decrease in phosphatidylethanolamine content from 23% of total phospholipid to 7%, accumulation of 14C-PL to 2.6% of total phospholipid, and increase in lysophosphatidylethanolamine from 1 to 7% of total phospholipid durkng 2-hexanone + 14CHCl3 treatment indicated that the amine moiety of phosphatidylethanolamine polar head groups was the probable target of phosgene -lipid interaction, and that a degradative pathway existed which removed the abnormal phospholipid from hepatic membranes. (cdc.gov)
  • No phospholipid other than phosphatidylethanolamine was depleted. (cdc.gov)
  • As a lecithin, phosphatidylethanolamine consists of a combination of glycerol esterified with two fatty acids and phosphoric acid. (wikipedia.org)
  • Phosphatidylethanolamine is an important precursor, substrate, or donor in several biological pathways. (wikipedia.org)
  • Phosphatidylethanolamine-binding protein is the precursor of hippocampal cholinergic neurostimulating peptide, which is cleaved from the N-terminal region of the protein. (bvsalud.org)
  • In humans, metabolism of phosphatidylethanolamine is thought to be important in the heart. (wikipedia.org)
  • Phosphatidylethanolamine metabolism in health and disease. (alfa-chemistry.com)
  • Additionally, it is thought that phosphatidylethanolamine regulates membrane curvature. (wikipedia.org)
  • Phosphatidylethanolamine is composed of glycerol, two fatty acids and phosphoric acid, where the ethanolamine is attached to the phosphoric acid group. (alfa-chemistry.com)
  • The glycerol molecules in phosphatidylethanolamine esterify at the sn-1 and sn-2 positions to form acid chain fatty acids with 16 to 20 carbon atoms. (alfa-chemistry.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Phosphatidylethanolamine Binding Protein 1 (PEBP1) in tissue homogenates, cell lysates and other biological fluids. (marchforscienceshop.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Phosphatidylethanolamine Binding Protein 1 (PEBP1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (marchforscienceshop.com)
  • Description: A sandwich ELISA kit for detection of Phosphatidylethanolamine Binding Protein 1 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (marchforscienceshop.com)
  • Results: Increased concentrations of beta-synuclein, gamma-synuclein, neurogranin, phosphatidylethanolamine-binding protein 1, and 14-3-3 proteins were observed in AD patients compared to controls, while neuronal pentraxin-2 and. (lu.se)
  • A ubiquitously found basic protein that binds to phosphatidylethanolamine and NUCLEOTIDES. (bvsalud.org)
  • Phosphatidylethanolamines interact with a wide range of proteins, thus influencing biological processes such as neuronal development or signaling pathways. (lipotype.com)
  • Phosphatidylethanolamines serve as key building blocks for biological membranes. (lipotype.com)
  • Phosphatidylethanolamine has also shown to be able to propagate infectious prions without the assistance of any proteins or nucleic acids, which is a unique characteristic of it. (wikipedia.org)
  • Phosphatidylethanolamine series are important excipients for nucleic acid delivery. (alfa-chemistry.com)
  • During model studies, 12% phosgene in toluene was reacted with liver phosphatidylethanolamine for 6 hr at 37 degrees C. Two reaction products were formed, further substantiating that phosphatidylethanolamine (PE) may react with [14C] phosgene in liver. (cdc.gov)
  • Alfa Chemistry supplies a wide range of phosphatidylethanolamine products for companies researching vaccines. (alfa-chemistry.com)
  • Phosphatidylethanolamines play a role in membrane fusion and in disassembly of the contractile ring during cytokinesis in cell division. (wikipedia.org)
  • In the bacterium E. coli, phosphatidylethanolamine play a role in supporting lactose permeases active transport of lactose into the cell, and may play a role in other transport systems as well. (wikipedia.org)
  • When phosphatidylethanolamine is not present, the transport proteins have incorrect tertiary structures and do not function correctly. (wikipedia.org)
  • Phosphatidylethanolamine also enables bacterial multidrug transporters to function properly and allows the formation of intermediates that are needed for the transporters to properly open and close. (wikipedia.org)
  • ABCA4 enables this process by moving all- trans retinal into the cytoplasm, likely in the form of its phosphatidylethanolamine (PE) conjugates, N-retinylidene-PE ( Figure 1A ). (elifesciences.org)
  • When blood flow to the heart is restricted, the asymmetrical distribution of phosphatidylethanolamine between membrane leaflets is disrupted, and as a result the membrane is disrupted. (wikipedia.org)