• Phenylethylmalonamide (PEMA) is an active metabolite of the anticonvulsant drug primidone, although it is produced in a much lower concentration than phenobarbital, the other active metabolite. (wikipedia.org)
  • Primidone per se has anticonvulsant activity as do its two metabolites, phenobarbital and phenylethylmalonamide (PEMA). (ebmconsult.com)